Xiaochuan Huo
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View article: Predictors of futile recanalisation in patients with large infarct: a post-hoc analysis of the ANGEL-ASPECT trial
Predictors of futile recanalisation in patients with large infarct: a post-hoc analysis of the ANGEL-ASPECT trial Open
Background Studies on futile recanalisation after endovascular therapy (EVT) for anterior circulation large vessel occlusion with large infarct were scarce. The present study aimed to explore the incidence and independent predictors of fut…
View article: Selection by Noncontrast Computed Tomography With or Without Computed Tomography Angiography Versus Computed Tomography Perfusion for Endovascular Therapy in Patients With Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis
Selection by Noncontrast Computed Tomography With or Without Computed Tomography Angiography Versus Computed Tomography Perfusion for Endovascular Therapy in Patients With Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis Open
Background The effect of imaging selection on endovascular therapy for acute ischemic stroke remains debated. We compared the efficacy and safety of imaging modalities using computed tomography perfusion with using noncontrast computed tom…
View article: Safety and Efficacy of Endovascular Thrombectomy for Acute Ischemic Stroke After Cardiac Surgery: A Retrospective Analysis of Readmission Nationwide Database Data
Safety and Efficacy of Endovascular Thrombectomy for Acute Ischemic Stroke After Cardiac Surgery: A Retrospective Analysis of Readmission Nationwide Database Data Open
Background There is limited evidence regarding outcomes of endovascular thrombectomy (EVT) in patients with acute ischemic stroke after cardiac surgery (CS). Therefore, we aimed to evaluate the outcomes of EVT in patients with acute ischem…
View article: E<b>F</b>fects of Y-6 S<b>U</b>blingual Tablets for Pa<b>T</b>ients with Ac<b>U</b>te Ischemic St<b>R</b>ok<b>E</b> (FUTURE): a phase II, randomised, double-blind, double-dummy, placebo-controlled, parallel trial
E<b>F</b>fects of Y-6 S<b>U</b>blingual Tablets for Pa<b>T</b>ients with Ac<b>U</b>te Ischemic St<b>R</b>ok<b>E</b> (FUTURE): a phase II, randomised, double-blind, double-dummy, placebo-controlled, parallel trial Open
Background Acute ischaemic stroke, due to its high mortality and disability rates, imposes a significant economic and social burden worldwide. Typically, endovascular treatment within the therapeutic window is provided to salvage the ischa…
View article: Edaravone Dexborneol vs Placebo on Functional Outcomes in Patients with Acute Ischaemic Stroke Who Underwent Endovascular Thrombectomy (Taste-2): A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial
Edaravone Dexborneol vs Placebo on Functional Outcomes in Patients with Acute Ischaemic Stroke Who Underwent Endovascular Thrombectomy (Taste-2): A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial Open
View article: International practice patterns and perspectives on endovascular therapy for the treatment of cerebral venous thrombosis
International practice patterns and perspectives on endovascular therapy for the treatment of cerebral venous thrombosis Open
Background: Cerebral venous thrombosis (CVT) accounts for 0.5–1% of all strokes. The role of endovascular therapy (EVT) in the management of CVT remains controversial and variations in practice patterns are not well known. Aims: Here, we p…
View article: Sex-Related Differences in Endovascular Treatment Outcomes for Acute Large Infarcts: The ANGEL-ASPECT Subgroup Analysis
Sex-Related Differences in Endovascular Treatment Outcomes for Acute Large Infarcts: The ANGEL-ASPECT Subgroup Analysis Open
Background and Purpose The outcomes of endovascular therapy (EVT) across sexes for large infarcts remains unclear. This study aimed to evaluate the impact of sex on the outcomes of EVT for patients with large infarct. Methods In this secon…
View article: Intra-arterial tenecteplase after successful endovascular therapy (ANGEL-TNK): protocol of a multicentre, open-label, blinded end-point, prospective, randomised trial
Intra-arterial tenecteplase after successful endovascular therapy (ANGEL-TNK): protocol of a multicentre, open-label, blinded end-point, prospective, randomised trial Open
Background Despite successful reperfusion after thrombectomy for large vessel occlusion (LVO) stroke, up to half of patients are dependent or dead at 3-month follow-up. The aim of the current study is to demonstrate safety and efficacy of …
View article: Association between stroke subtypes and outcomes of endovascular therapy: a post-hoc analysis of the ANGEL-ASPECT Trial
Association between stroke subtypes and outcomes of endovascular therapy: a post-hoc analysis of the ANGEL-ASPECT Trial Open
