Yanyan Zhao
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View article: No effect of pyrroloquinoline quinone on mouse body weight and energy metabolism with the concomitant increase in mitochondrial biogenesis and antioxidant ability
No effect of pyrroloquinoline quinone on mouse body weight and energy metabolism with the concomitant increase in mitochondrial biogenesis and antioxidant ability Open
View article: Recognition of multiple potential diagnostic biomarkers and therapeutic targets for ovarian serous cystadenocarcinoma (OSOC)
Recognition of multiple potential diagnostic biomarkers and therapeutic targets for ovarian serous cystadenocarcinoma (OSOC) Open
Background: Ovarian serous cystadenocarcinoma (OSOC) is the most common gynecologic cancer (GC), but existing therapeutics are limited. Therefore, novel molecular pathways that contribute to OSOC therapy and diagnostics are urgently needed…
View article: Hyperthermia correlates with low incidence of radiation pneumonitis after thoracic radiotherapy: a retrospective study
Hyperthermia correlates with low incidence of radiation pneumonitis after thoracic radiotherapy: a retrospective study Open
Objective This study aims to investigate the impact of radiotherapy combined with hyperthermia (RHT) on the incidence of radiation pneumonitis (RP) in patients with thoracic malignancies. Method This study enrolled 233 patients with thorac…
View article: Marketing behind charity: Media narratives of tobacco industry donations in China
Marketing behind charity: Media narratives of tobacco industry donations in China Open
News coverage of tobacco industry donations employs sophisticated narrative strategies that function as a form of tobacco promotion and marketing with implications for World Health Organization Framework Convention on Tobacco Control (WHO …
View article: Effects of Continuous Care on Gestational Diabetes Mellitus Patients: A Systematic Review and Meta-analysis of 22 RCTs
Effects of Continuous Care on Gestational Diabetes Mellitus Patients: A Systematic Review and Meta-analysis of 22 RCTs Open
Background This study aimed to investigate the effects of continuous care on blood glucose and pregnancy outcomes in patients with gestational diabetes mellitus (GDM) through meta-analysis. Method Searches were conducted in PubMed, Web of …
View article: The cucumber (Cucumis sativus L.) mitochondrial genome: intraspecific structural variation, repetitive architecture, and comparative evolutionary dynamics
The cucumber (Cucumis sativus L.) mitochondrial genome: intraspecific structural variation, repetitive architecture, and comparative evolutionary dynamics Open
View article: Advances in Cytoplasmic Male Sterility in Sugar Beet from Mitochondrial Genome Structural Dynamics and Nuclear-Cytoplasmic Coordination
Advances in Cytoplasmic Male Sterility in Sugar Beet from Mitochondrial Genome Structural Dynamics and Nuclear-Cytoplasmic Coordination Open
Sugar beet (Beta vulgaris L.) is a globally important sugar crop whose hybrid breeding system relies heavily on cytoplasmic male sterility (CMS) lines. Recent advances in sugar beet genomics, particularly the release of high-quality refere…
View article: Opioid-free anaesthesia based on paravertebral block for thoracotomic paediatric congenital cardiac surgery—effectiveness of postoperative analgesia: a protocol for a prospective, single-blinded, randomised controlled trial (OPTION trial)
Opioid-free anaesthesia based on paravertebral block for thoracotomic paediatric congenital cardiac surgery—effectiveness of postoperative analgesia: a protocol for a prospective, single-blinded, randomised controlled trial (OPTION trial) Open
Chinese Clinical Trial Registry: ChiCTR2200066517 ( www.chictr.org.cn ), Registered on December 7, 2022.
