Explanipedia

CGSim: A Simulation Framework for Large Scale Distributed Computing Environment Open

Sairam Sri Vatsavai, Raees Khan, Kuan-Chieh Hsu, Ozgur O. Kilic, P. Nilsson , et al. · 2025

Large-scale distributed computing infrastructures such as the Worldwide LHC Computing Grid (WLCG) require comprehensive simulation tools for evaluating performance, testing new algorithms, and optimizing resource allocation strategies. How…

Data Management System Analysis for Distributed Computing Workloads Open

Kuan-Chieh Hsu, Sairam Sri Vatsavai, Ozgur O. Kilic, Tatiana Korchuganova, P. Nilsson , et al. · 2025

Large-scale international collaborations such as ATLAS rely on globally distributed workflows and data management to process, move, and store vast volumes of data. ATLAS's Production and Distributed Analysis (PanDA) workflow system and the…

Alternative mixed integer linear programming optimization for joint job scheduling and data allocation in grid computing Open

Shengyu Feng, Jaehyung Kim, Yiming Yang, Joseph Boudreau, T. Chowdhury , et al. · 2025

Towards an Introspective Dynamic Model of Globally Distributed Computing Infrastructures Open

Ozgur O. Kilic, David S. Park, Yihui Ren, Tatiana Korchuganova, Sairam Sri Vatsavai , et al. · 2025

Large-scale scientific collaborations like ATLAS, Belle II, CMS, DUNE, and others involve hundreds of research institutes and thousands of researchers spread across the globe. These experiments generate petabytes of data, with volumes soon…

BCLAF1 restrains stress responses in hematopoietic stem cells to support expansion and repopulation Open

Stephanie J. Crowley, Wei Yang, Lynn S. White, Jun Wu, Yanan Li , et al. · 2025

Hematopoietic stem cells (HSCs) rapidly expand during fetal development and after stress. Here, we identify B-cell lymphoma-2-associated factor 1 (BCLAF1) as a regulator of HSC repopulation activity, with roles in the expansion of fetal HS…

Advances in Diagnostic Techniques for Influenza Virus Infection: A Comprehensive Review Open

Qian Qi, Guohao Fan, Wei Yang, Chenguang Shen, Yang Yang , et al. · 2025

Influenza poses a significant global health burden due to its high transmissibility, antigenic variability, and substantial morbidity. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has further complicated influe…

Cyclization of archaeal membrane lipids impacts membrane protein activity and archaellum formation Open

Wei Yang, Xi Feng, Huahui Chen, Geraldy L. S. Liman, Thomas J. Santangelo , et al. · 2025

Enhancement of the cyclization of membrane lipids GDGTs (glycerol dialkyl glycerol tetraethers) is a critical strategy for archaea to adapt to various environmental stresses. However, the physiological function of membrane lipid cyclizatio…

A Rare Cause of Abdominal Pain and Diarrhea-cystic Lymphangioma Located in the Descending Colon Open

Wei Yang, Chendong He · 2025

Cystic lymphangiomas of the colon are rare, benign tumors that arise from the lymphatic vessels and are typically asymptomatic. These lesions are often discovered incidentally during imaging or endoscopic evaluations for unrelated conditio…

Engineering archaeal membrane‐spanning lipid GDGT biosynthesis in bacteria: Implications for early life membrane transformations Open

Huahui Chen, Fengfeng Zheng, Xi Feng, Zijing Huang, Wei Yang , et al. · 2025

Eukaryotes are hypothesized to be archaeal–bacterial chimeras. Given the different chemical structures of membrane phospholipids in archaea and bacteria, transformations of membranes during eukaryogenesis that led to the bacterial‐type mem…

Alternative Mixed Integer Linear Programming Optimization for Joint Job Scheduling and Data Allocation in Grid Computing Open

Feng Shi, Jaehyung Kim, Yiming Yang, Joseph Boudreau, T. Chowdhury , et al. · 2025

