Xiaobo Zhang
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View article: Analysis of the efficacy and prognostic factors of gemcitabine combined with oxaliplatin in non‑Hodgkin lymphoma
Analysis of the efficacy and prognostic factors of gemcitabine combined with oxaliplatin in non‑Hodgkin lymphoma Open
Non-Hodgkin lymphoma (NHL), a heterogeneous malignancy accounting for ~90% of lymphomas, often requires chemotherapy as the primary treatment for patients unsuitable for stem cell transplantation. This study aimed to analyze the therapeuti…
View article: B cell and anti-PLA2R antibody-guided rituximab therapy in idiopathic membranous nephropathy: a prospective multi-center cohort study in the East Coastal Region of China
B cell and anti-PLA2R antibody-guided rituximab therapy in idiopathic membranous nephropathy: a prospective multi-center cohort study in the East Coastal Region of China Open
Introduction This study assessed the safety and efficacy of B cell- and anti-PLA2R antibody-targeted low-dose rituximab therapy in patients with idiopathic membranous nephropathy (IMN). Methods This was a multicenter, investigator-initiate…
View article: Prognostic influences and prediction model construction for traumatic cervical spinal cord injury
Prognostic influences and prediction model construction for traumatic cervical spinal cord injury Open
Background: Traumatic cervical spinal cord injury (TCSCI), a critical neurological disorder with rising global incidence, burdens patients physically, psychologically and socially, but has relatively scarce prognostic assessment research c…
View article: Strontium isotope ratio in medicinal plant as a geochemical tracer: Application to the geographic provenance of the relics of Magnoliae Officinalis Cortex in imperial pharmacy of Qing Dynasty
Strontium isotope ratio in medicinal plant as a geochemical tracer: Application to the geographic provenance of the relics of Magnoliae Officinalis Cortex in imperial pharmacy of Qing Dynasty Open
View article: Analysis of the Spatiotemporal Evolution of the Net Primary Productivity of Glycyrrhiza uralensis Fisch. and Its Influencing Factors from 2014- 2022
Analysis of the Spatiotemporal Evolution of the Net Primary Productivity of Glycyrrhiza uralensis Fisch. and Its Influencing Factors from 2014- 2022 Open
Glycyrrhiza uralensis Fisch. is widely used in medicine for its roots and rhizomes, and it plays a significant role in enhancing the regional ecological environment. In this study, firstly, based on the spectral characteristics of G. urale…
View article: Early Severe Midline Shift in Acute Ischemic Stroke Following Endovascular Thrombectomy Within 24 Hours
Early Severe Midline Shift in Acute Ischemic Stroke Following Endovascular Thrombectomy Within 24 Hours Open
Purpose: Early and severe (ES) midline shift (MLS ≥10 mm) simultaneously occurring within 24 hours after endovascular thrombectomy (EVT) is a life-threatening emergency that requires immediate intervention. This study aims to describe ES-M…
View article: Inhibiting cathepsin B alleviates acute lung injury caused by sepsis through suppression of pyroptosis in lung epithelial cells
Inhibiting cathepsin B alleviates acute lung injury caused by sepsis through suppression of pyroptosis in lung epithelial cells Open
View article: Polystyrene nanoplastics aggravate house dust mite induced allergic airway inflammation through EGFR/ERK-dependent lung epithelial barrier dysfunction
Polystyrene nanoplastics aggravate house dust mite induced allergic airway inflammation through EGFR/ERK-dependent lung epithelial barrier dysfunction Open
View article: Unveiling purine metabolism dysregulation orchestrated immunosuppression in advanced pancreatic cancer and concentrating on the central role of NT5E
Unveiling purine metabolism dysregulation orchestrated immunosuppression in advanced pancreatic cancer and concentrating on the central role of NT5E Open
