Xiaochen Zhou
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View article: Sotorasib inhibits ubiquitination degradation of TXNIP and suppresses glucose metabolism in KRASG12C mutant bladder cancer
Sotorasib inhibits ubiquitination degradation of TXNIP and suppresses glucose metabolism in KRASG12C mutant bladder cancer Open
Bladder cancer is the most common malignant tumor of the urinary system. Currently, treatment strategies for bladder cancer remain limited, highlighting the urgent need to explore novel therapeutic approaches. Sotorasib, the first successf…
View article: Targeted therapies in bladder cancer: signaling pathways, applications, and challenges
Targeted therapies in bladder cancer: signaling pathways, applications, and challenges Open
Bladder cancer (BC) is one of the most prevalent malignancies in men. Understanding molecular characteristics via studying signaling pathways has made tremendous breakthroughs in BC therapies. Thus, targeted therapies including immune chec…
View article: Flexible ureteroscopy with novel flexible ureteral access sheath versus mini‐percutaneous nephrolithotomy for treatment of 2–3 cm renal stones
Flexible ureteroscopy with novel flexible ureteral access sheath versus mini‐percutaneous nephrolithotomy for treatment of 2–3 cm renal stones Open
Objectives To assess and compare the effectiveness and safety of flexible ureteroscopy (f‐URS) with a novel flexible ureteral access sheath (f‐UAS) versus mini‐percutaneous nephrolithotripsy (mini‐PCNL) in treating 2–3 cm renal stones. Met…
View article: Preliminary experience of transurethral endoscopic laser lithotripsy for bladder calculi under local anesthesia in ambulatory surgery mode
Preliminary experience of transurethral endoscopic laser lithotripsy for bladder calculi under local anesthesia in ambulatory surgery mode Open
Objective: To explore the efficacy and safety of transurethral endoscopic laser lithotripsy for bladder calculi under local anesthesia in ambulatory surgery mode and share preliminary experience. Methods: A retrospective study was conducte…
View article: Optimal placement of flexible ureteral access sheath in retrograde intrarenal surgery
Optimal placement of flexible ureteral access sheath in retrograde intrarenal surgery Open
This study aims to explore the optimal location of flexible ureteral access sheath (f-UAS) in retrograde intrarenal lithotripsy (RIRS). RIRS model was built by AutoCAD 2011 software, and imported COMSOL 5.6 software to computer simulation.…
View article: [Corrigendum] Celecoxib inhibits the epithelial‑to‑mesenchymal transition in bladder cancer via the miRNA‑145/TGFBR2/Smad3 axis
[Corrigendum] Celecoxib inhibits the epithelial‑to‑mesenchymal transition in bladder cancer via the miRNA‑145/TGFBR2/Smad3 axis Open
Following the publication of the above article, an interested reader drew to the authors' attention that, for the Transwell migration assays shown in Figs. 1B and 3B on p. 685 and p. 688 respectively, the images selected for the '5637 / DM…
View article: Initial experience and short-term outcomes of single-port extraperitoneal transvesical robot-assisted radical prostatectomy: a two-center study
Initial experience and short-term outcomes of single-port extraperitoneal transvesical robot-assisted radical prostatectomy: a two-center study Open
SETvRARP using the da Vinci Xi system coupling with a 4-channel single port is a valid radical prostatectomy technique in well-selected PCa patients, resulting in superior postoperative recovery of urinary continence. Meanwhile, the outcom…
View article: Synergistic augmentation of osimertinib‐induced autophagic death by proguanil or rapamycin in bladder cancer
Synergistic augmentation of osimertinib‐induced autophagic death by proguanil or rapamycin in bladder cancer Open
Dear Editor, According to the latest global regional cancer data statistics, bladder cancer (BC) is the fourth most common cancer in men, and its mortality is also among the top 10 of all cancers.1 At present, the major treatment for BC is…
View article: Robotic-assisted laparoscopic adrenalectomy (RARLA): What advantages and disadvantages compared to retroperitoneal laparoscopic adrenalectomy (RLA)?
