Xiaodi Yu
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View article: Structural insights into MERS and SARS coronavirus membrane proteins
Structural insights into MERS and SARS coronavirus membrane proteins Open
The membrane (M) protein of coronaviruses is essential for maintaining structural integrity during membrane virion budding and viral pathogenesis. Given its high conservation in lineages within the betacoronavirus genus, such as sarbecovir…
View article: Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase
Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase Open
Respiratory syncytial virus (RSV) is a major cause of severe respiratory tract infections in infants, young children, and the elderly. We report herein the discovery and characterization of a novel RSV polymerase (RSVpol) non-nucleoside in…
View article: Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome
Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome Open
View article: A foldon-free prefusion F trimer vaccine for respiratory syncytial virus to reduce off-target immune responses
A foldon-free prefusion F trimer vaccine for respiratory syncytial virus to reduce off-target immune responses Open
View article: Engineering a cleaved, prefusion-stabilized influenza B virus hemagglutinin by identification and locking of all six pH switches
Engineering a cleaved, prefusion-stabilized influenza B virus hemagglutinin by identification and locking of all six pH switches Open
Vaccine components based on viral fusion proteins require high stability of the native prefusion conformation for optimal potency and manufacturability. In the case of influenza B virus hemagglutinin (HA), the stem's conformation relies on…
View article: Synthesis of Ultrahigh Molecular Weight Poly (Trifluoroethyl Methacrylate) Initiated by the Combination of Palladium Nanoparticles with Organic Halides
Synthesis of Ultrahigh Molecular Weight Poly (Trifluoroethyl Methacrylate) Initiated by the Combination of Palladium Nanoparticles with Organic Halides Open
Ultrahigh molecular weight polymers display outstanding properties and have great application potential. However, the traditional polymerization methods have inevitable disadvantages that challenge the green synthesis of ultrahigh molecula…
View article: Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimer
Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimer Open
The prefusion conformation of human metapneumovirus fusion protein (hMPV Pre-F) is critical for eliciting the most potent neutralizing antibodies and is the preferred immunogen for an efficacious vaccine against hMPV respiratory infections…
View article: Structural basis for the oligomerization-facilitated NLRP3 activation
Structural basis for the oligomerization-facilitated NLRP3 activation Open
The NACHT-, leucine-rich-repeat-, and pyrin domain-containing protein 3 (NLRP3) is a critical intracellular inflammasome sensor and an important clinical target against inflammation-driven human diseases. Recent studies have elucidated its…
View article: Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing
Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing Open
View article: Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor
Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor Open
View article: Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike
Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike Open
The global spread of the SARS-CoV-2 virus has resulted in emergence of lineages which impact the effectiveness of immunotherapies and vaccines that are based on the early Wuhan isolate. All currently approved vaccines employ the spike prot…
View article: Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer
Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer Open
Malic enzymes (ME1, ME2, and ME3) are involved in cellular energy regulation, redox homeostasis, and biosynthetic processes, through the production of pyruvate and reducing agent NAD(P)H. Recent studies have implicated the third and least …
View article: Simple non-fused ring electron acceptors with well-controlled terminal group stacking
Simple non-fused ring electron acceptors with well-controlled terminal group stacking Open
Producing high-performance and inexpensive non-fullerene acceptors is a great challenge in the field of organic photovoltaics. Herein, three non-fused ring electron acceptors (NFREAs), TT-O-2F, TT-S-2F, and TT-Se-2F, have been designed and…
View article: Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike
Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike Open
The SARS-CoV-2 spike protein is the target of neutralizing antibodies and the immunogen used in all currently approved vaccines. The global spread of the virus has resulted in emergence of lineages which are of concern for the effectivenes…
View article: Refined Capsid Structure of Human Adenovirus D26 at 3.4 Å Resolution
Refined Capsid Structure of Human Adenovirus D26 at 3.4 Å Resolution Open
Various adenoviruses are being used as viral vectors for the generation of vaccines against chronic and emerging diseases (e.g., AIDS, COVID-19). Here, we report the improved capsid structure for one of these vectors, human adenovirus D26 …
