Xueying Zhu
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View article: scSelector: A Flexible Single-Cell Data Analysis Assistant for Biomedical Researchers
scSelector: A Flexible Single-Cell Data Analysis Assistant for Biomedical Researchers Open
Background: Standard single-cell RNA sequencing (scRNA-seq) analysis workflows face significant limitations, particularly the rigidity of clustering-dependent methods that can obscure subtle cellular heterogeneity and the potential loss of…
View article: Da‐Bu‐Yin‐Wan and Qian‐Zheng‐San Alleviate Parkinson's Disease by Activating the Keap1/Nrf2/ <scp>HO</scp> ‐1 Pathway to Positively Regulate Oxidative Stress
Da‐Bu‐Yin‐Wan and Qian‐Zheng‐San Alleviate Parkinson's Disease by Activating the Keap1/Nrf2/ <span>HO</span> ‐1 Pathway to Positively Regulate Oxidative Stress Open
Background Parkinson's disease (PD) is a neurodegenerative disorder that worsens progressively. Different pathological mechanisms are involved in the progression of PD, including the loss of dopaminergic (DA) neurons and exacerbated oxidat…
View article: Exploration of the treatment mechanism of Rehmanniae Radix Praeparata for Parkinson's disease, based on network pharmacology, molecular docking, and experimental validation
Exploration of the treatment mechanism of Rehmanniae Radix Praeparata for Parkinson's disease, based on network pharmacology, molecular docking, and experimental validation Open
Parkinson's disease (PD) is the most rapidly increasing neurological disorder. At present, no therapy exists that modifies the disease to slow its progression. Rehmanniae Radix Praeparata (RRP) is a widely used traditional Chinese medicine…
View article: Development and Validation of a Frailty Index for Ischemic Stroke Patients
Development and Validation of a Frailty Index for Ischemic Stroke Patients Open
This study aimed to develop and validate a frailty index (FI) tailored to ischemic stroke patients based on the cumulative deficit model. Using data from 537 patients, 34 health-related variables were initially selected through literature …
View article: Robust Deep Signed Graph Clustering via Weak Balance Theory
Robust Deep Signed Graph Clustering via Weak Balance Theory Open
Signed graph clustering is a critical technique for discovering community structures in graphs that exhibit both positive and negative relationships. We have identified two significant challenges in this domain: i) existing signed spectral…
View article: Change in choroid thickness and vascularity index associated with accommodation and aberration after small-incision lenticule extraction
Change in choroid thickness and vascularity index associated with accommodation and aberration after small-incision lenticule extraction Open
AIM: To explore choroidal thickness (CT) and choroidal vascularity index (CVI) changes around the macula and optic nerve head (ONH) using swept-source optical coherence tomography (SS-OCT) after small-incision lenticule extraction (SMILE) …
View article: Single-cell transcriptome sequencing reveals the cell populations and functions associated with stony coral Pocillopora damicornis
Single-cell transcriptome sequencing reveals the cell populations and functions associated with stony coral Pocillopora damicornis Open
Introduction Pocillopora damicornis , a key species of stony corals, has been the subject of considerable scientific study. However, the cellular composition of P. damicornis and the roles of these cells in endosymbiosis and biomineralizat…
View article: Bushen Huoxue Yiqi formula alleviates cardiac fibrosis in ischemic heart failure through SIRT1/Notch1 pathway-mediated EndMT
Bushen Huoxue Yiqi formula alleviates cardiac fibrosis in ischemic heart failure through SIRT1/Notch1 pathway-mediated EndMT Open
Targeting EndMT based on the SIRT1/Notch1 pathway, BHYF may represent a novel antifibrotic therapeutic strategy, providing a scientific basis for the development of new cardiovascular drugs.
View article: Investigating the molecular mechanisms of Fuzheng Yiliu Shenji prescription in SH-SY5Y neuroblastoma cells
Investigating the molecular mechanisms of Fuzheng Yiliu Shenji prescription in SH-SY5Y neuroblastoma cells Open
Background Neuroblastoma is the most common extracranial solid tumor in childhood. Fuzheng Yiliu Shenji Prescription (FYSP) has shown potential in treating malignant pediatric tumors in clinical settings. This study aims to explore the mol…
View article: Application of optical coherence tomography in cardiovascular diseases: bibliometric and meta-analysis
Application of optical coherence tomography in cardiovascular diseases: bibliometric and meta-analysis Open
Significance Since the advent of Optical Coherence Tomography (OCT) two decades ago, there has been substantial advancement in our understanding of intravascular biology. Identifying culprit lesion pathology through OCT could precipitate a…
View article: A Highly Stable, Multifunctional Janus Dressing for Treating Infected Wounds
A Highly Stable, Multifunctional Janus Dressing for Treating Infected Wounds Open
The limited and unstable absorption of excess exudate is a major challenge during the healing of infected wounds. In this study, a highly stable, multifunctional Janus dressing with unidirectional exudate transfer capacity is fabricated ba…
View article: Clinical prediction of insufficient vaults after implantable collamer lens implantation
Clinical prediction of insufficient vaults after implantable collamer lens implantation Open
AIM: To determine the factors related to preoperative ocular characters that are predictive of insufficient vault (<250 μm) after implantable collamer lens (ICL V4c; STAAR Surgical) implantation. METHODS: The participants underwent …
View article: Tension-Type Headache Management: A Systematic Review and Network Meta-analysis of Complementary and Alternative Medicine
Tension-Type Headache Management: A Systematic Review and Network Meta-analysis of Complementary and Alternative Medicine Open
CRD42021252073.
