Xiaobing Tian
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View article: Corrigendum to “P53-independent partial restoration of the p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9” [Neoplasia, volume 23 (2021) 304325]
Corrigendum to “P53-independent partial restoration of the p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9” [Neoplasia, volume 23 (2021) 304325] Open
View article: Corrigendum to Targeting apoptotic pathways for cancer therapy
Corrigendum to Targeting apoptotic pathways for cancer therapy Open
View article: Integrated stress response (ISR) activation and apoptosis through HRI kinase by PG3 and other p53 pathway-restoring cancer therapeutics
Integrated stress response (ISR) activation and apoptosis through HRI kinase by PG3 and other p53 pathway-restoring cancer therapeutics Open
Restoration of the p53 pathway has been a long-term goal in the field of cancer research to treat tumors with mutated p53 and aggressive clinical behavior. p53 pathway restoration in p53-deficient cancers can be achieved by small molecules…
View article: Targeting apoptotic pathways for cancer therapy
Targeting apoptotic pathways for cancer therapy Open
Apoptosis is a form of programmed cell death that is mediated by intrinsic and extrinsic pathways. Dysregulation of and resistance to cell death are hallmarks of cancer. For over three decades, the development of therapies to promote treat…
View article: Inflammatory biomarkers may be associated with poor outcomes after mechanical thrombectomy
Inflammatory biomarkers may be associated with poor outcomes after mechanical thrombectomy Open
Background Mechanical thrombectomy (MT) has become the mainstay of treatment for acute ischemic stroke (AIS) recently. This case-control study aimed to identify the pivotal role of inflammation in the prognosis of AIS patients after MT. Me…
View article: The association between symptomatic remission and social support in community-dwelling schizophrenia patients during COVID-19
The association between symptomatic remission and social support in community-dwelling schizophrenia patients during COVID-19 Open
Introduction Schizophrenia is a severe and enduring psychiatric disorder, characterized by substantial challenges in achieving symptomatic remission. Up to now, there have been limited studies examining the association between remission st…
View article: Dehydration in cerebral venous sinus thrombosis
Dehydration in cerebral venous sinus thrombosis Open
Aims This study aimed to unravel the dehydration status of patients with cerebral venous sinus thrombosis (CVST) to facilitate the understanding of dehydration in CVST. Methods This was a multicenter retrospective study and three populatio…
View article: Association between social support and the severity of positive symptoms in rural community-dwelling patients with schizophrenia during the COVID-19 pandemic
Association between social support and the severity of positive symptoms in rural community-dwelling patients with schizophrenia during the COVID-19 pandemic Open
Background This study examined the association between social support and the severity of positive symptoms in rural community-dwelling schizophrenia patients during the COVID-19 pandemic. Method The cross-sectional study included 665 rura…
View article: The Association between Symptomatic Remission and Social Support in Community- Dwelling Schizophrenia Patients During COVID-19
The Association between Symptomatic Remission and Social Support in Community- Dwelling Schizophrenia Patients During COVID-19 Open
Background: Schizophrenia is a severe and enduring psychiatric disorder, characterized by substantial challenges in achieving symptomatic remission. Up to now, there have been limited studies examining the association between remission sta…
View article: Inflammatory biomarkers may be associated with poor outcomes after mechanical thrombectomy
Inflammatory biomarkers may be associated with poor outcomes after mechanical thrombectomy Open
Background: Mechanical thrombectomy (MT) has become the mainstay of treatment for acute ischemic stroke (AIS) in recent years. This case-control study aimed to identify the pivotal role of inflammation in the prognosis of AIS patients afte…
View article: The role of p53 in anti-tumor immunity and response to immunotherapy
The role of p53 in anti-tumor immunity and response to immunotherapy Open
p53 is a transcription factor that regulates the expression of genes involved in tumor suppression. p53 mutations mediate tumorigenesis and occur in approximately 50% of human cancers. p53 regulates hundreds of target genes that induce var…
