Xiankun Zeng
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View article: Characterization of a STAT-1 Knockout Mouse Model for Machupo Virus Infection and Pathogenesis
Characterization of a STAT-1 Knockout Mouse Model for Machupo Virus Infection and Pathogenesis Open
Machupo virus (MACV), a member of the Arenaviridae family and causative agent of Bolivian hemorrhagic fever, results in lethality rates of 25–35% in humans. Mice lacking the signal transducer and activator of transcription 1 (STAT-1−/−) ha…
View article: Understanding the pathogenesis of uveitis in Ebola virus disease survivors: a study protocol for clinical, molecular virologic, and immunologic characterization
Understanding the pathogenesis of uveitis in Ebola virus disease survivors: a study protocol for clinical, molecular virologic, and immunologic characterization Open
The 2013-2016 Western African outbreak of the Ebola virus disease (EVD), the largest recorded outbreak since the discovery of Ebola virus (EBOV) in 1976, destabilized local health systems and left thousands of survivors at risk for post-ac…
View article: Clade IIb Mpox virus (MPXV) vertical transmission and fetal demise in a pregnant rhesus macaque model
Clade IIb Mpox virus (MPXV) vertical transmission and fetal demise in a pregnant rhesus macaque model Open
Infection with clade I Mpox virus (MPXV) results in adverse pregnancy outcomes, yet the potential for vertical transmission resulting in fetal harm with clade IIb MPXV, the clade that is currently circulating in the Western Hemisphere, rem…
View article: Targeting cytokine signaling in mice infected with bunyaviruses provides protection from severe disease and death
Targeting cytokine signaling in mice infected with bunyaviruses provides protection from severe disease and death Open
Introduction: Crimean-Congo hemorrhagic fever virus (CCHFV) is an important human pathogen in the Bunyavirales order. CCHFV causes a spectrum of disease in humans that can range from minimally symptomatic to a catastrophic and lethal infec…
View article: Sudan Virus Persistence in Immune-Privileged Organs of Nonhuman Primates
Sudan Virus Persistence in Immune-Privileged Organs of Nonhuman Primates Open
After the 2022-2023 Sudan virus (SUDV) disease outbreak in Uganda, we studied SUDV persistence in nonhuman primates that had survived acute infection without therapeutic intervention. We identified SUDV persistence in the vitreous chamber …
View article: A Randomized, Blinded, Vehicle-Controlled Dose-Ranging Study to Evaluate and Characterize Remdesivir Efficacy Against Ebola Virus in Rhesus Macaques
A Randomized, Blinded, Vehicle-Controlled Dose-Ranging Study to Evaluate and Characterize Remdesivir Efficacy Against Ebola Virus in Rhesus Macaques Open
Ebola virus (EBOV) causes severe disease in humans, with mortality as high as 90%. The small-molecule antiviral drug remdesivir (RDV) has demonstrated a survival benefit in EBOV-exposed rhesus macaques. Here, we characterize the efficacy o…
View article: Long-term visual outcomes and histopathologic findings after cataract surgery in Ebola virus disease survivors in the Ebola virus RNA persistence in ocular tissues and fluids (EVICT) study
Long-term visual outcomes and histopathologic findings after cataract surgery in Ebola virus disease survivors in the Ebola virus RNA persistence in ocular tissues and fluids (EVICT) study Open
Background/Objectives Ebola virus disease (EVD) survivors develop post-acute ophthalmic sequelae, including a high prevalence of uveitis that may be complicated by vision-threatening cataract. After the non-detection of Ebola virus (EBOV) …
View article: A Small-Particle Aerosol Model of Ebolavirus Zaire Infection in Ferrets
A Small-Particle Aerosol Model of Ebolavirus Zaire Infection in Ferrets Open
The Ebola virus (EBOV) causes severe disease in humans, and animal models are needed to evaluate the efficacy of vaccines and therapeutics. While non-human primate (NHP) and rodent EBOV infection models have been well characterized, there …
View article: Virulence of <i>Burkholderia pseudomallei</i> ATS2021 Unintentionally Imported to United States in Aromatherapy Spray
Virulence of <i>Burkholderia pseudomallei</i> ATS2021 Unintentionally Imported to United States in Aromatherapy Spray Open
In the United States in 2021, an outbreak of 4 cases of Burkholderia pseudomallei, the etiologic agent of melioidosis and a Tier One Select Agent (potential for deliberate misuse and subsequent harm), resulted in 2 deaths. The causative st…
