Xiangyong Hao
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View article: Integrated analysis of the prognostic and immunotherapeutic significance of ZEB1-AS1 in hepatocellular carcinoma
Integrated analysis of the prognostic and immunotherapeutic significance of ZEB1-AS1 in hepatocellular carcinoma Open
Background Zinc finger E-box binding homeobox 1 antisense 1 (ZEB1-AS1) is a lncRNA related to the progression of several malignancies and a regulator of oncogenesis in several cancers. Therefore, the aim of our study was to explore the pro…
View article: Predictive value of biomarkers for lenvatinib in hepatocellular carcinoma
Predictive value of biomarkers for lenvatinib in hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is a highly lethal disease that exhibits a rising global incidence, and most HCC patients are at an advanced stage at the time of diagnosis. Although lenvatinib has become the first-line option for HCC and it…
View article: Prophylactic effects of nutrition, dietary strategies, exercise, lifestyle and environment on nonalcoholic fatty liver disease
Prophylactic effects of nutrition, dietary strategies, exercise, lifestyle and environment on nonalcoholic fatty liver disease Open
Nutrition, dietary strategies, exercise, lifestyle and environment play an important role in the prevention of NAFLD. Moreover, this review offers comprehensive prevention recommendations for people at high risk of NAFLD.
View article: Strategies to enhance the therapeutic efficacy of anti-PD-1 antibody, anti-PD-L1 antibody and anti-CTLA-4 antibody in cancer therapy
Strategies to enhance the therapeutic efficacy of anti-PD-1 antibody, anti-PD-L1 antibody and anti-CTLA-4 antibody in cancer therapy Open
Although immune checkpoint inhibitors (anti-PD-1 antibody, anti-PD-L1 antibody, and anti-CTLA-4 antibody) have displayed considerable success in the treatment of malignant tumors, the therapeutic effect is still unsatisfactory for a portio…
View article: Analysis of the characteristics, efficiency, and influencing factors of third-party mediation mechanisms for resolving medical disputes in public hospitals in China
Analysis of the characteristics, efficiency, and influencing factors of third-party mediation mechanisms for resolving medical disputes in public hospitals in China Open
View article: Impact of hepatic inflammation and fibrosis on the recurrence and long-term survival of hepatitis B virus-related hepatocellular carcinoma patients after hepatectomy
Impact of hepatic inflammation and fibrosis on the recurrence and long-term survival of hepatitis B virus-related hepatocellular carcinoma patients after hepatectomy Open
View article: Impact of hepatic inflammation and fibrosis on the recurrence and long-term survival of hepatitis B virus-related hepatocellular carcinoma patients after hepatectomy
Impact of hepatic inflammation and fibrosis on the recurrence and long-term survival of hepatitis B virus-related hepatocellular carcinoma patients after hepatectomy Open
Background: Underlying liver disease is correlated with hepatocellular carcinoma (HCC) development in patients with hepatitis B virus (HBV) infection. However, the impact of hepatic inflammation and fibrosis on the patients’ prognoses rema…
View article: Preoperative prediction and risk assessment of microvascular invasion in hepatocellular carcinoma
Preoperative prediction and risk assessment of microvascular invasion in hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is one of the most common and highly lethal tumors worldwide. Microvascular invasion (MVI) is a significant risk factor for recurrence and poor prognosis after surgical resection for HCC patients. Accurately …
View article: Analysis of the characteristics, efficiency, and influencing factors of third-party mediation mechanisms for resolving medical disputes in public hospitals in China using 5,948 cases
Analysis of the characteristics, efficiency, and influencing factors of third-party mediation mechanisms for resolving medical disputes in public hospitals in China using 5,948 cases Open
Background: Medical disputes, which are prevalent in China, are a growing global public health problem. The Chinese government has proposed third-party mediation (TPM) to resolve this issue. However, the characteristics, efficiency, and in…
View article: Analysis of the characteristics and risk factors affecting the judgment results of medical damage liability disputes in 3172 second-instance and retrial cases in China
Analysis of the characteristics and risk factors affecting the judgment results of medical damage liability disputes in 3172 second-instance and retrial cases in China Open
Background Medical disputes remain a global public health problem. However, an analysis of the characteristics and risk factors affecting the judgment results of medical damage liability disputes in second-instance and retrial cases in Chi…
View article: The efficacy and safety of glucocorticoid for perioperative patients with hepatectomy: a systematic review and meta-analysis
The efficacy and safety of glucocorticoid for perioperative patients with hepatectomy: a systematic review and meta-analysis Open
Glucocorticoids have been used in patients undergoing perioperative hepatectomy, however their safety and efficacy remain controversial. This meta-analysis was conducted to investigate this issue and further provide reference for clinical …
