Xianjing Hu
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View article: Gentiopicroside improves DSS-induced ulcerative colitis and secondary liver injury in mice by enhancing the intestinal barrier and regulating the gut microbiome
Gentiopicroside improves DSS-induced ulcerative colitis and secondary liver injury in mice by enhancing the intestinal barrier and regulating the gut microbiome Open
Ulcerative colitis (UC) is a chronic inflammatory bowel disease frequently accompanied by intestinal barrier dysfunction and gut microbiome dysbiosis. Emerging evidence suggests that these impairments can contribute to secondary liver inju…
View article: Exploration of the antitumor effect and mechanism of gambogic acid on osteosarcoma through network pharmacology and experimental pharmacology study
Exploration of the antitumor effect and mechanism of gambogic acid on osteosarcoma through network pharmacology and experimental pharmacology study Open
Osteosarcoma (OS) is a highly aggressive bone cancer in children and adolescents with extremely poor prognosis. Gambogic acid (GA) is a natural compound derived from the resin of Garcinia hanburyi trees and has been reported to possess mul…
View article: IRF1 Suppresses Gastric Tumorigenesis via Dual PI3K/AKT-ERK Pathway Modulation and Functional Antagonism of Oncogenic MX2
IRF1 Suppresses Gastric Tumorigenesis via Dual PI3K/AKT-ERK Pathway Modulation and Functional Antagonism of Oncogenic MX2 Open
Background Interferon regulatory factor 1 (IRF1) plays a crucial role in the type I interferon (IFN) response. However, its functional role and underlying mechanisms in gastric cancer (GC) remain unclear. This study aims to investigate the…
View article: The Relationship Between Nurse Leadership and Structural Empowerment With Clinical Teaching Competencies: A Cross‐Sectional Study
The Relationship Between Nurse Leadership and Structural Empowerment With Clinical Teaching Competencies: A Cross‐Sectional Study Open
Aims To examine the relationship among leadership, clinical teaching competencies, and structural empowerment of nursing clinical instructors in China. Design A cross‐sectional study. Methods A total of 152 nurses who come from three Grade…
View article: Ficus pandurata Hance suppresses colorectal cancer by targeting PI3K/Akt/mTOR pathway: A network pharmacology-guided experimental validation
Ficus pandurata Hance suppresses colorectal cancer by targeting PI3K/Akt/mTOR pathway: A network pharmacology-guided experimental validation Open
Background: Ficus pandurata Hance (FPH), a traditional Chinese medicinal herb, is known for its antioxidant and anti-inflammatory activities. While its efficacy against ulcerative colitis has been reported, its potential role in colorectal…
View article: Clinacanthus nutans restores the intestinal barrier in UC via regulatings oxidative stress to suppress the occurrence of ferroptosis
Clinacanthus nutans restores the intestinal barrier in UC via regulatings oxidative stress to suppress the occurrence of ferroptosis Open
Clinacanthus nutans (CN) is an edible plant with anti-inflammatory and antioxidant properties.Ulcerative colitis (UC) is an inflammatory bowel disease affecting the colonic mucosa and submucosa, but its therapeutic effects on UC have not b…
View article: The experience of pain symptoms in patients with amyotrophic lateral sclerosis: a qualitative study
The experience of pain symptoms in patients with amyotrophic lateral sclerosis: a qualitative study Open
ALS is a progressive neurodegenerative disease that has a serious impact on patients and their caregivers. For a long time in the past, ALS was considered a painless disease that was largely ignored by clinicians. Describing the complexity…
View article: Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review
Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review Open
Chronic atrophic gastritis (CAG) is a prevalent digestive system disease characterized by atrophy of the gastric mucosa and the disappearance of inherent gastric glands. According to the theory of Correa’s cascade, CAG is an important path…
View article: Causal relationships between uremic metabolites or toxins and heart failure: Univariate and multivariate Mendelian randomization
Causal relationships between uremic metabolites or toxins and heart failure: Univariate and multivariate Mendelian randomization Open
Studies have shown that uremia, renal failure and heart failure (HF) are closely related. However, whether this association reflects a causal effect is still unclear. The aim of this study was to evaluate the causal effect of uremic metabo…
View article: The applications and challenges of artificial intelligence in nursing
The applications and challenges of artificial intelligence in nursing Open
