Xiaojun Liu
YOU?
Author Swipe
View article: BPTF-665aa mediate chromatin remodeling drives chemoresistance in T-LBL/ALL
BPTF-665aa mediate chromatin remodeling drives chemoresistance in T-LBL/ALL Open
Chemoresistance remains a major challenge in addressing T-cell lymphoblastic lymphoma/leukemia (T-LBL/ALL), underscoring the necessity for novel strategies to unravel the molecular factors driving resistance. Through transcriptomic profili…
View article: Genome-wide identification and expression analysis of the PYL gene family in response to salt, drought and cold stresses in Solanum melongena L.
Genome-wide identification and expression analysis of the PYL gene family in response to salt, drought and cold stresses in Solanum melongena L. Open
This study presents the first genome-wide identification of 24 Sm-PYL genes in eggplant, classified into three subfamilies. Structural and evolutionary analyses revealed conserved motifs, purifying selection, and gene family expansion thro…
View article: CD4 as a Potential Biomarker for Differentiating Cirrhosis with Dysplastic Nodules from Well-Differentiated Hepatocellular Carcinoma
CD4 as a Potential Biomarker for Differentiating Cirrhosis with Dysplastic Nodules from Well-Differentiated Hepatocellular Carcinoma Open
Distinguishing high-grade dysplastic nodules in cirrhotic livers from well-differentiated hepatocellular carcinoma (HCC) remains difficult due to overlapping histological features and limited biomarker specificity. In this study, 85 liver …
View article: Alcoholic Metabolic Activation in Mice: The Role of A Small Cluster Mineral Water
Alcoholic Metabolic Activation in Mice: The Role of A Small Cluster Mineral Water Open
To explore the molecular mechanisms underlying the effects of a specific small cluster mineral water (C-cell mineral water) on ethanol metabolism, we conducted a series of assessments comprising anti-acute alcohol toxicity experiments incl…
View article: Identification of an antifungal lipopeptide from <i>Bacillus amyloliquefaciens</i> HAU3 inhibiting the growth of <i>Fusarium graminearum</i> using preparative chromatography and 2D-NMR
Identification of an antifungal lipopeptide from <i>Bacillus amyloliquefaciens</i> HAU3 inhibiting the growth of <i>Fusarium graminearum</i> using preparative chromatography and 2D-NMR Open
The presence of fungal contamination and its mycotoxins in animal feed is pervasive, posing a significant threat to the well-being and performance of animals, as well as the safety of animal-derived food products. In this work, we screened…
View article: Whole-genome resequencing revealed genetic structure and specific breed identification loci of Ningxia Jingyuan chicken breed (Gallus gallus)
Whole-genome resequencing revealed genetic structure and specific breed identification loci of Ningxia Jingyuan chicken breed (Gallus gallus) Open
View article: Accessing the success of implementation of the 2020 Chinese clinical practice guideline for prevention and treatment of type 2 diabetes mellitus in hospitals: a cross-sectional study using A-GIST
Accessing the success of implementation of the 2020 Chinese clinical practice guideline for prevention and treatment of type 2 diabetes mellitus in hospitals: a cross-sectional study using A-GIST Open
Background Type 2 diabetes mellitus (T2DM) is the leading cause of morbidity and mortality in China. The 2020 Chinese clinical practice guideline for prevention and treatment of T2DM was published at April 2021, yet its status of implement…
View article: Global, regional, and national burden of endocarditis, 1990−2021: a systematic analysis of the GBD 2021 study
Global, regional, and national burden of endocarditis, 1990−2021: a systematic analysis of the GBD 2021 study Open
View article: Global, regional and national burden of Metabolic dysfunction-associated steatotic liver disease in adolescents and adults aged 15–49 years from 1990 to 2021: results from the 2021 Global Burden of Disease study
Global, regional and national burden of Metabolic dysfunction-associated steatotic liver disease in adolescents and adults aged 15–49 years from 1990 to 2021: results from the 2021 Global Burden of Disease study Open
Background With rising obesity and diabetes rates, the incidence of Metabolic dysfunction-associated steatotic liver disease (MASLD) among individuals aged 15–49 is increasing, affecting their productivity, health, and quality of life. How…
View article: Estimate the Association of Dexamethasone Prescription with Acute Kidney Injury among Hospitalized Children with Inverse Probability Weighting
Estimate the Association of Dexamethasone Prescription with Acute Kidney Injury among Hospitalized Children with Inverse Probability Weighting Open
View article: Neferine alleviates alcohol-induced liver injury in mice by inhibiting oxidative stress and inflammation
Neferine alleviates alcohol-induced liver injury in mice by inhibiting oxidative stress and inflammation Open
View article: miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury: Erratum
miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury: Erratum Open
[This corrects the article DOI: 10.7150/thno.15162.].
