Explanipedia

Modulation of intestinal mucosal immunity in human microbiota-associated rat by 2′-Fucosyllactose and Lacto-N-neotetraose Open

Bailiang Li, Wei Lv, Lan Wang, Xiaodan Shi, Ignatius Man‐Yau Szeto , et al. · 2025

Generation and validation of a iPSC line from a healthy female donor using integration-free Sendai virus reprogramming Open

Yuanyuan Chen, Xiaodan Shi, Wei Long, Qing Shao, Haijiang Yu · 2025

We generated a characterized integration-free iPSC line derived via Sendai virus reprogramming from healthy female donor PBMCs. This method preserves genomic integrity and pluripotent potential. Validated markers include nuclear/membrane-b…

Genome-Wide Identification and Expression Profiling of AP2/ERF Transcription Factor Genes in Prunus armeniaca L. Open

Yanguang He, Wang Lin, Nan Jiang, Donglin Zhang, Xiaodan Shi , et al. · 2025

The APETALA2/Ethylene Responsive Factor (AP2/ERF transcription factor) family plays pivotal roles in plant growth, stress responses, and metabolic regulation. Here, we identified 118 AP2/ERF family members in the apricot (Prunus armeniaca …

Role of ZBED3 in PALD1/PIP2- dependent calcium homeostasis during oocyte maturation Open

Danyu Ni, Qijun Xie, Yuting Chen, Yi Wei, Lang Peng , et al. · 2025

Transcutaneous auricular vagus nerve stimulation to treat narcolepsy type 1 (TARGET-NT1): A two-arm, randomised, sham-controlled trial Open

Yuanhang Pan, Yingchi Zhang, Zijie Xu, Zihan Wei, Rui Pan , et al. · 2025

To assess exploratorily the safety and efficacy of transcutaneous auricular vagus nerve stimulation (tVNS) as an adjunctive therapy in improving symptoms in patients with narcolepsy type 1 (NT1). The TARGET-NT1 trial, a two-arm, double-bli…

Abnormal glymphatic system in patients with autoimmune encephalitis: Relationship with cognitive performance Open

Yingchi Zhang, Dianwei Wu, Zhirong Fan, Xiuxiu Leng, Ting Wan , et al. · 2025

The glymphatic system is impaired in AE patients. A decreased DTI-ALPS index is associated with a decline in cognitive performance. Additionally, a low baseline ALPS index may predict an increased risk of long-term cognitive impairment in …

Oligosaccharides from Pachyrhizus erosus Degraded by Ultrasound-Assisted Fenton Reaction Retain Structural Integrity and Prebiotic Activity in Colitis Management Open

Yan Wang, Hongmei Yin, Jing Zhang, Xinyang Liu, Xiong Zuo , et al. · 2025

Cloning and Identification of Common Carp (Cyprinus carpio) PI3KC3 and Its Expression in Response to CyHV-3 Infection Open

Xiaona Jiang, Lijing Tian, Wanying Ren, Chitao Li, Xuesong Hu , et al. · 2024

Phosphoinositide 3-kinases (PI3Ks) are a class of key regulatory factors in eukaryotes that can inhibit viral replication by influencing autophagy. Currently, cyprinid herpesvirus 3 (CyHV-3) poses a serious threat to common carp culture. H…

CircCamsap1 is dispensable for male fertility in mice Open

Shu Zhang, Haojie Li, Wei Jiang, Xia Chen, Han Zhou , et al. · 2024

Background Circular RNAs (circRNAs) are a large class of RNAs present in mammals. Among these, circCamsap1 is a well-acknowledged circRNA with significant implications, particularly in the development and progression of diverse tumors. How…

Prognostic Nutritional Index (PNI) in patients with severe encephalitis as a useful prognostic indicator:a multivariate analysis Open

Bo Hui, Di Zhao, Fang Du, Xiao Zhang, Xiaodan Shi , et al. · 2024

Background The prognostic impact of poor nutritional status in severe encephalitis is not clearly understood. We aim to investigate the relationship between the prognostic nutritional index (PNI) and poor outcomes of severe encephalitis. M…

