Xiaochen Hu
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View article: Homocysteine and risk of interstitial lung disease: A mendelian randomization approach to causal inference.
Homocysteine and risk of interstitial lung disease: A mendelian randomization approach to causal inference. Open
The levels of total plasma Hcy may bear a significant association with the risk of developing IPF, a specific form of ILD. However, to definitively establish a causal relationship between elevated Hcy levels and the pathogenesis of ILD, ad…
View article: Association between hippocampal subfield volume estimated from ultra‐high field scans and cognitive and clinical symptoms in patients with late‐life depression and healthy controls
Association between hippocampal subfield volume estimated from ultra‐high field scans and cognitive and clinical symptoms in patients with late‐life depression and healthy controls Open
Background Late‐life depression (LLD) is a risk factor for Alzheimer's disease (AD) dementia. Previous morphological studies have often associated LLD with atrophy within the medial temporal lobe (MTL), including the hippocampus. A number …
View article: Amyloid and SCD jointly predict cognitive decline across Chinese and German cohorts
Amyloid and SCD jointly predict cognitive decline across Chinese and German cohorts Open
INTRODUCTION Subjective cognitive decline (SCD) in amyloid‐positive (Aβ+) individuals was proposed as a clinical indicator of Stage 2 in the Alzheimer's disease (AD) continuum, but this requires further validation across cultures, measures…
View article: Brain Topological Changes in Subjective Cognitive Decline and Associations with Amyloid Stages
Brain Topological Changes in Subjective Cognitive Decline and Associations with Amyloid Stages Open
Background Amyloid spreads throughout the cortex in Alzheimer's disease (AD), which is thought to cause disturbances in brain networks. It is not clear how structural and functional connectivity change as amyloid accumulates progressively …
View article: Prediction of depressive symptoms at high age (80+) by psychological, biological and functional factors
Prediction of depressive symptoms at high age (80+) by psychological, biological and functional factors Open
Psychological factors such as autonomy and contentment are critical for the occurrence of depressive symptoms at higher age, independent of the functional and somatic status and may serve as specific targets for psychotherapy.
View article: Baseline differences of cognition and psychiatric symptoms according to plasma amyloid‐status in the SILCODE study
Baseline differences of cognition and psychiatric symptoms according to plasma amyloid‐status in the SILCODE study Open
Background Subjective cognitive decline (SCD) is supposed to appear early in the course of Alzheimer’s Disease (AD). Although subtle cognitive deficits and psychiatric symptoms have been described in SCD, their association with amyloid pat…
View article: Altered limbic functional connectivity in individuals with subjective cognitive decline: Converging and diverging findings across Chinese and German cohorts
Altered limbic functional connectivity in individuals with subjective cognitive decline: Converging and diverging findings across Chinese and German cohorts Open
INTRODUCTION It remains unclear whether functional brain networks are consistently altered in individuals with subjective cognitive decline (SCD) of diverse ethnic and cultural backgrounds and whether the network alterations are associated…
View article: Altered attentive bias towards interpersonal communication information across phases of schizophrenia: an eye-tracking study
Altered attentive bias towards interpersonal communication information across phases of schizophrenia: an eye-tracking study Open
Background Eye movement abnormality in schizophrenia has been studied for several decades. However, patient differences in eye movements across phases of schizophrenia from eye-tracking studies have not been well documented. Aims This pilo…
View article: Alterations in metamemory capacity and neural correlates in a subtype of subjective cognitive decline
Alterations in metamemory capacity and neural correlates in a subtype of subjective cognitive decline Open
SCD S+P- showed the worst episodic memory performance, altered metamemory capacity (overconfidence and less accuracy of judgment), and altered neuroimaging measures, though they had feelings of similar performance with peers. Our results i…
View article: InvGAN: Invertible GANs
InvGAN: Invertible GANs Open
View article: Decreased cortical thickness in individuals with subjective cognitive decline with and without CSF‐AD‐pathology: Data from the DELCODE Study
Decreased cortical thickness in individuals with subjective cognitive decline with and without CSF‐AD‐pathology: Data from the DELCODE Study Open
Background Subjective cognitive decline (SCD) without objective performance deficits reflects in some individuals the earliest symptomatic manifestation of Alzheimer’s Disease (AD) at the late preclinical stage 1,2 . It is crucial to delin…
View article: Differential Atrophy in the Hippocampal Subfield Volumes in Four Types of Mild Dementia
Differential Atrophy in the Hippocampal Subfield Volumes in Four Types of Mild Dementia Open
Differential atrophy patterns in the bilateral hippocampal subfield volumes could serve the differential diagnosis in patients with different causes of mild dementia: left CA1 for tAD; left presubiculum for LSD; right CA4/DG, right presubi…
View article: Sino Longitudinal Study on Cognitive Decline (SILCODE): protocol for a Chinese longitudinal observational study to develop risk prediction models of conversion to mild cognitive impairment in individuals with subjective cognitive decline
