Xian‐Zheng Zhang
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View article: Nanomedicine for targeting cancer-associated fibroblasts in cancer therapy
Nanomedicine for targeting cancer-associated fibroblasts in cancer therapy Open
View article: Directly Evolved Nanovaccines Modulate Disrupted Circadian Rhythm and Enhance Cancer Immunotherapy
Directly Evolved Nanovaccines Modulate Disrupted Circadian Rhythm and Enhance Cancer Immunotherapy Open
The circadian rhythm, as a crucial endogenous biological oscillator, often undergoes disruptions, thus fostering severe immunosuppression within tumors. Here, this work develops directly evolved biovesicles as biological clock‐modulated na…
View article: Layer‐by‐Layer Deposition of Antigen Peptides on <i>Bifidobacterium</i> for Subintestinal Lymphatic System‐Guided Personalized Tumor Immunotherapy
Layer‐by‐Layer Deposition of Antigen Peptides on <i>Bifidobacterium</i> for Subintestinal Lymphatic System‐Guided Personalized Tumor Immunotherapy Open
Gut‐associated lymphoid tissue (GALT) possesses a highly specialized immune system and is rational as a foothold for oral tumor vaccines. Here, a noninvasive oral vaccine (Bif‐OVA‐Ocur) is designed to engage GALT, inducing both intestinal …
View article: Engineered bacillus subtilis enhances bone regeneration via immunoregulation and anti-Infection
Engineered bacillus subtilis enhances bone regeneration via immunoregulation and anti-Infection Open
View article: Tea leaf-derived nanovesicles for ferric-supply-amplified ICD and macrophage reprogramming to boost immunotherapy against head and neck squamous carcinoma
Tea leaf-derived nanovesicles for ferric-supply-amplified ICD and macrophage reprogramming to boost immunotherapy against head and neck squamous carcinoma Open
View article: Harnessing the Engineered Probiotic‐Nanosystem to Remodulate Tumor Extracellular Matrix and Regulate Tumor‐Colonizing Bacteria for Improving Pancreatic Cancer Chemo‐Immunotherapy
Harnessing the Engineered Probiotic‐Nanosystem to Remodulate Tumor Extracellular Matrix and Regulate Tumor‐Colonizing Bacteria for Improving Pancreatic Cancer Chemo‐Immunotherapy Open
Poor chemotherapy efficacy in pancreatic cancer is attributed to limited drug permeation caused by the dense extracellular matrix (ECM) and drug degradation induced by tumor‐colonizing bacteria. Here, a tumor‐targeting probiotic‐nanosystem…
View article: Living Biomaterials: Fabrication Strategies and Biomedical Applications
Living Biomaterials: Fabrication Strategies and Biomedical Applications Open
View article: Immune isolation-enabled nanoencapsulation of donor T cells: a promising strategy for mitigating GVHD and treating AML in preclinical models
Immune isolation-enabled nanoencapsulation of donor T cells: a promising strategy for mitigating GVHD and treating AML in preclinical models Open
Background In allogeneic-hematopoietic stem cell transplantation for acute myeloid leukemia (AML), donor T cells combat leukemia through the graft-versus-leukemia (GVL) effect, while they also pose a risk of triggering life-threatening gra…
View article: Drug‐Free “Triboelectric Immunotherapy” Activating Immunity for Osteomyelitis Treatment and Recurrence Prevention
Drug‐Free “Triboelectric Immunotherapy” Activating Immunity for Osteomyelitis Treatment and Recurrence Prevention Open
Treatment of osteomyelitis is clinically challenging with low therapeutic efficacy and high risk of recurrence owing to the immunosuppressive microenvironment. Existing therapies are limited by drug concentration and single regulatory effe…
View article: Probiotics functionalized with a gallium-polyphenol network modulate the intratumor microbiota and promote anti-tumor immune responses in pancreatic cancer
Probiotics functionalized with a gallium-polyphenol network modulate the intratumor microbiota and promote anti-tumor immune responses in pancreatic cancer Open
View article: Construction of Ferric-Oxide-Doped Nickel–Iron Hydroxide Electrocatalysts by Magnetic-Field-Assisted Chemical Corrosion toward Boosted Oxygen Evolution Reaction
Construction of Ferric-Oxide-Doped Nickel–Iron Hydroxide Electrocatalysts by Magnetic-Field-Assisted Chemical Corrosion toward Boosted Oxygen Evolution Reaction Open
Transition-metal-based oxygen evolution reaction (OER) catalysts have attracted widespread attention due to their inexpensive prices, unique layered structures, and rich active sites. Currently, designing low-cost, sustainable, and simple …
