Explanipedia

Corrigendum to “Electrodeposition of p-type Cu2O on n-type TiO2 nanosheet arrays for enhanced photoelectrochemical water splitting” [Electrochem. Commun. 178 (2025) 108009] Open

Lin Wang, Hai Yu, Yian Wang, Chun Miao, Lei Qian , et al. · 2025

FBLN2 promoter hypermethylation: a negative prognostic biomarker and anti-PD-1 response predictor in clear cell renal cell carcinoma via high-throughput CpG Island screening Open

Wenfeng Liao, Lianzi Yu, Lufang Zhang, Jie Shao, Guanhua Li , et al. · 2025

Electrodeposition of p-type Cu2O on n-type TiO2 nanosheet arrays for enhanced photoelectrochemical water splitting Open

Lin Wang, Hai Yu, Yian Wang, Miao Chun, Lei Qian , et al. · 2025

This study synthesized p-type Cu2O using an electrodeposition method and firmly attached it to TiO2 nanosheets based on fluorine-doped tin oxide (FTO) substrates, forming a dense film that serves directly as a photoanode for photoelectroch…

The management of type 2 inflammatory respiratory diseases: a Chinese expert consensus [2024] Open

Nan Jia, Meiling Jin, Yun Liu, Nan Su, Ying Sun , et al. · 2025

This consensus outlines the pathogenesis, assessment of T2 inflammation, biological therapies targeted at T2 inflammation, and management strategies for T2 inflammatory respiratory diseases and their comorbidities. It will serve as a valua…

Proteogenomic Analysis Identifies Clinically Relevant Subgroups of Collecting Duct Carcinoma Open

Yuanyuan Qu, Xiaoru Pei, Jinwen Feng, Xin Yan, Linhui Zhang , et al. · 2025

Collecting duct carcinoma (CDC) is a rare but aggressive form of renal cell carcinoma (RCC) that has limited understanding and an undefined systemic therapeutic regimen. Herein, we conducted a comprehensive proteogenomic analysis of CDC tu…

FBLN2 Promoter Hypermethylation: A Negative Prognostic Biomarker and Anti-Pd-1 Response Predictor in Clear Cell Renal Cell Carcinoma Via High-Throughput Cpg Island Screening Open

Wenfeng Liao, Lianzi Yu, Lufang Zhang, Jie Shao, Guanhua Li , et al. · 2025

Electrodeposition of P-Type Cu2o on N-Type Tio2 Nanosheet Arrays for Enhanced Photoelectrochemical Water Splitting Open

Hai Yu, Lin Wang, Yian Wang, Chun Miao, Lei Qian , et al. · 2025

The Dual Role of Cellular Senescence in Macrophages: Unveiling the Hidden Driver of Age-Related Inflammation in Kidney Disease Open

Yibing Wang, Tong Li, Fengyu Wang, Xin Yao, Qianrong Bai , et al. · 2024

Aging is a complex biological process that involves the gradual decline of cellular, tissue, and organ functions. In kidney, aging manifests as tubular atrophy, glomerulosclerosis, and progressive renal function decline. The critical role …

TLE1 corepressor promotes gefitinib resistance in lung cancer A549 cells via E‑cadherin silencing Open

Xin Yao, Nasir Roberts, Prince Iheukwumere, Alana Carmouche, Renwei Chen , et al. · 2024

As a putative lung specific oncogene, the transducin-like enhancer of split 1 (TLE1) corepressor drives an anti-apoptotic and pro-epithelial-mesenchymal transition (EMT) gene transcriptional programs in human lung adenocarcinoma (LUAD) cel…

Epigenetic modifications and emerging therapeutic targets in cardiovascular aging and diseases Open

Y. Qiu, Qing Xu, Peng Xie, Chao He, Qiuchan Li , et al. · 2024

The complex mechanisms underlying the development of cardiovascular diseases remain not fully elucidated. Epigenetics, which modulates gene expression without DNA sequence changes, is shedding light on these mechanisms and their heritable …

