Xianyang Luo
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View article: Establishing a Zonal Anatomic Scheme for the Parapharyngeal Space and Infratemporal Fossa Based on Five Surgical Approaches
Establishing a Zonal Anatomic Scheme for the Parapharyngeal Space and Infratemporal Fossa Based on Five Surgical Approaches Open
Objective To develop an anatomical zonal scheme for the parapharyngeal space and infratemporal fossa based on various surgical approaches, including the transnasal posterior maxillary sinus wall approach, the transnasal antrostomy approach…
View article: Systematic Evaluation of Extracellular Coating Matrix on the Differentiation of Human-Induced Pluripotent Stem Cells to Cortical Neurons
Systematic Evaluation of Extracellular Coating Matrix on the Differentiation of Human-Induced Pluripotent Stem Cells to Cortical Neurons Open
Induced pluripotent stem cell (iPSC)-derived neurons (iNs) have been widely used as models of neurodevelopment and neurodegenerative diseases. Coating cell culture vessels with extracellular matrixes (ECMs) gives structural support and fac…
View article: Endoscopic morphology of gastric MALT lymphoma correlate with API2/MALT1 fusion and predict treatment response after helicobacter pylori eradication
Endoscopic morphology of gastric MALT lymphoma correlate with API2/MALT1 fusion and predict treatment response after helicobacter pylori eradication Open
Gastric MALT lymphomas with superficial-type morphology, particularly those with defined borders resembling early gastric cancer, were associated with API2/MALT1 fusion and a lower remission rate after Hp eradication therapy. This suggests…
View article: Efficacy of PD-1 inhibitor with neoadjuvant chemotherapy in hypopharyngeal and oropharyngeal cancer
Efficacy of PD-1 inhibitor with neoadjuvant chemotherapy in hypopharyngeal and oropharyngeal cancer Open
Objective This study is aimed to evaluate the efficacy and safety of PD-1 inhibitors combined with neoadjuvant chemotherapy in patients with locally advanced hypopharyngeal and oropharyngeal cancer prior to surgical resection. Methods This…
View article: Expression of p16 and Ki67 in laryngeal squamous cell carcinoma and their clinical significance
Expression of p16 and Ki67 in laryngeal squamous cell carcinoma and their clinical significance Open
Objective The objective of this study is to assess the prognostic value of Ki67 and p16 proteins in laryngeal cancer. Materials and methods This retrospective cohort analysis comprised 260 patients diagnosed with laryngeal cancer. Immunohi…
View article: Polycyclic Aromatic Hydrocarbons Regulate the Occurrence and Development of Nasopharyngeal Carcinoma by Regulating Aryl Hydrocarbon Receptor
Polycyclic Aromatic Hydrocarbons Regulate the Occurrence and Development of Nasopharyngeal Carcinoma by Regulating Aryl Hydrocarbon Receptor Open
Nasopharyngeal carcinoma (NPC) has hidden onset, low rate of early diagnosis, and most of them have metastases at the time of diagnosis. The specific pathogenesis of NPC is still unclear. Polycyclic aromatic hydrocarbons (PAHs) are a large…
View article: Complete mitochondrial genome assembly of Zizania latifolia and comparative genome analysis
Complete mitochondrial genome assembly of Zizania latifolia and comparative genome analysis Open
