Explanipedia

NUAK1 promotes diabetic kidney disease by accelerating renal tubular senescence via the ROS/p53 axis Open

Lei Guo, Peili Wu, Qing Li, Xiaochun Lin, Yuan Wang , et al. · 2025

Diabetic kidney disease (DKD) progression involves intricate interactions among senescence, oxidative stress, inflammation, and fibrosis. This study systematically investigates the regulatory role and molecular mechanisms of NUAK1 in DKD p…

NUAK1 promotes diabetic kidney disease by accelerating renal tubular senescence via the ROS/p53 axis Open

Lei Guo, Peili Wu, Qijian Feng, Xiaochun Lin, Yuling Luo , et al. · 2025

Diabetic kidney disease (DKD) progression involves intricate interactions among senescence, oxidative stress, inflammation, and fibrosis. This study systematically investigates the regulatory role and molecular mechanisms of NUAK1 in DKD p…

Asiatic Acid Alleviates Renal Damage by Upregulating STBD1-Mediated Glycophagy in Diabetic Kidney Disease Open

Lei Guo, Peili Wu, Qijian Feng, Xiaochun Lin, Yuan Wang , et al. · 2025

Background/Objectives: The role of glycogen metabolism in diabetic kidney disease (DKD) remains unclear. This study investigated the therapeutic potential of asiatic acid (AA) on glycogen metabolism in DKD and its underlying mechanisms. Me…

MicroRNA-24-3p targeting Top1 in perirenal fat is involved in circulating inflammation and high cardiovascular disease risk in patients with primary aldosteronism Open

Xuelin Li, Min Luo, Yanmei Zeng, Renyi Zhang, Xiaochun Lin , et al. · 2025

Correction: Relative fat mass as a predictor of gallstones: insights from national health and nutrition examination survey data Open

Xiaochun Lin, Hao Lin, Jing Xu, Shouxing Yang, Lei Miao · 2025

Relative fat mass as a predictor of gallstones: insights from national health and nutrition examination survey data Open

Xiaochun Lin, Hao Lin, Jing Xu, Shouxing Yang, Lei Miao · 2025

Arginine accumulation suppresses heat production during fermentation of the biocontrol fungus <i>Beauveria bassiana</i> Open

Tong Tong Wu, Fangfang Zhan, Liqiong Zeng, Yanli Sun, Shiyu Fu , et al. · 2025

Beauveria bassiana ( Bb ) is one of the most widely used biocontrol agents, and its products constitute more than one-third of the global market share of fungal insecticides. Solid-state fermentation (SSF) is widely used in the production …

Necroptosis-related lncRNAs: biomarkers for predicting prognosis and immune response in lung adenocarcinoma Open

Chunxuan Lin, Kunpeng Lin, Xiaochun Lin, Hai Yuan, Yingying Zhang , et al. · 2024

Necro-related lnc can affect disease progression and patient prognosis. In addition, these lncRNAs can be used to design therapeutic strategies, such as immunotherapy, to treat patients with LUAD.

All-Optical Switching Using Cavity Modes in Photonic Crystals Embedded with Hyperbolic Metamaterials Open

Chang Liu, Dong Wei, Xiaochun Lin, Yaoxian Zheng · 2024

Hyperbolic metamaterials (HMMs) are highly anisotropic materials with the unique property of generating electromagnetic modes. Understanding how these materials can be applied to control the propagation of light waves remains a major focus…

A genomic instability-associated lncRNA signature for predicting prognosis and biomarkers in lung adenocarcinoma Open

Chunxuan Lin, Kunpeng Lin, Pan Li, Hai Yuan, Xiaochun Lin , et al. · 2024

Genomic instability (GI) was associated with tumorigenesis. However, GI-related lncRNA signature (GILncSig) in lung adenocarcinoma (LUAD) is still unknown. In this study, the lncRNA expression data, somatic mutation information and clinica…

Transcriptome Analysis Reveals the Response of Cryptomeria japonica to Feeding Stress of Dendrolimus houi Lajonquière Larvae Open

Yuwen Que, Weiwei Xie, Xinyuan Fang, Han Xu, Shuting Ye , et al. · 2023

The Japanese fir, Cryptomeria japonica, is ecologically and commercially vital in China. However, infestations by Dendrolimus houi Lajonquière larvae cause widespread dieback, mimicking mechanical damage effects, with unclear differential …

