Xianrang Song
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View article: LAPTM5 confers cisplatin resistance in NSCLC by suppressing LAMP1 ubiquitination to stabilize lysosomal membranes and sustain autophagic flux
LAPTM5 confers cisplatin resistance in NSCLC by suppressing LAMP1 ubiquitination to stabilize lysosomal membranes and sustain autophagic flux Open
Cisplatin is a widely used chemotherapeutic agent in the treatment of non-small cell lung cancer (NSCLC), but cisplatin resistance remains a significant clinical challenge. Lysosomal transmembrane protein 5 (LAPTM5) is a lysosomal membrane…
View article: Identification of biomarkers of shrinkage modes after neoadjuvant therapy in HER-2 positive breast cancer
Identification of biomarkers of shrinkage modes after neoadjuvant therapy in HER-2 positive breast cancer Open
Purpose: A nomogram to predict shrinkage modes after neoadjuvant therapy (NAT) was constructed in HER-2 positive (HER2+) breast cancer. The value and mechanism of targeting long noncoding RNA (lncRNA) as efficacy prediction biomarker was a…
View article: TEP SNORD12B, SNORA63, and SNORD14E as novel biomarkers for hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC)
TEP SNORD12B, SNORA63, and SNORD14E as novel biomarkers for hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) Open
Purpose The alterations of RNA profile in tumor-educated platelets (TEPs) have been described as a novel biosource for cancer diagnostics. This study aimed to explore the potential snoRNAs in TEP as biomarkers for diagnostics of hepatitis …
View article: DNA methylation profiling to determine the primary sites of metastatic cancers using formalin-fixed paraffin-embedded tissues
DNA methylation profiling to determine the primary sites of metastatic cancers using formalin-fixed paraffin-embedded tissues Open
Identifying the primary site of metastatic cancer is critical to guiding the subsequent treatment. Approximately 3–9% of metastatic patients are diagnosed with cancer of unknown primary sites (CUP) even after a comprehensive diagnostic wor…
View article: A three-snoRNA signature: SNORD15A, SNORD35B and SNORD60 as novel biomarker for renal cell carcinoma
A three-snoRNA signature: SNORD15A, SNORD35B and SNORD60 as novel biomarker for renal cell carcinoma Open
Background Accumulating evidence has confirmed the role of snoRNAs in a variety of cancer, but rare in renal cell carcinoma (RCC). This study aims to clarify the role of snoRNAs in RCC tumorigenesis and their potential as novel tumor bioma…
View article: Contents in tumor-educated platelets as the novel biosource for cancer diagnostics
Contents in tumor-educated platelets as the novel biosource for cancer diagnostics Open
Liquid biopsy, a powerful non-invasive test, has been widely used in cancer diagnosis and treatment. Platelets, the second most abundant cells in peripheral blood, are becoming one of the richest sources of liquid biopsy with the capacity …
View article: The clonal heterogeneity of colon cancer with liver metastases
The clonal heterogeneity of colon cancer with liver metastases Open
Background Colon cancer with liver metastases (CCLM) characterized by genetic heterogeneity is an evolutionary process leading to variations in response to selective pressure, but the underlying evolutionary models still remains unclear. M…
View article: Plasma exosomal miR-320d, miR-4479, and miR-6763-5p as diagnostic biomarkers in epithelial ovarian cancer
Plasma exosomal miR-320d, miR-4479, and miR-6763-5p as diagnostic biomarkers in epithelial ovarian cancer Open
Background Exosomal miRNA had been proved as the promising biomarkers for multiple cancers including epithelial ovarian cancer (EOC). This study aimed to validate the diagnostic accuracy of exosomal miR-320d, miR-4479, and miR-6763-5p for …
View article: The modified shrinkage classification modes could help to guide breast conserving surgery after neoadjuvant therapy in breast cancer
The modified shrinkage classification modes could help to guide breast conserving surgery after neoadjuvant therapy in breast cancer Open