Objectives Our study aims to examine the value of endovascular therapy (EVT) and its comparison to medical management (MM) in ischaemic stroke patients accompanied by large artery atherosclerosis (LAA) and non-LAA Methods modified Rankin s…
View article: Balloon Angioplasty vs Medical Management for Intracranial Artery Stenosis
Balloon Angioplasty vs Medical Management for Intracranial Artery Stenosis Open
Importance Previous randomized clinical trials did not demonstrate the superiority of endovascular stenting over aggressive medical management for patients with symptomatic intracranial atherosclerotic stenosis (sICAS). However, balloon an…
View article: Anaesthesia modality on endovascular therapy outcomes in patients with large infarcts: a post hoc analysis of the ANGEL-ASPECT trial
Anaesthesia modality on endovascular therapy outcomes in patients with large infarcts: a post hoc analysis of the ANGEL-ASPECT trial Open
Objectives Endovascular therapy (EVT) now penetrates the once obscure realm of large infarct core volume acute ischaemic stroke (LICV-AIS). This research aimed to investigate the potential correlation between different anaesthetic approach…
View article: Exploring the Limits of Endovascular Therapy for Large Core Patients: Where Do We Need More Data?
Exploring the Limits of Endovascular Therapy for Large Core Patients: Where Do We Need More Data? Open
International audience
View article: Cytomegalovirus pneumonia with intermittent pulmonary hemorrhage leading to asphyxia death: a case report and literature review
Cytomegalovirus pneumonia with intermittent pulmonary hemorrhage leading to asphyxia death: a case report and literature review Open
Neonatal pulmonary hemorrhage is a late manifestation of various diseases. Premature delivery and low body weight are frequently observed as high-risk factors, characterized by acute onset, rapid progression, and high mortality rates. Pulm…
View article: Effectiveness and safety of bridging therapy and endovascular therapy in patients with large cerebral infarctions: from ANGEL-ASPECT
Effectiveness and safety of bridging therapy and endovascular therapy in patients with large cerebral infarctions: from ANGEL-ASPECT Open
Background and purpose The benefits of thrombolytic therapy before endovascular thrombectomy in cases of acute ischaemic stroke, with a large infarction volume, remain unclear. This analysis aims to evaluate the effectiveness and safety of…
View article: Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trial
Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trial Open
Unrestricted grants from industry [Covidien Healthcare International Trading (Shanghai), Johnson & Johnson MedTech, Genesis MedTech (Shanghai), and Shanghai HeartCare Medical Technology].
View article: The impact of intraarterial, intravenous, and combined tirofiban on endovascular treatment for acute intracranial atherosclerotic occlusion
The impact of intraarterial, intravenous, and combined tirofiban on endovascular treatment for acute intracranial atherosclerotic occlusion Open
Background and purpose Adjunctive tirofiban administration in patients undergoing endovascular treatment (EVT) for acute large vessel occlusion (LVO) has been investigated in several studies. However, the findings are conflict. This study …
View article: Time to Treatment With Intravenous Thrombolysis Before Thrombectomy and Functional Outcomes in Acute Ischemic Stroke
Time to Treatment With Intravenous Thrombolysis Before Thrombectomy and Functional Outcomes in Acute Ischemic Stroke Open
Importance The benefit of intravenous thrombolysis (IVT) for acute ischemic stroke declines with longer time from symptom onset, but it is not known whether a similar time dependency exists for IVT followed by thrombectomy. Objective To de…
View article: Outcome Comparison of Endovascular Treatment for Acute Large Vessel Occlusion Due to Large Artery Atherosclerosis and Cardioembolism in the Chinese Population: Data from the ANGEL Registry
Outcome Comparison of Endovascular Treatment for Acute Large Vessel Occlusion Due to Large Artery Atherosclerosis and Cardioembolism in the Chinese Population: Data from the ANGEL Registry Open
In the ANGEL registry, a higher prevalence of patients undergoing EVT for acute anterior circulation LVO with LAA was found than those with CE. However, our study revealed that the efficacy and safety of EVT remained consistent regardless …
View article: Mechanical thrombectomy for large vessel occlusion with large ischaemic core
Mechanical thrombectomy for large vessel occlusion with large ischaemic core Open
Endovascular therapy in acute ischemic stroke with large vessel occlusion changed the landscape of stroke treatment. Early randomised trials largely focused on patients with small to moderate ischemic core defined as ASPECTS 6 or greater. …