Background The dismal efficacy of immunotherapy for Pancreatic cancer (PC) can be predominantly ascribed to its distinctive cold-tumor properties. The by-products of purine metabolic reprogramming are extensively engaged in tumor immune mo…
View article: Synthesis and Anti-Inflammatory Evaluation of Novel Hybrids of 7-Oxodehydroabietic Acid Bearing a 1,2,3-Triazole Moiety
Synthesis and Anti-Inflammatory Evaluation of Novel Hybrids of 7-Oxodehydroabietic Acid Bearing a 1,2,3-Triazole Moiety Open
To discover novel, potent anti-inflammatory diterpenoids, a series of hybrids of 7-oxodehydroabietic acid bearing a 1,2,3-triazole moiety was designed and synthesized. The target compounds were characterized by means of 1H NMR, 13C NMR, an…
View article: Improvement of glucocorticoid sensitivity and attenuation of pulmonary allergic reactions by exogenous supplementation with betaine in HDM and LPS‐induced allergic mouse model
Improvement of glucocorticoid sensitivity and attenuation of pulmonary allergic reactions by exogenous supplementation with betaine in HDM and LPS‐induced allergic mouse model Open
Background Childhood asthma is a heterogeneous disease that exhibits different characteristics and varying severity; however, the metabolite alterations underlying the difference in asthma severity, especially in severe asthma, are not wel…
View article: Study on the Effect of the Envelope of Terahertz Unipolar Stimulation on Cell Membrane Communication-Related Variables
Study on the Effect of the Envelope of Terahertz Unipolar Stimulation on Cell Membrane Communication-Related Variables Open
The development of terahertz science and technology has shown new application prospects in artificial intelligence. Terahertz stimulation can lead to information communication of cells. Terahertz unipolar picosecond pulse train stimulation…
View article: GLiM: Integrating Graph Transformer and LLM for Document-Level Biomedical Relation Extraction with Incomplete Labeling
GLiM: Integrating Graph Transformer and LLM for Document-Level Biomedical Relation Extraction with Incomplete Labeling Open
View article: Accurate puncture of targets in the lower lung lobes with respiratory motion using a teleoperated robotic system and low-dose computed tomography fluoroscopy: an experimental animal study
Accurate puncture of targets in the lower lung lobes with respiratory motion using a teleoperated robotic system and low-dose computed tomography fluoroscopy: an experimental animal study Open
Teleoperated robotic systems combined with low-dose CT can accurately puncture millimeter-level targets in the lower lung lobes in real time during breathing under fluoroscopic guidance. Compared with freehand puncture with intermittent sc…
View article: Single-cell characterization of intra-tumoral heterogeneity and the immunosuppressive microenvironment in uterine serous carcinoma
Single-cell characterization of intra-tumoral heterogeneity and the immunosuppressive microenvironment in uterine serous carcinoma Open
Uterine serous carcinoma (USC) has a much worse chemotherapy response and prognosis than endometrioid endometrial carcinoma (EEC). A comprehensive understanding of the intra-tumoral heterogeneity and tumor-specific ecosystem of USC is esse…
View article: Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children
Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children Open
Background Mycoplasma pneumoniae ( M. pneumoniae ) is a significant contributor to community-acquired pneumonia among children. Since 1968, when a strain of M. pneumoniae resistant to macrolide antibiotics was initially reported in Japan, …
View article: Bronchoalveolar Lavage Fluid Metagenomic Second-Generation Sequencing Assists in Guiding the Treatment of Visceral Leishmaniasis: A Case Report
Bronchoalveolar Lavage Fluid Metagenomic Second-Generation Sequencing Assists in Guiding the Treatment of Visceral Leishmaniasis: A Case Report Open
BALF mNGS may assist in evaluating the therapeutic efficacy of VL with respiratory failure, especially in patients with negative blood and bone marrow cytology.