The application of artificial intelligence (AI) is expanding rapidly in many fields. Over the past 40 years, AI has developed and diversified in many different areas of health care. Within nursing specifically, AI currently performs functi…
View article: A nanozyme-functionalized bilayer hydrogel scaffold for modulating the inflammatory microenvironment to promote osteochondral regeneration
A nanozyme-functionalized bilayer hydrogel scaffold for modulating the inflammatory microenvironment to promote osteochondral regeneration Open
Background The incidence of osteochondral defects caused by trauma, arthritis or tumours is increasing annually, but progress has not been made in terms of treatment methods. Due to the heterogeneous structure and biological characteristic…
View article: Correction: NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation
Correction: NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation Open
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View article: <i>Astragalus</i> Polysaccharide Enhances Voriconazole Metabolism under Inflammatory Conditions through the Gut Microbiota
<i>Astragalus</i> Polysaccharide Enhances Voriconazole Metabolism under Inflammatory Conditions through the Gut Microbiota Open
The study offers valuable insights into the mechanism by which APS alleviates VRC-induced liver damage, highlighting its immunomodulatory influence on hepatic tissues and its indirect regulatory control of VRC-metabolizing enzymes within h…
View article: Liver Protection of a Low-Polarity Fraction from Ficus pandurata Hance, Prepared by Supercritical CO2 Fluid Extraction, on CCl4-Induced Acute Liver Injury in Mice via Inhibiting Apoptosis and Ferroptosis Mediated by Strengthened Antioxidation
Liver Protection of a Low-Polarity Fraction from Ficus pandurata Hance, Prepared by Supercritical CO2 Fluid Extraction, on CCl4-Induced Acute Liver Injury in Mice via Inhibiting Apoptosis and Ferroptosis Mediated by Strengthened Antioxidation Open
Ficus pandurata Hance (FPH) is a Chinese herbal medicine widely used for health care. This study was designed to investigate the alleviation efficacy of the low-polarity ingredients of FPH (FPHLP), prepared by supercritical CO2 fluid extra…
View article: Recent Progress in Electrochemical Nano-Biosensors for Detection of Pesticides and Mycotoxins in Foods
Recent Progress in Electrochemical Nano-Biosensors for Detection of Pesticides and Mycotoxins in Foods Open
Pesticide and mycotoxin residues in food are concerning as they are harmful to human health. Traditional methods, such as high-performance liquid chromatography (HPLC) for such detection lack sensitivity and operation convenience. Efficien…
View article: Alleviation of Fufang Fanshiliu decoction on type II diabetes mellitus by reducing insulin resistance: A comprehensive network prediction and experimental validation
Alleviation of Fufang Fanshiliu decoction on type II diabetes mellitus by reducing insulin resistance: A comprehensive network prediction and experimental validation Open
This study demonstrated that the therapeutic effect of FFSLD on T2DM was related to IR alleviation. The underlying mechanisms were associated with the regulation of PI3K/AKT, JAK/STAT, oxidative stress, and ESR signaling pathways.
View article: Anti-colorectal cancer of Ardisia gigantifolia Stapf. and targets prediction via network pharmacology and molecular docking study
Anti-colorectal cancer of Ardisia gigantifolia Stapf. and targets prediction via network pharmacology and molecular docking study Open
Background: Ardisia gigantifolia Stapf. (AGS), a Chinese folk medicine widely grows in the south of China and is traditionally used for treating rheumatism, the pain of bone and muscle, and traumatic injury. Several studies reported that A…
View article: Polysaccharides from Garlic Protect against Liver Injury in DSS‐Induced Inflammatory Bowel Disease of Mice via Suppressing Pyroptosis and Oxidative Damage
Polysaccharides from Garlic Protect against Liver Injury in DSS‐Induced Inflammatory Bowel Disease of Mice via Suppressing Pyroptosis and Oxidative Damage Open
Inflammatory bowel disease (IBD), a widespread intestinal disease threatening human health, is commonly accompanied by secondary liver injury (SLI). Pyroptosis and oxidative stress act as an important role underlying the pathophysiology of…
View article: Dihydroartemisinin is potential therapeutics for treating late-stage CRC by targeting the elevated c-Myc level
Dihydroartemisinin is potential therapeutics for treating late-stage CRC by targeting the elevated c-Myc level Open
Currently, no frontline treatment is effective for the late-stage colorectal cancer (CRC). Understanding the molecular differences in different stages of CRC can help us to identify the critical therapeutic targets for designing therapeuti…