Correction to: Prevalence of Diabetic Kidney Disease with Different Subtypes in Hospitalized Patients with Diabetes and Correlation Between eGFR and LncRNA XIST Expression in PBMCs Open

Yingbei Lin, Peili Wu, Lei Guo, Qijian Feng, Ling Wang , et al. · 2023

In the abstract, the result ''NA-DKD, A-DKD, and Mixed groups accounted for 23.7%, 3.3%, and 12.9%, respectively'' should be corrected to ''NA-DKD, A-DKD, and Mixed groups accounted for 3.3%, 23.7%, and 12.9%, respectively''.In Key Summary…

Prevalence of Diabetic Kidney Disease with Different Subtypes in Hospitalized Patients with Diabetes and Correlation Between eGFR and LncRNA XIST Expression in PBMCs Open

Yingbei Lin, Peili Wu, Lei Guo, Qijian Feng, Ling Wang , et al. · 2023

A genomic instability-associated lncRNA signature for predicting prognosis and biomarkers in lung adenocarcinoma Open

Chunxuan Lin, Kunpeng Lin, Pan Li, Xiaochun Lin, Yong Dai , et al. · 2023

Genomic instability (GI) was associated with tumorigenesis. However, GI-related lncRNA signature (GILncSig) in lung adenocarcinoma (LUAD) is still unknown. In this study, the lncRNA expression data, somatic mutation information and clinica…

Ponatinib modulates the metabolic profile of obese mice by inhibiting adipose tissue macrophage inflammation Open

Zhuomiao Lin, Xiaochun Lin, Ying Lai, Congcong Han, Xinran Fan , et al. · 2022

Obesity-induced metabolic syndrome is a rapidly growing conundrum, reaching epidemic proportions globally. Chronic inflammation in obese adipose tissue plays a key role in metabolic syndrome with a series of local and systemic effects such…

Comprehensive analysis of epigenomics and transcriptome data to identify potential target genes associated with obesity Open

Peili Wu, Lei Guo, Xuelin Li, Yuejun Du, Xiaochun Lin , et al. · 2022

DNA methylation is closely related to the occurrence and development of many diseases, but its role in obesity is still unclear. This study aimed to find the potential differentially methylated genes associated with obesity occurrence and …

Genetic Association of ERCC6 rs2228526 Polymorphism with the Risk of Cancer: Evidence from a Meta‐Analysis Open

Xiaochun Lin, Yongfu Wu, Qingde Li, Hongying Yu, Xugui Li , et al. · 2022

At present, several studies have assessed the association between ERCC6 rs2228526 polymorphism and the risk of cancer. However, the association remained controversial. To provide a more accurate estimate on the association, we performed a …

LKB1 expression and the prognosis of lung cancer Open

Chunxuan Lin, Xiaochun Lin, Kunpeng Lin, Jialiang Tan, Chenggong Wei , et al. · 2021

Background: In the past few decades, many lines of evidence implicate the importance of liver kinase B1 (LKB1) as a tumor suppressor gene in the development and progression of solid tumours. However, the prognostic and clinicopathological …

Brown adipose tissue transplantation ameliorates diabetic nephropathy through the miR-30b pathway by targeting Runx1 Open

Yudan Zhang, Yingying Cai, Hongbin Zhang, Jiajun Zhang, Yanmei Zeng , et al. · 2021

Macrophage NFATc3 prevents foam cell formation and atherosclerosis: evidence and mechanisms Open

Xiu Liu, Jiawei Guo, Xiaochun Lin, Yonghua Tuo, Wan-Li Peng , et al. · 2021

Aims Our previous study demonstrated that Ca2+ influx through the Orai1 store-operated Ca2+ channel in macrophages contributes to foam cell formation and atherosclerosis via the calcineurin–ASK1 pathway, not the classical calcineurin–nucle…

Reduced intracellular chloride concentration impairs angiogenesis by inhibiting oxidative stress-mediated VEGFR2 activation Open

Kai Li, Yingying Liu, Xiaofei Lv, Zhuomiao Lin, Tingting Zhang , et al. · 2020

Hepatocyte TMEM16A Deletion Retards NAFLD Progression by Ameliorating Hepatic Glucose Metabolic Disorder Open

