Xiaocen Liu
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View article: Global, regional, and national burden of genitourinary cancers in 204 countries and territories, 1990–2021: a systematic analysis for the global burden of disease study 2021
Global, regional, and national burden of genitourinary cancers in 204 countries and territories, 1990–2021: a systematic analysis for the global burden of disease study 2021 Open
Although the results demonstrate a marginal decline in ASRs caused by genitourinary cancers, they still impose a considerable global burden and result in numerous deaths. Our study obtained and analyzed the latest epidemiological data of g…
View article: Co-construction with deathbots: a form of existentialist practice
Co-construction with deathbots: a form of existentialist practice Open
This article adopts an interdisciplinary lens integrating psychology and existentialism to examine how digital resurrection technology, epitomized by deathbots, reshapes human perceptions of death and elevates interaction between us and de…
View article: O-GlcNAcylation regulation of RIPK1-dependent apoptosis dictates sensitivity to sunitinib in renal cell carcinoma
O-GlcNAcylation regulation of RIPK1-dependent apoptosis dictates sensitivity to sunitinib in renal cell carcinoma Open
Receptor interacting protein kinase 1 (RIPK1) has emerged as a key regulatory molecule that influences the balance between cell death and cell survival. Under external stress, RIPK1 determines whether a cell undergoes RIPK-dependent apopto…
View article: The role of EMG1 in lung adenocarcinoma progression: Implications for prognosis and immune cell infiltration
The role of EMG1 in lung adenocarcinoma progression: Implications for prognosis and immune cell infiltration Open
EMG1 regulated various functions in LUAD by directly mediating Akt/mTOR/p70s6k signaling pathways activation. The results suggest that EMG1 may be a novel biomarker for assessing prognosis and immune cell infiltration in LUAD.
View article: Integrative analysis of genomic and epigenomic regulation reveals microRNA regulatory network mediated tumor heterogeneity and immune evasion in lower grade glioma
Integrative analysis of genomic and epigenomic regulation reveals microRNA regulatory network mediated tumor heterogeneity and immune evasion in lower grade glioma Open
Background Lower grade glioma (LGG) is the most frequent primary tumors of the central nervous system and has been a major healthcare burden, however, the specific molecular mechanism underlying its initiation and progression remains to be…
View article: CircPPAP2B controls metastasis of clear cell renal cell carcinoma via HNRNPC-dependent alternative splicing and targeting the miR-182-5p/CYP1B1 axis
CircPPAP2B controls metastasis of clear cell renal cell carcinoma via HNRNPC-dependent alternative splicing and targeting the miR-182-5p/CYP1B1 axis Open
Background Renal cell carcinoma (RCC) is one of the most common malignant tumor worldwide. Metastasis is a leading case of cancer-related deaths of RCC. Circular RNAs (circRNAs), a class of noncoding RNAs, have emerged as important regulat…
View article: Intravesical cascade delivery of active monoterpene coumarin for bladder cancer therapy
Intravesical cascade delivery of active monoterpene coumarin for bladder cancer therapy Open
Albumin nanocarriers encapsulate the active monoterpene coumarin UM-15 and assemble with fluorinated chitosan (FCS) to form UM-15@BSA/FCS nanoparticles.
View article: CCDC 2201427: Experimental Crystal Structure Determination
CCDC 2201427: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma
m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma Open
Background Long non-coding RNAs (lncRNAs) play important roles in the progression of glioma. Here, we examined the potential functions of a lncRNA, LINC01003, in glioma and characterized the underlying molecular mechanisms. Methods The GEI…
View article: Additional file 5 of m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma
Additional file 5 of m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma Open
Additional file 5: Table S3. The m6A sites on LINC01003 were predicted by the GEIPA2 database.
View article: Additional file 1 of m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma
Additional file 1 of m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma Open
Additional file 1: Table S1. The DEGs between NC and LINC01003 smart silencer siRNA.
View article: Additional file 2 of m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma
Additional file 2 of m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma Open
Additional file 2: Table S2. Top 20 KEGG enrichment pathways in the downregulated mRNAs.
View article: m6A RNA Methylation Regulator-Based Signature for Prognostic Prediction and its Potential Immunological Role in Uterine Corpus Endometrial Carcinoma
m6A RNA Methylation Regulator-Based Signature for Prognostic Prediction and its Potential Immunological Role in Uterine Corpus Endometrial Carcinoma Open
Background Uterine corpus endometrial carcinoma (UCEC) is the most common female pelvic malignancy worldwide. N6-methyladenosine (m 6 A) plays an important role in various cellular responses, especially in cancer progression. However, the …
View article: Activation of MAT2A-ACSL3 pathway protects cells from ferroptosis in gastric cancer
Activation of MAT2A-ACSL3 pathway protects cells from ferroptosis in gastric cancer Open
Collectively, these results established a link between methionine cycle activity and ferroptosis vulnerability in gastric cancer.
View article: YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells
YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells Open
Background Glioma is a common type of malignant brain tumor with a high mortality and relapse rate. The endosomal sorting complex required for transport (ESCRT) has been reported to be involved in tumorigenesis. However, the molecular mech…
View article: CPVL promotes glioma progression via STAT1 pathway inhibition through interactions with the BTK/p300 axis
CPVL promotes glioma progression via STAT1 pathway inhibition through interactions with the BTK/p300 axis Open
CPVL (carboxypeptidase, vitellogenic-like) is a serine carboxypeptidase that was first characterized in human macrophages. However, the function of CPVL remains unclear in a variety of tumors. The quantitative PCR (qPCR), Western blotting,…
View article: Hypoxia inducible lncRNA-CBSLR modulates ferroptosis through m6A-YTHDF2-dependent modulation of CBS in gastric cancer
Hypoxia inducible lncRNA-CBSLR modulates ferroptosis through m6A-YTHDF2-dependent modulation of CBS in gastric cancer Open
Our study reveals a novel mechanism in how HIF1α/CBSLR modulates ferroptosis/chemoresistance in GC, illuminating potential therapeutic targets for refractory hypoxic tumors.
View article: Additional file 7 of YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells
Additional file 7 of YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells Open
Additional file 7: Table S1. The mRNAs expression between NC and siVPS25.
View article: Additional file 8 of YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells
Additional file 8 of YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells Open
Additional file 8: Table S2. Top KEGG enrichment for the down-expressed mRNAs.
View article: PhotoactivatedH2 Nanogenerator for EnhancedChemotherapy of Bladder Cancer
PhotoactivatedH2 Nanogenerator for EnhancedChemotherapy of Bladder Cancer Open
Hydrogen
gas can mitigate oxidative stress in many diseases and
is regarded to be safe and free of side effects. Inspired by a metalloenzyme
in a variety of microorganisms, here, we propose a photoactivated
H2 nanogenerator that comprises …
View article: Identification of hub genes related to prognosis in glioma
Identification of hub genes related to prognosis in glioma Open
Glioma, a common malignant tumor of the central nervous system, has high invasiveness. The objective of the present study was to identify genes playing an important role in the development of glioma and to reveal their potential research v…