View article: Improvement of semen quality in Longyou Partridge Chicken by dietary N-acetyl-L-glutamic acid and its mechanism study
Improvement of semen quality in Longyou Partridge Chicken by dietary N-acetyl-L-glutamic acid and its mechanism study Open
View article: Andrographolide reverses the susceptibility of Streptococcus suis to aminoglycoside antibiotics by proton motive force
Andrographolide reverses the susceptibility of Streptococcus suis to aminoglycoside antibiotics by proton motive force Open
AP holds promise as an adjuvant to aminoglycoside antibiotics for combating S. suis-induced infections, offering a theoretical foundation for clinical applications.
View article: Adrenocorticotropic Hormone versus Prednisolone for Infantile Epileptic Spasms Syndrome: A Systematic Review and Economic Evaluation
Adrenocorticotropic Hormone versus Prednisolone for Infantile Epileptic Spasms Syndrome: A Systematic Review and Economic Evaluation Open
Background Infantile epileptic spasms syndrome (IESS) is the most common epileptic encephalopathy in infancy and early childhood. At present, adrenocorticotropic hormone (ACTH) and prednisolone are commonly used as drug treatment regimens …
View article: Can physical trauma trigger relapsing polychondritis? The first report from a Chinese cohort and comparison with rheumatoid arthritis and psoriatic arthritis
Can physical trauma trigger relapsing polychondritis? The first report from a Chinese cohort and comparison with rheumatoid arthritis and psoriatic arthritis Open
Objectives The triggers of relapsing polychondritis (RPC) are not fully characterized. This study was performed to explore the association between physical trauma and RPC. Methods The history of physical trauma of 208 patients with RPC fro…
View article: Transcriptomic Insights into Dual Temperature–Salinity Stress Response in “Shuike No. 1”, a Pioneering Rainbow Trout Strain Bred in China
Transcriptomic Insights into Dual Temperature–Salinity Stress Response in “Shuike No. 1”, a Pioneering Rainbow Trout Strain Bred in China Open
Global warming poses a significant threat to aquaculture, particularly for cold-water species like rainbow trout (Oncorhynchus mykiss). Understanding the molecular mechanisms underlying stress responses is crucial for developing resilient …
View article: PGK1: A Common Biomarker and Therapeutic Target Linking Sarcopenia and Osteoporosis Through Fibroblast‐Mediated Pathways
PGK1: A Common Biomarker and Therapeutic Target Linking Sarcopenia and Osteoporosis Through Fibroblast‐Mediated Pathways Open
Sarcopenia and osteoporosis share pathophysiological links, but their co‐occurrence mechanisms remain unclear. This study aimed to identify molecular mediators of their co‐development using bioinformatics. Datasets for sarcopenia (GSE56815…
View article: Engineered Macrophages Rejuvenate the Tumor Microenvironment and Enhance Anti-Pd-1 Therapy in Renal Cancer
Engineered Macrophages Rejuvenate the Tumor Microenvironment and Enhance Anti-Pd-1 Therapy in Renal Cancer Open
View article: Identification of HIBCH and MGME1 as Mitochondrial Dynamics‐Related Biomarkers in Alzheimer's Disease Via Integrated Bioinformatics Analysis
Identification of HIBCH and MGME1 as Mitochondrial Dynamics‐Related Biomarkers in Alzheimer's Disease Via Integrated Bioinformatics Analysis Open
Mitochondrial dynamics (MD) play a crucial role in the genesis of Alzheimer's disease (AD); however, the molecular mechanisms underlying MD dysregulation in AD remain unclear. This study aimed to identify critical molecules of MD that cont…
View article: Dual oncogenic roles of TPD52 and TPD52L2 in gastric cancer progression <i>via</i> PI3K/AKT activation and immunosuppressive microenvironment remodeling
Dual oncogenic roles of TPD52 and TPD52L2 in gastric cancer progression <i>via</i> PI3K/AKT activation and immunosuppressive microenvironment remodeling Open
Aim TPD52 (tumor protein D52) and TPD52L2 (tumor protein D52-like 2), members of the TPD52 gene family, have been implicated in multiple malignancies. However, their roles in gastric cancer (GC) remain elusive. Herein, we integrated multio…
