Xia Chu
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View article: Application of composite layered repair system using titanium mesh, bone cement and vacuum sealing drainage for chest wall defect
Application of composite layered repair system using titanium mesh, bone cement and vacuum sealing drainage for chest wall defect Open
Objective To evaluate the therapeutic efficacy of a composite layered repair system utilizing titanium mesh (TM), bone cement (BC) and vacuum sealing drainage (VSD) for chest wall defect reconstruction, providing a reliable theoretical fou…
View article: Exploration of Issues in Carbon Accounting Services of Accounting Firms under the "Dual Carbon" Targets
Exploration of Issues in Carbon Accounting Services of Accounting Firms under the "Dual Carbon" Targets Open
Under the background of the "dual carbon" targets, accounting firms, as professional service institutions, play an increasingly important role in the field of carbon accounting services. This paper deeply explores the issues in carbon acco…
View article: Advances in the regulation of the role of Myeloid-derived suppressor cells in the Tumor microenvironment by Tumor-derived exosomes
Advances in the regulation of the role of Myeloid-derived suppressor cells in the Tumor microenvironment by Tumor-derived exosomes Open
In the progression of malignancies, myeloid-derived suppressor cells (MDSCs) play a crucial role in modulating tumor immunology within the tumor microenvironment (TME), which is often characterized by the extensive infiltration of immune c…
View article: Single-walled carbon nanotubes hitchhike on Ly-6C<sup>hi</sup> monocytes for photoacoustic image-guided photothermal shock therapy of metabolic inflammation
Single-walled carbon nanotubes hitchhike on Ly-6C<sup>hi</sup> monocytes for photoacoustic image-guided photothermal shock therapy of metabolic inflammation Open
Single-walled carbon nanotubes target inflammatory macrophages via Ly-6C hi monocyte hitchhiking, enabling photoacoustic image-guided photothermal shock therapy for metabolic inflammation.
View article: The Mediating Role of Body Mass Index in the Association Between Dietary Index for Gut Microbiota and Biological Age: A Study Based on NHANES 2007–2018
The Mediating Role of Body Mass Index in the Association Between Dietary Index for Gut Microbiota and Biological Age: A Study Based on NHANES 2007–2018 Open
Objective: The dietary index for gut microbiota (DI-GM) is a newly proposed metric for assessing diet quality, and its relationship with biological age is unclear. We hypothesize that consuming foods conducive to a healthy gut microbiota e…
View article: Assessing the Co-Exposure Patterns of Volatile Organic Compounds and the Risk of Hyperuricemia: An Analysis of the National Health and Nutrition Examination Survey 2003–2012
Assessing the Co-Exposure Patterns of Volatile Organic Compounds and the Risk of Hyperuricemia: An Analysis of the National Health and Nutrition Examination Survey 2003–2012 Open
Background: Co-exposure to multiple volatile organic compounds (VOCs) is common in daily life. However, few studies have evaluated the associations between the patterns of simultaneous exposure to multiple VOCs and the risk of hyperuricemi…
View article: Electroreduction of CO<sub>2</sub> by Hybrid Cu‐TiO<sub>2</sub>/rGO Catalyst: Qualitative Detection of Products using Rotating Ring Disc Electrode
Electroreduction of CO<sub>2</sub> by Hybrid Cu‐TiO<sub>2</sub>/rGO Catalyst: Qualitative Detection of Products using Rotating Ring Disc Electrode Open
The electrochemical reduction of CO 2 (ERCO 2 ) to valuable chemicals such as acetic acid/acetate offers a promising route to revolutionize chemical production and enhance sustainability. Here, we report the hydrothermal preparation of an …
View article: G‐Quadruplex RNA Based PROTAC Enables Targeted Degradation of RNA Binding Protein FMRP for Tumor Immunotherapy
G‐Quadruplex RNA Based PROTAC Enables Targeted Degradation of RNA Binding Protein FMRP for Tumor Immunotherapy Open
Fragile X mental retardation protein (FMRP), an RNA binding protein (RBP), is aberrantly hyper‐expressed in human tumors and plays an essential role in tumor invasion, metastasis and immune evasion. However, there is no small‐molecule inhi…
View article: Surgical tumor–derived nanoplatform targets tumor-associated macrophage for personalized postsurgical cancer immunotherapy
Surgical tumor–derived nanoplatform targets tumor-associated macrophage for personalized postsurgical cancer immunotherapy Open
Directly activating CD8 + T cells within the tumor through antigen-presenting cells (APCs) hold promise for tumor elimination. However, M2-like tumor-associated macrophages (TAMs), the most abundant APCs in tumors, hinder CD8 + T cell acti…
View article: The cGAS-STING signaling pathway is modulated by urolithin A
The cGAS-STING signaling pathway is modulated by urolithin A Open
