Explanipedia

Senescent B cells regulate CD38 expression via FOXO1 in pneumonia resulting from <i>PIK3CD</i> (R437C) mutations Open

Ju Liu, Yuxin Bai, Jianing Tang, Peng Jin, Yanmei Huang , et al. · 2025

Activated phosphoinositide 3-kinase delta syndrome (APDS) is a primary immunodeficiency characterized by hyperactivated lymphocytes and recurrent infections. This study presents a 2.5-year-old patient with a novel PIK3CD gene mutation (c.1…

Performance of EMA algorithm, 2022 ACR/EULAR criteria, and EMA-ACR/EULAR algorithm in classifying pediatric ANCA-associated vasculitis: a national cohort study in China Open

Zhe Lü, Liwen Tan, Hong Xu, Zhengkun Xia, Xiaoyun Jiang , et al. · 2025

Programmed enhancement of endogenous iron-mediated lysosomal membrane permeabilization for tumor ferroptosis/pyroptosis dual-induction Open

Luwen Zhu, Jiahao Hu, Xiaochuan Wu, Jucong Zhang, Xinyi Xu , et al. · 2025

Ferroptosis and pyroptosis, as emerging regulated forms of cell death capable of overcoming apoptotic resistance, demonstrate promising potential in tumor therapy. Given that iron manipulation and reactive oxygen species elevation serve as…

Infection-Associated Versus Non-Infection-Associated Pulmonary Embolism in Children: A Multicenter Retrospective Cohort Study Open

Fengqin Liu, Sixian Liu, Zhilang Lin, Lejia Zhang, Jing Zhang , et al. · 2025

Corrosion resistance and biocompatibility of magnesium alloy with bioactive glass-reinforced hydrogel composite coatings Open

Rong Xu, Wuxiang Zhang, Zhenzong Shao, Yong Wang, Baolin Xu , et al. · 2024

Magnesium (Mg) alloy is a promising candidate for biodegradable implants; however, its rapid degradation can create an unstable physiological environment that hampers tissue regeneration. To address this challenge, a polyvinyl alcohol (PVA…

Clinical characteristics and outcomes of COVID-19 in pediatric patients with rheumatic diseases Open

Yating Wang, Shichao Su, Mingsheng Ma, Ruohang Weng, Zhiyong Zhang , et al. · 2024

Background This study investigates the clinical characteristics and outcomes of pediatric patients with rheumatic diseases infected with COVID-19 in China. Methods We conducted a retrospective analysis of pediatric patients with rheumatic …

Exosomes secreted by podocytes regulate the differentiation of Th17/Treg cells in idiopathic nephrotic syndrome Open

Yang Jia, Shiqiu Xiong, Hạixia Chen, Qiang Cai, Xiaochuan Wu · 2024

[Correlation of anti-C1q antibodies with active systemic lupus erythematosus and lupus nephritis in children]. Open

Yongzhen Li, Jinrong Yang, Yudi Zhang, Yan Cao, Xiaoyan Li , et al. · 2024

Anti-C1q antibodies can serve as non-invasive biomarkers for evaluating the activity of SLE or predicting the activity of LN in children.

[Clinical characteristics of children with anti-neutrophil cytoplasmic antibody-associated vasculitis]. Open

Jingqi Liu, Yongzhen Li, Lanjun Shuai, Yan Cao, Xiaoyan Li , et al. · 2024

AAV is more common in school-age female children, with MPA being the most common clinical subtype. The onset of AAV in children is mainly characterized by renal involvement, followed by respiratory system involvement. The renal pathology o…

Rituximab as a Maintenance Therapy in Pediatric Patients with Frequent-Relapsing or Steroid Dependent Nephrotic Syndrome: Efficacy, Safety, and Steroid Reduction Open

Xiaochuan Wu, Qiaoping Chen, Yan Cao, Lanjun Shuai, Xiaoyan Li , et al. · 2024

Background: Nephrotic syndrome is the most common glomerular disease in pediatrics. Rituximab has been shown to induce remission in nephrotic syndrome, yet the necessity and safety of its use in maintenance therapy remain uncertain. In thi…

