Di Xia
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View article: Elementary School Students Exposure to Emission of BTEX From Scented Stationery
Elementary School Students Exposure to Emission of BTEX From Scented Stationery Open
The popularity of scented stationery among primary school students has raised concerns about exposure to BTEX (benzene, toluene, ethylbenzene, xylene) emissions. This study introduces a novel method for assessing inhalation exposure by int…
View article: Artificial intelligence-based prediction of second stage duration in labor: a multicenter retrospective cohort analysis
Artificial intelligence-based prediction of second stage duration in labor: a multicenter retrospective cohort analysis Open
National Natural Science Foundation of China (No.82371689, N0.81771602), and National Key Research and Development Program of China (No.2021YFC2700703).
View article: Analysis of the effect of combined rehabilitation training and transcutaneous vagus nerve electrical stimulation on promoting central nervous system remodeling in stroke patients
Analysis of the effect of combined rehabilitation training and transcutaneous vagus nerve electrical stimulation on promoting central nervous system remodeling in stroke patients Open
Combined rehabilitation training and transcutaneous vagus nerve electrical stimulation have significant effects on neurological function recovery and central nervous system remodeling in stroke patients, effectively improving patients' mot…
View article: Study on the Electric Field Distribution Characteristics of 66 kV Dry-Type Transformer Based on Functional Graded Material (FGM) Treatment
Study on the Electric Field Distribution Characteristics of 66 kV Dry-Type Transformer Based on Functional Graded Material (FGM) Treatment Open
Functional graded materials (FGMs) have been successfully applied for improving the insulation performance of insulators, yet there is currently no relevant literature on their application in dry-type transformers. Therefore, it is meaning…
View article: Optimizing Genome Editing in Bovine Cells: A Comparative Study of Cas9 Variants and CRISPR Delivery Methods
Optimizing Genome Editing in Bovine Cells: A Comparative Study of Cas9 Variants and CRISPR Delivery Methods Open
To assist in the establishment of an efficient CRISPR/Cas9 gene editing workflow in bovine cells, we compared the efficiency of four Streptococcus pyogenes Cas9 (SpCas9) nuclease variants (produced in-house or commercially) and two differe…
View article: Study on the Electric Field Distribution Characteristics of 66kV Dry-type Transformer Based on Functional Graded Material (FGM) Treatment
Study on the Electric Field Distribution Characteristics of 66kV Dry-type Transformer Based on Functional Graded Material (FGM) Treatment Open
Functional graded materials (FGMs) have been successfully applied in improving the insulation performance of insulators, yet there is currently no relevant literature on their application in dry-type transformers. Therefore, it is meaningf…
View article: The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening
The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening Open
A mechanistic connection between aging and development is largely unexplored. Through profiling age-related chromatin and transcriptional changes across 22 murine cell types, analyzed alongside previous mouse and human organismal maturatio…
View article: Identification and characterization of TM4SF1+ tumor self-seeded cells
Identification and characterization of TM4SF1+ tumor self-seeded cells Open
Tumor self-seeding is a process whereby circulating tumor cells (CTCs) recolonize the primary tumor, which promotes tumor growth, angiogenesis, and invasion. However, the detailed nature and functions of tumor self-seeded cells (TSCs) have…
View article: Differences between resident self-assessments and faculty- assessments on Anesthesiology Milestones and associated factors: a cross-sectional study
Differences between resident self-assessments and faculty- assessments on Anesthesiology Milestones and associated factors: a cross-sectional study Open
Background Accurate self-assessment is crucial for the professional development of physicians. There has been sparse data on the accuracy of self-assessments on Anesthesiology Milestones. The aim of this study was to investigate the differ…
View article: Individualised monitoring programme for pulmonary rehabilitation of patients with chronic obstructive pulmonary disease—study protocol for a randomised controlled trial
Individualised monitoring programme for pulmonary rehabilitation of patients with chronic obstructive pulmonary disease—study protocol for a randomised controlled trial Open
The study was registered in the Chinese Clinical Trial Registry: ChiCTR2000040723.