Zizania latifolia (Griseb.) Turcz. ex Stapf has been cultivated as a popular aquatic vegetable in China due to its important nutritional, medicinal, ecological, and economic values. The complete mitochondrial genome (mitogenome) of Z. lati…
View article: CD74 facilitates immunotherapy response by shaping the tumor microenvironment of hepatocellular carcinoma
CD74 facilitates immunotherapy response by shaping the tumor microenvironment of hepatocellular carcinoma Open
Background CD74 is ectopically expressed in many tumors and can regulate tumor immunity. However, there are many gaps in the study of the prognostic value of CD74 expression and immune infiltration in hepatocellular carcinoma (HCC). Method…
View article: Neoadjuvant therapy with chemotherapy and immune checkpoint inhibitor for laryngeal function preservation in locally advanced hypopharyngeal cancer
Neoadjuvant therapy with chemotherapy and immune checkpoint inhibitor for laryngeal function preservation in locally advanced hypopharyngeal cancer Open
Purpose To evaluate the efficacy and laryngeal function preservation of neoadjuvant treatment with chemotherapy and immune checkpoint inhibitor for locally advanced hypopharyngeal cancer (LAHPC). Methods We retrospectively collected LAHPC …
View article: 经口腔内窥镜在三维可视化及实时导航技术下切除咽旁及侧颅底良性肿瘤初探
经口腔内窥镜在三维可视化及实时导航技术下切除咽旁及侧颅底良性肿瘤初探 Open
OBJECTIVE: With the assistance of 3D visualization and real-time navigation technologies, the tumors in the parapharyngeal and lateral skull base should be removed through oral the approach with endoscopy. METHODS: The preoperative CT data…
View article: Biological functions of miRNA-203b-3p/ZNF324 in laryngeal carcinoma
Biological functions of miRNA-203b-3p/ZNF324 in laryngeal carcinoma Open
The present study aimed to elucidate the role of MicroRNA-203b-3p (miRNA-203b-3p) in protecting the deterioration of laryngeal carcinoma through targeting ZNF324. Relative levels of miRNA-203b-3p and ZNF324 in laryngeal carcinoma tissues w…
View article: Depletion of circ_0001313 suppresses the carcinogenesis of laryngeal carcinoma through miR 512 5p/HMGA1 pathway
Depletion of circ_0001313 suppresses the carcinogenesis of laryngeal carcinoma through miR 512 5p/HMGA1 pathway Open
Purpose: To probe the influence of circ_0001313 on the occurrence and development of laryngeal carcinoma and the potential molecular mechanism. Methods: 27 cases of laryngeal carcinoma attending health facility from January 2017 to Septemb…
View article: Donafenib in Locally Advanced/Metastatic Radioactive Iodine-Refractory Differentiated Thyroid Cancer: A Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Phase III Clinical Trial (DIRECTION)
Donafenib in Locally Advanced/Metastatic Radioactive Iodine-Refractory Differentiated Thyroid Cancer: A Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Phase III Clinical Trial (DIRECTION) Open
Background No available treatment existed in Chinese patients with progressive radioactive iodine–refractory differentiated thyroid cancer (RAIR-DTC) in terms of both affordability and safety upon the initiation of DIRECTION study. Donafen…
View article: miR-491-5p inhibits Emilin 1 to promote fibroblasts proliferation and fibrosis in gluteal muscle contracture via TGF-Beta1/Smad2 pathway.
