Xiao-Dan Yao
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View article: Assessing programming education needs of primary and secondary teachers in Guangxi border areas
Assessing programming education needs of primary and secondary teachers in Guangxi border areas Open
The development of artificial intelligence (AI) education shows shortcomings in China's border areas. To bridge the gap in programming education between border and developed regions, enhancing the programming instructional capacity of prim…
View article: Expression profiling of human milk derived exosomal microRNAs and their targets in HIV-1 infected mothers
Expression profiling of human milk derived exosomal microRNAs and their targets in HIV-1 infected mothers Open
Despite the use of antiretroviral therapy (ART) in HIV-1 infected mothers approximately 5% of new HIV-1 infections still occur in breastfed infants annually, which warrants for the development of novel strategies to prevent new HIV-1 infec…
View article: TLR10 Senses HIV-1 Proteins and Significantly Enhances HIV-1 Infection
TLR10 Senses HIV-1 Proteins and Significantly Enhances HIV-1 Infection Open
Toll-like receptors (TLRs) play a crucial role in innate immunity and provide a first line of host defense against invading pathogens. Of the identified human TLRs, TLR10 remains an orphan receptor whose ligands and functions are poorly un…
View article: Breastfeeding Behaviors and the Innate Immune System of Human Milk: Working Together to Protect Infants against Inflammation, HIV-1, and Other Infections
Breastfeeding Behaviors and the Innate Immune System of Human Milk: Working Together to Protect Infants against Inflammation, HIV-1, and Other Infections Open
The majority of infants' breastfeeding from their HIV-infected mothers do not acquire HIV-1 infection despite exposure to cell-free virus and cell-associated virus in HIV-infected breast milk. Paradoxically, exclusive breastfeeding regardl…
View article: Afri-Can Forum 2
Afri-Can Forum 2 Open
CITATION: Mukudu, H., et al. 2016. Afri-Can Forum 2. BMC Infectious Diseases, 16:315, doi:10.1186/s12879-016-1466-6.
View article: sTLR2-mediated augmentation of pro-inflammatory cytokines during bacterial lipoprotein exposure.
sTLR2-mediated augmentation of pro-inflammatory cytokines during bacterial lipoprotein exposure. Open
(A) Immunodepletion of ∼38 kDa sTLR2 in breast milk (BM) described in materials and methods. Quantitative analysis using TLR2 ELISA indicated a significant (P<0.05) decrease in sTLR2-depleted (sTLR2-D) compared to mock-D breast milk (BM). …
View article: HIV-1 Structural Proteins Serve as PAMPs for TLR2 Heterodimers Significantly Increasing Infection and Innate Immune Activation
HIV-1 Structural Proteins Serve as PAMPs for TLR2 Heterodimers Significantly Increasing Infection and Innate Immune Activation Open
Immune activation is critical to HIV infection and pathogenesis; however, our understanding of HIV innate immune activation remains incomplete. Recently we demonstrated that soluble TLR2 (sTLR2) physically inhibited HIV-induced NFκB activa…