Explanipedia

Meta-sGWAS: Integrating brain spatial interactions to uncover genetic variants in Bipolar Disorder Open

Wentao Li, Aoqi Wang, Yanfei Wang, Hongbo Bao, Kai Chen , et al. · 2025

Bipolar Disorder (BD) is influenced by both genetic factors and structural changes in brain regions, along with the impact of external environmental factors on brain network interactions. Conventional genome-wide association studies (GWAS)…

KnockRBP: an integrated multi-omics database of functional perturbation profiles for RNA-binding proteins Open

Mengyuan Yang, Jiawei Li, Jiajia Liu, Xin Lü, Xiaobo Zhou , et al. · 2025

RNA-binding proteins (RBPs) regulate diverse post-transcriptional processes, yet their functional impacts across multiple molecular layers remain incompletely characterized. KnockRBP (https://knockrbp.xu-bioinfo.com) is presented as a comp…

Using multiple machine learning algorithms to predict spinal cord injury in patients with cervical spondylosis: a multicenter study Open

Zhongxian Zhou, Sitan Feng, Xiaobo Zhou, Jing Yu, Jichong Zhu , et al. · 2025

Spatial2GWAS: a database for linking spatial transcriptomic regions with GWAS traits Open

Xi Hu, Aoqi Wang, Huan Yu, Pora Kim, Xiaobo Zhou · 2025

Spatial heterogeneity of gene expression within tissue regions has a critical influence on biological functions, thereby affecting disease pathogenesis. However, systematic associations between spatially resolved transcriptomes and phenoty…

Time-aware attention-based deep representation learning for multi-source longitudinal data with structured missingness in electronic medical records Open

Jiawei Luo, Liren Yang, Xixi Nie, Lan Lan, Shixin Huang , et al. · 2025

Comparison of in‐Hospital Complication Rates After Transcatheter Aortic Valve Replacement in Patients With Bicuspid Versus Tricuspid Aortic Valves: A Retrospective Cohort Study Open

Tingxi Zhu, Jiawei Luo, Xuan Huang, Lulu Liu, Kehan Li , et al. · 2025

Background Transcatheter aortic valve replacement (TAVR) has become a popular alternative to surgical aortic valve replacement (SAVR) for patients with valvular heart disease (VHD), particularly for those with aortic anomalies. Aims The st…

Integration of Genetic and Imaging Data for Alzheimer's Disease Diagnosis and Interpretation Open

Yanfei Wang, Qing Wang, Minghao Zhou, Jialu Liang, Lei You , et al. · 2025

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by complex interactions between genetic risk factors and structural brain changes. Traditional diagnostic approaches that rely on single‐modality data, such…

Development and Validation of a Dynamic Real-Time Risk Prediction Model for Intensive Care Units Patients Based on Longitudinal Irregular Data: Multicenter Retrospective Study Open

Zhuo Zheng, Jiawei Luo, Yingchao Zhu, Lei Du, Lan Lan , et al. · 2025

Background Timely and accurate prediction of short-term mortality is critical in intensive care units (ICUs), where patients’ conditions change rapidly. Traditional scoring systems, such as the Simplified Acute Physiology Score and Acute P…

Exploration of working memory retrieval stage for mild cognitive impairment: time-varying causality analysis of electroencephalogram based on dynamic brain networks Open

Yi Jiang, Zhiwei Guo, Xiaobo Zhou, Ning Jiang, Jiayuan He · 2025

Comparative efficacy of NIBS and Physical Exercise on cognitive function in patients with MCI or AD: a systematic review and meta-analysis Open

Yi Jiang, Zhiwei Guo, Xiaobo Zhou, Jiayuan He, Yanyan Wang , et al. · 2025

Non-invasive brain stimulation (NIBS) and physical exercise (PE) intervention are currently the main and promising non-pharmacologic therapies for Alzheimer’s Disease (AD) or Mild cognitive impairment (MCI), but it is not clear which one i…

Modeling and Vulnerability Analysis of Power Cyber-Physical System Based on Reactive Power Partition Theory Open

Funian Hu, Zhu Yanyan, Yueyang Li, Xiaobo Zhou, Bin Xie , et al. · 2025

Survival analysis of clear cell renal cell carcinoma based on radiomics and deep learning features from CT images Open

Zhennan Lu, Sijia Wu, Dan Ni, Meng Zhou, Tao Wang , et al. · 2024

Purpose: To create a nomogram for accurate prognosis of patients with clear cell renal cell carcinoma (ccRCC) based on computed tomography images. Methods: Eight hundred twenty-two ccRCC patients with contrast-enhanced computed tomography …

Transformer-Based Multi-Scale Feature Remote Sensing Image Classification Model Open

Ting Sun, Jun Li, Xiaobo Zhou, Zan Chen · 2024

To address the challenge of poor classification accuracy due to complex backgrounds, large intra-scale variations, and high inter-scale similarity in remote sensing scene classification (RSSC), we propose a new remote sensing scene classif…

CRISPRoffT: comprehensive database of CRISPR/Cas off-targets Open

Grant Wang, Xiaona Liu, Aoqi Wang, Jianguo Wen, Pora Kim , et al. · 2024

The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas (CRISPR-associated protein) programmable nuclease system continues to evolve, with in vivo therapeutic gene editing increasingly applied in clinical settings. Howev…

scProAtlas: an atlas of multiplexed single-cell spatial proteomics imaging in human tissues Open

Tiangang Wang, Xuanmin Chen, Yujuan Han, Jiahao Yi, X. Liu , et al. · 2024

Spatial proteomics can visualize and quantify protein expression profiles within tissues at single-cell resolution. Although spatial proteomics can only detect a limited number of proteins compared to spatial transcriptomics, it provides c…