View article: Mechanoelectronic stimulation of autologous extracellular vesicle biosynthesis implant for gut microbiota modulation
Mechanoelectronic stimulation of autologous extracellular vesicle biosynthesis implant for gut microbiota modulation Open
Pathogenic gut microbiota is responsible for a few debilitating gastrointestinal diseases. While the host immune cells do produce extracellular vesicles to counteract some deleterious effects of the microbiota, the extracellular vesicles a…
View article: Invasive cardiac lipoma at the left ventricular intermuscular region: A case report
Invasive cardiac lipoma at the left ventricular intermuscular region: A case report Open
The present study described the case of a 22-year-old woman who had symptoms of left chest pain for >6 months, with further aggravation over 2 days. Computed tomography (CT) images of the mediastinal and pulmonary windows showed low-densit…
View article: History, present, and future of polymer science at Wuhan University
History, present, and future of polymer science at Wuhan University Open
As an integral part of the College of Chemistry and Molecular Sciences at Wuhan University (WHU Chemistry), the Department of Polymer Science at Wuhan University (WHU Polymer) originated from the disciplines of Organic Chemistry and Polyme…
View article: Sodium chloride promotes macrophage pyroptosis and aggravates rheumatoid arthritis by activating SGK1 through GABA receptors Slc6a12
Sodium chloride promotes macrophage pyroptosis and aggravates rheumatoid arthritis by activating SGK1 through GABA receptors Slc6a12 Open
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovial inflammation and the production of autoantibodies. Previous studies have indicated an association between high-salt diets (HSD) and an increased r…
View article: Analysis of debris flow control effect and hazard assessment in Xinqiao Gully, Wenchuan <i>M</i><sub>s</sub> 8.0 earthquake area based on numerical simulation
Analysis of debris flow control effect and hazard assessment in Xinqiao Gully, Wenchuan <i>M</i><sub>s</sub> 8.0 earthquake area based on numerical simulation Open
Xinqiao Gully is located in the area of the 2008 Wenchuan Ms 8.0 earthquake in Sichuan province, China. Based on the investigation of the 2023 “6-26” Xinqiao Gully debris flow event, this study assessed the effectiveness of the debris flow…
View article: Chimeric Exosomes Functionalized with STING Activation for Personalized Glioblastoma Immunotherapy
Chimeric Exosomes Functionalized with STING Activation for Personalized Glioblastoma Immunotherapy Open
A critical challenge of existing cancer vaccines is to orchestrate the demands of antigen‐enriched furnishment and optimal antigen‐presentation functionality within antigen‐presenting cells (APCs). Here, a complementary immunotherapeutic s…
View article: The complete mitochondrial genome of <i>Nycteribia formosana</i> (Diptera, Nycteribiidae)
The complete mitochondrial genome of <i>Nycteribia formosana</i> (Diptera, Nycteribiidae) Open
The family Hippoboscidae is an ectoparasite that primarily inhabits bats and relies on the host's blood for sustenance. This research provides the first complete mitochondrial genome of Nycteribia formosana, which shares similar cha…
View article: Polymer materials for constructing therapeutical nanoparticles in photothermal therapy
Polymer materials for constructing therapeutical nanoparticles in photothermal therapy Open
Photothermal therapy (PTT) ablates tumors by thermal effects of photothermal agents (PTAs), and attracts wide attention due to the non‐invasive characteristic. The ideal PTAs are expected to have high photothermal conversion effect under N…
View article: Targeting fusion proteins of the interleukin family: A promising new strategy for the treatment of autoinflammatory diseases
Targeting fusion proteins of the interleukin family: A promising new strategy for the treatment of autoinflammatory diseases Open
As a means of communication between immune cells and non-immune cells, Interleukins (ILs) has the main functions of stimulating the proliferation and activation of inflammatory immune cells such as dendritic cells and lymphocytes, promote …
View article: Assembled polyphenol‐based systems as advanced therapeutics
Assembled polyphenol‐based systems as advanced therapeutics Open