DNA methylation of IFI44L as a potential blood biomarker for childhood-onset systemic lupus erythematosus Open

Jingwei Wang, Xiqiang Dang, Xiaochuan Wu, Zhongyuan Xiang, Yongzhen Li , et al. · 2024

Anti-VEGFR2 F(ab′)2 drug conjugate promotes renal accumulation and glomerular repair in diabetic nephropathy Open

Di Liu, Yanling Song, Hui Chen, Yuchan You, Luwen Zhu , et al. · 2023

Risk factors for renal outcomes in children with antineutrophil cytoplasmic antibody-associated vasculitis: a nationwide retrospective study in China Open

Liwen Tan, Junli Wan, Chunhua Zhu, Hong Xu, Zhengkun Xia , et al. · 2023

Congenital Neutropenia with ELANE Gene Mutation Complicated with MPO-ANCA Positivity Open

Yudi Zhang, Jingqi Liu, Yongzhen Li, Xiaochuan Wu · 2023

Multifunctional Drugs-Loaded Carbomol Hydrogel Promotes Diabetic Wound Healing via Antimicrobial and Immunoregulation Open

Hehui Wang, Jiale Jin, Chi Zhang, Fangyi Gong, Baiwen Hu , et al. · 2023

Diabetic wound healing poses a significant clinical dilemma. Bacterial infection and immune dysregulation are the predominant reasons. However, conventional wound dressings with a single treatment approach often limit therapeutic efficacy …

Adipose‐Derived Mesenchymal Stem Cell‐Derived Exosomes Biopotentiated Extracellular Matrix Hydrogels Accelerate Diabetic Wound Healing and Skin Regeneration Open

Yanling Song, Yuchan You, Xinyi Xu, Jingyi Lu, Xiajie Huang , et al. · 2023

Wound healing is an urgent clinical challenge, particularly in the case of chronic wounds. Traditional approaches to wound healing have limited therapeutic efficacy due to lengthy healing times, risk of immune rejection, and susceptibility…

Altered Expressions of Long-noncoding RNAs involved in development and pathogenesis of Child-onset lupus nephritis Open

Yang Jia, Mariame Mohamed Ahamada, Shiqiu Xiong, Hạixia Chen, donghai liu , et al. · 2023

Background We aimed to assess the expression profiles of long noncoding RNAs (lncRNAs) and mRNAs in children with lupus nephritis (LN) by microarray analysis. Method 26 venous blood samples were obtained from LN patients and controls for t…

Comparison Between the Clinical Effect of Percutaneous Kyphoplasty for Osteoporosis Vertebral Compression Fracture Patient with or Without Sarcopenia: A Retrospective Cohort Study Open

Yujie Peng, Xiaochuan Wu, Xinyu Ma, Dingli Xu, Yang Wang , et al. · 2023

Sarcopenia could reduce the clinical effect of percutaneous kyphoplasty, and furthermore. Related studies are needed to verify the effect of sarcopenia on OVCF patients.

Anti-VEGFR2 F(ab′)2 drug conjugate promotes renal accumulation and glomerular repair in diabetic nephropathy Open

Di Liu, Yanling Song, Hui Chen, Yuchan You, Luwen Zhu , et al. · 2023

Poor renal distribution of antibody-based drugs is the key factor contributing to low treatment efficiency for renal diseases and side effects. Here, we prepared F(ab′)₂ fragmented vascular endothelial growth factor receptor 2 a…

Clinical features and familial mutations in the coexistence of Wilson's disease and Alport syndrome: A case report Open

Ying Wang, Qingnan He, Xiqiang Dang, Xiaochuan Wu, Xiaoyan Li · 2023

Background Alport syndrome (AS) and Wilson's disease (WD) are genetic diseases that could lead to kidney damage. Herein, we report the clinical features and gene variants in a patient with WD and X-linked AS. Case presentation The proband …

Bartter syndrome type III with glomerular dysplasia and chronic kidney disease: A case report Open

