Xiaobin Ma
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View article: Conservation Effectiveness and Heterogeneity of the National Park in Promoting Ecosystem Health: Causal Evidence from Huangshan, China
Conservation Effectiveness and Heterogeneity of the National Park in Promoting Ecosystem Health: Causal Evidence from Huangshan, China Open
National parks are key tools for safeguarding ecosystem health, yet their conservation performance remains unclear. Comprehensive evaluations are crucial for guiding targeted and effective conservation strategies. This study employed the V…
View article: Bisecting GlcNAc enhances CD8+ T cell-mediated killing of breast cancer by suppressing PD-L1 expression and its binding to PD-1
Bisecting GlcNAc enhances CD8+ T cell-mediated killing of breast cancer by suppressing PD-L1 expression and its binding to PD-1 Open
Background The abundance of PD-L1 on the surface of tumor cells is a critical factor in sensitizing these cells to T cell-mediated immune killing. While abnormal glycosylation of PD-L1 is known to influence its expression and function, the…
View article: Characteristics and Influencing Factors of Cropland Function Trade-Off in Highly Urbanized Areas: Insights from the Yangtze River Delta Region in China
Characteristics and Influencing Factors of Cropland Function Trade-Off in Highly Urbanized Areas: Insights from the Yangtze River Delta Region in China Open
Exploring the characteristics of changes in cropland function trade-off and the influencing factors in highly urbanized areas can promote the synergistic development of urbanization and fine cropland management. Taking the Yangtze River De…
View article: Analysis of Filial Ethics of Offspring in the Care Process of Disabled Elderly in the Context of Low Birth and Aging Population: A Cross‑sectional Study
Analysis of Filial Ethics of Offspring in the Care Process of Disabled Elderly in the Context of Low Birth and Aging Population: A Cross‑sectional Study Open
Background With the rapid aging of the population and a significant decline in fertility rates, elderly individuals with disabilities face enormous pressure to meet their old-age needs. The filial beliefs and behaviors of offspring play a …
View article: Integrated pan-cancer analysis and experimental verification of the roles of meiotic nuclear divisions 1 in breast cancer
Integrated pan-cancer analysis and experimental verification of the roles of meiotic nuclear divisions 1 in breast cancer Open
MND1 emerges as a promising biomarker for diagnostic and therapeutic targeting in various cancers, including BRCA. The abnormal up-regulation and activation of MND1 are linked to carcinogenesis and poor prognosis among BRCA patients, which…
View article: Breast cancer is associated with coronary heart disease: a cross-sectional survey of NHANES 1999–2018
Breast cancer is associated with coronary heart disease: a cross-sectional survey of NHANES 1999–2018 Open
Background Understanding the correlation between female breast cancer (BC) and the prevalence of coronary heart disease (CHD) is important for developing prevention strategies and reducing the burden of female social disease. This study ai…
View article: Prognostic Value and Mode Selection of Locoregional Treatment in Stage-IV Breast Cancer Patients
Prognostic Value and Mode Selection of Locoregional Treatment in Stage-IV Breast Cancer Patients Open
Purpose: This study aimed to assess the actual prognostic significance of different LRT (surgery and radiotherapy) modalities for stage-IV BC patients, and construct a competing risk nomogram to make precise predictions of the breast cance…
View article: Impact of <i>NOTCH1</i> polymorphisms on liver cancer in a Chinese Han population
Impact of <i>NOTCH1</i> polymorphisms on liver cancer in a Chinese Han population Open
NOTCH1, a member of the Notch family, is up-expression in advanced liver cancer (LC) patients and is associated with tumor sizes, tumor stage, metastasis, and invasion. A few studies have discovered the contribution of NOTCH1 variants to L…
View article: Progress in Ecosystem Health Research and Future Prospects
Progress in Ecosystem Health Research and Future Prospects Open
Since the Anthropocene, drastic changes in the relationship between humans and the earth have prompted human beings to pay more attention to the living environment. As a metaphor to reveal the state of humanity and nature, ecosystem health…
View article: Spatial-temporal changes in ecosystem services and social-ecological drivers in a typical coastal tourism city: A case study of Sanya, China
Spatial-temporal changes in ecosystem services and social-ecological drivers in a typical coastal tourism city: A case study of Sanya, China Open
Tourism is an important economic and social activity with distinct characteristics of human-land interaction, which creates increasingly pronounced ecological and environmental challenges. The changes in four ecosystem services, including …
View article: Accidental venous port placement <i>via</i> the persistent left superior vena cava: Two case reports
Accidental venous port placement <i>via</i> the persistent left superior vena cava: Two case reports Open
Correct assessment of PLSVC status and ultrasound-guided PORT placement generally does not affect breast cancer patients chemotherapy.