Robotic-assisted laparoscopic adrenalectomy (RARLA): What advantages and disadvantages compared to retroperitoneal laparoscopic adrenalectomy (RLA)? Open
Objective To explore the advantages and disadvantages of robot-assisted laparoscopic adrenalectomy compared with retroperitoneal laparoscopic adrenalectomy. Methods A total of 101 patients with adrenal tumors who received retroperitoneal l…
View article: Assessment of oligometastasis status of prostate cancer following combined robot-assisted radical prostatectomy and androgen deprivation versus androgen deprivation therapy alone using PSA percentage decline rate
Assessment of oligometastasis status of prostate cancer following combined robot-assisted radical prostatectomy and androgen deprivation versus androgen deprivation therapy alone using PSA percentage decline rate Open
Objective To compare the tumor control in prostate cancer patients with oligo-metastasis following combined robot-assisted radical prostatectomy and androgen deprivation versus androgen deprivation therapy alone based on total prostate-spe…
View article: For small (1-3cm) nonfunctional adrenal incidentaloma (NFAI), which option is more appropriate for conservative treatment or surgery?
For small (1-3cm) nonfunctional adrenal incidentaloma (NFAI), which option is more appropriate for conservative treatment or surgery? Open
Objective To compare the efficacy and safety between conservative treatment and surgery for the patients with small (1-3cm) nonfunctional adrenal incidentaloma (NFAI). Methods The patients with small (1-3cm) NFAI who received conservative …
View article: Effect of the biosynthesis of the volatile compound phenylacetaldehyde on chloroplast modifications in tea (<i>Camellia sinensis</i>) plants
Effect of the biosynthesis of the volatile compound phenylacetaldehyde on chloroplast modifications in tea (<i>Camellia sinensis</i>) plants Open
Plant volatile compounds have important physiological and ecological functions. Phenylacetaldehyde (PAld), a volatile phenylpropanoid/benzenoid, accumulates in the leaves of tea (Camellia sinensis) plants grown under continuous shading. Th…
View article: Additional file 1 of Novel cuproptosis-related long non-coding RNA signature to predict prognosis in prostate carcinoma
Additional file 1 of Novel cuproptosis-related long non-coding RNA signature to predict prognosis in prostate carcinoma Open
Additional file 1: Supplementary Table S1. Cuproptosis-related gene from previous literatures. Supplementary Table S2. The metagenes list of pan-cancer immune. Supplementary Table S3. The primer sequences of β-actin, AC005790.1, AC011472.4…
View article: Retroperitoneal laparoscopic partial adrenalectomy (RLPA) for 20-40 mm nonfunctional adrenal tumors in the day surgery mode
Retroperitoneal laparoscopic partial adrenalectomy (RLPA) for 20-40 mm nonfunctional adrenal tumors in the day surgery mode Open
Objectives To investigate the outcome and safety of retroperitoneal laparoscopic partial adrenalectomy in the treatment of nonfunctional unilateral adrenal tumors in the day surgery mode. Methods Nineteen patients bearing nonfunctional uni…
View article: The ADRENAL score: A comprehensive scoring system for standardized evaluation of adrenal tumor
The ADRENAL score: A comprehensive scoring system for standardized evaluation of adrenal tumor Open
Objectives To propose an original and standardized scoring system to quantify the functional and anatomical characteristics of adrenal tumor. Materials and methods Four groups of consecutive adrenalectomies (n = 458) with heterogeneity in …
View article: MAPK8IP2 is a potential prognostic biomarker and promote tumor progression in prostate cancer
MAPK8IP2 is a potential prognostic biomarker and promote tumor progression in prostate cancer Open
Background MAPK8IP2 is one of the JNK-interacting proteins (JIPs) family members, and is involved in the regulation of the JNK and P38 MAPK signaling pathways. MAPK8IP2 has been reported to be closely associated with several cancers. Howev…
View article: Characterization of Key Odorants in Lingtou Dancong Oolong Tea and Their Differences Induced by Environmental Conditions from Different Altitudes
Characterization of Key Odorants in Lingtou Dancong Oolong Tea and Their Differences Induced by Environmental Conditions from Different Altitudes Open
Lingtou Dancong oolong tea is a famous Chinese oolong tea due to its special honey-like aroma. However, little is known about its specific aroma profile and key contributors. Furthermore, whether the aroma characteristics of Lingtou Dancon…
