Xinyu Han
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View article: N6-methyladenosine modification regulates cell death in cognitive impairment
N6-methyladenosine modification regulates cell death in cognitive impairment Open
Neurodegenerative diseases are characterized by a decline in brain structure and function. Their pathology involves multiple cell death pathways, including ferroptosis, cuproptosis, and pyroptosis. These pathways are intricately linked to …
View article: Analysis of human brain RNA-seq data reveals combined effects of 4 types of RNA modifications and 18 types of programmed cell death on Alzheimer’s disease
Analysis of human brain RNA-seq data reveals combined effects of 4 types of RNA modifications and 18 types of programmed cell death on Alzheimer’s disease Open
This study uncovered that RNA modification-related PCD is of significance for AD progression and early prediction, providing insights from a new perspective for the study of disease mechanisms in AD.
View article: Contents of flavonoid compounds in Dendrobium officinale Kimura et Migo determined by QuEChERS-HPLC-MS/MS: Method validation and influencing factors
Contents of flavonoid compounds in Dendrobium officinale Kimura et Migo determined by QuEChERS-HPLC-MS/MS: Method validation and influencing factors Open
Dendrobium officinale Kimura et Migo (D. officinale), a dual-use plant with both botanical medicine and food applications, has gained global popularity. Flavonoids are important bioactive compounds of D. officinale; nevertheless, the quant…
View article: Ultra-small lipid carriers with adjustable release profiles for synergistic treatment of drug-resistant ovarian cancer
Ultra-small lipid carriers with adjustable release profiles for synergistic treatment of drug-resistant ovarian cancer Open
Multidrug resistance has dramatically compromised the effectiveness of paclitaxel (PTX). The combined application of PTX and tetrandrine (TET) is a promising avenue in drug-resistant cancer therapy. However, poor drug release and limited i…
View article: DPPC-coated lipid nanoparticles as an inhalable carrier for accumulation of resveratrol in the pulmonary vasculature, a new strategy for pulmonary arterial hypertension treatment
DPPC-coated lipid nanoparticles as an inhalable carrier for accumulation of resveratrol in the pulmonary vasculature, a new strategy for pulmonary arterial hypertension treatment Open
In this study, we investigated the feasibility of dipalmitoylphosphatidylcholine-coated lipid nanoparticles (DPPC-LNs) as a carrier for preferential accumulation into lungs of Resveratrol (Res), a potentially promising drug for the treatme…