View article: The relationship between immediate postmastectomy reconstruction modalities and survival benefits in patients with triple negative breast cancer
The relationship between immediate postmastectomy reconstruction modalities and survival benefits in patients with triple negative breast cancer Open
Introduction Immediate postmastectomy reconstruction for breast cancer has been widely used due to its unique esthetic and psychological effects. However, no other population‐based study has investigated the effects of different reconstruc…
View article: Disseminated Strongyloidiasis Misdiagnosed as Guillain-Barré Syndrome: The Value of High-Throughput Genetic Sequencing of Pathogenic Microorganisms in Parasitic Infections
Disseminated Strongyloidiasis Misdiagnosed as Guillain-Barré Syndrome: The Value of High-Throughput Genetic Sequencing of Pathogenic Microorganisms in Parasitic Infections Open
This case highlights the combined application of mNGS and traditional testing in the clinical diagnosis of difficult and critical parasitic infections in immunocompromised patients. mNGS is a new, adjunct diagnostic method to rapidly scree…
View article: Nomogram Predicts the Role of Primary Tumor Surgery on De Novo Stage-IV Breast Cancer Patients: A SEER-Based Competing Risk Analysis Model
Nomogram Predicts the Role of Primary Tumor Surgery on De Novo Stage-IV Breast Cancer Patients: A SEER-Based Competing Risk Analysis Model Open
Objective The efficacy of primary tumor surgery on survival in female patients with de novo stage IV breast cancer (BC) remains unclear. Our study endeavored to develop comprehensive competing risk nomograms to predict clinical outcomes an…
View article: Marsdenia tenacissima Extract Induces Autophagy and Apoptosis of Hepatocellular Cells via MIF/mToR Signaling
Marsdenia tenacissima Extract Induces Autophagy and Apoptosis of Hepatocellular Cells via MIF/mToR Signaling Open
Hepatocellular carcinoma (HCC) seriously endangers humans. In traditional Chinese medicine, Marsdenia tenacissima (MTE) has anti-inflammatory, antiasthmatic, antihypertensive, and anticancer effects. This study reveals the antiproliferativ…
View article: Study on Smart Numerical Simulation Mechanism in Complex Reservoir Using Embedded Discrete Fracture Model
Study on Smart Numerical Simulation Mechanism in Complex Reservoir Using Embedded Discrete Fracture Model Open
The embedded discrete fracture model (EDFM) method is used to study the mechanism model of the reservoir with a complex fracture system, and the sensitivity analysis of the development effect is carried out. The results show that: 1) the E…
View article: MicroRNA-1292-5p inhibits cell growth, migration and invasion of gastric carcinoma by targeting DEK.