Purpose The traditional shrinkage classification modes might not suitable for guiding breast conserving surgery (BCS) after neoadjuvant therapy (NAT). Aim was to explore the modified shrinkage classification modes to guide BCS after NAT. M…
View article: Plasma exosomal tRNA‐derived fragments as diagnostic biomarkers in non-small cell lung cancer
Plasma exosomal tRNA‐derived fragments as diagnostic biomarkers in non-small cell lung cancer Open
Background tRNA derived small RNAs (tRFs) have recently received extensive attention; however, the effects of tRFs in exosome as biomarkers has been less studied. The objective of this study was to validate novel diagnostic exosomal tRFs w…
View article: Plasma <scp>SNORD42B</scp> and <scp>SNORD111</scp> as potential biomarkers for early diagnosis of non‐small cell lung cancer
Plasma <span>SNORD42B</span> and <span>SNORD111</span> as potential biomarkers for early diagnosis of non‐small cell lung cancer Open
Background Non‐small‐cell lung cancer (NSCLC) still occupied the leading reason of cancer death due to lack of availability of early detection. This study aimed to identify the effective biomarkers for the early‐stage NSCLC diagnostics bas…
View article: Identification of Diagnostic Exosomal LncRNA-miRNA-mRNA Biomarkers in Colorectal Cancer Based on the ceRNA Network
Identification of Diagnostic Exosomal LncRNA-miRNA-mRNA Biomarkers in Colorectal Cancer Based on the ceRNA Network Open
Background: Colorectal cancer (CRC) is currently the fourth most common cancer worldwide. The roles of exosomal competing endogenous RNAs (ceRNAs) in CRC remain unclear. In this study, we constructed an exosomal ceRNA network to identify t…
View article: Liensinine Inhibits Cell Growth and Blocks Autophagic Flux in Nonsmall-Cell Lung Cancer
Liensinine Inhibits Cell Growth and Blocks Autophagic Flux in Nonsmall-Cell Lung Cancer Open
Liensinine is a bioactive component of Plumula Nelumbinis extracted from the green embryo of the mature seeds of Nelumbonaceae and exhibits therapeutic functions and noteworthy anti-tumor effects in recent studies. However, the potential a…
View article: Prognostic Characteristics of Immune-Related Genes and the Related Regulatory Axis in Patients With Stage N+M0 Breast Cancer
Prognostic Characteristics of Immune-Related Genes and the Related Regulatory Axis in Patients With Stage N+M0 Breast Cancer Open
Breast cancer (BRCA) has the highest incidence rate among female tumours. The function of the immune system affects treatment efficacy and prognosis in patients with BRCA. However, the exact role of immune-related genes (IRGs) in stage N+M…
View article: Construction and validation of four-metabolism related-long non-coding RNAs as potential signature in prognosis of colon cancer
Construction and validation of four-metabolism related-long non-coding RNAs as potential signature in prognosis of colon cancer Open
We developed a four-metabolism related-lncRNA signature for prognostic prediction of CC, which may help select high-risk subpopulation patients who require more aggressive therapy or intervention.
View article: A Clinical Study on Pulsed Low Dose Rate Radiation Therapy for Recurrent Cancers
A Clinical Study on Pulsed Low Dose Rate Radiation Therapy for Recurrent Cancers Open
A consensus standard of care has not been established for treating recurrent cancer patients who have previously undergone radiation therapy (RT).Several in vitro and in vivo studies have shown that pulsed low-dose-rate RT (PLDR) has the p…
View article: A Three lncRNA Set: AC009975.1, POTEH-AS1 and AL390243.1 as Nodal Efficacy Biomarker of Neoadjuvant Therapy for HER-2 Positive Breast Cancer
A Three lncRNA Set: AC009975.1, POTEH-AS1 and AL390243.1 as Nodal Efficacy Biomarker of Neoadjuvant Therapy for HER-2 Positive Breast Cancer Open
Purpose The study aimed to explore whether the expression of lncRNAs in primary tumors could predict nodal efficacy after neoadjuvant therapy (NAT) for HER2+ breast cancer. Methods Total RNA was extracted from HER2+ breast cancer tissues b…