View article: Prognostic significance of lymphovascular space invasion in early-stage low-grade endometrioid endometrial cancer: a fifteen-year retrospective Chinese cohort study
Prognostic significance of lymphovascular space invasion in early-stage low-grade endometrioid endometrial cancer: a fifteen-year retrospective Chinese cohort study Open
Objective In 2016, the ESMO-ESGO-ESTRO consensus included LVSI (Lymph-vascular space invasion, LVSI) status as a risk stratification factor for stage I endometrioid endometrial cancer (EEC) patients and as one of the indications for adjuva…
View article: Oncogenic LINC00698 suppresses apoptosis of melanoma stem cells to promote tumorigenesis via LINC00698-miR-3132-TCF7/hnRNPM axis
Oncogenic LINC00698 suppresses apoptosis of melanoma stem cells to promote tumorigenesis via LINC00698-miR-3132-TCF7/hnRNPM axis Open
Melanoma progression depends on melanoma stem cells (MSCs), which are distinguished by the distinct dysregulated genes. As the key factors in the dysregulation of genes, long non-coding RNAs (lncRNAs) take great effects on MSCs. However, t…
View article: Thermal Analysis of THz Schottky Diode Chips with Single and Double-Row Anode Arrangement
Thermal Analysis of THz Schottky Diode Chips with Single and Double-Row Anode Arrangement Open
GaN Schottky diodes show great potential in high-power terahertz frequency multipliers. The thermal characteristics of GaN Schottky diodes with single and double-row anode arrangements are described in this paper. The temperature distribut…
View article: Endovascular thrombectomy versus medical management on outcomes with infarct volumes more than 70 mL
Endovascular thrombectomy versus medical management on outcomes with infarct volumes more than 70 mL Open
Objective Endovascular thrombectomy (EVT) in patients with large infarct volume remains controversial. The aim of this study is to compare clinical outcomes between EVT and medical management in acute large vessel occlusion with infarct vo…
View article: Effectiveness of the six-step approach guided online training program to improve knowledge of Mycoplasma pneumoniae pneumonia among pediatricians: a pretest-posttest study
Effectiveness of the six-step approach guided online training program to improve knowledge of Mycoplasma pneumoniae pneumonia among pediatricians: a pretest-posttest study Open
The online training program effectively enhanced pediatricians' understanding of diagnosing and treating MPP. It is recommended to maintain continuous education and training targeting all healthcare providers.
View article: Incidence and analysis of intraoperative complications in femtosecond laser-assisted cataract surgery: a large-scale cohort study to establish the learning curve
Incidence and analysis of intraoperative complications in femtosecond laser-assisted cataract surgery: a large-scale cohort study to establish the learning curve Open
Aims To assess the safety of femtosecond laser-assisted cataract surgery (FLACS) based on surgical parameters and intraoperative complications analysis and to determine the length of the learning curve for FLACS. Methods A prospective cons…
View article: PAX1/JAM3 Methylation and HPV Viral Load in Women with Persistent HPV Infection
PAX1/JAM3 Methylation and HPV Viral Load in Women with Persistent HPV Infection Open
The relationship of PAX1/JAM3 methylation as well as HPV viral load (VL) with cervical lesions has been reported, but their role in persistent HPV infection without cervical high-grade lesions has not been fully elucidated. A total of 231 …
View article: Anatomical Structure-Guided Medical Vision-Language Pre-training
Anatomical Structure-Guided Medical Vision-Language Pre-training Open
Learning medical visual representations through vision-language pre-training has reached remarkable progress. Despite the promising performance, it still faces challenges, i.e., local alignment lacks interpretability and clinical relevance…
View article: Checkpoint CD24 function on tumor and immunotherapy
Checkpoint CD24 function on tumor and immunotherapy Open
CD24 is a protein found on the surface of cells that plays a crucial role in the proliferation, invasion, and spread of cancer cells. It adheres to cell membranes through glycosylphosphatidylinositol (GPI) and is associated with the progno…
View article: Validation of a one-step genomics-based molecular classifier for endometrial carcinoma in a large Chinese population
Validation of a one-step genomics-based molecular classifier for endometrial carcinoma in a large Chinese population Open
Chinese ECs exhibit distinctive molecular attributes. For accurate molecular subtyping of Chinese ECs, additional molecular markers that align with the Chinese population's characteristics should be incorporated into existing classifiers. …
View article: The comparison of pure uterine serous carcinoma and mixed tumor with serous component: a single-institution review of 91 cases
The comparison of pure uterine serous carcinoma and mixed tumor with serous component: a single-institution review of 91 cases Open
Background Pure uterine serous carcinoma (p-USC) and mixed tumors with serous component (m-USC) are aggressive subtypes of endometrial cancer associated with high mortality rates. This retrospective study aimed to compare clinicopathologic…
View article: Current Mycoplasma pneumoniae epidemic among children in Shanghai: unusual pneumonia caused by usual pathogen
Current Mycoplasma pneumoniae epidemic among children in Shanghai: unusual pneumonia caused by usual pathogen Open
View article: The combination of astragalus injection and ambroxol hydrochloride in the adjuvant treatment of COPD: a systematic review and meta-analysis
The combination of astragalus injection and ambroxol hydrochloride in the adjuvant treatment of COPD: a systematic review and meta-analysis Open
Chronic obstructive pulmonary disease (COPD) is a severe condition that leads to premature mortality and places a significant financial burden on healthcare systems. An adjunctive therapy in COPD includes the simultaneous administration of…