Xiangzhu Xiao
YOU?
Author Swipe
View article: Further Characterization of Glycoform-Selective Prions of Variably Protease-Sensitive Prionopathy
Further Characterization of Glycoform-Selective Prions of Variably Protease-Sensitive Prionopathy Open
Prion is an infectious protein (PrPSc) that is derived from a cellular glycoprotein (PrPC) through a conformational transition and associated with a group of prion diseases in animals and humans. Characterization of proteinase K (PK)-resis…
View article: A novel mechanism of phenotypic heterogeneity in Creutzfeldt-Jakob disease
A novel mechanism of phenotypic heterogeneity in Creutzfeldt-Jakob disease Open
View article: Gerstmann-Sträussler-Scheinker disease revisited: accumulation of covalently-linked multimers of internal prion protein fragments
Gerstmann-Sträussler-Scheinker disease revisited: accumulation of covalently-linked multimers of internal prion protein fragments Open
View article: Gerstmann-Sträussler-Scheinker disease revisited: accumulation of covalently-linked multimers of internal prion protein fragments
Gerstmann-Sträussler-Scheinker disease revisited: accumulation of covalently-linked multimers of internal prion protein fragments Open
Despite their phenotypic heterogeneity, most human prion diseases belong to two broadly defined groups: Creutzfeldt-Jakob disease (CJD) and Gerstmann-Sträussler-Scheinker disease (GSS). While the structural characteristics of the disease-r…
View article: A Metastable Contact and Structural Disorder in the Estrogen Receptor Transactivation Domain
A Metastable Contact and Structural Disorder in the Estrogen Receptor Transactivation Domain Open
View article: Structural attributes of mammalian prion infectivity: Insights from studies with synthetic prions
Structural attributes of mammalian prion infectivity: Insights from studies with synthetic prions Open
View article: Artificial strain of human prions created in vitro
Artificial strain of human prions created in vitro Open
The molecular mechanism that determines under physiological conditions transmissibility of the most common human prion disease, sporadic Creutzfeldt-Jakob disease (sCJD) is unknown. We report the synthesis of new human prion from the recom…
View article: A metastable contact and structural disorder in the estrogen receptor transactivation domain
A metastable contact and structural disorder in the estrogen receptor transactivation domain Open
The N-terminal transactivation domain (NTD) of estrogen receptor alpha, a well-known member of the family of intrinsically disordered proteins (IDPs), mediates the receptor's transactivation function to regulate gene expression. However, a…
View article: Characterization of physiochemical properties of caveolin-1 from normal and prion-infected human brains
Characterization of physiochemical properties of caveolin-1 from normal and prion-infected human brains Open
Caveolin-1 is a major component protein of the caveolae—a type of flask shaped, 50-100 nm, nonclathrin-coated, microdomain present in the plasma membrane of most mammalian cells. Caveolin-1 functions as a scaffolding protein to organize an…
View article: Post-translational modifications in PrP expand the conformational diversity of prions in vivo
Post-translational modifications in PrP expand the conformational diversity of prions in vivo Open
View article: Deuterium incorporation for peptic fragments derived from MM1 rPrP<sup>Sc</sup> (red) and MM2 rPrP<sup>Sc</sup>(blue).
Deuterium incorporation for peptic fragments derived from MM1 rPrP<sup>Sc</sup> (red) and MM2 rPrP<sup>Sc</sup>(blue). Open
(a) 5 min incubation in D2O. (b) 240 h incubation in D2O. Error bars indicate standard deviation (3 independent experiments). *, P<0.05; **, P<0.02.
View article: Schematic representation of PK-resistant fragments in rPrP<sup>Sc</sup> corresponding to Type 1 (MM1) and Type 2 (MM2) sCJD prions and molecular characteristics of purified human rPrPSc used in structural studies.
Schematic representation of PK-resistant fragments in rPrP<sup>Sc</sup> corresponding to Type 1 (MM1) and Type 2 (MM2) sCJD prions and molecular characteristics of purified human rPrPSc used in structural studies. Open
(a) Outline of classification of Type 1 and Type 2 human prions based on proteolytic fragmentation of PrPSc [5,52]. Major cleavage sites by PK are indicated by arrows; GLP—glycolipid; CHO- complex N-glycosylation chains. The cod…
View article: Source, biophysical characteristics, and replication rate of Type 1 and Type 2 sCJD prions.
Source, biophysical characteristics, and replication rate of Type 1 and Type 2 sCJD prions. Open
Source, biophysical characteristics, and replication rate of Type 1 and Type 2 sCJD prions.
View article: Structural Determinants of Phenotypic Diversity and Replication Rate of Human Prions
Structural Determinants of Phenotypic Diversity and Replication Rate of Human Prions Open
The infectious pathogen responsible for prion diseases is the misfolded, aggregated form of the prion protein, PrPSc. In contrast to recent progress in studies of laboratory rodent-adapted prions, current understanding of the molecular bas…