Yi Xiao
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View article: The PER2:BRCA1:POU2F1(OCT-1) ternary complex represents a multi-component scaffold model for circadian gene regulation
The PER2:BRCA1:POU2F1(OCT-1) ternary complex represents a multi-component scaffold model for circadian gene regulation Open
View article: Fecal Microbiota Transplantation for Attention-Deficit/Hyperactivity Disorder: Mechanisms, Evidence, and Future Directions
Fecal Microbiota Transplantation for Attention-Deficit/Hyperactivity Disorder: Mechanisms, Evidence, and Future Directions Open
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental condition characterized by inattention, hyperactivity, and impulsivity. While pharmacological and behavioral therapies remain first-line treatments, their limit…
View article: Validity and clinical utility of a wrist-worn device against polysomnography
Validity and clinical utility of a wrist-worn device against polysomnography Open
Objective Sleep-wearable technology has developed rapidly. However, few carried out validation in the real clinical settings. This study aimed to validate the performance of a consumer-grade sleep-tracking device compared to polysomnograph…
View article: Efficiency and Safety of HAIC Combined with Lenvatinib and PD-1 Inhibitor for Advanced Hepatocellular Carcinoma with Lung Metastasis: A Multicenter Propensity Score Matching Analysis
Efficiency and Safety of HAIC Combined with Lenvatinib and PD-1 Inhibitor for Advanced Hepatocellular Carcinoma with Lung Metastasis: A Multicenter Propensity Score Matching Analysis Open
HAIC combined with lenvatinib and PD-1 inhibitor shows promise as a treatment for advanced HCC with lung metastases, offering improved prognosis and a manageable safety profile.
View article: Association between sensory impairment and cognitive frailty among older people: Evidence from four nationwide cohort studies
Association between sensory impairment and cognitive frailty among older people: Evidence from four nationwide cohort studies Open
This study identifies an association between combined hearing and vision impairments and an increased risk of cognitive frailty. These findings suggest that assessing sensory impairments, particularly dual sensory impairment, in older adul…
View article: Aromatherapy With Nardostachys Jatamansi <scp>DC.</scp> Essential Oil Targeting the <scp>MAOA</scp> Gene Regulates Cardiac Neural Remodeling and Amino Acid Metabolism to Alleviate Sleep Deprivation‐Induced Myocardial Injury
Aromatherapy With Nardostachys Jatamansi <span>DC.</span> Essential Oil Targeting the <span>MAOA</span> Gene Regulates Cardiac Neural Remodeling and Amino Acid Metabolism to Alleviate Sleep Deprivation‐Induced Myocardial Injury Open
Sleep deprivation (SD) adversely affects cognition, as well as physical and mental health, and is closely linked to an increased risk of cardiovascular disease. The therapeutic efficacy and underlying mechanisms of aromatherapy with Nardos…
View article: [1]¿p#1 Mucinous Versus Non-Mucinous Gastric Adenocarcinoma: A Systematic Review and Meta-Analysis of Prognostic and Clinicopathological Differences
[1]¿p#1 Mucinous Versus Non-Mucinous Gastric Adenocarcinoma: A Systematic Review and Meta-Analysis of Prognostic and Clinicopathological Differences Open
View article: Enhancing Hepatopathy Clinical Trial Efficiency: A Secure, Large Language Model-Powered Pre-Screening Pipeline
Enhancing Hepatopathy Clinical Trial Efficiency: A Secure, Large Language Model-Powered Pre-Screening Pipeline Open
Background: Recruitment for cohorts involving complex liver diseases, such as hepatocellular carcinoma and liver cirrhosis, often requires interpreting semantically complex criteria. Traditional manual screening methods are time-consuming …
View article: Lenvatinib and tislelizumab versus atezolizumab and bevacizumab in combination with TAE-HAIC for unresectable hepatocellular carcinoma with high tumor burden: a multicenter retrospective cohort study
Lenvatinib and tislelizumab versus atezolizumab and bevacizumab in combination with TAE-HAIC for unresectable hepatocellular carcinoma with high tumor burden: a multicenter retrospective cohort study Open
TAE-HAIC plus lenvatinib and tislelizumab or TAE-HAIC plus atezolizumab and bevacizumab showed similar outcomes for unresectable HCC with high tumor burden, and manageable safety. The results need further validation.
