Xianyou Xia
YOU?
Author Swipe
View article: SLC6A6 alleviates cellular senescence in glioblastoma via the CSK/AKT/FoxO1 signaling
SLC6A6 alleviates cellular senescence in glioblastoma via the CSK/AKT/FoxO1 signaling Open
・Background: Malignant glioblastoma exhibits cellular senescence characterized by changing tumor microenvironment. Solute carrier family 6 member 6 (SLC6A6), a multichannel transmembrane protein, plays a crucial role in regulating cell pro…
View article: Synthesis and performance of hydroxyapatite- <bold>β</bold>-cyclodextrin composite microspheres
Synthesis and performance of hydroxyapatite- <bold>β</bold>-cyclodextrin composite microspheres Open
Hydroxyapatite (HA) is a widely used drug loading material, and combining HA with related materials to form drug loaded microspheres can effectively alleviate the phenomenon of drug burst release. For this purpose, the synthesis was involv…
View article: The divergence of PD-1+CXCR5+CD4+ T cell differentiation and stage-specific regulation of GC-Tfh cells
The divergence of PD-1+CXCR5+CD4+ T cell differentiation and stage-specific regulation of GC-Tfh cells Open
T follicular helper (Tfh) cells were discovered as CD4+ T cells in the B cell follicles that express CXCR5 and help germinal center (GC) B cell responses. However, it is not clear which PD-1+CXCR5+Bcl6+CD4+ T cells will differentiate into …
View article: LRIG2 promotes glioblastoma progression by modulating innate antitumor immunity through macrophage infiltration and polarization
LRIG2 promotes glioblastoma progression by modulating innate antitumor immunity through macrophage infiltration and polarization Open
Background Glioblastoma (GBM) is the most common malignant brain tumor with poor clinical outcomes. Immunotherapy has recently been an attractive and promising treatment of extracranial malignancies, however, most of clinical trials for GB…
View article: Targeting of BMI-1 with PTC-209 inhibits glioblastoma development
Targeting of BMI-1 with PTC-209 inhibits glioblastoma development Open
Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor and refractory to existing therapies. The oncogene BMI-1, a member of Polycomb Repressive Complex 1 (PRC1) plays essential roles in various human cancers and becom…
View article: Generation and validation of versatile inducible CRISPRi embryonic stem cell and mouse model
Generation and validation of versatile inducible CRISPRi embryonic stem cell and mouse model Open
Clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated (Cas) 9 has been widely used far beyond genome editing. Fusions of deactivated Cas9 (dCas9) to transcription effectors enable interrogation of the epigenom…
View article: Hierarchical Micro-Nano Topography Promotes Cell Adhesion and Osteogenic Differentiation via Integrin α2-PI3K-AKT Signaling Axis
Hierarchical Micro-Nano Topography Promotes Cell Adhesion and Osteogenic Differentiation via Integrin α2-PI3K-AKT Signaling Axis Open
Surface topography dictates important aspects of cell biological behaviors. In our study, hierarchical micro-nano topography (SLM-AHT) with micro-scale grooves and nano-scale pores was fabricated and compared with smooth topography (S) and…
View article: Generation and Validation of Versatile Inducible CRISPRi Embryonic Stem Cell and Mouse Models
Generation and Validation of Versatile Inducible CRISPRi Embryonic Stem Cell and Mouse Models Open
CRISPR-Cas9 has been widely used far beyond genome editing. Fusions of deactivated Cas9 (dCas9) to transcription effectors enable interrogation of the epigenome and controlling of gene expression. However the large transgene size of dCas9-…
View article: Deregulation of tumor suppressive ASXL1−PTEN/AKT axis in myeloid malignancies
Deregulation of tumor suppressive ASXL1−PTEN/AKT axis in myeloid malignancies Open
Mutations of epigenetic regulators are pervasive in human tumors. ASXL1 is frequently mutated in myeloid malignancies. We previously found that ASXL1 forms together with BAP1 a complex that can deubiquitinylate mono-ubiquitinylated lysine …
View article: Targeting of BMI-1 with PTC-209 inhibits glioblastoma development
Targeting of BMI-1 with PTC-209 inhibits glioblastoma development Open
Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor and refractory to existing therapies. The oncogene BMI-1, a member of Polycomb Repressive Complex 1 (PRC1) plays essential roles in various human cancers and becom…
View article: Targeting of BMI-1 with PTC-209 inhibits glioblastoma development
Targeting of BMI-1 with PTC-209 inhibits glioblastoma development Open
Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor and refractory to existing therapies. The oncogene BMI-1, a member of Polycomb Repressive Complex 1 (PRC1) plays essential roles in various human cancers and becom…