View article: When treating acute ischaemic stroke of LVO type, time window prevails over tissue window
When treating acute ischaemic stroke of LVO type, time window prevails over tissue window Open
View article: Chinese Stroke Association guidelines for clinical management of ischaemic cerebrovascular diseases: executive summary and 2023 update
Chinese Stroke Association guidelines for clinical management of ischaemic cerebrovascular diseases: executive summary and 2023 update Open
Background China is one of the countries with the highest burden of stroke. Implementing multidimensional management guidelines will help clinicians practise evidence-based care, improve patient outcomes and alleviate societal burdens. Thi…
View article: Alberta Stroke Program Early Computed Tomography Score, Infarct Core Volume, and Endovascular Therapy Outcomes in Patients With Large Infarct
Alberta Stroke Program Early Computed Tomography Score, Infarct Core Volume, and Endovascular Therapy Outcomes in Patients With Large Infarct Open
Importance Endovascular therapy (EVT) demonstrated better outcomes compared with medical management in recent randomized clinical trials (RCTs) of patients with large infarct. Objective To compare outcomes of EVT vs medical management acro…
View article: Incidence and predictors of futile recanalisation after endovascular therapy in acute vertebrobasilar artery occlusion patients: insight from the ANGEL-ACT registry
Incidence and predictors of futile recanalisation after endovascular therapy in acute vertebrobasilar artery occlusion patients: insight from the ANGEL-ACT registry Open
Objectives To identify the occurrence rate and predictors of futile recanalisation after endovascular therapy (EVT) for acute vertebrobasilar artery occlusion (VBAO). Methods Participants of the Endovascular Treatment Key Technique and Eme…
View article: Predictors of futile recanalization in patients with large infarct: a post hoc analysis of the ANGEL-ASPECT trial
Predictors of futile recanalization in patients with large infarct: a post hoc analysis of the ANGEL-ASPECT trial Open
Background Few studies have focused on factors associated with futile recanalization in acute anterior circulation stroke patients with large infarct cores who were treated with modern endovascular therapy (EVT). The aim of this study was …
View article: Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised trials
Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised trials Open
View article: Efficacy and Safety of Butylphthalide in Patients With Acute Ischemic Stroke
Efficacy and Safety of Butylphthalide in Patients With Acute Ischemic Stroke Open
Importance DL-3-n-butylphthalide (NBP) is a drug for treating acute ischemic stroke and may play a neuroprotective role by acting on multiple active targets. The efficacy of NBP in patients with acute ischemic stroke receiving reperfusion …
View article: Effectiveness of a Quality Improvement Intervention on Reperfusion Treatment for Patients With Acute Ischemic Stroke
Effectiveness of a Quality Improvement Intervention on Reperfusion Treatment for Patients With Acute Ischemic Stroke Open
Importance Reperfusion therapy is the most effective treatment for acute ischemic stroke but remains underused in China. Objective To evaluate the effect of a problem-oriented, culturally adapted, targeted quality improvement intervention …
View article: Does MRI add value in selecting patients for thrombectomy beyond the 6 h window? A matched-control analysis
Does MRI add value in selecting patients for thrombectomy beyond the 6 h window? A matched-control analysis Open
Background Controversy exists regarding the need of advanced imaging for patient selection in the extended window. Aims To analyze the effect of initial imaging modalities on clinical outcomes of patients underwent MT in the extended windo…
View article: Specialist Perspectives on the Imaging Selection of Large Vessel Occlusion in the Late Window
Specialist Perspectives on the Imaging Selection of Large Vessel Occlusion in the Late Window Open
View article: Necessity and timing of angioplasty in acute large-vessel occlusion strokes due to intracranial atherosclerotic disease: A cohort analysis with data from the angel-ACT registry
Necessity and timing of angioplasty in acute large-vessel occlusion strokes due to intracranial atherosclerotic disease: A cohort analysis with data from the angel-ACT registry Open
Background The effects of angioplasty on intracranial atherosclerotic disease (ICAD)-related acute large-vessel occlusion stroke (LVOS) are unknown. We analyzed the efficacy and safety of angioplasty or stenting for ICAD-related LVOS and t…