CACA guidelines for holistic integrative management of urothelial carcinoma Open

Xusheng Chen, Wasilijiang Wahafu, Yijun Shen, Jinhai Fan, Xin Yao · 2024

Bladder urothelial carcinoma (UC) is the most common malignant tumor of the urinary system. It has the characteristics of high recurrence rate and poor prognosis. It is a malignant disease that threatens the safety of human life. The incid…

A mechanistic insight into severe COPD: the nose as a surrogate for the airways Open

Xin Yao, Ian M. Adcock, Sharon Mumby · 2023

A severe COPD signature in bronchial and nasal epithelial cells reflects reduced tissue repair and ECM regulation https://bit.ly/476S3PJ.

659MO Preliminary results from a phase I/II study of 9MW2821, an antibody-drug conjugate targeting nectin-4, in patients with advanced solid tumors Open

Jian Zhang, Runhan Liu, Sujun Gao, X. Li, Jie Chen , et al. · 2023

<span>DEL</span>‐1, as an anti‐neutrophil transepithelial migration molecule, inhibits airway neutrophilic inflammation in asthma Open

Man Jia, Heng Fu, Xinyu Jiang, Lina Wang, Jiayan Xu , et al. · 2023

Background Neutrophil migration into the airways is a key process in neutrophilic asthma. Developmental endothelial locus‐1 (DEL‐1), an extracellular matrix protein, is a neutrophil adhesion inhibitor that attenuates neutrophilic inflammat…

Circumferential Pulmonary Vein Isolation With vs Without Additional Low-Voltage-Area Ablation in Older Patients With Paroxysmal Atrial Fibrillation Open

Hongwu Chen, Chengzong Li, Bing Han, Fangyi Xiao, Fu Yi , et al. · 2023

Importance The overall success rate of circumferential pulmonary vein isolation (CPVI) treatment in patients with paroxysmal atrial fibrillation (AF) remains suboptimal, especially in older patients. Objective To explore the incremental be…

Use of PARP inhibitors in prostate cancer: from specific to broader application Open

Zhenting Zhang, Lei Diao, Chao Zhang, Fangfang Wang, Xin Guan , et al. · 2023

Prostate cancer (PC) is one of the major health issues of elderly men in the word. It is showed that there were approximately 1.414 million patients with PC in 2020 worldwide, with a high mortality rate in metastatic cases. In the present …

A Diagnostic Classifier Based on Circulating miRNA Pairs for COPD Using a Machine Learning Approach Open

Shurui Xuan, Jiayue Zhang, Qinxing Guo, Liang Zhao, Xin Yao · 2023

Chronic obstructive pulmonary disease (COPD) is highly underdiagnosed, and early detection is urgent to prevent advanced progression. Circulating microRNAs (miRNAs) have been diagnostic candidates for multiple diseases. However, their diag…

Anticancer activity of Zinc-Sodium alginate-Polyethylene glycol- Brucine nanocomposite in gallbladder cancer NOZ cells via modulation of apoptosis and P13K/mTOR pathway Open

Xin Yao, Ling-Di Li, Wei Lu, Xin Yin, Leitao Cao · 2023

Background: Gallbladder cancer (GBC) is the sixth most predominant gastrointestinal tumor worldwide. Malignant tumors with distinctive biological characteristics, like the human GBC, are incredibly aggressive and challenging to diagnose an…

Assessment of the expression pattern of HER2 and its correlation with HER2-targeting antibody-drug conjugate therapy in urothelial cancer Open

Huizi Lei, Yun Ling, Yuan Pei, Xieqiao Yan, Lin Wang , et al. · 2023

L-carnitine reduces acute lung injury via mitochondria modulation and inflammation control in pulmonary macrophages Open

Dandan Wu, Haiyan He, Jinliang Chen, Sumei Yao, Haiqin Xie , et al. · 2023

Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is a critical respiratory syndrome with limited effective interventions. Lung macrophages play a critical role in the pathogenesis of abnormal inflammatory response in t…