View article: Development and validation of a prediction score for subtype diagnosis of primary aldosteronism
Development and validation of a prediction score for subtype diagnosis of primary aldosteronism Open
View article: Epigenetic regulation in cognitive impairment: Focus on N6‐methyladenosine modification and its potential role in perioperative neurocognitive disorders
Epigenetic regulation in cognitive impairment: Focus on N6‐methyladenosine modification and its potential role in perioperative neurocognitive disorders Open
N6‐methyladenosine (m6A), the most abundant internal modification in mammalian mRNA, plays a critical role in cognitive function by dynamically regulating gene expression. This narrative review examines m6A's role in cognitive processes an…
View article: Surgical left atrial appendage occlusion in valvular heart disease without atrial fibrillation: the OPINION trial
Surgical left atrial appendage occlusion in valvular heart disease without atrial fibrillation: the OPINION trial Open
Background and Aims While surgical left atrial appendage occlusion (SLAAO) reduces stroke in atrial fibrillation (AF) patients, its efficacy in patients without pre-operative AF but with CHA₂DS₂-VASc ≥2 remains uncertain despite their high…
View article: The Valvular Heart Disease-specific Age-adjusted Comorbidity Index (VHD-ACI) score in patients with moderate or severe valvular heart disease
The Valvular Heart Disease-specific Age-adjusted Comorbidity Index (VHD-ACI) score in patients with moderate or severe valvular heart disease Open
The VHD-ACI is a simple 13-comorbidity algorithm for the prediction of mortality in VHD patients and providing a simple and rapid tool for risk stratification.
View article: Traditional Chinese Medicine for Alzheimer’s disease: A Scoping Review
Traditional Chinese Medicine for Alzheimer’s disease: A Scoping Review Open
View article: Plasma FGF2 and YAP1 as novel biomarkers for MCI in the elderly: analysis via bioinformatics and clinical study
Plasma FGF2 and YAP1 as novel biomarkers for MCI in the elderly: analysis via bioinformatics and clinical study Open
The contemporary consensus firmly emphasizes the urgent need to reorient research efforts toward the early detection of preclinical Alzheimer’s disease (AD) or mild cognitive impairment (MCI). However, there is still a notable absence of n…
View article: Relationships of triglyceride–glucose index and body mass index with 5-year all-cause mortality in patients with diabetes and comorbid hypertension: Evidence from two prospective cohort studies
Relationships of triglyceride–glucose index and body mass index with 5-year all-cause mortality in patients with diabetes and comorbid hypertension: Evidence from two prospective cohort studies Open
View article: Clinical outcomes of selective laser trabeculoplasty in military pilots with open-angle glaucoma: Implications for intraocular pressure control and aeromedical certification
Clinical outcomes of selective laser trabeculoplasty in military pilots with open-angle glaucoma: Implications for intraocular pressure control and aeromedical certification Open
Based upon the 4 cases of primary open-angle glaucoma investigated, SLT demonstrated favourable safety and efficacy in lowering IOP and reducing medication dependencey in this cohort. Among military pilots with open-angle glaucoma or ocula…
View article: Relationship between non-suicidal self-injury and sleep among college students: a multifactorial analysis
Relationship between non-suicidal self-injury and sleep among college students: a multifactorial analysis Open
Objective To investigate the relationship between non-suicidal self-injury (NSSI) and sleep quality, and associated psychosocial factors among college students. Methods A cross-sectional study was conducted using cluster sampling at a univ…
View article: Exploring the mechanism of Epimedium in diabetes mellitus treatment based on network pharmacology and molecular dynamics simulation
Exploring the mechanism of Epimedium in diabetes mellitus treatment based on network pharmacology and molecular dynamics simulation Open
View article: Prognostic value of C-reactive protein to albumin ratio in patients with valvular heart disease: nationwide prospective cohort study
Prognostic value of C-reactive protein to albumin ratio in patients with valvular heart disease: nationwide prospective cohort study Open
Background: The C-reactive to albumin ratio (CAR) integrates the pro-inflammatory and nutritional status of patients, which may provide superior prognostic information over either parameter alone in valvular heart disease (VHD). The study …
View article: <italic>Scleromitrion diffusum</italic> reverses epithelial-mesenchymal transi-tion of gastric mucosa in rats with gastric precancerous lesions
<italic>Scleromitrion diffusum</italic> reverses epithelial-mesenchymal transi-tion of gastric mucosa in rats with gastric precancerous lesions Open
Scleromitrion diffusum can ameliorate gastric mucosal injury in rats with gastric precancerous lesion by reversing the EMT.
View article: Prognostic Impact of Anemia in Patients with Significant Mitral Regurgitation: A Multicenter Cohort Study
Prognostic Impact of Anemia in Patients with Significant Mitral Regurgitation: A Multicenter Cohort Study Open
Anemia was common in patients with MR, and it was a significant predictor of poor prognosis. The high prevalence and negative impact of anemia make it as an important risk factor for prognostic evaluation and clinical decision-making.
