Xiangyu Gong
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View article: Epidermal stem cells control periderm injury repair via matrix-driven specialization of intercellular junctions
Epidermal stem cells control periderm injury repair via matrix-driven specialization of intercellular junctions Open
View article: LZTR1 is a melanoma oncogene that promotes invasion and suppresses apoptosis
LZTR1 is a melanoma oncogene that promotes invasion and suppresses apoptosis Open
View article: Supplementary Video 4 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Supplementary Video 4 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Abaqus FEA visualization showing the strain field (strain in the horizontal direction) generated by a 1-mm tumor expanding by 6% in diameter within a softer liver tissue.
View article: Data from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Data from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Physical constraints like compression influence cancer cell invasion and transcriptional dynamics in various tumors. Liver cancer is characterized by the rapid proliferation of tumor cells within a densely packed tissue matrix, subjecting …
View article: Figure S19 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Figure S19 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Analysis of ITPR3 expression using publicly available spatial transcriptomic data of HCC tissues.
View article: Figure S3 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Figure S3 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Cell volume measurement under volumetric compression.
View article: Figure S9 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Figure S9 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Regulations of volumetric and mechanical compressions in liver cancer cell line Hep3B.
View article: Figure S4 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Figure S4 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
YAP nuclear translocation in HepG2 cells under mechanical compression.
View article: Figure S11 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Figure S11 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Expression of “compression signature genes” spatially mapped on the HCC patient samples from publicly available data.
View article: Supplementary Video 3 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Supplementary Video 3 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Abaqus FEA visualization showing the stress field (stress in the horizontal direction) generated by a 1-mm tumor expanding by 6% in diameter within a softer liver tissue.
View article: Supplementary Video 6 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Supplementary Video 6 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Abaqus FEA visualization showing the strain field (strain in the horizontal direction) generated by a 1-mm tumor expanding by 6% in diameter within a stiffer (20kPa) 100 micrometer-thick fibrotic capsule.
View article: Figure S6 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Figure S6 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Characterizations of cell protrusive phenotype and cell-ECM interaction in 3D collagen under mechanical compression.
View article: Supplementary Video 5 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Supplementary Video 5 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Abaqus FEA visualization showing the stress field (stress in the horizontal direction) generated by a 1-mm tumor expanding by 6% in diameter within a stiffer (20kPa) 100 micrometer-thick fibrotic capsule.
View article: Supplementary Video 2 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Supplementary Video 2 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Time-lapse imaging (14 hours) of the morphology and actin dynamics of HepG2-LifeAct cells from Day 3 to Day 4 under 4% PEG compression compared to the cells cultured in the isotonic medium. The observed colonies are the same colonies monit…
View article: Figure S7 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Figure S7 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Tracking actin cytoskeleton reorganization in isotonic condition and under volumetric compression (4% PEG).
View article: Figure S13 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Figure S13 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Daily tracking of HepG2-LifeAct cell morphology in the control (no compression applied) and under mechanical compression.
View article: Figure S14 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Figure S14 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Nuclear translocation of β-catenin in HepG2 under volumetric compression.
View article: Figure S20 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Figure S20 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Expression analysis of BCL-2 family members (MCL1, BCL2L1, and BCL10) using publicly available spatial transcriptomic data of HCC tissues.
View article: Figure S8 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Figure S8 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Gene expressions of ITPRs in HepG2 under compression and TCGA survival analysis on liver cancer patients.
View article: Supplementary Table 1 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Supplementary Table 1 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Osmolarity measurements of isotonic (control) culture medium and the media supplemented with 2% and 4% PEG300.
View article: Figure S18 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Figure S18 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Gene expression of mechanosensitive calcium channels under volumetric vs. mechanical compression.
View article: Figure S21 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Figure S21 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Morphological characterization and cytoskeletal organization of primary mouse hepatocytes under mechanical compression.
View article: Figure S17 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Figure S17 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Cell morphology and growth in 3D with the treatment of microtubule stabilizer PTX.
View article: Figure S2 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Figure S2 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Hallmark GSEA comparing transcriptomes of volumetrically and mechanically compressed cells.
View article: Supplementary Table 2 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Supplementary Table 2 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Liver compression signature genes
View article: Figure S12 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Figure S12 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Morphological changes and signaling of β-catenin and YAP in liver cancer cell line Hep3B under volumetric compression.
View article: Figure S5 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Figure S5 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Cell spreading and nuclear translocations of YAP and β-catenin on physiologically relevant substrates under volumetric compression.
View article: Figure S10 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Figure S10 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Characterizations of compression-like features in multiple liver cancer patients.
View article: Figure S15 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Figure S15 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Nuclear translocation of β-catenin in HepG2 under mechanical compression.
View article: Figure S1 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer
Figure S1 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer Open
Validation of apoptosis vs. necrosis in volumetrically compressed HepG2 cells using AnnexinV/PI staining.