View article: Association between inflammatory biomarkers and venous thromboembolism: a systematic review and meta-analysis
Association between inflammatory biomarkers and venous thromboembolism: a systematic review and meta-analysis Open
Background Venous thromboembolism (VTE) is a common thrombotic vascular disease that has a significant impact on people’s well-being and quality of life. A plethora of clinical studies explore the relationship between inflammatory biomarke…
View article: Supplementary Figures 1-9, Supplementary Tables 1-3 from An Integrated Stress Response Agent that Modulates DR5-Dependent TRAIL Synergy Reduces Patient-Derived Glioma Stem Cell Viability
Supplementary Figures 1-9, Supplementary Tables 1-3 from An Integrated Stress Response Agent that Modulates DR5-Dependent TRAIL Synergy Reduces Patient-Derived Glioma Stem Cell Viability Open
S1: Raw bioluminescence data obtained from screens of kinase, protease, and redox inhibitors. S2: Bioluminescent and viability data from U251 DR5 Luciferase cells treated with an NH125 dilution series. S3: Representative images of T4213 ne…
View article: Supplementary Figures 1-9, Supplementary Tables 1-3 from An Integrated Stress Response Agent that Modulates DR5-Dependent TRAIL Synergy Reduces Patient-Derived Glioma Stem Cell Viability
Supplementary Figures 1-9, Supplementary Tables 1-3 from An Integrated Stress Response Agent that Modulates DR5-Dependent TRAIL Synergy Reduces Patient-Derived Glioma Stem Cell Viability Open
S1: Raw bioluminescence data obtained from screens of kinase, protease, and redox inhibitors. S2: Bioluminescent and viability data from U251 DR5 Luciferase cells treated with an NH125 dilution series. S3: Representative images of T4213 ne…
View article: Data from An Integrated Stress Response Agent that Modulates DR5-Dependent TRAIL Synergy Reduces Patient-Derived Glioma Stem Cell Viability
Data from An Integrated Stress Response Agent that Modulates DR5-Dependent TRAIL Synergy Reduces Patient-Derived Glioma Stem Cell Viability Open
The high incidence of glioblastoma recurrence necessitates additional therapeutic strategies. Heterogeneous populations of cells, including glioma stem cells (GSC) have been implicated in disease recurrence. GSCs are able to survive irradi…
View article: Data from An Integrated Stress Response Agent that Modulates DR5-Dependent TRAIL Synergy Reduces Patient-Derived Glioma Stem Cell Viability
Data from An Integrated Stress Response Agent that Modulates DR5-Dependent TRAIL Synergy Reduces Patient-Derived Glioma Stem Cell Viability Open
The high incidence of glioblastoma recurrence necessitates additional therapeutic strategies. Heterogeneous populations of cells, including glioma stem cells (GSC) have been implicated in disease recurrence. GSCs are able to survive irradi…
View article: Data from Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) and paclitaxel have cooperative <i>in vivo</i> effects against glioblastoma multiforme cells
Data from Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) and paclitaxel have cooperative <i>in vivo</i> effects against glioblastoma multiforme cells Open
Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) in conjunction with microtubule-targeting agents may be a promising novel anticancer treatment strategy. In vitro studies have suggested that relatively low concentrati…
View article: Supplementary Figures 1-2 from Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) and paclitaxel have cooperative <i>in vivo</i> effects against glioblastoma multiforme cells
Supplementary Figures 1-2 from Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) and paclitaxel have cooperative <i>in vivo</i> effects against glioblastoma multiforme cells Open
Supplementary Figures 1-2 from Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) and paclitaxel have cooperative in vivo effects against glioblastoma multiforme cells
View article: Data from Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) and paclitaxel have cooperative <i>in vivo</i> effects against glioblastoma multiforme cells
Data from Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) and paclitaxel have cooperative <i>in vivo</i> effects against glioblastoma multiforme cells Open
Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) in conjunction with microtubule-targeting agents may be a promising novel anticancer treatment strategy. In vitro studies have suggested that relatively low concentrati…