IMPA1-derived inositol maintains stemness in castration-resistant prostate cancer via IMPDH2 activation Open

Che-Chia Hsu, Guihua Wang, Chien‐Feng Li, Xian Zhang, Zhen Cai , et al. · 2024

Acquisition of prostate cancer stem cells (PCSCs) manifested during androgen ablation therapy (ABT) contributes to castration-resistant prostate cancer (CRPC). However, little is known about the specific metabolites critically orchestratin…

metsDB: a knowledgebase of cancer metastasis at bulk, single-cell and spatial levels Open

Sijia Wu, Jiajin Zhang, Yanfei Wang, Xinyu Qin, Zhaocan Zhang , et al. · 2024

Cancer metastasis, the process by which tumour cells migrate and colonize distant organs from a primary site, is responsible for the majority of cancer-related deaths. Understanding the cellular and molecular mechanisms underlying this com…

Whole Genome Sequence Analysis of Pulmonary Function and COPD in 44,287 Multi-ancestry Participants Open

Wonji Kim, Xiaowei Hu, Kangjin Kim, Sung Chun, Peter Orchard , et al. · 2024

Background Whole genome sequence (WGS) data in multi-ancestry samples provide the opportunity to identify low-frequency or population-specific genetic variants associated with chronic obstructive pulmonary disease (COPD) and lung function.…

CircaKB: a comprehensive knowledgebase of circadian genes across multiple species Open

Xingchen Zhu, Xiao Han, Zhijin Li, Xiaobo Zhou, Seung‐Hee Yoo , et al. · 2024

Circadian rhythms, which are the natural cycles that dictate various physiological processes over a 24-h period, have been increasingly recognized as important in the management and treatment of various human diseases. However, the lack of…

Comparison of in-hospital complication rates after transcatheter aortic valve replacement in patients with bicuspid versus tricuspid aortic valves: a retrospective cohort study Open

Tingxi Zhu, Jiawei Luo, Xuan Huang, Lulu Liu, Kehan Li , et al. · 2024

Background: Transcatheter aortic valve replacement (TAVR) has become a popular alternative to surgical aortic valve replacement (SAVR) for patients with valvular heart disease (VHD), particularly for those with aortic anomalies. Objectives…

SexAnnoDB, a knowledgebase of sex-specific regulations from multi-omics data of human cancers Open

Mengyuan Yang, Yuzhou Feng, Jiajia Liu, Hong Wang, Sijia Wu , et al. · 2024

A Study on the Pragmatic Function of New Year Addresses in External Communication Open

Xiaobo Zhou · 2024

Extreme Case Formulations (ECFs) play an important pragmatic function in the English translation of New Year addresses over the years. This research, grounded in Iñigo-Mora’s theoretical model, utilizes the English renditions of the New Ye…

A Cell Cycle‐Aware Network for Data Integration and Label Transferring of Single‐Cell RNA‐Seq and ATAC‐Seq Open

Jiajia Liu, Jian Ma, Jianguo Wen, Xiaobo Zhou · 2024

In recent years, the integration of single‐cell multi‐omics data has provided a more comprehensive understanding of cell functions and internal regulatory mechanisms from a non‐single omics perspective, but it still suffers many challenges…

Radiogenomics-Based Risk Prediction of Glioblastoma Multiforme with Clinical Relevance Open

Xiaohua Qian, Hua Tan, Xiaona Liu, Weiling Zhao, Michael D. Chan , et al. · 2024

Glioblastoma multiforme (GBM)is the most common and aggressive primary brain tumor. Although temozolomide (TMZ)-based radiochemotherapy improves overall GBM patients’ survival, it also increases the frequency of false positive post-treatme…

Multi-scale Modeling in Clinical Oncology: Opportunities and Barriers to Success Open

Thomas E. Yankeelov, Gary An, Oliver Saut, Guy M. Genin, E. Georg Luebeck , et al. · 2024

Study of prognostic splicing factors in cancer using machine learning approaches Open

Mengyuan Yang, Jiajia Liu, Pora Kim, Xiaobo Zhou · 2024

Splicing factors (SFs) are the major RNA-binding proteins (RBPs) and key molecules that regulate the splicing of mRNA molecules through binding to mRNAs. The expression of splicing factors is frequently deregulated in different cancer type…

DS-NeRV: Implicit Neural Video Representation with Decomposed Static and Dynamic Codes Open

Hao Yan, Zhihui Ke, Xiaobo Zhou, Tie Qiu, Xidong Shi , et al. · 2024

Implicit neural representations for video (NeRV) have recently become a novel way for high-quality video representation. However, existing works employ a single network to represent the entire video, which implicitly confuse static and dyn…

Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cells Open

Feng Guo, Li Zhang, Yuzhen Yu, Lu Gong, Shiyue Tao , et al. · 2024

A Cell Cycle-aware Network for Data Integration and Label Transferring of Single-cell RNA-seq and ATAC-seq Open

Jiajia Liu, Jian Ma, Jianguo Wen, Xiaobo Zhou · 2024

In recent years, the integration of single-cell multi-omics data has provided a more comprehensive understanding of cell functions and internal regulatory mechanisms from a non-single omics perspective, but it still suffers many challenges…

Roles and Mechanisms of Dopamine Receptor Signaling in Catecholamine Excess Induced Endothelial Dysfunctions Open

Zhen Yang, Yingrui Li, Mengying Huang, Xin Li, Xuehui Fan , et al. · 2024

Endothelial dysfunction may contribute to pathogenesis of Takotsubo cardiomyopathy, but mechanism underlying endothelial dysfunction in the setting of catecholamine excess has not been clarified. The study reports that D1/D5 dopamine recep…

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