View article: Performing percutaneous nephrolithotomy under modified local anesthesia
Performing percutaneous nephrolithotomy under modified local anesthesia Open
Objective This pilot study aimed to assess the practicability and effectiveness of percutaneous nephrolithotomy (PCNL) with vacuum-assisted nephrostomy sheaths for patients under modified local anesthesia (m-LA). Methods PCNL with a vacuum…
View article: Novel amino acid metabolism‐related gene signature to predict prognosis in clear cell renal cell carcinoma
Novel amino acid metabolism‐related gene signature to predict prognosis in clear cell renal cell carcinoma Open
Background: Amino acid metabolism (AAM) deregulation, an emerging metabolic hallmark of malignancy, plays an essential role in tumour proliferation, invasion, and metastasis. However, the expression of AAM-related genes and their correlati…
View article: The survival benefit of different lymph node yields in radical prostatectomy for pN1M0 prostate cancer patients: Implications from a population-based study
The survival benefit of different lymph node yields in radical prostatectomy for pN1M0 prostate cancer patients: Implications from a population-based study Open
Background and objectives The extent and survival benefits of lymph node dissection (LND) in radical prostatectomy (RP) for pN1M0 prostate cancer (PCa) patients remained unclear and were controversial. This study aimed to determine the sur…
View article: Comprehensive analysis of the expression and prognosis of YPEL family members in clear cell renal cell cancer
Comprehensive analysis of the expression and prognosis of YPEL family members in clear cell renal cell cancer Open
The Yippee‑like (YPEL) gene family is composed of five members encoding a protein containing a zinc finger‑like metal‑binding domain. Due to its structure and location in cells, this domain is considered to be involved in cell multiplicati…
View article: Integrated Analysis of Microarray Studies to Identify Novel Diagnostic Markers in Bladder Pain Syndrome/Interstitial Cystitis with Hunner Lesion
Integrated Analysis of Microarray Studies to Identify Novel Diagnostic Markers in Bladder Pain Syndrome/Interstitial Cystitis with Hunner Lesion Open
Xiao-Feng Cheng,* Zhen-Hao Zeng,* Wen Deng, Yi-Fu Liu, Xiao-Chen Zhou, Cheng Zhang, Gong-Xian Wang Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang City, People’s Republic of China*These authors contrib…
View article: Involvement of histone deacetylase CsHDA2 in regulating (<i>E</i>)-nerolidol formation in tea (<i>Camellia sinensis</i>) exposed to tea green leafhopper infestation
Involvement of histone deacetylase CsHDA2 in regulating (<i>E</i>)-nerolidol formation in tea (<i>Camellia sinensis</i>) exposed to tea green leafhopper infestation Open
Herbivore-induced plant volatiles (HIPVs) help the tea plant (Camellia sinensis) adapt to environmental stress, and they are also quality-related components of tea. However, the upstream mechanism regulating the herbivore-induced expressio…
View article: Identification of the Risk Factors for the Failure of Ureteral Access Sheath Placement
Identification of the Risk Factors for the Failure of Ureteral Access Sheath Placement Open
Purpose . Insertion of a ureteral access sheath (UAS) may fail in some patients in retrograde intrarenal surgery (RIRS), and this study aimed to seek preoperative risk factors for the failure of 12/14F UAS placement. Methods . We retrospec…
View article: CT‐Based Predictor for the Success of 12/14‐Fr Ureteral Access Sheath Placement
CT‐Based Predictor for the Success of 12/14‐Fr Ureteral Access Sheath Placement Open
Purpose . Ureteral access sheaths (UAS) are widely used in retrograde intrarenal surgery (RIRS), and this study aimed to develop a model for predicting the success of UAS placement based on computed tomography. Methods . We analyzed the cl…
View article: Additional file 6 of MAPK8IP2 is a potential prognostic biomarker and promote tumor progression in prostate cancer
Additional file 6 of MAPK8IP2 is a potential prognostic biomarker and promote tumor progression in prostate cancer Open
Additional file 6 Table S1. Browse interactions in tabular form.
View article: Additional file 7 of MAPK8IP2 is a potential prognostic biomarker and promote tumor progression in prostate cancer
Additional file 7 of MAPK8IP2 is a potential prognostic biomarker and promote tumor progression in prostate cancer Open
Additional file 7 Table S2. Gene Ontology term enrichment analysis of the MAPK8IP2 gene and its partner genes.