Jiawei Guo, Xiu Liu, Tingting Zhang, Xiaochun Lin, Hong Yu , et al. · 2020

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease, and the mechanisms underpinning its pathogenesis have not been completely established. Transmembrane member 16A (TMEM16A), a component of the Ca …

Transplantation of brown adipose tissue up-regulates miR-99a to ameliorate liver metabolic disorders in diabetic mice by targeting NOX4 Open

Ping Li, Cunxia Fan, Yingying Cai, Shu Fang, Yanmei Zeng , et al. · 2020

Nonalcoholic fatty liver disease (NAFLD), main cause of liver damage, is inextricably linked to diabetes. However, there is no specific means to improve the pathology of fatty liver in diabetic patients. Brown adipose tissue (BAT) is an im…

The Total Flavonoid Extract from <i>Glycyrrhiza inflat</i> Bat. Suppresses Atrophic Gastritis in Rats through the Akt/MAPK Pathway Open

Jun-Shan Liu, Jun Zheng, Xiaochun Lin, Shutong Bai, Qiudi Deng , et al. · 2020

Ethnopharmacological Relevance . Glycyrrhiza inflat Bat. is widely used to treat gastric ulcer and gastritis in clinic in China. Aim of the Study . To investigate the protective effects and possible mechanisms of the total flavonoid extrac…

MiR-455 targeting SOCS3 improve liver lipid disorders in diabetic mice Open

Shu Fang, Jie Feng, Hongbin Zhang, Ping Li, Yudan Zhang , et al. · 2020

MiR-455 has been verified a key regulator of brown adipose tissue and adipose tissue-specific overexpression of miR-455 (ap2-miR-455) mice could combat high-fat-diet-induced obesity. This study is to verify overexpression of miR-455 could …

TMEM16A ameliorates vascular remodeling by suppressing autophagy via inhibiting Bcl-2-p62 complex formation Open

Xiaofei Lv, Yajuan Zhang, Xiu Liu, Huaqing Zheng, Canzhao Liu , et al. · 2020

Rationale: Transmembrane member 16A (TMEM16A) is a component of calcium-activated chloride channels that regulate vascular smooth muscle cell (SMC) proliferation and remodeling. Autophagy, a highly conserved cellular catabolic proce…

Pristimerin Inhibits Adjuvant Arthritis Fibroblast Like Synoviocytes Cell Proliferation through Cell Cycle Arrest and Induction of Apoptosisa Open

Shuang Bai, WANJIAO GAO Q. DENG, Xiaochun Lin, Jiaojiao Zheng, Yuyao Chen , et al. · 2020

To investigate the effect of pristimerin, an effective component of maple leaf, on the cell cycle and apoptosis of adjuvant arthritis fibroblast like synoviocytes adjuvant arthritis fibroblast like synoviocytes cells. Adjuvant arthritis fi…

Genetic Analysis of SLC12A3 Gene in Chinese Patients with Gitelman Syndrome Open

Yanmei Zeng, Ping Li, Shu Fang, Chunyan Wu, Yudan Zhang , et al. · 2019

BACKGROUND The incidence of Gitelman syndrome (GS) has been increasing in our hospital. The aim of this study was to explore the diagnostic accuracy and features of SLC12A3 gene in Chinese patients with GS. MATERIAL AND METHODS We searched…

Increased oxidative stress, inflammation and fibrosis in perirenal adipose tissue of patients with cortisol-producing adenoma Open

Chunyan Wu, Huijian Zhang, Jiajun Zhang, Hongbin Zhang, Yanmei Zeng , et al. · 2019

Although much is known about that corticosteroids affect the functions of adipose tissues, little genetic information is available for perirenal adipose tissue (peri-N) from patients with cortisol-producing adenoma (CPA). We conducted micr…

Two‐dimensional speckle tracking to image ventricular‐arterial coupling in uremia Open

Fuyong Ye, Yin‐Ting Liang, Xiaochun Lin · 2018

Objective To study ventricular‐arterial coupling(VAC) in uremic patients by application of two‐dimensional speckle tracing imaging (2DSTI). Methods One hundred uremic patients were divided into two groups based on left ventricular ejection…

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