MicroRNA-1292-5p inhibits cell growth, migration and invasion of gastric carcinoma by targeting DEK. Open
Gastric cancer ranks as the third most lethal cancer worldwide. Although many efforts have been made to identify novel markers for early diagnosis and effective drugs for the treatment of gastric cancer, the outcome is still poor due to de…
View article: Genetic polymorphisms in caveolin-1 associate with breast cancer risk in Chinese Han population
Genetic polymorphisms in caveolin-1 associate with breast cancer risk in Chinese Han population Open
Caveolin-1(CAV-1) was demonstrated to be a tumor suppressor gene and be implicated in the development of breast cancer (BC). Numerous potentially functional polymorphisms in CAV-1 have been identified, but their effects on BC were not clea…
View article: Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in mice dependent on c‐Myc expression
Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in mice dependent on c‐Myc expression Open
c‐Myc overexpression has been implicated in several malignancies including gastric cancer. Here, we report that acidified bile acids enhance tumor progression and telomerase activity in gastric cancer via c‐Myc activation both in vivo and …
View article: Association of transcription factor 7-like 2 gene polymorphisms with breast cancer risk in northwest Chinese women
Association of transcription factor 7-like 2 gene polymorphisms with breast cancer risk in northwest Chinese women Open
Genetic variations in transcription factor 7-like 2 (TCF7L2) are associated with cancer risk. This study was conducted to establish the relationship between TCF7L2 polymorphisms (rs1225404, rs7003146, and rs7903146) and clinical features a…
View article: Impact of the PARP1 rs1136410 and rs3219145 polymorphisms on susceptibility and clinicopathologic features of breast cancer in a Chinese population
Impact of the PARP1 rs1136410 and rs3219145 polymorphisms on susceptibility and clinicopathologic features of breast cancer in a Chinese population Open
Background: Poly(ADP-ribose) polymerase-1 (PARP1) is the important one in the PARP family. PARP1 participates in the development of tumors and its polymorphisms were reported to relate to various tumors risk. The case-control study aimed t…
View article: The accuracy of magnetic resonance imaging and ultrasound in evaluating the size of early-stage breast neoplasms
The accuracy of magnetic resonance imaging and ultrasound in evaluating the size of early-stage breast neoplasms Open
Objective Breast cancer is the most frequently diagnosed cancer in women. Accurate evaluation of the size and extent of the tumor is crucial in selecting a suitable surgical method for patients with breast cancer. Both overestimation and u…
View article: Polymorphisms in <i>TIM-3</i> and breast cancer susceptibility in Chinese women: A case-control study
Polymorphisms in <i>TIM-3</i> and breast cancer susceptibility in Chinese women: A case-control study Open
Previous studies have found associations between polymorphisms in T cell immunoglobulin and mucin domain 3 (TIM-3) and increased risks of various cancers. However, the association between TIM-3 polymorphisms and breast cancer (BC) remains …
View article: PD-1 rs2227982 Polymorphism Is Associated With the Decreased Risk of Breast Cancer in Northwest Chinese Women
PD-1 rs2227982 Polymorphism Is Associated With the Decreased Risk of Breast Cancer in Northwest Chinese Women Open
Programmed death-1 (PD-1) is crucial in cancer and is well characterized as a negative T-cell regulator that functions by delivering inhibitory signals. We aimed to evaluate the relationship between PD-1 polymorphisms (rs10204525, rs222798…
View article: Genetic association of deleted in colorectal carcinoma variants with breast cancer risk: A case-control study
Genetic association of deleted in colorectal carcinoma variants with breast cancer risk: A case-control study Open
Deleted in colorectal carcinoma (DCC), a netrin-1 dependence receptor, is correlated with cell progression, migration, and adhesion. Evidence indicated that DCC was frequently down-regulated in many cancers. However, the association of DCC…
View article: Single-nucleotide polymorphisms in <i>PSCA</i> and the risk of breast cancer in a Chinese population
Single-nucleotide polymorphisms in <i>PSCA</i> and the risk of breast cancer in a Chinese population Open
This study explored the associations between common PSCA single-nucleotide polymorphisms (rs2294008, rs2978974, and rs2976392) and breast cancer among 560 breast cancer cases and 583 controls (Chinese Han women). We found rs2294008 was sig…
View article: Genetic Variation in Metastasis-Associated in Colon Cancer-1 and the Risk of Breast Cancer Among the Chinese Han Population
Genetic Variation in Metastasis-Associated in Colon Cancer-1 and the Risk of Breast Cancer Among the Chinese Han Population Open
Metastasis-associated in colon cancer-1 (MACC1), a newly identified oncogene, is involved in angiogenesis, invasiveness, and metastasis in many cancers. Epidemiological studies have indicated the associations between MACC1 polymorphisms an…