View article: Modeling Techno-Economic Boundaries for Undeveloped Reservoirs: Integrated Simulation-Regression Approach with Xinjiang Case Study
Modeling Techno-Economic Boundaries for Undeveloped Reservoirs: Integrated Simulation-Regression Approach with Xinjiang Case Study Open
View article: Optimized Non-Maximum Suppression for Multi-Source Local Discharge PRPD Pattern Identification
Optimized Non-Maximum Suppression for Multi-Source Local Discharge PRPD Pattern Identification Open
The multi-source partial discharge PRPD pattern can realize the pattern recognition of multi-source partial discharge types through the target detection algorithm training and identification of shape features. However, when the characteris…
View article: The role of SGK1 in neurologic diseases: A friend or foe?
The role of SGK1 in neurologic diseases: A friend or foe? Open
View article: The association between triglyceride glucose index and the risk of cardiovascular disease in obstructive sleep apnea
The association between triglyceride glucose index and the risk of cardiovascular disease in obstructive sleep apnea Open
The TyG index, independent of the HOMA-IR index and obesity, was linked to an increased lifetime CVD risk. In predicting cardiovascular outcomes, the TyG index could potentially outperform the HOMA-IR index among individuals with OSA.
View article: The association between chemosensitivity and the 10-year risk of type 2 diabetes in male patients with obstructive sleep apnea
The association between chemosensitivity and the 10-year risk of type 2 diabetes in male patients with obstructive sleep apnea Open
Higher peripheral chemosensitivity was associated with an increased 10-year T2D risk, as calculated using a risk calculator based on clinical variables. For outcomes that reflect a moderate-to-high 10-year risk of T2D, the severity of OSA …
View article: Novel sampling strategy for regular nucleic acid testing in low risk areas during epidemics
Novel sampling strategy for regular nucleic acid testing in low risk areas during epidemics Open
View article: The association between endothelial dysfunction and subclinical myocardial injury in male obstructive sleep apnoea patients
The association between endothelial dysfunction and subclinical myocardial injury in male obstructive sleep apnoea patients Open
Background Endothelial dysfunction was shown to contribute significantly to the elevated cardiovascular risk observed in the general population. However, the relationship between endothelial dysfunction and subclinical myocardial injury in…
View article: The association between triglyceride glucose index and the risk of cardiovascular disease in obstructive sleep apnea
The association between triglyceride glucose index and the risk of cardiovascular disease in obstructive sleep apnea Open
Background The triglyceride glucose (TyG) index is a dependable indicator of insulin resistance (IR), serves as a valuable biomarker for identifying obstructive sleep apnea (OSA) and predicting its comorbidities. Both OSA and the TyG index…
View article: Excessive daytime sleepiness in obstructive sleep apnea: Indirect treatment comparison of wake-promoting agents in patients adherent/nonadherent to primary OSA therapy
Excessive daytime sleepiness in obstructive sleep apnea: Indirect treatment comparison of wake-promoting agents in patients adherent/nonadherent to primary OSA therapy Open
There remains an unmet need for a targeted treatment to address residual excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea (OSA) after primary treatment. This network meta-analysis evaluated the efficacy and safet…
View article: Pan-immune-inflammation value as a prognostic biomarker for colon cancer and its variation by primary tumor location
Pan-immune-inflammation value as a prognostic biomarker for colon cancer and its variation by primary tumor location Open
BACKGROUND A growing body of research indicates significant differences between left-sided colon cancers (LCC) and right-sided colon cancers (RCC). Pan-immune-inflammation value (PIV) is a systemic immune response marker that can predict t…
View article: Urinary Epinephrine Sulfate Can Predict Cardiovascular Risk in Moderate-to-Severe OSA: A Metabolomics-Based Study
Urinary Epinephrine Sulfate Can Predict Cardiovascular Risk in Moderate-to-Severe OSA: A Metabolomics-Based Study Open
There are significant metabolic pathway alterations in moderate-to-severe OSA patients. Urinary epinephrine sulfate markedly predicts early cardiovascular risk in OSA patients.