View article: The role and therapeutic potential of macrophages in the pathogenesis of diabetic cardiomyopathy
The role and therapeutic potential of macrophages in the pathogenesis of diabetic cardiomyopathy Open
This review provides a comprehensive analysis of the critical role played by macrophages and their underlying mechanisms in the progression of diabetic cardiomyopathy (DCM). It begins by discussing the origins and diverse subtypes of macro…
View article: Magnetic nanoparticles-based electrochemical aptasensor for the detection of enrofloxacin in chicken
Magnetic nanoparticles-based electrochemical aptasensor for the detection of enrofloxacin in chicken Open
Enrofloxacin (ENR) is widely applied in preventing and treating animal diseases and hence directly passed into animal-derived foods. Therefore, the detection of this drug in food samples must be strengthened to ensure food safety. In this …
View article: Energy metabolism and redox balance: How phytochemicals influence heart failure treatment
Energy metabolism and redox balance: How phytochemicals influence heart failure treatment Open
Heart Failure (HF) epitomizes a formidable global health quandary characterized by marked morbidity and mortality. It has been established that severe derangements in energy metabolism are central to the pathogenesis of HF, culminating in …
View article: Metabolomic profiling of Marek’s disease virus infection in host cell based on untargeted LC-MS
Metabolomic profiling of Marek’s disease virus infection in host cell based on untargeted LC-MS Open
Marek’s disease (MD) caused by Marek’s disease virus (MDV), poses a serious threat to the poultry industry by inducing neurological disease and malignant lymphoma in infected chickens. However, the underlying mechanisms how MDV disrupts ho…
View article: Efficacy of perampanel in pediatric epilepsy with known and presumed genetic etiology
Efficacy of perampanel in pediatric epilepsy with known and presumed genetic etiology Open
Objective The efficacy of perampanel (PER) in pediatric epilepsy with specific etiologies has not been well established. Here, we investigated outcome and predictors of PER treatment in a pediatric cohort with known and presumed genetic et…
View article: Intraoperative optical coherence tomography angiography for intraocular surgery
Intraoperative optical coherence tomography angiography for intraocular surgery Open
Purpose: To evaluate the feasibility of an intraoperative optical coherence tomography angiography (iOCTA) system integrated with a surgical microscope, and further investigate the real-time retinal vascular change in intraocular pressure …
View article: The relationship between the monocyte-to-lymphocyte ratio and osteoporosis in postmenopausal females with T2DM: A retrospective study in Chinese population
The relationship between the monocyte-to-lymphocyte ratio and osteoporosis in postmenopausal females with T2DM: A retrospective study in Chinese population Open
Introduction The risk of fragility fractures is increased in patients with type 2 diabetes mellitus (T2DM). Many reports indicate that inflammatory and immune responses are associated with osteoporosis and osteopenia. The monocyte-to-lymph…
View article: The essential role of forkhead box P4 (FOXP4) in thyroid cancer: a study related to The Cancer Genome Atlas and experimental data
The essential role of forkhead box P4 (FOXP4) in thyroid cancer: a study related to The Cancer Genome Atlas and experimental data Open
Objective Thyroid cancer (THCA) is the most common endocrine cancer in the world. Although most patients with THCA have a good prognosis, the prognosis of those with THCA who have an extra-glandular invasion, vascular invasion, and distant…
View article: BTK is a Prognostic Biomarker for Multiple Human Tumors
BTK is a Prognostic Biomarker for Multiple Human Tumors Open
Bruton's tyrosine kinase (BTK), a key B-cell and macrophage kinase, plays a pivotal role in oncogenic pathways in many B-cell malignancies. BTK inhibitors have shown promising anti-tumor activity, first in B-cell malignancies and subsequen…
View article: Composition Diversity and Expression Specificity of the TPS Gene Family among 24 Ficus Species
Composition Diversity and Expression Specificity of the TPS Gene Family among 24 Ficus Species Open
Volatile organic compounds (VOCs) released by the receptive syconia of Ficus species play a vital role in attracting highly species-specific pollinating fig wasps. The components of VOCs vary considerably among Ficus species, but are gener…
View article: Physical Therapies for Psychosomatic Symptoms and Quality of Life Induced by Aromatase Inhibitors in Breast Cancer Patients: A Systematic Review and Meta-Analysis
Physical Therapies for Psychosomatic Symptoms and Quality of Life Induced by Aromatase Inhibitors in Breast Cancer Patients: A Systematic Review and Meta-Analysis Open
Objective To evaluate the effects of Physical Therapies (PTs) on improvement in psychosomatic symptoms and quality of life (QOL) in breast cancer patients. Data Sources Seven databases (MEDLINE, EMBASE, Cochrane CENTRAL, China National Kno…
View article: Prognostic And Immunological Implications of BTK Expression In Pan-Cancer
Prognostic And Immunological Implications of BTK Expression In Pan-Cancer Open
Background : Cancer poses a serious threat to human health. Clarifying the potential significance of Bruton's tyrosine kinase (BTK)in cancer has potential clinical value. This study examined the prognostic and immunological value of BTK ge…
View article: Pre-clinical Evidence: Berberine as a Promising Cardioprotective Candidate for Myocardial Ischemia/Reperfusion Injury, a Systematic Review, and Meta-Analysis
Pre-clinical Evidence: Berberine as a Promising Cardioprotective Candidate for Myocardial Ischemia/Reperfusion Injury, a Systematic Review, and Meta-Analysis Open
Objective: Myocardial ischemia/reperfusion (I/R) injury is one of the causes of most cardiomyocyte injuries and deaths. Berberine (BBR) has been suggested a potential to exert protective effects against myocardial I/R injury. This systemat…