This paper presents a novel approach to the joint optimization of job scheduling and data allocation in grid computing environments. We formulate this joint optimization problem as a mixed integer quadratically constrained program. To tack…

RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia Open

Tim Kong, Angelo B. A. Laranjeira, Christopher T. Letson, LaYow Yu, Shuyang Lin , et al. · 2025

Alternative Mixed Integer Linear Programming Optimization for Joint Job Scheduling and Data Allocation in Grid Computing Open

Feng Shi, Jaehyung Kim, Yiming Yang, Joseph Boudreau, T. Chowdhury , et al. · 2025

AI Surrogate Model for Distributed Computing Workloads Open

David S. Park, Yihui Ren, Ozgur O. Kilic, Tatiana Korchuganova, Sairam Sri Vatsavai , et al. · 2024

Large-scale international scientific collaborations, such as ATLAS, Belle II, CMS, and DUNE, generate vast volumes of data. These experiments necessitate substantial computational power for varied tasks, including structured data processin…

AI Surrogate Model for Distributed Computing Workloads Open

David S. Park, Yihui Ren, Ozgur O. Kilic, Tatiana Korchuganova, Sairam Sri Vatsavai , et al. · 2024

Large-scale international scientific collaborations, such as ATLAS, Belle II, CMS, and DUNE, generate vast volumes of data. These experiments necessitate substantial computational power for varied tasks, including structured data processin…

Kmt2c restricts G-CSF-driven HSC mobilization and granulocyte production in a methyltransferase-independent manner Open

Helen C. Wang, Ran Chen, Wei Yang, Yanan Li, Rohini Muthukumar , et al. · 2024

Tetrandrine inhibits aldosterone synthesis by covalently targeting CYP11A1 to attenuate hypertension Open

Simeng Chu, Wei Yang, Yujie Lu, Junjie Li, Jiamin Peng , et al. · 2024

Introduction Tetrandrine (Tet) is the main pharmacological component of Stephania tetrandra S. Moore, which is a well-documented traditional Chinese medicine known for its diuretic and antihypertensive properties. Unraveling the specific t…

Genomic and metabolic analyses reveal antagonistic lanthipeptides in archaea Open

Haoyu Liang, Zhi‐Man Song, Zheng Zhong, Dengwei Zhang, Wei Yang , et al. · 2023

Isolation of archaeal viruses with lipid membrane from Tengchong acidic hot springs Open

Xi Feng, Yanan Li, Chang Tian, Wei Yang, Xinyu Liu , et al. · 2023

Archaeal viruses are one of the most mysterious parts of the virosphere because of their diverse morphologies and unique genome contents. The crenarchaeal viruses are commonly found in high temperature and acidic hot springs, and the numbe…

Basal type I interferon signaling has only modest effects on neonatal and juvenile hematopoiesis Open

Yanan Li, Wei Yang, Helen C. Wang, Riddhi Patel, Emily B. Casey , et al. · 2023

Type I interferon (IFN-1) regulates gene expression and hematopoiesis both during development and in response to inflammatory stress. We previously showed that during development in mice, hematopoietic stem cells (HSCs) and multipotent pro…

The thylakoid membrane protein NTA1 is an assembly factor of the cytochrome bf complex essential for chloroplast development in Arabidopsis Open

Na Li, Wing Shing Wong, Lei Feng, Chunming Wang, King Shing Wong , et al. · 2022

The cytochrome b_6f (Cyt b_6f) complex is a multisubunit protein complex in chloroplast thylakoid membranes required for photosynthetic electron transport. Here we report the isolation and characterization of the new ti…

The Lobed-Leaf Phenotype in Brassica juncea Is Associated with the BjLMI1 Locus as Evidenced Using GradedPool-Seq Open