View article: Supplementary Figures 1-2 from Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) and paclitaxel have cooperative <i>in vivo</i> effects against glioblastoma multiforme cells
Supplementary Figures 1-2 from Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) and paclitaxel have cooperative <i>in vivo</i> effects against glioblastoma multiforme cells Open
Supplementary Figures 1-2 from Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) and paclitaxel have cooperative in vivo effects against glioblastoma multiforme cells
View article: Medication adherence among community-dwelling schizophrenia patients during the COVID-19 pandemic: A cross-sectional study
Medication adherence among community-dwelling schizophrenia patients during the COVID-19 pandemic: A cross-sectional study Open
View article: Advanced Strategies for Therapeutic Targeting of Wild-Type and Mutant p53 in Cancer
Advanced Strategies for Therapeutic Targeting of Wild-Type and Mutant p53 in Cancer Open
TP53 is a tumor suppressor gene that encodes a sequence-specific DNA-binding transcription factor activated by stressful stimuli; it upregulates target genes involved in growth suppression, cell death, DNA repair, metabolism, among others.…
View article: Advanced Strategies for Therapeutic Targeting of Wild-Type and Mutant p53 in Cancer
Advanced Strategies for Therapeutic Targeting of Wild-Type and Mutant p53 in Cancer Open
TP53 is a tumor suppressor gene that encodes a sequence-specific DNA-binding transcription factor activated by stressful stimuli and upregulates target genes involved in growth suppression, cell death, DNA repair, metabolism, among others.…
View article: Therapeutic Targeting of Autophagy in Pancreatic Ductal Adenocarcinoma
Therapeutic Targeting of Autophagy in Pancreatic Ductal Adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease characterized by early metastasis, late detection, and poor prognosis. Progress towards effective therapy has been slow despite significant efforts. Novel treatment approache…
View article: Long-Term Trends in Stroke Management and Burden Among Low-Income Women in a Rural Area From China (1992–2019): A Prospective Population-Based Study
Long-Term Trends in Stroke Management and Burden Among Low-Income Women in a Rural Area From China (1992–2019): A Prospective Population-Based Study Open
Although an increasing number of studies are considering sex-related differences in stroke burden, the trends in stroke burden and management among women in China, especially among low-income women, remain unclear. This study evaluated the…
View article: Targeting the Integrated Stress Response in Cancer Therapy
Targeting the Integrated Stress Response in Cancer Therapy Open
The integrated stress response (ISR) is an evolutionarily conserved intra-cellular signaling network which is activated in response to intrinsic and extrinsic stresses. Various stresses are sensed by four specialized kinases, PKR-like ER k…
View article: Epidemiology of Isolated Impaired Glucose Tolerance Among Adults Aged Above 50 Years in Rural China
Epidemiology of Isolated Impaired Glucose Tolerance Among Adults Aged Above 50 Years in Rural China Open
Health promotion education and a standardized approach to managing body weight, BP, and lipid and uric acid levels would benefit this low-income population in rural China for reducing the risk of cardiovascular disease.
View article: A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53
A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53 Open
Mutations in TP53 occur commonly in the majority of human tumors and confer aggressive tumor phenotypes, including metastasis and therapy resistance. CB002 and structural-analogs restore p53 signaling in tumors with mutant-p53 but we find …
View article: Author response: A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53
Author response: A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53 Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Mutations in TP53 occur commonly in the ma…
View article: A subset of CB002 xanthine analogues bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53
A subset of CB002 xanthine analogues bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53 Open
Mutations in TP53 occur commonly in the majority of human tumors and confer aggressive tumor phenotypes including metastasis and therapy resistance. CB002 and structural-analogues restore p53 signaling in tumors with mutant-p53 but we find…