Xiaobin Fang
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View article: Iterative delivery of mRNA by MEFI
Iterative delivery of mRNA by MEFI Open
Conventional therapeutic mRNA delivery systems are inherently single-use, limiting expression potency, duration, and penetration across biological barriers. To address this, we engineered the mRNA Exporting and Ferrying Implement (MEFI), a…
View article: Ferroptosis in Pneumoconiosis: From Molecular and Cellular Mechanisms to Therapeutic Strategies
Ferroptosis in Pneumoconiosis: From Molecular and Cellular Mechanisms to Therapeutic Strategies Open
Pneumoconiosis, caused by exposure to inorganic hazardous materials, is a highly prevalent and severe occupational disease. It is characterized by a progressive inflammatory process and the development of permanent lung fibrosis, which ult…
View article: Transfusion‐Related Acute Lung Injury: from Mechanistic Insights to Therapeutic Strategies (Adv. Sci. 11/2025)
Transfusion‐Related Acute Lung Injury: from Mechanistic Insights to Therapeutic Strategies (Adv. Sci. 11/2025) Open
Transfusion‐Related Acute Lung Injury In this frontispiece, a transfusion bag, Taiji symbol, and alveolar structure highlight the immune imbalance triggered by exogenous blood products, resulting in acute lung injury. Article number 241336…
View article: Transfusion‐Related Acute Lung Injury: from Mechanistic Insights to Therapeutic Strategies
Transfusion‐Related Acute Lung Injury: from Mechanistic Insights to Therapeutic Strategies Open
Transfusion‐related acute lung injury (TRALI) is a potentially lethal complication of blood transfusions, characterized by the rapid onset of pulmonary edema and hypoxemia within six hours post‐transfusion. As one of the primary causes of …
View article: SQSTM1 upregulation-induced iron overload triggers endothelial ferroptosis in nicotine-exacerbated atherosclerosis
SQSTM1 upregulation-induced iron overload triggers endothelial ferroptosis in nicotine-exacerbated atherosclerosis Open
This study has been registered in the Chinese Clinical Trial Registry (ChiCTR2400083484, Registration Date: April 26, 2024).
View article: Targeting mast cell activation alleviates anti-MHC I antibody and LPS-induced TRALI in mice by pharmacologically blocking the TLR3 and MAPK pathway
Targeting mast cell activation alleviates anti-MHC I antibody and LPS-induced TRALI in mice by pharmacologically blocking the TLR3 and MAPK pathway Open
Transfusion-related lung injury (TRALI) poses a significant risk following blood transfusion and remains the primary cause of transfusion-related morbidity and mortality, primarily driven by the activation of immune cells through anti-majo…
View article: The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential
The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential Open
Pulmonary fibrosis is a progressive and ultimately fatal lung disease, exhibiting the excessive production of extracellular matrix and aberrant activation of fibroblast. While Pirfenidone and Nintedanib are FDA-approved drugs that can slow…
View article: Involvement of CCL2 and CH25H Genes and TNF signaling pathways in mast cell activation and pathogenesis of chronic spontaneous urticaria
Involvement of CCL2 and CH25H Genes and TNF signaling pathways in mast cell activation and pathogenesis of chronic spontaneous urticaria Open
Chronic spontaneous urticaria (CSU), a mast cell-driven disease, substantially affects the quality of life. While genetics affect CSU susceptibility and severity, the specific genetic factors associated with mast cell activation in CSU rem…
View article: The influence of water vapor on the structural response of asphalt pavement
The influence of water vapor on the structural response of asphalt pavement Open
A series of water damage phenomena of asphalt pavement during service show that water is very important. To comprehensively analyze the influence of water vapor factors on the response of pavement structure, this article first tests the wa…
View article: Exosomes From Packed Red Cells Induce Human Mast Cell Activation and the Production of Multiple Inflammatory Mediators
Exosomes From Packed Red Cells Induce Human Mast Cell Activation and the Production of Multiple Inflammatory Mediators Open
Most blood transfusion-related adverse reactions involve the immunologic responses of recipients to exogenous blood components. Extracellular vesicles isolated from packed red cells can affect the recipient’s immune system. Mast cells are …
View article: Thrombin Induces Secretion of Multiple Cytokines and Expression of Protease-Activated Receptors in Mouse Mast Cell Line
Thrombin Induces Secretion of Multiple Cytokines and Expression of Protease-Activated Receptors in Mouse Mast Cell Line Open
Background . Thrombin could elicit degranulation of mast cells involved in numerous physiologic and pathologic processes; however, the detailed scrutiny of this procedure and further research of possible cell signaling pathways are lacking…
View article: Manufacture of low-fat Cheddar cheese by exopolysaccharide-producing Lactobacillus plantarum JLK0142 and its functional properties
Manufacture of low-fat Cheddar cheese by exopolysaccharide-producing Lactobacillus plantarum JLK0142 and its functional properties Open
This study aimed to evaluate the effect of exopolysaccharide (EPS)-producing Lactobacillus plantarum JLK0142 on the ripening characteristics and in vitro health-promoting benefits of low-fat Cheddar cheese. Three batches of cheese were mad…
View article: Redox-sensitive micelles composed of disulfide-linked Pluronic-linoleic acid for enhanced anticancer efficiency of brusatol
Redox-sensitive micelles composed of disulfide-linked Pluronic-linoleic acid for enhanced anticancer efficiency of brusatol Open
Brusatol (Bru) exhibits promising anticancer effects, with both proliferation inhibition and chemoresistance amelioration activity. However, the poor solubility and insufficient intracellular delivery of Bru greatly restrict its applicatio…