Jingqi Liu, Yudi Zhang, Xiaochuan Wu, Yongzhen Li · 2023

Background Bartter syndrome (BS) type III is a rare autosomal recessive genetic disease. Its clinical features are polyuria, hypokalemia, hypochloremia, metabolic alkalosis, and hyperreninaemia. A few BS type III can be complicated with ch…

Glucagon-like peptide-1 receptor agonists as add-on therapy to insulin for type 1 diabetes mellitus Open

Xinrui Tan, Xiongfeng Pan, Xiaochuan Wu, Songjia Zheng, Yuyao Chen , et al. · 2023

Background: To assess the efficacy and safety of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) used as an adjunct to insulin therapy in adults with type 1 diabetes. Methods: A search of electronic databases (Medline, Embase, and th…

Real-word adrenocorticotropic hormone treatment for childhood-onset nephrotic syndrome Open

Ying Wang, Xiqiang Dang, Xiaochuan Wu, Yongzhen Li, Qingnan He , et al. · 2023

Background Current first-line anti-proteinuric treatments do not produce a satisfactory therapeutic effect in a considerable number of patients with nephrotic syndrome (NS). Interest in adrenocorticotropic hormone (ACTH) for the treatment …

Dent disease manifesting as nephrotic syndrome Open

Qiaoping Chen, Yongzhen Li, Xiaochuan Wu · 2023

Dent disease is an X-linked recessive renal tubular disorder, which is mainly caused by mutations of the CLCN5 gene and OCRL gene. It is characterized by low molecular weight proteinuria, hypercalciuria, nephrocalcinosis or n…

Identification of Potential Diagnostic Biomarkers for Systemic Juvenile Idiopathic Arthritis by Integrative Transcriptomic Analysis Open

Jingwei Wang, Xiaochuan Wu, Yaqian Fu, Shen Tian · 2023

Introduction: Currently the diagnostic criteria for systemic juvenile idiopathic arthritis (sJIA) is lack of specificity. Diagnostic biomarkers are needed to be identified to help with the early diagnosis of sJIA and prevent lethal complic…

A retrospective study on the characteristics of renal pathological grades in HSPN children with mild to moderate proteinuria Open

Yan Cao, Tian Shen, Yongzhen Li, Lanjun Shuai, Qiaoping Chen , et al. · 2022

Objective To investigate the characteristics of renal pathological grades in Henoch–Schönlein purpura nephritis (HSPN) children with mild to moderate proteinuria and the correlation between pathological grade and severity of proteinuria am…

Alveolar soft part sarcoma in childhood and adolescence: Report of three cases and review of literature Open

Yudi Zhang, Ying Wang, Hao Wang, Chuan Wen, Xiaochuan Wu · 2022

Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma with unique tumor characteristics, which is rare in children. Herein, we present the immunophenotype, treatment, and prognosis of three children with ASPS from The Second Xian…

Case report: Unilateral panuveitis as a manifestation of Alport syndrome in a Chinese pediatric patient Open

Yu Tian, Xiaochuan Wu, Yongzhen Li, Wenbin He, Zibin Liu , et al. · 2022

Purpose: The study aimed to report a rare case of a patient with Alport syndrome, which was manifested as unilateral non-infectious uveitis after bilateral cataract surgery. Methods: A case report. Results: A 2-year-old boy was diagnosed w…

IgA vasculitis update: Epidemiology, pathogenesis, and biomarkers Open

Liyun Xu, Yongzhen Li, Xiaochuan Wu · 2022

Immunoglobulin A vasculitis (IgAV), formerly known as Henoch-Schönlein purpura, is the most common systemic vasculitis in children, characterized by diverse clinical manifestations with a wide spectrum ranging from isolated cutaneous vascu…

Macrophage Polarization and Plasticity in Systemic Lupus Erythematosus Open

Mariame Mohamed Ahamada, Yang Jia, Xiaochuan Wu · 2021

Systemic lupus erythematosus (SLE) is an autoimmune disease that attacks almost every organ. The condition mostly happens to adults but is also found in children, and the latter have the most severe manifestations. Among adults, females, e…

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