Xiaoqing Fan
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View article: Epigallocatechin-3-gallate ameliorates lipopolysaccharide-induced inflammation via the 67LR/JAK2/STAT3 signaling pathway
Epigallocatechin-3-gallate ameliorates lipopolysaccharide-induced inflammation via the 67LR/JAK2/STAT3 signaling pathway Open
Lipopolysaccharide (LPS) can trigger an inflammatory response in lung epithelial cells, which may contribute to the development of Acute Respiratory Distress Syndrome (ARDS). Epigallocatechin-3- gallate (EGCG), a bioactive constituent in g…
View article: Clinical characteristics of Chlamydia psittaci pneumonia: a single-center, retrospective study over 5 years
Clinical characteristics of Chlamydia psittaci pneumonia: a single-center, retrospective study over 5 years Open
Impaired consciousness indicates severe illness and myocardial injury is an independent risk factor for severe C. psittaci pneumonia.
View article: Recent advances in the interaction between acute respiratory distress syndrome and gut microbiota: A narrative review
Recent advances in the interaction between acute respiratory distress syndrome and gut microbiota: A narrative review Open
Acute respiratory distress syndrome (ARDS) is a sudden, widespread inflammatory damage to the lungs resulting from multiple etiologies. ARDS is characterized by high sickness rates, mortality, and costly treatments and is a significant glo…
View article: Drug-resistant fungi: the unintended consequence of modern immunosuppression
Drug-resistant fungi: the unintended consequence of modern immunosuppression Open
View article: Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling for Iron-Regulated Hematopoietic Stem and Progenitor Cells’ Commitment toward Erythroid and Megakaryocytic Lineages
Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling for Iron-Regulated Hematopoietic Stem and Progenitor Cells’ Commitment toward Erythroid and Megakaryocytic Lineages Open
Iron replenishment is a cornerstone therapy for anemia in diverse diseases. While its role in erythrocyte hemoglobinization is well-established, the broader impact of iron on other aspects of hematopoiesis, such as thrombopoiesis, remains …
View article: A mechanism-based pharmacokinetic/pharmacodynamic model for iron-regulated hematopoietic stem and progenitor cells commitment towards erythroid and megakaryocyte lineages
A mechanism-based pharmacokinetic/pharmacodynamic model for iron-regulated hematopoietic stem and progenitor cells commitment towards erythroid and megakaryocyte lineages Open
View article: Author correction to ‘Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice’ [Acta Pharmaceutica Sinica B 13 (2023) 1164–1179]
Author correction to ‘Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice’ [Acta Pharmaceutica Sinica B 13 (2023) 1164–1179] Open
View article: Pharmacokinetics, absorption and transport mechanism for ginseng polysaccharides
Pharmacokinetics, absorption and transport mechanism for ginseng polysaccharides Open
Our results confirm that the uptake of GPs by small intestinal epithelial cells is primarily mediated via lattice proteins and the cytosolic cellar. The discovery of important pharmacokinetic properties and the uncovering of the absorption…
View article: Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice
Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice Open
View article: Propofol enhances stem-like properties of glioma via GABAAR‐dependent Src modulation of ZDHHC5-EZH2 palmitoylation mechanism
Propofol enhances stem-like properties of glioma via GABAAR‐dependent Src modulation of ZDHHC5-EZH2 palmitoylation mechanism Open
View article: Oct4A palmitoylation modulates tumorigenicity and stemness in human glioblastoma cells
Oct4A palmitoylation modulates tumorigenicity and stemness in human glioblastoma cells Open
Background Glioblastoma multiforme and other solid malignancies are heterogeneous, containing subpopulations of tumor cells that exhibit stem characteristics. Oct4, also known as POU5F1, is a key transcription factor in the self-renewal, p…
View article: GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2–STAT3 axis
GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2–STAT3 axis Open
View article: Additional file 2 of Propofol enhances stem-like properties of glioma via GABAAR‐dependent Src modulation of ZDHHC5-EZH2 palmitoylation mechanism
Additional file 2 of Propofol enhances stem-like properties of glioma via GABAAR‐dependent Src modulation of ZDHHC5-EZH2 palmitoylation mechanism Open
Additional file 2. Supplementary Table.
View article: Correction: Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation
Correction: Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation Open
View article: Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation
Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation Open
View article: Propofol impairs specification of retinal cell types in zebrafish by inhibiting Zisp-mediated Noggin-1 palmitoylation and trafficking
Propofol impairs specification of retinal cell types in zebrafish by inhibiting Zisp-mediated Noggin-1 palmitoylation and trafficking Open
Background Propofol can have adverse effects on developing neurons, leading to cognitive disorders, but the mechanism of such an effect remains elusive. Here, we aimed to investigate the effect of propofol on neuronal development in zebraf…
View article: Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation
Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation Open
View article: Molecular subtyping of glioblastoma based on immune-related genes for prognosis
Molecular subtyping of glioblastoma based on immune-related genes for prognosis Open
Glioblastoma (GBM) is associated with an increasing mortality and morbidity and is considered as an aggressive brain tumor. Recently, extensive studies have been carried out to examine the molecular biology of GBM, and the progression of G…
View article: <p>Effects of Anesthesia on Postoperative Recurrence and Metastasis of Malignant Tumors</p>
Effects of Anesthesia on Postoperative Recurrence and Metastasis of Malignant Tumors Open
It is difficult to control the recurrence and metastasis of malignant tumors; furthermore, anesthesia is considered one of the main influencing factors. There has been increasing clinical attention on the effects of anesthetic drugs and me…
View article: Modulation of gut microbiota to overcome resistance to immune checkpoint blockade in cancer immunotherapy
Modulation of gut microbiota to overcome resistance to immune checkpoint blockade in cancer immunotherapy Open
Immune checkpoint blockade therapies that target CTLA-4 and PD-1/PD-L1 have ushered in a new era of cancer treatment. Nevertheless, a significant proportion of patients demonstrated primary or acquired resistance. Harnessing gut microbiota…
View article: Protein Palmitoylation Regulates Cell Survival by Modulating XBP1 Activity in Glioblastoma Multiforme
Protein Palmitoylation Regulates Cell Survival by Modulating XBP1 Activity in Glioblastoma Multiforme Open