Sino Longitudinal Study on Cognitive Decline (SILCODE): protocol for a Chinese longitudinal observational study to develop risk prediction models of conversion to mild cognitive impairment in individuals with subjective cognitive decline Open
Introduction Understanding the biological mechanism of subjective cognitive decline (SCD) in preclinical Alzheimer’s disease (AD) and identifying those who will soon convert to mild cognitive impairment (MCI) are critical for developing ap…
View article: IC‐P‐122: ALTERATIONS OF INTRINSIC CONNECTIVITY IN POSTERIOR DEFAULT MODE NETWORK ACROSS AT RISK STAGES OF ALZHEIMER'S DEMENTIA
IC‐P‐122: ALTERATIONS OF INTRINSIC CONNECTIVITY IN POSTERIOR DEFAULT MODE NETWORK ACROSS AT RISK STAGES OF ALZHEIMER'S DEMENTIA Open
Altered intrinsic connectivity within the default mode network (DMN) has been frequently observed in patients with Alzheimer's disease (AD) as well as in its at risk stages such as mild cognitive impairment (MCI) and subjective cognitive d…
View article: P1‐407: RELATIONSHIP BETWEEN GLOBAL CONNECTIVITY, AMYLOID AND TAU IN DIFFERENT STAGES DURING THE DEVELOPMENT OF ALZHEIMER'S DISEASE AS DEMONSTRATED IN THE DZNE DELCODE COHORT
P1‐407: RELATIONSHIP BETWEEN GLOBAL CONNECTIVITY, AMYLOID AND TAU IN DIFFERENT STAGES DURING THE DEVELOPMENT OF ALZHEIMER'S DISEASE AS DEMONSTRATED IN THE DZNE DELCODE COHORT Open
Recent multicenter studies provide rich insights in restingstate alterations, while different scanning protocols between sites sometimes lower interpretability (Teipel et al., 2017a, 2017b). Global brain connectivity (GBC) is a local resti…
View article: Prediction of Conversion From Amnestic Mild Cognitive Impairment to Alzheimer's Disease Based on the Brain Structural Connectome
Prediction of Conversion From Amnestic Mild Cognitive Impairment to Alzheimer's Disease Based on the Brain Structural Connectome Open
Background: Early prediction of disease progression in patients with amnestic mild cognitive impairment (aMCI) is important for early diagnosis and intervention of Alzheimer's disease (AD). Previous brain network studies have sugges…
View article: Gradual Disturbances of the Amplitude of Low-Frequency Fluctuations (ALFF) and Fractional ALFF in Alzheimer Spectrum
Gradual Disturbances of the Amplitude of Low-Frequency Fluctuations (ALFF) and Fractional ALFF in Alzheimer Spectrum Open
Background: Alzheimer's disease (AD) is a common neurodegenerative disease in which the brain undergoes alterations for decades before symptoms become obvious. Subjective cognitive decline (SCD) have self-complain of persistent decl…
View article: Smaller medial temporal lobe volumes in individuals with subjective cognitive decline and biomarker evidence of Alzheimer's disease—Data from three memory clinic studies
Smaller medial temporal lobe volumes in individuals with subjective cognitive decline and biomarker evidence of Alzheimer's disease—Data from three memory clinic studies Open
Introduction Previous studies showed associations of brain volume differences and biomarker evidence for Alzheimer's disease (AD) in subjective cognitive decline (SCD). The consistency of this finding across SCD studies has not been invest…
View article: [IC‐P‐139]: THE PHENOMENOLOGY AND THE NEURONAL CORRELATES OF EPISODIC FUTURE IMAGINATION IN PERSONS WITH SUBJECTIVE COGNITIVE DECLINE AND HEALTHY CONTROLS
[IC‐P‐139]: THE PHENOMENOLOGY AND THE NEURONAL CORRELATES OF EPISODIC FUTURE IMAGINATION IN PERSONS WITH SUBJECTIVE COGNITIVE DECLINE AND HEALTHY CONTROLS Open
Subjective cognitive decline (SCD) refers to the self-experienced worsening of the cognitive capacity in elderlies, who still perform within normal range on standardized neuropsychological tests. Episodic memory system is important for bot…
View article: A Reduction in Delay Discounting by Using Episodic Future Imagination and the Association with Episodic Memory Capacity
A Reduction in Delay Discounting by Using Episodic Future Imagination and the Association with Episodic Memory Capacity Open
Delay discounting (DD) refers to the phenomenon that individuals discount future consequences. Previous studies showed that future imagination reduces DD, which was mediated by functional connectivity between medial prefrontal valuation ar…
View article: Reduced future‐oriented decision making in individuals with subjective cognitive decline: A functional MRI study
Reduced future‐oriented decision making in individuals with subjective cognitive decline: A functional MRI study Open
Introduction Subjective cognitive decline (SCD) refers to an at‐risk state of Alzheimer's disease and subtle cognitive deficits that have been observed in this condition. Currently, it is unknown whether complex cognitive processes relevan…
View article: IC‐P‐046: Abnormal Functional Connectivity Within Default Mode Network in Persons With Subjective Cognitive Decline: Self‐Reflection of Own Memory Deficits?
IC‐P‐046: Abnormal Functional Connectivity Within Default Mode Network in Persons With Subjective Cognitive Decline: Self‐Reflection of Own Memory Deficits? Open
Subjective cognitive decline (SCD) refers to the self-experienced worsening of the cognitive capacity in elderlies, who still perform within normal range on standardized neuropsychological tests (Jessen et al., 2014). Abnormal functional c…
View article: Abnormal Resting-State Functional Connectivity Strength in Mild Cognitive Impairment and Its Conversion to Alzheimer’s Disease
Abnormal Resting-State Functional Connectivity Strength in Mild Cognitive Impairment and Its Conversion to Alzheimer’s Disease Open
Individuals diagnosed with mild cognitive impairment (MCI) are at high risk of transition to Alzheimer’s disease (AD). However, little is known about functional characteristics of the conversion from MCI to AD. Resting-state functional mag…