Xianzhe Wang
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View article: The Effect of Fanshi Tongfeng Fang on Hyperuricemia-Induced Apoptosis and Inflammation
The Effect of Fanshi Tongfeng Fang on Hyperuricemia-Induced Apoptosis and Inflammation Open
Hyperuricemia (HUA) is a metabolic disorder caused by purine metabolism. Our study attempts to explore the therapeutic effect of the Fanshi Tongfeng Fang (TFF) formula against HUA and the underlying mechanism. The uric acid (UA), aspartate…
View article: Correction: The improvement of modified Si-Miao granule on hepatic insulin resistance and glycogen synthesis in type 2 diabetes mellitus involves the inhibition of TNF-α/JNK1/IRS-2 pathway: network pharmacology, molecular docking, and experimental validation
Correction: The improvement of modified Si-Miao granule on hepatic insulin resistance and glycogen synthesis in type 2 diabetes mellitus involves the inhibition of TNF-α/JNK1/IRS-2 pathway: network pharmacology, molecular docking, and experimental validation Open
View article: The improvement of modified Si-Miao granule on hepatic insulin resistance and glycogen synthesis in type 2 diabetes mellitus involves the inhibition of TNF-α/JNK1/IRS-2 pathway: network pharmacology, molecular docking, and experimental validation
The improvement of modified Si-Miao granule on hepatic insulin resistance and glycogen synthesis in type 2 diabetes mellitus involves the inhibition of TNF-α/JNK1/IRS-2 pathway: network pharmacology, molecular docking, and experimental validation Open
View article: A single-cell 3D spatiotemporal multi-omics atlas from<i>Drosophila</i>embryogenesis to metamorphosis
A single-cell 3D spatiotemporal multi-omics atlas from<i>Drosophila</i>embryogenesis to metamorphosis Open
SUMMARY The development of a multicellular organism is a highly intricate process tightly regulated by numerous genes and pathways in both spatial and temporal manners. Here, we present Flysta3D, a comprehensive multi-omics atlas of the mo…
View article: Anti-4-1BB immunotherapy enhances systemic immune effects of radiotherapy to induce B and T cell-dependent anti-tumor immune activation and improve tumor control at unirradiated sites
Anti-4-1BB immunotherapy enhances systemic immune effects of radiotherapy to induce B and T cell-dependent anti-tumor immune activation and improve tumor control at unirradiated sites Open
View article: Flavonoids for viral acute respiratory tract infections: protocol for a systematic review and meta-analysis of randomised controlled trials
Flavonoids for viral acute respiratory tract infections: protocol for a systematic review and meta-analysis of randomised controlled trials Open
Introduction Herbal and ‘natural’ products are a growing industry in today’s society because they reportedly help with numerous diseases and ailments. To date, there are some randomised controlled trials (RCTs) conducted on patients concer…
View article: Elucidating the mechanism of cellular uptake of fullerene nanoparticles
Elucidating the mechanism of cellular uptake of fullerene nanoparticles Open
Understanding the molecular interactions between biological cells and engineered nanoparticles is a key to evaluating potential toxicities to humans and the environment. This study developed a method to determine the mechanisms by which fu…
View article: Anti-diabetic agents for prevention of type 2 diabetes mellitus in people with pre-diabetes: a systematic review and network meta-analysis protocol
Anti-diabetic agents for prevention of type 2 diabetes mellitus in people with pre-diabetes: a systematic review and network meta-analysis protocol Open
Introduction Type 2 diabetes mellitus (T2DM) is a substantial health problem worldwide. Pre-diabetic state is associated with increased risk for the development of diabetes. There are various pharmacological therapies with glucose-lowering…
View article: Fine Epitope Mapping of Two Antibodies Neutralizing the <i>Bordetella</i> Adenylate Cyclase Toxin
Fine Epitope Mapping of Two Antibodies Neutralizing the <i>Bordetella</i> Adenylate Cyclase Toxin Open
Adenylate cyclase toxin (ACT) is an important Bordetella pertussis virulence factor that is not included in current acellular pertussis vaccines. We previously demonstrated that immunization with the repeat-in-toxin (RTX) domain of ACT eli…
View article: Synergistic Neutralization of Pertussis Toxin by a Bispecific Antibody <i>In Vitro</i> and <i>In Vivo</i>
Synergistic Neutralization of Pertussis Toxin by a Bispecific Antibody <i>In Vitro</i> and <i>In Vivo</i> Open
Bispecific antibodies are a rapidly growing class of therapeutic molecules, originally developed for the treatment of cancer but recently explored for the treatment of autoimmune and infectious diseases. Bordetella pertussis is a reemergin…
View article: Nano LC/MS ultratrace proteomic analysis using narrow bore porous layer open tubular based platform
Nano LC/MS ultratrace proteomic analysis using narrow bore porous layer open tubular based platform Open
Liquid chromatography coupled to a mass spectrometer as detector (LC-MS) are important tools for modern sample analysis especially in protein characterization and complex biological sample profiling. One specific challenge in medical analy…
View article: The Bordetella adenylate cyclase repeat-in-toxin (RTX) domain is immunodominant and elicits neutralizing antibodies.
The Bordetella adenylate cyclase repeat-in-toxin (RTX) domain is immunodominant and elicits neutralizing antibodies. Open
The Bordetella adenylate cyclase repeat
View article: An Integrated Platform for Isolation, Processing, and Mass Spectrometry-based Proteomic Profiling of Rare Cells in Whole Blood*
An Integrated Platform for Isolation, Processing, and Mass Spectrometry-based Proteomic Profiling of Rare Cells in Whole Blood* Open
Isolation and molecular characterization of rare cells (e.g. circulating tumor and stem cells) within biological fluids and tissues has significant potential in clinical diagnostics and personalized medicine. The present work describes an …