View article: Inactivated rabies-based Lassa fever virus vaccine candidate LASSARAB protects nonhuman primates from lethal disease
Inactivated rabies-based Lassa fever virus vaccine candidate LASSARAB protects nonhuman primates from lethal disease Open
Lassa fever virus (LASV), a member of the Arenavirus family, is the etiological agent of Lassa fever, a severe hemorrhagic disease that causes considerable morbidity and mortality in the endemic areas of West Africa. LASV is a rodent-borne…
View article: Preparation and Characterization of Improved Barrier Beverage Packaging Bottle and Its Inhibitory Effect on Dissolved Oxygen Content of Chestnut Rose Beverage
Preparation and Characterization of Improved Barrier Beverage Packaging Bottle and Its Inhibitory Effect on Dissolved Oxygen Content of Chestnut Rose Beverage Open
Food packaging plays a crucial role in product storage, transportation and distribution. This study is dedicated to the development of high barrier blends for food packaging through the melt blending of polyethylene terephthalate (PET) and…
View article: Mpox virus (MPXV) vertical transmission and fetal demise in a pregnant rhesus macaque model
Mpox virus (MPXV) vertical transmission and fetal demise in a pregnant rhesus macaque model Open
Infection with clade I Mpox virus (MPXV) results in adverse pregnancy outcomes, yet the potential for vertical transmission resulting in fetal harm with clade IIb MPXV, the clade that is currently circulating in the Western Hemisphere, rem…
View article: Nucleocapsid protein-specific monoclonal antibodies protect mice against Crimean-Congo hemorrhagic fever virus
Nucleocapsid protein-specific monoclonal antibodies protect mice against Crimean-Congo hemorrhagic fever virus Open
View article: Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease
Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease Open
Although smallpox has been eradicated, other orthopoxviruses continue to be a public health concern as exemplified by the ongoing Mpox (formerly monkeypox) global outbreak. While medical countermeasures (MCMs) previously approved by the Fo…
View article: Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods
Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods Open
Smallpox was the most rampant infectious disease killer of the 20 th century, yet much remains unknown about the pathogenesis of the variola virus. Using archived tissue from a study conducted at the Centers for Disease Control and Prevent…
View article: An Inactivated Rabies-based Lassa Fever Virus Vaccine Candidate, LASSARAB, Protects Nonhuman Primates from Lethal Disease
An Inactivated Rabies-based Lassa Fever Virus Vaccine Candidate, LASSARAB, Protects Nonhuman Primates from Lethal Disease Open
Lassa fever virus (LASV), a member of the Arenavirus family, is the etiological agent of Lassa fever, a severe hemorrhagic disease that causes considerable morbidity and mortality in the endemic areas of West Africa. LASV is a rodent-borne…
View article: SARS-CoV-2 Aerosol and Intranasal Exposure Models in Ferrets
SARS-CoV-2 Aerosol and Intranasal Exposure Models in Ferrets Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the worldwide COVID-19 pandemic. Animal models are extremely helpful for testing vaccines and therapeutics and for dissecting the viral and host factors…
View article: Characterization of the Cynomolgus Macaque Model of Marburg Virus Disease and Assessment of Timing for Therapeutic Treatment Testing
Characterization of the Cynomolgus Macaque Model of Marburg Virus Disease and Assessment of Timing for Therapeutic Treatment Testing Open
Marburg virus (MARV) causes severe disease and high mortality in humans. The objective of this study was to characterize disease manifestations and pathogenesis in cynomolgus macaques exposed to MARV. The results of this natural history st…
View article: Author Correction: Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection
Author Correction: Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection Open
View article: Temporal changes in pathology and viral RNA distribution in guinea pigs following separate infection with two New World Arenaviruses
Temporal changes in pathology and viral RNA distribution in guinea pigs following separate infection with two New World Arenaviruses Open