Polymeric assemblies have emerged as a kind of promising platform in biomedical fields. The strong potency of polyphenols to form versatile interactions with other small or polymeric molecules via covalent and noncovalent linkages enables …
View article: Comparative Study About Different Doses of Remimazolam in Short Laparoscopic Surgery: A Randomized Controlled Double-Blind Trial
Comparative Study About Different Doses of Remimazolam in Short Laparoscopic Surgery: A Randomized Controlled Double-Blind Trial Open
Compared to propofol, total intravenous induction and maintenance with high and median dosages of remimazolam may prolong postoperative extubation time. Remimazolam can be safely used for induction and maintenance at various doses while no…
View article: Editorial: The role of maintenance therapy (immunotherapy, targeted therapy, etc) in cancer control and biologic behavior of recurrent/metastatic cervical cancer
Editorial: The role of maintenance therapy (immunotherapy, targeted therapy, etc) in cancer control and biologic behavior of recurrent/metastatic cervical cancer Open
EDITORIAL article Front. Immunol., 07 September 2023Sec. Cancer Immunity and Immunotherapy Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1281775
View article: Inhalable Capsular Polysaccharide‐Camouflaged Gallium‐Polyphenol Nanoparticles Enhance Lung Cancer Chemotherapy by Depleting Local Lung Microbiota
Inhalable Capsular Polysaccharide‐Camouflaged Gallium‐Polyphenol Nanoparticles Enhance Lung Cancer Chemotherapy by Depleting Local Lung Microbiota Open
Local lung microbiota is closely associated with lung tumorigenesis and therapeutic response. It is found that lung commensal microbes induce chemoresistance in lung cancer by directly inactivating therapeutic drugs via biotransformation. …
View article: Electroactive Microorganisms in Advanced Energy Technologies
Electroactive Microorganisms in Advanced Energy Technologies Open
Large-scale production of green and pollution-free materials is crucial for deploying sustainable clean energy. Currently, the fabrication of traditional energy materials involves complex technological conditions and high costs, which sign…
View article: Light-driven biohybrid system utilizes N2 for photochemical CO2 reduction
Light-driven biohybrid system utilizes N2 for photochemical CO2 reduction Open
Attempting to couple photochemical CO2 reduction with N2 fixation is usually difficult, because the reaction conditions for these two processes are typically incompatible. Here, we report that a light-driven biohybrid system can utilize ab…
View article: GRK2 Mediates Macrophage Polarization by Regulating EP4-cAMP-pCREB Signaling in Ulcerative Colitis and the Therapeutic Effect of Paroxetine on Mice with DSS-Induced Colitis
GRK2 Mediates Macrophage Polarization by Regulating EP4-cAMP-pCREB Signaling in Ulcerative Colitis and the Therapeutic Effect of Paroxetine on Mice with DSS-Induced Colitis Open
G protein-coupled receptor kinase 2 (GRK2) is one of the cytosolic enzymes, and GRK2 translocation induces prostaglandin E2 receptor 4 (EP4) over-desensitization and reduces the level of cyclic adenosine monophosphate (cAMP) to regulate ma…
View article: Complete mitochondrial genome of <i>Penicillidia jenynsii</i> (Diptera: Hippoboscoidea: Nycteribiidae) and phylogenetic relationship
Complete mitochondrial genome of <i>Penicillidia jenynsii</i> (Diptera: Hippoboscoidea: Nycteribiidae) and phylogenetic relationship Open
In recent years, bat-associated pathogens, such as 2019 novel coronavirus, have been ravaging the world, and ectoparasites of bats have received increasing attention. Penicillidia jenynsii is a member of the family Nycteribiidae which is a…
View article: Size-Controllable Nanosystem with Double Responsive for Deep Photodynamic Therapy
Size-Controllable Nanosystem with Double Responsive for Deep Photodynamic Therapy Open
Photodynamic therapy (PDT) is a promising strategy for cancer treatment. However, a poor tissue penetration of activation light and low target specificity seriously hindered the clinical application of PDT. Here, we designed and constructe…
View article: The complete mitochondrial genome of <i>Phthiridium szechuanum</i> (Nycteribiidae, Diptera)
The complete mitochondrial genome of <i>Phthiridium szechuanum</i> (Nycteribiidae, Diptera) Open
Phthiridium szechuanum is a bat surface parasite under the family Nycteribiidae that prefers to roost in the hair of bats to feed on their blood. In this study, the complete mitochondrial genome of P. szechuanum was studied f…