Wenyuan Fu, Jiu-Cui Teng, Bing Tang, Qingqing Wang, Wei Yang , et al. · 2022

The shape of the leaf is the primary phenotype which determines the commercial value of leaf mustard (Brassica juncea). However, there arefew reports on the lobed-leaf gene of B. juncea, and the molecular regulatory mechanisms underlying l…

The production of diverse brGDGTs by an Acidobacterium providing a physiological basis for paleoclimate proxies Open

Yufei Chen, Fengfeng Zheng, Huan Yang, Wei Yang, Ruijie Wu , et al. · 2022

Genetic Diversity and Gene Flow Observed in Two Cereal Aphid (Hemiptera: Aphididae) Species and Populations in the Chinese Corn Belt Region Open

Wei Sun, Qianfu Su, Wei Yang, Jiachun Zhou, Yuebo Gao · 2022

The cereal aphids, Rhopalosiphum maidis (Fitch) and Rhopalosiphum padi (L.) (Hemiptera: Aphididae), are serious pests of maize, Zea mays L., globally. Basic information about the genetic structure of these aphids is unknown. We, therefore,…

The production of diverse brGDGTs by an Acidobacterium allows a direct test of temperature and pH controls on their distribution Open

Yufei Chen, Fengfeng Zheng, Huan Yang, Wei Yang, Ruijie Wu , et al. · 2022

Microbial lipid biomarkers preserved in geological archives can be used to explore past climate changes. Branched glycerol dialkyl glycerol tetraethers (brGDGTs) are unique bacterial biomarkers that have been used as molecular tools for th…

Mining of the biosynthetic potential of archaea reveals diverse anti-archaeal lanthipeptides Open

Haoyu Liang, Zhiman Song, Zheng Zhong, Dengwei Zhang, Wei Yang , et al. · 2022

Microbes produce diverse secondary metabolites (SMs) such as signaling molecules and antimicrobials that meditate microbe-microbe interaction. Archaea, the third domain of life, are a large and diverse group of microbes that not only exist…

Identification of a protein responsible for the synthesis of archaeal membrane-spanning GDGT lipids Open

Zhirui Zeng, Huahui Chen, Huan Yang, Yufei Chen, Wei Yang , et al. · 2022

Glycerol dibiphytanyl glycerol tetraethers (GDGTs) are archaeal monolayer membrane lipids that can provide a competitive advantage in extreme environments. Here, we identify a radical SAM protein, tetraether synthase (Tes), that participat…

Performance Limitation of Sequence Alignment on the NUMA-based Architecture Open

Shao-Long Chen, Zhenzhen Luo, Xiaolin Gui, Wei Yang · 2021

In recent years NUMA architecture based on multicore system leads a mainstream solution to tackle the rapidly expanding computation in bioinformatics analysis. Sequence alignment is the most computing cost in the workflow of variant analys…

Resistance band training after triamcinolone acetonide injection for subacromial bursitis: A randomized clinical trial Open

Pengfei Zhu, Bokai Liao, Zhengchao Wang, Zhenxing Sun, Wei Yang , et al. · 2020

Progressive resistance training with resistance (elastic) bands has the advantages of extending the benefits of corticosteroid injection and maintaining long-term effects on shoulder function in patients with subacromial bursitis.

Genome-Wide Identification and Expression Analysis of the Protease Inhibitor Gene Families in Tomato Open

Yuxuan Fan, Wei Yang, Qingxia Yan, Chunrui Chen, Jinhua Li · 2019

The protease inhibitors (PIs) in plants are involved primarily in defense against pathogens and pests and in response to abiotic stresses. However, information about the PI gene families in tomato (Solanum lycopersicum), one of the most im…

Clinical characteristics of malignant melanoma in central China and predictors of metastasis Open

Ke Shi, Xuran Zhu, Zhongyang Liu, Nan Sun, Luosha Gu , et al. · 2019

Cutaneous malignant melanoma (MM) is the most malignant type of all skin neoplasms. There is wide variability in the characteristics of MM between patients of different races. The aim of the present study was to investigate the clinicopath…

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