Langerin-expressing dendritic cells in pulmonary immune-related diseases Open

Shurui Xuan, Yuebei Li, Yunhui Wu, Ian M. Adcock, Xiaoning Zeng , et al. · 2022

Dendritic cells (DCs) are “frontline” immune cells dedicated to antigen presentation. They serve as an important bridge connecting innate and adaptive immunity, and express various receptors for antigen capture. DCs are divided into variou…

Phase 1 study of C-CAR088, a novel humanized anti-BCMA CAR T-cell therapy in relapsed/refractory multiple myeloma Open

Xiaoyan Qu, Gang An, Weiwei Sui, Tingyu Wang, Xian Zhang , et al. · 2022

Background Anti-B-cell maturation antigen (BCMA) chimeric antigen receptor T-cell (CAR T) therapy showed remarkable efficacy in patients with relapsed or refractory multiple myeloma (RRMM). This phase 1 dose-escalation and expansion study …

A Pancancer Study of PIEZO1 as a Prognosis and Immune Biomarker of Human Tumors Open

Yunhui Wu, Jingying Zhang, Can Hou, Hongyu Wang, Min Zhu , et al. · 2022

PIEZO1, a mechanosensitive ion channel protein, has been identified in the correlation between several cancers. However, the systematic pancancer study of PIEZO1 still lacks. We examined PIEZO1 across thirty-three types of cancers to explo…

Structural reconstruction and anisotropic conductance in 4f-ferromagnetic monolayer Open

Huilin You, Jie Chen, J.-J. Zhang, Nan Ding, Xiaoping Zhang , et al. · 2022

LncRNA expression in idiopathic achalasia: New insight and preliminary exploration into pathogenesis Open

Chao Lu, Furong Wei, Xinjue He, Xin Yao, Chaohui Yu · 2022

Idiopathic achalasia is a primary esophageal motility disorder characterized by the absence of esophageal peristalsis and impaired relaxation of the lower esophageal sphincter (LES). However, the pathogenesis of idiopathic achalasia remain…

Clinical significance of serum IgM and IgG levels in COVID-19 patients in Hubei Province, China Open

Zhenjiang Bai, Qing Li, Qinghui Chen, Changming Niu, Yu Wei , et al. · 2021

Identifying a Six-Gene Signature Predicting Response to TACE in Hepatocellular Carcinoma by Bioinformatics Analysis Open

Xin Yao, Xin Yin, Wei Lu, Leitao Cao · 2021

Background and Aim. With regard to patients with intermediate-stage, irresectable hepatocellular carcinoma (HCC), transcatheter arterial chemoembolization (TACE) is the mainstay of treatment. There is an urgent clinical requirement to iden…

Mechanisms and biomarkers of airway epithelial cell damage in asthma: A review Open

Yuemei Yang, Man Jia, Yingwei Ou, Ian M. Adcock, Xin Yao · 2021

Bronchial asthma is a heterogeneous disease with complex pathological mechanisms representing different phenotypes, including severe asthma. The airway epithelium is a major site of complex pathological changes in severe asthma due, in par…

A novel diagnostic signature based on three circulating exosomal mircoRNAs for chronic obstructive pulmonary disease Open

Yahui Shen, Lina Wang, Yunhui Wu, Yingwei Ou, Huiyu Lu , et al. · 2021

Exosomal microRNAs (exo-miRNAs or miRs) have demonstrated diagnostic value in various diseases. However, their diagnostic value in chronic obstructive pulmonary disease (COPD) has yet to be fully established. The purpose of the present stu…

Myeloid Cell–associated Resistance to PD-1/PD-L1 Blockade in Urothelial Cancer Revealed Through Bulk and Single-cell RNA Sequencing Open

Li Wang, John P. Sfakianos, Kristin G. Beaumont, Güray Aktürk, Amir Horowitz , et al. · 2021

Purpose: To define dominant molecular and cellular features associated with PD-1/PD-L1 blockade resistance in metastatic urothelial cancer. Experimental Design: We pursued an unbiased approach using bulk RNA sequencing data from two clinic…

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