miR-491-5p inhibits Emilin 1 to promote fibroblasts proliferation and fibrosis in gluteal muscle contracture via TGF-Beta1/Smad2 pathway. Open
Gluteal muscle contracture (GMC) is a chronic fibrotic disease of gluteal muscles due to multiple etiologies. Emilin 1 plays a determinant role in fibers formation, but its role in the progression of GMC remains unclear. The present study …
View article: L22 ribosomal protein is involved in dynamin-related protein 1-mediated gastric carcinoma progression
L22 ribosomal protein is involved in dynamin-related protein 1-mediated gastric carcinoma progression Open
Mitochondrial fission depends on dynamin-related protein 1 (Drp1) guanosine triphosphatase activity. Although there is some association between Drp1 and gastric cancer, the detailed mechanism remains largely unknown. In this study, the ele…
View article: Study on heat storage performance of a single hot water tank with heat insulation board as thermocline layer
Study on heat storage performance of a single hot water tank with heat insulation board as thermocline layer Open
The mixing of cold and hot fluids caused by inlet and outlet or natural convection in a heat strorage tank, interfere with temperature stratification will reduce the thermal performance of the heat storage tank.In this paper, a method of i…
View article: L22 ribosomal protein is involved in dynamin-related protein 1-mediated gastric carcinoma progression
L22 ribosomal protein is involved in dynamin-related protein 1-mediated gastric carcinoma progression Open
Mitochondrial fission depends on dynamin-related protein 1 (Drp1) guanosine triphosphatase activity. Although there is some association between Drp1 and gastric cancer, the detailed mechanism remains largely unknown. In this study, the ele…
View article: Histone Demethylase PHF8 Is Required for the Development of the Zebrafish Inner Ear and Posterior Lateral Line
Histone Demethylase PHF8 Is Required for the Development of the Zebrafish Inner Ear and Posterior Lateral Line Open
Histone demethylase PHF8 is crucial for multiple developmental processes, and hence, the awareness of its function in developing auditory organs needs to be increased. Using in situ hybridization (ISH) labeling, the mRNA expression of PHF8…
View article: Intranasal fluticasone furoate in pediatric allergic rhinitis: randomized controlled study
Intranasal fluticasone furoate in pediatric allergic rhinitis: randomized controlled study Open
Background Intranasal corticosteroids are the most efficacious anti-inflammatory medications for allergic rhinitis (AR). However, the efficacy and safety of intranasal corticosteroids in children have not yet been subject to specific resea…
View article: Estrogen receptor α is involved in the regulation of ITGA8 methylation in estrogen receptor-positive breast cancer
Estrogen receptor α is involved in the regulation of ITGA8 methylation in estrogen receptor-positive breast cancer Open
Low ITGA8 expression in ER-positive breast cancer might be caused by the hypermethylation of ITGA8, a process dependent on ERα. Our findings provide an important foundation for investigations into ITGA8-targeted treatment strategies for ER…
View article: Tinnitus severity correlated with zinc, copper, risk factors: a large-scale case-control study
Tinnitus severity correlated with zinc, copper, risk factors: a large-scale case-control study Open
Objectives This large-scale case-control study aimed to explore the trace elements (Zn & Cu) and risk factors associated with tinnitus severity (mild and moderate-to-severe tinnitus). Methods The serum levels of Zn & Cu of participants wer…
View article: Inhibition of esophageal-carcinoma cell proliferation by genistein via suppression of JAK1/2-STAT3 and AKT/MDM2/p53 signaling pathways
Inhibition of esophageal-carcinoma cell proliferation by genistein via suppression of JAK1/2-STAT3 and AKT/MDM2/p53 signaling pathways Open
Esophageal carcinoma (EsC) is a clinically challenging neoplastic disease. Genistein, a natural isoflavone product, has anti-tumor properties. Through in vitro and in vivo studies, we found that genistein suppressed EsC cell proliferation …
View article: Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for tumor stages detection and histologic grades classification of oral squamous cell carcinoma [corrigendum]
Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for tumor stages detection and histologic grades classification of oral squamous cell carcinoma [corrigendum] Open
[This corrects the article on p. 4977 in vol. 13, PMID: 30214201.].
View article: Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for tumor stages detection and histologic grades classification of oral squamous cell carcinoma
Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for tumor stages detection and histologic grades classification of oral squamous cell carcinoma Open
This study demonstrated that the SERS based on blood serum test had an enormous potential to carry out the preoperative assessment and prediction of the OSCC patients in different tumor stages and histologic classification.
View article: Anti-oncogenic activity of Chibby in the development of human nasopharyngeal carcinoma
Anti-oncogenic activity of Chibby in the development of human nasopharyngeal carcinoma Open
The Wnt/β-catenin pathway serves important roles in cancer development. The expression and function of Chibby (Cby), as a direct antagonist of β-catenin, in nasopharyngeal carcinoma (NPC) has not been fully investigated. The present study …