View article: Early predictive value of circulating biomarkers for sorafenib in advanced hepatocellular carcinoma
Early predictive value of circulating biomarkers for sorafenib in advanced hepatocellular carcinoma Open
Sorafenib is currently the first-line therapeutic regimen for patients with advanced hepatocellular carcinoma (HCC). However, many patients did not experience any benefit and suffered extreme adverse events and heavy economic burden. Thus,…
View article: N-2-(phenylamino) benzamide derivatives as novel anti-glioblastoma agents: Synthesis and biological evaluation
N-2-(phenylamino) benzamide derivatives as novel anti-glioblastoma agents: Synthesis and biological evaluation Open
View article: A novel DNA methylation-based model that effectively predicts prognosis in hepatocellular carcinoma
A novel DNA methylation-based model that effectively predicts prognosis in hepatocellular carcinoma Open
Purpose: To build a novel predictive model for hepatocellular carcinoma (HCC) patients based on DNA methylation data. Methods: Four independent DNA methylation datasets for HCC were used to screen for common differentially methylated genes…
View article: Ribosome assembly factor URB1 contributes to colorectal cancer proliferation through transcriptional activation of ATF4
Ribosome assembly factor URB1 contributes to colorectal cancer proliferation through transcriptional activation of ATF4 Open
Ribosome assembly factor URB1 is essential for ribosome biogenesis. However, its latent role in cancer remains unclear. Analysis of The Cancer Genome Atlas database and clinical tissue microarray staining showed that URB1 expression was up…
View article: Correlation between the expressions of circular RNAs in peripheral venous blood and clinicopathological features in hepatocellular carcinoma
Correlation between the expressions of circular RNAs in peripheral venous blood and clinicopathological features in hepatocellular carcinoma Open
CircRNAs were stably present in peripheral venous blood and associated with multiple clinicopathological characteristics of HCC patients. Venous circSETD3 was an independent risk factor of MVI and shows ability to predict MVI in HCC patien…
View article: RAPTOR promotes colorectal cancer proliferation by inducing mTORC1 and upregulating ribosome assembly factor URB1
RAPTOR promotes colorectal cancer proliferation by inducing mTORC1 and upregulating ribosome assembly factor URB1 Open
Mammalian target of rapamycin complex 1 (mTORC1) is evolutionally conserved and frequently activated in various tumors, including colorectal cancer (CRC). It has been reported that the ribosome assembly factor Urb1 acts downstream of mTORC…
View article: KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3
KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3 Open
Background N6-methyladenosine (m6A) modification, the most abundant internal methylation of eukaryotic RNA transcripts, is critically implicated in RNA processing. As the largest known component in the m6A methyltransferase complex, KIAA14…
View article: Botulinum toxin for the treatment of chronic idiopathic constipation
Botulinum toxin for the treatment of chronic idiopathic constipation Open
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The primary objective is to assess the efficacy and safety of botulinum toxin for the treatment of chronic idiopathic constipation.
View article: Novel Prognostic Nomograms for Hepatocellular Carcinoma Patients with Microvascular Invasion: Experience from a Single Center
Novel Prognostic Nomograms for Hepatocellular Carcinoma Patients with Microvascular Invasion: Experience from a Single Center Open
These novel predictive models have satisfactory accuracy and discriminatory abilities in predicting the prognosis of HCC patients with MVI after hepatectomy.
View article: CircSETD3 (Hsa_circ_0000567) acts as a sponge for microRNA-421 inhibiting hepatocellular carcinoma growth
CircSETD3 (Hsa_circ_0000567) acts as a sponge for microRNA-421 inhibiting hepatocellular carcinoma growth Open
CircSETD3 is a novel tumour suppressor of HCC and is a valuable prognostic biomarker. Moreover, circSETD3 inhibits the growth of HCC partly through the circSETD3/miR-421/MAPK14 pathway.
View article: Histone Methyltransferase SETD3 Is Regulated by a Couple of microRNAs and Plays Opposing Roles in Proliferation and Metastasis of Hepatocellular Carcinoma
Histone Methyltransferase SETD3 Is Regulated by a Couple of microRNAs and Plays Opposing Roles in Proliferation and Metastasis of Hepatocellular Carcinoma Open
View article: Importance of gene expression signatures in pancreatic cancer prognosis and the establishment of a prediction model
Importance of gene expression signatures in pancreatic cancer prognosis and the establishment of a prediction model Open
This study identified four new biomarkers that are significantly associated with the carcinogenesis, progression, and prognosis of PC, which may be helpful in studying the underlying mechanism of PC carcinogenesis. The predictive nomogram …
View article: Clinical significance of expression of chemokine factor receptor 7 in gastric cancer: A meta-analysis
Clinical significance of expression of chemokine factor receptor 7 in gastric cancer: A meta-analysis Open