View article: Efficacy and Safety of Dulaglutide Biosimilar <scp>LY05008</scp> Versus the Reference Product Dulaglutide (Trulicity) in Chinese Adults With Type 2 Diabetes Mellitus: A Randomized, Open‐Label, Active Comparator Study
Efficacy and Safety of Dulaglutide Biosimilar <span>LY05008</span> Versus the Reference Product Dulaglutide (Trulicity) in Chinese Adults With Type 2 Diabetes Mellitus: A Randomized, Open‐Label, Active Comparator Study Open
Background Dulaglutide, a glucagon‐like peptide‐1 (GLP‐1) receptor agonist, has been approved for improving glycemic control and reducing the risk of cardiovascular (CV) adverse events. A previous result in healthy Chinese male subjects de…
View article: Angiographic Quantitative Flow Ratio–Guided Treatment of Patients With Physiologically Intermediate Coronary Lesions
Angiographic Quantitative Flow Ratio–Guided Treatment of Patients With Physiologically Intermediate Coronary Lesions Open
Background The FAVOR III (Comparison of Quantitative Flow Ratio Guided and Angiography Guided Percutaneous Intervention in Patients With Coronary Artery Disease) China trial reported improved clinical outcomes with percutaneous coronary in…
View article: Primary regional disparities in clinical characteristics, treatments, and outcomes of a typically designed study of valvular heart disease at 46 tertiary hospitals in China: Insights from the China-VHD Study
Primary regional disparities in clinical characteristics, treatments, and outcomes of a typically designed study of valvular heart disease at 46 tertiary hospitals in China: Insights from the China-VHD Study Open
Background: Valvular heart disease (VHD) has become increasingly common with the aging in China. This study aimed to evaluate regional differences in the clinical features, management strategies, and outcomes of patients with VHD across di…
View article: The role of PD-L1 in EGFR-mutant non-small cell lung cancer
The role of PD-L1 in EGFR-mutant non-small cell lung cancer Open
View article: Cost-effectiveness of angiographic quantitative flow ratio-guided coronary intervention: A multicenter, randomized, sham-controlled trial
Cost-effectiveness of angiographic quantitative flow ratio-guided coronary intervention: A multicenter, randomized, sham-controlled trial Open
Background: The FAVOR (Comparison of Quantitative Flow Ratio Guided and Angiography Guided Percutaneous Intervention in Patients with Coronary Artery Disease) III China trial demonstrated that percutaneous coronary intervention (PCI) lesio…
View article: Study on Tobacco Donations in China: An Analysis Based on Tobacco Industry Literature
Study on Tobacco Donations in China: An Analysis Based on Tobacco Industry Literature Open
Objective: This study aims to investigate the philanthropic donations of the tobacco industry in China under the guise of charity, providing recommendations for national tobacco control efforts and policies. Methods: By analyzing the secti…
View article: Exploration of the Antitumor Mechanism of Fruquintinib in Colorectal Cancer via Autophagy Regulation
Exploration of the Antitumor Mechanism of Fruquintinib in Colorectal Cancer via Autophagy Regulation Open
Colorectal cancer (CRC) ranks as the second leading cause of cancer-related mortality worldwide, with treatment challenges largely attributed to late-stage diagnoses, frequent recurrences, and resistance to therapy. In recent years, Fruqui…
View article: Can Large Language Models Understand You Better? An MBTI Personality Detection Dataset Aligned with Population Traits
Can Large Language Models Understand You Better? An MBTI Personality Detection Dataset Aligned with Population Traits Open
The Myers-Briggs Type Indicator (MBTI) is one of the most influential personality theories reflecting individual differences in thinking, feeling, and behaving. MBTI personality detection has garnered considerable research interest and has…
View article: Cardiovascular Risk Factors in Patients with Valvular Heart Disease: A Nationwide Observational Cohort Study
Cardiovascular Risk Factors in Patients with Valvular Heart Disease: A Nationwide Observational Cohort Study Open
More than one of five VHD patients had at least two conventional cardiovascular risk factors. The increasing number of risk factors indicated poor prognosis in patients with significant MR. Optimizing risk factor control may improve second…