View article: Estrogen promotes the proliferation and migration of endometrial cancer cells by upregulating the expression of lncRNA HOTAIR
Estrogen promotes the proliferation and migration of endometrial cancer cells by upregulating the expression of lncRNA HOTAIR Open
Objective Estrogen (E2) is the main contributor to the progression of endometrial cancer (EC). The long noncoding RNA HOX antisense intergenic RNA (HOTAIR) is emerging as a new regulator in several cancer types. This study aimed to investi…
View article: A pluripotent stem cell atlas of multilineage differentiation reveals<i>TMEM88</i>as a developmental regulator of mammalian blood pressure
A pluripotent stem cell atlas of multilineage differentiation reveals<i>TMEM88</i>as a developmental regulator of mammalian blood pressure Open
SUMMARY Pluripotent stem cells provide a scalable approach to analyse molecular regulation of cell differentiation across multiple developmental lineage trajectories. In this study, we engineered barcoded iPSCs to generate an atlas of mult…
View article: Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle
Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle Open
The cavin proteins are essential for caveola biogenesis and function. Here, we identify a role for the muscle-specific component, Cavin4, in skeletal muscle T-tubule development by analyzing two vertebrate systems, mouse and zebrafish. In …
View article: Therapeutic Inhibition of Acid-Sensing Ion Channel 1a Recovers Heart Function After Ischemia–Reperfusion Injury
Therapeutic Inhibition of Acid-Sensing Ion Channel 1a Recovers Heart Function After Ischemia–Reperfusion Injury Open
Background: Ischemia–reperfusion injury (IRI) is one of the major risk factors implicated in morbidity and mortality associated with cardiovascular disease. During cardiac ischemia, the buildup of acidic metabolites results in decreased in…
View article: Muscle-specific Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle
Muscle-specific Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle Open
Summary The cavin proteins are essential for caveola biogenesis and function. Here, we identify a role for the muscle-specific component, Cavin4, in skeletal muscle T-tubule development by analyzing two vertebrate systems: mouse and zebraf…
View article: Expression and Significance of MyD88 in Patients With Gastric Cardia Cancer in a High-Incidence Area of China
Expression and Significance of MyD88 in Patients With Gastric Cardia Cancer in a High-Incidence Area of China Open
Background: Gastric cardia cancer (GCC) arises in the area of the stomach adjoining the esophageal-gastric junction and has unique risk factors. It was suggested that the involvement of Helicobacter pylori is associated with GCC from high-…
View article: Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines
Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines Open
The Src kinase Fyn plays critical roles in memory formation and Alzheimer’s disease. Its targeting to neuronal dendrites is regulated by Tau via an unknown mechanism. As nanoclustering is essential for efficient signaling, we used single-m…
View article: Author response: Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines
Author response: Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The Src kinase Fyn plays critical roles in…
View article: Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment
Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment Open
Hyperphosphorylated tau has a critical role in tauopathies such as Alzheimer's disease and frontotemporal dementia, impairing neuronal function and eventually leading to neurodegeneration. A critical role for tau is supported by studies in…
View article: Combining Carcinoembryonic Antigen and Platelet to Lymphocyte Ratio to Predict Brain Metastasis of Resected Lung Adenocarcinoma Patients
Combining Carcinoembryonic Antigen and Platelet to Lymphocyte Ratio to Predict Brain Metastasis of Resected Lung Adenocarcinoma Patients Open
We aimed to evaluate the role of pretreatment carcinoembryonic antigen (CEA) and platelet to lymphocyte ratio (PLR) in predicting brain metastasis after radical surgery for lung adenocarcinoma patients. The records of 103 patients with com…
View article: Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation
Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation Open
Munc18-1 is a key component of the exocytic machinery that controls neurotransmitter release. Munc18-1 heterozygous mutations cause developmental defects and epileptic phenotypes, including infantile epileptic encephalopathy (EIEE), sugges…
View article: Mobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant Tau
Mobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant Tau Open
Alzheimer’s disease (AD) and a subset of frontotemporal dementia termed FTLD-Tau are characterized by a massive, yet incompletely characterized and understood redistribution of Tau. To establish a framework for understanding this pathology…