View article: Association between waist-to-height ratio and osteoporosis in the National Health and Nutrition Examination Survey: a cross-sectional study
Association between waist-to-height ratio and osteoporosis in the National Health and Nutrition Examination Survey: a cross-sectional study Open
Background The link between waist-to-height ratio (WHtR) and osteoporosis (OP) remains a contentious issue in the field of medical research. Currently, the available evidence on this association is deemed insufficient. This topic has garne…
View article: Risk factors of renal function deterioration after radical nephroureterectomy for upper tract urothelial carcinoma
Risk factors of renal function deterioration after radical nephroureterectomy for upper tract urothelial carcinoma Open
Background and objectives To investigate the risk factors of renal function deterioration after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). Methods A total of 153 patients with UTUC who underwent radical s…
View article: Deciphering MOSPD1’s impact on breast cancer progression and therapeutic response
Deciphering MOSPD1’s impact on breast cancer progression and therapeutic response Open
Elevated MOSPD1 levels in BC suggest its potential as a biomarker for adverse outcomes. Targeting MOSPD1, particularly with anti-PD-L1 therapy, may effectively inhibit BC tumor growth and modulate immune responses. This study emphasizes th…
View article: The association between neutrophil percentage-to-albumin ratio (NPAR) and depression among US adults: a cross-sectional study
The association between neutrophil percentage-to-albumin ratio (NPAR) and depression among US adults: a cross-sectional study Open
Inflammation plays an important role in depression, and the neutrophil-to-albumin ratio (NPAR) is a cost-effective and readily available novel biomarker of inflammation. The association between NPAR and depression is unclear; therefore, to…
View article: Investigating the hub genes and genetic basis regulating fatty acid metabolictraits in chicken breast muscle based on combined genomic and transcriptomic approaches
Investigating the hub genes and genetic basis regulating fatty acid metabolictraits in chicken breast muscle based on combined genomic and transcriptomic approaches Open
Background The composition of various fatty acids in meat plays a crucial role in the evaluation of the nutritional indicators of poultry and human health. Fatty acid metabolic indicators can more accurately reflect the nutritional status …
View article: Single‐cell <scp>RNA</scp> sequencing reveals the heterogeneity of <scp>MYH11</scp>+ tumour‐associated fibroblasts between left‐sided and right‐sided colorectal cancer
Single‐cell <span>RNA</span> sequencing reveals the heterogeneity of <span>MYH11</span>+ tumour‐associated fibroblasts between left‐sided and right‐sided colorectal cancer Open
Colorectal cancer (CRC) exhibits considerable heterogeneity on tumour location. However, there is still a lack of comprehensive annotation regarding the characteristics and differences between the left‐sided (L‐CRC) and right‐sided (R‐CRC)…
View article: CITED4 gene therapy protects against maladaptive cardiac remodeling after ischemia/reperfusion injury in mice
CITED4 gene therapy protects against maladaptive cardiac remodeling after ischemia/reperfusion injury in mice Open
View article: SPACA6P-AS: a trailblazer in breast cancer pathobiology and therapeutics
SPACA6P-AS: a trailblazer in breast cancer pathobiology and therapeutics Open
View article: Real-time label-free three-dimensional invasion assay for anti-metastatic drug screening using impedance sensing
Real-time label-free three-dimensional invasion assay for anti-metastatic drug screening using impedance sensing Open
Tumor metastasis presents a formidable challenge in cancer treatment, necessitating effective tools for anti-cancer drug development. Conventional 2D cell culture methods, while considered the “gold standard” for invasive studies, exhibit …