View article: Integrative Structural and Functional Analysis of Human Malic Enzyme 3
Integrative Structural and Functional Analysis of Human Malic Enzyme 3 Open
View article: Simple High-Performance Nonfused Ring Electron Acceptors With Well-Controlled Terminal Group Stacking
Simple High-Performance Nonfused Ring Electron Acceptors With Well-Controlled Terminal Group Stacking Open
View article: Structure of a Cell Entry Defective Human Adenovirus Provides Insights into Precursor Proteins and Capsid Maturation
Structure of a Cell Entry Defective Human Adenovirus Provides Insights into Precursor Proteins and Capsid Maturation Open
View article: Uniform Distribution of Pd on GO-C Catalysts for Enhancing the Performance of Air Cathode Microbial Fuel Cell
Uniform Distribution of Pd on GO-C Catalysts for Enhancing the Performance of Air Cathode Microbial Fuel Cell Open
Metal, as a high-performance electrode catalyst, is a research hotspot in the construction of a high-performance microbial fuel cell (MFC). However, metal catalyst nanoparticles and their dispersed carriers are prone to aggregation, produc…
View article: Cryo-EM model validation recommendations based on outcomes of the 2019 EMDataResource challenge
Cryo-EM model validation recommendations based on outcomes of the 2019 EMDataResource challenge Open
This paper describes outcomes of the 2019 Cryo-EM Model Challenge. The goals were to (1) assess the quality of models that can be produced from cryogenic electron microscopy (cryo-EM) maps using current modeling software, (2) evaluate repr…
View article: 2019 EMDataResource Model Metrics Challenge Dataset
2019 EMDataResource Model Metrics Challenge Dataset Open
This is the full dataset of the 2019 Cryo-EM Map-based Model Metrics Challenge sponsored by EMDataResource (www.emdataresource.org, challenges.emdataresource.org, model-compare.emdataresource.org). The goals of this challenge were (1) to a…
View article: 2019 EMDataResource Model Metrics Challenge Dataset
2019 EMDataResource Model Metrics Challenge Dataset Open
This is the full dataset of the 2019 Cryo-EM Map-based Model Metrics Challenge sponsored by EMDataResource (www.emdataresource.org, challenges.emdataresource.org, model-compare.emdataresource.org). The goals of this challenge were (1) to a…
View article: Outcomes of the 2019 EMDataResource model challenge: validation of cryo-EM models at near-atomic resolution
Outcomes of the 2019 EMDataResource model challenge: validation of cryo-EM models at near-atomic resolution Open
This paper describes outcomes of the 2019 Cryo-EM Map-based Model Metrics Challenge sponsored by EMDataResource ( www.emdataresource.org ). The goals of this challenge were (1) to assess the quality of models that can be produced using cur…
View article: Localization for autonomous construction vehicles using monocular camera and AprilTag
Localization for autonomous construction vehicles using monocular camera and AprilTag Open
Global Navigation Satellite System (GNSS) is commonly used to provide thelocation to navigate the vehicles in outdoor environment. However, GNSS is unreliablein some complex environment such as an open-pit mining environment.Although local…
View article: Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation
Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation Open
Alanine-serine-cysteine transporter 2 (ASCT2, SLC1A5) is the primary transporter of glutamine in cancer cells and regulates the mTORC1 signaling pathway. The SLC1A5 function involves finely tuned orchestration of two domain movements that …
View article: Author response: Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation
Author response: Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Alanine-serine-cysteine transporter 2 (ASC…
View article: Lovastatin attenuates hypertension induced by renal tubule‐specific knockout of ATP‐binding cassette transporter A1, by inhibiting epithelial sodium channels
Lovastatin attenuates hypertension induced by renal tubule‐specific knockout of ATP‐binding cassette transporter A1, by inhibiting epithelial sodium channels Open
Background and Purpose We have shown that cholesterol is synthesized in the principal cells of renal cortical collecting ducts (CCD) and stimulates the epithelial sodium channels (ENaC). Here we have determined whether lovastatin, a choles…
View article: Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism
Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism Open
View article: Structural basis for the transport mechanism of the human glutamine transporter SLC1A5 (ASCT2)
Structural basis for the transport mechanism of the human glutamine transporter SLC1A5 (ASCT2) Open
Alanine-serine-cysteine transporter 2 (ASCT2, SLC1A5) is the primary transporter of glutamine in cancer cells and regulates the mTORC1 signaling pathway. The SLC1A5 function involves finely tuned orchestration of two domain movements that …
View article: Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1
Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1 Open