During aging, general cellular processes, including autophagic clearance and immunological responses become compromised; therefore, identifying compounds that target these cellular processes is an important approach to improve our health s…
View article: A programmable CRISPR-based light-up RNA stabilizer for fluorogenic RNA imaging
A programmable CRISPR-based light-up RNA stabilizer for fluorogenic RNA imaging Open
Live cell imaging of RNAs and dynamics is crucial for understanding their functions and pathological roles. However, fluorogenic imaging of endogenous RNAs remains a challenge. Here, we report the design of a programmable CRISPR-based ligh…
View article: MicroRNA-34a Mediates High-Fat-Induced Hepatic Insulin Resistance by Targeting ENO3
MicroRNA-34a Mediates High-Fat-Induced Hepatic Insulin Resistance by Targeting ENO3 Open
The etiology of numerous metabolic disorders is characterized by hepatic insulin resistance (IR). Uncertainty surrounds miR-34a’s contribution to high-fat-induced hepatic IR and its probable mechanism. The role and mechanism of miR-34a and…
View article: A programmable CRISPR-based light-up RNA stabilizer for fluorogenic RNA imaging
A programmable CRISPR-based light-up RNA stabilizer for fluorogenic RNA imaging Open
Live cell imaging of RNAs and dynamics is crucial for understanding their functions and pathological roles. However, fluorogenic imaging of endogenous RNAs remains a challenge. Here, we report the design of a programmable CRISPR-based ligh…
View article: Overexpression of miR-297b-5p in Mouse Insulin-Secreting Cells Promotes Metformin-Mediated Protection Against Stearic Acid-Induced Senescence by Targeting Igf1r
Overexpression of miR-297b-5p in Mouse Insulin-Secreting Cells Promotes Metformin-Mediated Protection Against Stearic Acid-Induced Senescence by Targeting Igf1r Open
Background: A long-term consumption of saturated fat significantly increases the concentration of saturated fatty acids in serum, which accelerates the appearance of senescence markers in β-cells and leads to their dysfunction. An understa…
View article: Acute Respiratory Infection Incidence and Outpatient Antibiotic Prescription Patterns in People With or Without Human Immunodeficiency Virus Infection: A Virtual Cohort Study
Acute Respiratory Infection Incidence and Outpatient Antibiotic Prescription Patterns in People With or Without Human Immunodeficiency Virus Infection: A Virtual Cohort Study Open
Background Inappropriate antibiotic use in acute respiratory infections (ARIs) is a major public health concern; however, data for people with human immunodeficiency virus (PWH) are limited. Methods The HIV Virtual Cohort Study is a retros…
View article: Membrane-tethered activation design of a photosensitizer boosts systemic antitumor immunity<i>via</i>pyroptosis
Membrane-tethered activation design of a photosensitizer boosts systemic antitumor immunity<i>via</i>pyroptosis Open
The membrane-tethered activation design of a new phenylbenzopyrylium photosensitizer (PS) with zwitterionic lipid pendants that allows long-lasting fluorogenic imaging of tumors, persistent photodynamic therapy and systemic anti-tumor immu…
View article: Inhibition of miR-146a-5p and miR-8114 in Insulin-Secreting Cells Contributes to the Protection of Melatonin against Stearic Acid-Induced Cellular Senescence by Targeting Mafa
Inhibition of miR-146a-5p and miR-8114 in Insulin-Secreting Cells Contributes to the Protection of Melatonin against Stearic Acid-Induced Cellular Senescence by Targeting Mafa Open
Background: Chronic exposure to elevated levels of saturated fatty acids results in pancreatic β-cell senescence. However, targets and effective agents for preventing stearic acid-induced β-cell senescence are still lacking. Although melat…
View article: A Newly Developed Indicator of Overeating Saturated Fat Based on Serum Fatty Acids and Amino Acids and Its Association With Incidence of Type 2 Diabetes: Evidence From Two Randomized Controlled Feeding Trials and a Prospective Study
A Newly Developed Indicator of Overeating Saturated Fat Based on Serum Fatty Acids and Amino Acids and Its Association With Incidence of Type 2 Diabetes: Evidence From Two Randomized Controlled Feeding Trials and a Prospective Study Open
Objective Hyper-caloric intake of saturated fatty acids (SFAs) is common in modern societies, probably contributing to the epidemic of type 2 diabetes mellitus (T2DM). This study conducted two randomized controlled trials (RCTs) for develo…
View article: A programmable CRISPR-based light-up RNA stabilizer for fluorogenic RNA imaging
A programmable CRISPR-based light-up RNA stabilizer for fluorogenic RNA imaging Open
Live cell imaging of RNAs and dynamics is crucial for understanding their functions and pathological roles. However, fluorogenic imaging of endogenous RNAs remains a challenge. Here, we report the design of a programmable CRISPR-based ligh…
View article: Intracoronary Ultrasound Imaging Combined with Traditional Chinese Medicine Nursing Applied in the Treatment of Coronary Heart Disease Patients with Phlegm and Blood Stasis Syndrome