View article: A three lncRNA set: AC009975.1, POTEH-AS1 and AL390243.1 as nodal efficacy biomarker of neoadjuvant therapy for HER-2 positive breast cancer
A three lncRNA set: AC009975.1, POTEH-AS1 and AL390243.1 as nodal efficacy biomarker of neoadjuvant therapy for HER-2 positive breast cancer Open
Background and purpose LncRNAs have been found to play regulatory role in the chemoresistance after neoadjuvant therapy (NAT) of breast cancers. The breast pathological complete response (pCR) was different from the axillary nodal pCR (apC…
View article: <scp>tRNA</scp>‐derived fragments: <scp>tRF‐Gly‐CCC</scp>‐046, <scp>tRF‐Tyr‐GTA</scp>‐010 and <scp>tRF‐Pro‐TGG</scp>‐001 as novel diagnostic biomarkers for breast cancer
<span>tRNA</span>‐derived fragments: <span>tRF‐Gly‐CCC</span>‐046, <span>tRF‐Tyr‐GTA</span>‐010 and <span>tRF‐Pro‐TGG</span>‐001 as novel diagnostic biomarkers for breast cancer Open
Background tRNA‐derived fragments (tRFs) have been found to play a regulatory role in the occurrence and development of many tumors. The aim of this study was to identify the expression of tRFs in breast cancer and their ability to serve a…
View article: TIPE1 Suppresses Growth and Metastasis of Ovarian Cancer
TIPE1 Suppresses Growth and Metastasis of Ovarian Cancer Open
TIPE1, a newly identified member in TIPE (TNFAIP8) family, plays an important role in tumorigenesis and immune regulation, but its role in ovarian cancer, especially in tumor metastasis, remains unknown. In the current study, we aimed to r…
View article: Circulating Serum Exosomal Long Non-Coding RNAs FOXD2-AS1, NRIR, and XLOC_009459 as Diagnostic Biomarkers for Colorectal Cancer
Circulating Serum Exosomal Long Non-Coding RNAs FOXD2-AS1, NRIR, and XLOC_009459 as Diagnostic Biomarkers for Colorectal Cancer Open
Background Exosomes derived from cancer cells encapsulate various kinds of tumor-specific molecules and thus can interact with adjacent or distant cells to mediate information exchange. Long non-coding RNAs (lncRNAs) in exosomes have the p…
View article: Prognosis and Genomic Landscape of Liver Metastasis in Patients With Breast Cancer
Prognosis and Genomic Landscape of Liver Metastasis in Patients With Breast Cancer Open
Objective The prognosis of breast cancer liver metastasis (BCLM) is poor, and its molecular mechanism is unclear. We aimed to determine the factors that affect the prognosis of patients with BCLM and investigate the genomic landscape of li…
View article: Tumor‐educated leukocytes <scp>mRNA</scp> as a diagnostic biomarker for non‐small cell lung cancer
Tumor‐educated leukocytes <span>mRNA</span> as a diagnostic biomarker for non‐small cell lung cancer Open
Background This study aimed to investigate the diagnostic and prognostic role of tumor‐educated leukocytes (TELs) mRNA in Chinese patients with non‐small cell lung cancer (NSCLC). Methods The TELs collected underwent total RNA isolation. R…
View article: Tumor‐educated platelet <scp>SNORD55</scp> as a potential biomarker for the early diagnosis of non‐small cell lung cancer
Tumor‐educated platelet <span>SNORD55</span> as a potential biomarker for the early diagnosis of non‐small cell lung cancer Open
Background Despite the emerging insights into many snoRNAs (small nucleolar RNAs) which are detectable in body fluids and serve as noninvasive biomarkers, few studies have previously discussed the role of snoRNAs in tumor‐educated platelet…
View article: Plasma <scp>miR</scp>‐1247‐5p, <scp>miR</scp>‐301b‐3p and <scp>miR</scp>‐105‐5p as potential biomarkers for early diagnosis of non‐small cell lung cancer
Plasma <span>miR</span>‐1247‐5p, <span>miR</span>‐301b‐3p and <span>miR</span>‐105‐5p as potential biomarkers for early diagnosis of non‐small cell lung cancer Open
Background Accumulating evidence shows that microRNAs are aberrantly expressed and exert essential roles in the tumorigenesis and tumor progression of non‐small cell lung cancer (NSCLC). Methods The plasma miRNAs from five healthy donors a…