Effect of Time-Limited Training on Endoscopic Submucosal Dissection in an Ex Vivo Porcine Stomach Model: A Prospective Randomized Controlled Study Open

Xu Liu, Xiaodong Shao, Xiaodan Shi, Wenjing Kou, Yayuan Luo , et al. · 2024

Introduction Endoscopic submucosal dissection (ESD) is the first choice for superficial tumor resection. There is no report on whether the training effect is affected by limiting the operation time of each ESD operation. This study aimed t…

Kidney Injury: An Overlooked Manifestation in Autoimmune Encephalitis Open

Zhirong Fan, Jing Li, Yingchi Zhang, Juan Kang, Di Wang , et al. · 2024

Personalized Federated Learning for Household Electricity Load Prediction with Imbalanced Historical Data Open

Shibo Zhu, Xiaodan Shi, Huan Zhao, Yuntian Chen, Haoran Zhang , et al. · 2024

Genome-Wide Identification and Expression Profiling of B3 Transcription Factor Genes in Prunus armeniaca Open

Xiaodan Shi, Wanwen Yu, Lin Wang, Han Zhao, Jingjing Hu , et al. · 2023

The B3 superfamily, which belongs to the plant-specific transcription factors, is widely involved in multiple biological processes. In apricot (Prunus armeniaca), the classification, structure, and function of the B3 superfamily are not ye…

Assessing the in vivo ameliorative effects of Lactobacillus acidophilus KLDS1.0901 for induced non-alcoholic fatty liver disease treatment Open

Yanbo Wang, Zengbo Wang, Yang Wan, Furong Jin, Xiaodan Shi , et al. · 2023

Reputed as a significant metabolic disorder, non-alcoholic fatty liver disease (NAFLD) is characterized by high-fat deposits in the liver and causes substantial economic challenges to any country's workforce. Previous studies have indicate…

Multivariate Time Series Prediction for Co2 Concentration and Flue Gas Flowrate from Biomass-Fired Power Plant Open

Shiyuan Pan, Xiaodan Shi, Beibei Dong, Jan Škvařil, Haoran Zhang , et al. · 2023

Vesicular stomatitis virus-based vaccine targeting plasmodium blood-stage antigens elicits immune response and protects against malaria with protein booster strategy Open

Yifan Sun, Xiaodan Shi, Feng Lu, Haitian Fu, Yi Hui Yin , et al. · 2022

Merozoite invasion of the erythrocytes in humans is a key step in the pathogenesis of malaria. The proteins involved in the merozoite invasion could be potential targets for the development of malaria vaccines. Novel viral-vector-based mal…

Triclosan has a strong influence on the development of mouse preimplantation embryo via activating miR-134/Nanog axis Open

Ye Yang, Danyu Ni, Li Wang, Xiaodan Shi, Xiaolan Zhang , et al. · 2022

Antimicrobial triclosan (TCS), one of the popular ingredients added to sanitizing products, has widespread use in personal care. However, it poses potential risks to reproduction and development. Unfortunately, the underlying mechanisms re…

Nutritional Components, Biochemical Characteristics, Enzyme Activities, and Growth Differences of Five Freshwater Fish Species? Open

Xiaona Jiang, Yan Li, Jingwen Tian, Chitao Li, Yanlong Ge , et al. · 2022

Common carp (Cyprinus carpio) is an economically important fish worldwide, with many of its species bred for consumption. However, there are few reports on the comprehensive comparative analysis of the muscle nutritional quality and stress…

Gut microbiome changes in anti-N-methyl-D-aspartate receptor encephalitis patients Open

Wei Jingya, Xiao Zhang, Fang Yang, Xiaodan Shi, Xuan Wang , et al. · 2022

Background Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a type of autoimmune encephalitis. The underlying mechanism(s) remain largely unknown. Recent evidence has indicated that the gut microbiome may be involved in neurologi…

Spatial distribution and network morphology of epicardial, endocardial, interstitial, and Purkinje cell-associated elastin fibers in porcine left ventricle Open