Numerous arenaviruses have been identified throughout the Americas and a subset of these viruses cause viral hemorrhagic fever in humans. This study compared the pathology and viral RNA distribution in Hartley guinea pigs challenged with t…
View article: Vertical transmission of African-lineage Zika virus through the fetal membranes in a rhesus macaque (Macaca mulatta) model
Vertical transmission of African-lineage Zika virus through the fetal membranes in a rhesus macaque (Macaca mulatta) model Open
Zika virus (ZIKV) can be transmitted vertically from mother to fetus during pregnancy, resulting in a range of outcomes including severe birth defects and fetal/infant death. Potential pathways of vertical transmission in utero have been p…
View article: Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection
Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection Open
View article: Infection of the maternal-fetal interface and vertical transmission following low-dose inoculation of pregnant rhesus macaques (Macaca mulatta) with an African-lineage Zika virus
Infection of the maternal-fetal interface and vertical transmission following low-dose inoculation of pregnant rhesus macaques (Macaca mulatta) with an African-lineage Zika virus Open
Background Congenital Zika virus (ZIKV) infection can result in birth defects, including malformations in the fetal brain and visual system. There are two distinct genetic lineages of ZIKV: African and Asian. Asian-lineage ZIKVs have been …
View article: Supplementary Figures 1-13 from The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in <i>Drosophila</i> Imaginal Tissues
Supplementary Figures 1-13 from The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in <i>Drosophila</i> Imaginal Tissues Open
Supplementary figure 1: Snr1 is required for cell survival in Drosophila wing imaginal disc. Supplementary figure 2: Tumorigenic overgrowth in wing discs carrying snr1-depletion by tissue-specific Gal4 drivers. Supplementary figure 3: Coex…
View article: Supplementary file 1 from The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in <i>Drosophila</i> Imaginal Tissues
Supplementary file 1 from The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in <i>Drosophila</i> Imaginal Tissues Open
Supplementary file 1
View article: Supplementary file 1 from The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in <i>Drosophila</i> Imaginal Tissues
Supplementary file 1 from The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in <i>Drosophila</i> Imaginal Tissues Open
Supplementary file 1
View article: Supplementary table 1 from The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in <i>Drosophila</i> Imaginal Tissues
Supplementary table 1 from The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in <i>Drosophila</i> Imaginal Tissues Open
Supplementary Table 1: The mRNA level changes of representative components or targets of JAK-STAT, JNK, and Notch signaling pathways in snr1-RNAi tumorous wing discs relative to control wildtype wing discs.
View article: Supplementary table 1 from The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in <i>Drosophila</i> Imaginal Tissues
Supplementary table 1 from The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in <i>Drosophila</i> Imaginal Tissues Open
Supplementary Table 1: The mRNA level changes of representative components or targets of JAK-STAT, JNK, and Notch signaling pathways in snr1-RNAi tumorous wing discs relative to control wildtype wing discs.
View article: Data from The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in <i>Drosophila</i> Imaginal Tissues
Data from The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in <i>Drosophila</i> Imaginal Tissues Open
Components of the SWI/SNF chromatin-remodeling complex are among the most frequently mutated genes in various human cancers, yet only SMARCB1/hSNF5, a core member of the SWI/SNF complex, is mutated in malignant rhabdoid tumors (MRT). How S…
View article: Data from The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in <i>Drosophila</i> Imaginal Tissues
Data from The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in <i>Drosophila</i> Imaginal Tissues Open
Components of the SWI/SNF chromatin-remodeling complex are among the most frequently mutated genes in various human cancers, yet only SMARCB1/hSNF5, a core member of the SWI/SNF complex, is mutated in malignant rhabdoid tumors (MRT). How S…