View article: Proteomic landscape of epithelial ovarian cancer
Proteomic landscape of epithelial ovarian cancer Open
Epithelial ovarian cancer (EOC) is a deadly disease with limited diagnostic biomarkers and therapeutic targets. Here we conduct a comprehensive proteomic profiling of ovarian tissue and plasma samples from 813 patients with different histo…
View article: Nocturnal urination is associated with the presence of higher ventilatory chemosensitivity in patients with obstructive sleep apnea
Nocturnal urination is associated with the presence of higher ventilatory chemosensitivity in patients with obstructive sleep apnea Open
Purpose Chemosensitivity is an essential part of the pathophysiological mechanisms of obstructive sleep apnea (OSA). This study aims to use the rebreathing method to assess hypercapnic ventilatory response (HCVR) and analyze the associatio…
View article: Peripheral immunity involvement in the cognitive impairment of sporadic amyotrophic lateral sclerosis
Peripheral immunity involvement in the cognitive impairment of sporadic amyotrophic lateral sclerosis Open
Background Recent research has indicated the significance of immune activation in amyotrophic lateral sclerosis (ALS). However, the impact of peripheral immunity on cognitive impairment in sporadic ALS remains poorly characterized. Therefo…
View article: The potential interaction between chemosensitivity and the development of cardiovascular disease in obstructive sleep apnea
The potential interaction between chemosensitivity and the development of cardiovascular disease in obstructive sleep apnea Open
Higher lifetime CVD risk was associated with participants who had greater peripheral chemosensitivity. In terms of the CVD outcomes, adult patients with a relatively low level of chemosensitivity may be primarily related to their diagnosis…
View article: Early bone loss in patients with obstructive sleep apnea: a cross-sectional study
Early bone loss in patients with obstructive sleep apnea: a cross-sectional study Open
View article: Cystatin C is associated with poor survival in amyotrophic lateral sclerosis patients
Cystatin C is associated with poor survival in amyotrophic lateral sclerosis patients Open
Background Cystatin C (CysC) levels in amyotrophic lateral sclerosis (ALS) have been found changes, however, the associations between serum CysC levels and the progression and survival of ALS remain largely unknown. Methods A total of 1,08…
View article: Short-and long-term outcomes of one-stage versus two-stage gastrectomy for perforated gastric cancer: a multicenter retrospective propensity score-matched study
Short-and long-term outcomes of one-stage versus two-stage gastrectomy for perforated gastric cancer: a multicenter retrospective propensity score-matched study Open
View article: Sexual Dimorphism on the Role of Lipid and Apolipoprotein Traits in the Risk of Parkinson's Disease
Sexual Dimorphism on the Role of Lipid and Apolipoprotein Traits in the Risk of Parkinson's Disease Open
View article: Advancing Rectal MRI Segmentation with Clip-Driven Semi-Supervised Learning and Semantic Alignment
Advancing Rectal MRI Segmentation with Clip-Driven Semi-Supervised Learning and Semantic Alignment Open
View article: Orthostatic Hypotension in Multiple System Atrophy: Related Factors and Disease Prognosis
Orthostatic Hypotension in Multiple System Atrophy: Related Factors and Disease Prognosis Open
Background: Multiple system atrophy (MSA) is a rare neurodegenerative disease characterized by Parkinsonism, ataxia, and autonomic nervous failure. Orthostatic hypotension (OH) is the main feature of central vascular autonomic failure in M…