Xiaoqian Ran
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View article: Mechanism of arsenic-induced liver injury in rats revealed by metabolomics and ionomics based approach
Mechanism of arsenic-induced liver injury in rats revealed by metabolomics and ionomics based approach Open
Arsenic (As) is an environmental toxicant and human carcinogen, long-term exposure to As can lead to varying degrees of liver injury. In this study, the liver injury model of As poisoned Sprague-Dawley (SD) rats was established, and the po…
View article: Selenium Intervention in Alzheimer's Disease Mice and its Possible Involvement of the Gut-Brain Axis
Selenium Intervention in Alzheimer's Disease Mice and its Possible Involvement of the Gut-Brain Axis Open
View article: Integration of proteomics and metabolomics analysis investigate mechanism of As-induced immune injury in rat spleen
Integration of proteomics and metabolomics analysis investigate mechanism of As-induced immune injury in rat spleen Open
Arsenic (As) is a widespread metalloid and human carcinogen found in the natural environment, and multiple toxic effects have been shown to be associated with As exposure. As can be accumulated in the spleen, the largest peripheral lymphat…
View article: Proteomic analysis of the effects of Dictyophora polysaccharide on arsenic-induced hepatotoxicity in rats
Proteomic analysis of the effects of Dictyophora polysaccharide on arsenic-induced hepatotoxicity in rats Open
Arsenic (As) is a highly toxic environmental toxicant and a known human carcinogen. Long-term exposure to As can cause liver injury. Dictyophora polysaccharide (DIP) is a biologically active natural compound found in the Dictyophora with e…
View article: Autism spectrum disorder: pathogenesis, biomarker, and intervention therapy
Autism spectrum disorder: pathogenesis, biomarker, and intervention therapy Open
Autism spectrum disorder (ASD) has become a common neurodevelopmental disorder. The heterogeneity of ASD poses great challenges for its research and clinical translation. On the basis of reviewing the heterogeneity of ASD, this review syst…
View article: Euphejolkinolide A, a new ent-abietane lactone from Euphorbia peplus L. with promising biological activity in activating the autophagy-lysosomal pathway
Euphejolkinolide A, a new ent-abietane lactone from Euphorbia peplus L. with promising biological activity in activating the autophagy-lysosomal pathway Open
View article: New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217)
New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217) Open
Eleven monoterpenoid indole alkaloids, including three new ones, tabercrassines A–C (1–3), were isolated from the seeds of Tabernaemontana crassa. Tabercrassine A (1) is an ibogan–ibogan-type bisindole alkaloid which is formed by the polym…
View article: Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology
Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology Open
Ten jatrophane diterpenoids were isolated from the whole plant Euphorbia peplus Linn. including seven new ones, named euphjatrophanes A-G (labeled compounds 1, 2, 4–8). Their structures were elucidated with a combination of spectroscopic a…
View article: Ganoapplins a and B with an Unprecedented 6/6/6/5/6-Fused Pentacyclic Skeleton from <i>Ganoderma</i> Inhibit Tau Pathology Through Activating Autophagy
Ganoapplins a and B with an Unprecedented 6/6/6/5/6-Fused Pentacyclic Skeleton from <i>Ganoderma</i> Inhibit Tau Pathology Through Activating Autophagy Open
View article: A novel missense variant in ACAA1 contributes to early-onset Alzheimer’s disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline
A novel missense variant in ACAA1 contributes to early-onset Alzheimer’s disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline Open