Intracoronary Ultrasound Imaging Combined with Traditional Chinese Medicine Nursing Applied in the Treatment of Coronary Heart Disease Patients with Phlegm and Blood Stasis Syndrome Open
This study was to explore the effect of traditional Chinese medicine (TCM) nursing intervention based on intracoronary ultrasound imaging on patients with coronary heart disease (CHD) and phlegm and blood stasis syndrome (PBSS). 100 hospit…
View article: Overexpression of miR-297b-5p Promotes Metformin-Mediated Protection Against Stearic Acid-Induced Senescence by Targeting Igf1r
Overexpression of miR-297b-5p Promotes Metformin-Mediated Protection Against Stearic Acid-Induced Senescence by Targeting Igf1r Open
View article: Inhibition of lncRNA TCONS_00077866 Ameliorates the High Stearic Acid Diet-Induced Mouse Pancreatic β-Cell Inflammatory Response by Increasing miR-297b-5p to Downregulate SAA3 Expression
Inhibition of lncRNA TCONS_00077866 Ameliorates the High Stearic Acid Diet-Induced Mouse Pancreatic β-Cell Inflammatory Response by Increasing miR-297b-5p to Downregulate SAA3 Expression Open
Long-term consumption of a high-fat diet increases the circulating concentration of stearic acid (SA), which has a potent toxic effect on β-cells, but the underlying molecular mechanisms of this action have not been fully elucidated. Here,…
View article: MiR-486-3p was downregulated at microRNA profiling of adrenals of multiple endocrine neoplasia type 1 mice, and inhibited human adrenocortical carcinoma cell lines
MiR-486-3p was downregulated at microRNA profiling of adrenals of multiple endocrine neoplasia type 1 mice, and inhibited human adrenocortical carcinoma cell lines Open
Adrenocortical carcinoma is a rare aggressive disease commonly recurring regardless of radical surgery. Although data on genomic alterations in malignant tumors are accumulating, knowledge of molecular events of importance for initiation o…
View article: Inhibition of lncRNA TCONS_00077866 Ameliorates the High Stearic Acid Diet-Induced Mouse Pancreatic β-Cell Inflammatory Response by Increasing miR-297b-5p to Downregulate SAA3 Expression
Inhibition of lncRNA TCONS_00077866 Ameliorates the High Stearic Acid Diet-Induced Mouse Pancreatic β-Cell Inflammatory Response by Increasing miR-297b-5p to Downregulate SAA3 Expression Open
Long-term consumption of a high-fat diet increases the circulating concentration of stearic acid (SA), which has a potent toxic effect on β-cells, but the underlying molecular mechanisms of this action have not been fully elucidated. Here,…
View article: Inhibition of lncRNA TCONS_00077866 Ameliorates the High Stearic Acid Diet-Induced Mouse Pancreatic β-Cell Inflammatory Response by Increasing miR-297b-5p to Downregulate SAA3 Expression
Inhibition of lncRNA TCONS_00077866 Ameliorates the High Stearic Acid Diet-Induced Mouse Pancreatic β-Cell Inflammatory Response by Increasing miR-297b-5p to Downregulate SAA3 Expression Open
Long-term consumption of a high-fat diet increases the circulating concentration of stearic acid (SA), which has a potent toxic effect on β-cells, but the underlying molecular mechanisms of this action have not been fully elucidated. Here,…
View article: Inhibition of lncRNA TCONS_00077866 Ameliorates the High Stearic Acid Diet-Induced Mouse Pancreatic β-Cell Inflammatory Response by Increasing miR-297b-5p to Downregulate SAA3 Expression
Inhibition of lncRNA TCONS_00077866 Ameliorates the High Stearic Acid Diet-Induced Mouse Pancreatic β-Cell Inflammatory Response by Increasing miR-297b-5p to Downregulate SAA3 Expression Open
Long-term consumption of a high-fat diet increases the circulating concentration of stearic acid (SA), which has a potent toxic effect on β-cells, but the underlying molecular mechanisms of this action have not been fully elucidated. Here,…
View article: Correction to: TCONS_00230836 silencing restores stearic acid-induced β cell dysfunction through alleviating endoplasmic reticulum stress rather than apoptosis
Correction to: TCONS_00230836 silencing restores stearic acid-induced β cell dysfunction through alleviating endoplasmic reticulum stress rather than apoptosis Open
chr 7 had been mistakenly written as chr 10 in Fig. 1A and in the "Upregulation of lncRNA TCONS_00230836 expression in stearic acid-treated β-TC6 cells and islets of mice fed a high-stearic-acid diet" section of the Results.
View article: TCONS_00230836 silencing restores stearic acid-induced β cell dysfunction through alleviating endoplasmic reticulum stress rather than apoptosis
TCONS_00230836 silencing restores stearic acid-induced β cell dysfunction through alleviating endoplasmic reticulum stress rather than apoptosis Open
View article: Clicking of organelle-enriched probes for fluorogenic imaging of autophagic and endocytic fluxes
Clicking of organelle-enriched probes for fluorogenic imaging of autophagic and endocytic fluxes Open
A new strategy is developed for direct fluorogenic imaging of autophagic and endocytic fluxes via clicking of organelle-enriched trans-cyclooctenol and tetrazine derived probes.