Xiaodan Shi, Song Zhang, Yue Liu, Bryn Brazile, A. James Cooley , et al. · 2022

Cardiac extracellular matrices (ECM) play crucial functional roles in cardiac biomechanics. Previous studies have mainly focused on collagen, the major structural ECM in heart wall. The role of elastin in cardiac mechanics, however, is poo…

BMI1 governs the maintenance of mouse GC-2 cells through epigenetic repression of <i>Foxl1</i> transcription. Open

Bo Zheng, Juanjuan Liu, Xiaodan Shi, Jin‐Fu Xu, Ke Zhang , et al. · 2022

Collectively, our study revealed for the first time the existence of an epigenetic mechanism involving BMI1-mediated gene silencing in GC-2 cells development and provided potential targets for the treatment of male infertility.

Essential thrombocythemia with CALR mutation and recurrent stroke: two case reports and literature review Open

Rong Chen, Xiaodan Shi, Luojun Wang, Xuan Wang, Wei Jingya , et al. · 2022

Cerebrovascular events, especially ischemic stroke, are common complications of essential thrombocythemia (ET). Compared to JAK2V617 F mutation, CALR mutation is considered as a lower risk factor of thrombosis in ET. Until now stroke in ET…

Ameliorating effects and mechanisms of transcutaneous auricular vagal nerve stimulation on abdominal pain and constipation Open

Xiaodan Shi, Yedong Hu, Bo Zhang, Wenna Li, Jiande DZ Chen , et al. · 2021

BackgroundAbdominal pain and constipation are 2 main symptoms in patients with constipation-predominant irritable bowel syndrome (IBS-C). This study aimed to investigate the effects and possible mechanisms of transcutaneous auricular vagal…

Ipriflavone Suppresses Growth of Esophageal Squamous Cell Carcinoma Through Inhibiting mTOR In Vitro and In Vivo Open

Xiaodan Shi, Yuanyuan Zhang, Xiaomeng Xie, Mengjun Pang, Kyle Vaughn Laster , et al. · 2021

Ipriflavone, a synthetic isoflavone that inhibits osteoclastic bone resorption, has been used clinically for the treatment of osteoporosis. However, the anticancer activity of Ipriflavone and its molecular mechanisms in the context of esop…

Eef2k is not required for fertility in male mice Open

Tianhao Feng, Shushu Zhou, Xiaodan Shi, Xin Zhang, Jintao Zhang , et al. · 2021

Male Eef2k-knockout mice remained fertile and were free of any evident developmental or spermatogenic abnormalities, suggesting Eef2k to be dispensable in the context of male fertility.

Clinical application of an NGS-based method in the preimplantation genetic testing for Duchenne muscular dystrophy Open

Yixin Ren, Ying Lian, Zhiqiang Yan, Fan Zhai, Ming Yang , et al. · 2021

Anwulignan is a novel JAK1 inhibitor that suppresses non‐small cell lung cancer growth Open

Xiaomeng Xie, Xiangyu Wang, Xiaodan Shi, Yuanyuan Zhang, Kyle Vaughn Laster , et al. · 2021

Anwulignan is a monomer compound derived from Schisandra sphenanthera lignans. It has been reported to possess a spectrum of pharmacological activities, including anti‐bacterial, anti‐inflammatory, anticancer and hepatoprotective propertie…

Cerebrospinal fluids from healthy pregnant women does not harbor a detectable microbial community Open

Yongyong Kang, Xinchao Ji, Li Guo, Han Xia, Xiaofei Yang , et al. · 2020

Cerebrospinal fluids circulating human central nervous system have long been considered aseptic in healthy individuals, because normally the blood-brain barrier protects against microbial invasions. However, this dogma has been questioned …

Maternal factor PABPN1L is essential for maternal mRNA degradation during maternal-to-zygotic transition Open

Ying Wang, Tianhao Feng, Xiaodan Shi, Siyu Liu, Zerui Wang , et al. · 2020

Infertility affects 10% - 15% of families worldwide. However, the pathogenesis of female infertility caused by abnormal early embryonic development is not clear. We constructed a mouse model (Pabpn1l -/-) simulating the splicing abnormalit…

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