Xiaodong Fang
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View article: Long-read genome sequencing provides novel insights into the harmful algal bloom species Prymnesium parvum
Long-read genome sequencing provides novel insights into the harmful algal bloom species Prymnesium parvum Open
View article: Dissimilar ultrasonic spot welding of AA6016 alloy-to-DP800 steel: The role of a novel AlSi(Fe) PVD coating
Dissimilar ultrasonic spot welding of AA6016 alloy-to-DP800 steel: The role of a novel AlSi(Fe) PVD coating Open
View article: Genomes of 211 Actinomycete Strains from Diverse Environments
Genomes of 211 Actinomycete Strains from Diverse Environments Open
Actinomycetes are a highly diverse group of microorganisms that have long been recognized as a valuable source of antibiotics and other bioactive metabolites. Recent advances in genome mining have revealed a wealth of previously unexplored…
View article: Single-cell RNA sequencing dataset of hearts from wild type and Cyp26b1 knockout mouse embryos
Single-cell RNA sequencing dataset of hearts from wild type and Cyp26b1 knockout mouse embryos Open
View article: Multi-kingdom microbiota analysis reveals bacteria-viral interplay in IBS with depression and anxiety
Multi-kingdom microbiota analysis reveals bacteria-viral interplay in IBS with depression and anxiety Open
Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder frequently accompanied by psychological symptoms. Bacterial microbiota plays a critical role in mediating local and systemic immunity, and alterations in these microbial …
View article: Advances in Cathode’s Microstructure Modification to Boost Performance of Lithium-Sulfur Batteries
Advances in Cathode’s Microstructure Modification to Boost Performance of Lithium-Sulfur Batteries Open
View article: Digital reconstruction of full embryos during early mouse organogenesis
Digital reconstruction of full embryos during early mouse organogenesis Open
Early organogenesis is a crucial stage in embryonic development, characterized by extensive cell fate specification to initiate organ formation but also by a high susceptibility to developmental defects. Here, we profiled 285 serial sectio…
View article: In vivo investigation of STN1 downregulation in melanoma formation in adult mice following UV irradiation
In vivo investigation of STN1 downregulation in melanoma formation in adult mice following UV irradiation Open
Genome instability is a major force driving tumorigenesis. The ssDNA-binding protein complex CTC1-STN1-TEN1 (CST) plays a pivotal role in maintaining genome stability by countering replication stress, modulating DNA damage repair, and main…
View article: Combination of epirubicin and cyclophosphamide for the treatment of advanced pulmonary sarcomatoid carcinoma: A case report and literature review
Combination of epirubicin and cyclophosphamide for the treatment of advanced pulmonary sarcomatoid carcinoma: A case report and literature review Open
Pulmonary sarcomatoid carcinoma (PSC) is a rare and atypical subset of non-small-cell lung cancer (NSCLC) characterized by its aggressive nature, poor prognosis, and limited responsiveness to conventional therapeutic modalities. The effect…
View article: Numerical simulation and control of early‐age cracking in a concrete cap beam: Considering high‐strength concrete and constraint of formwork
Numerical simulation and control of early‐age cracking in a concrete cap beam: Considering high‐strength concrete and constraint of formwork Open
Bridge cap beams, which are crucial components that connect girders and piers, are also prone to early‐age cracking despite the relatively small volume. This paper presents a thermo‐mechanical simulation of the construction process of a ca…
View article: Multimodal prediction of major adverse cardiovascular events in hypertensive patients with coronary artery disease: integrating pericoronary fat radiomics, CT-FFR, and clinicoradiological features
Multimodal prediction of major adverse cardiovascular events in hypertensive patients with coronary artery disease: integrating pericoronary fat radiomics, CT-FFR, and clinicoradiological features Open
View article: Cross-species comparison of single-cell landscapes reveals conservation and innovation in chicken immune systems
Cross-species comparison of single-cell landscapes reveals conservation and innovation in chicken immune systems Open
Molecular characterization of chicken cells is essential for understanding avian physiology and vertebrate evolution, yet an organism-wide single-cell atlas in chicken is still lacking. Here we describe a comprehensive reference atlas of t…
View article: Advances in gut microbiota-related treatment strategies for managing colorectal cancer in humans
Advances in gut microbiota-related treatment strategies for managing colorectal cancer in humans Open
Colorectal cancer (CRC) is a major contributor to global cancer-related mortality with increasing incidence rates in both developed and developing regions. Therefore, CRC presents a significant challenge to global health. The development o…
View article: Integrative single-cell and spatial transcriptome analysis reveals heterogeneity of human liver progenitor cells
Integrative single-cell and spatial transcriptome analysis reveals heterogeneity of human liver progenitor cells Open
Background: Liver progenitor cells (LPCs) with bipotential differentiation capacities are essential for restoring liver homeostasis and hepatocyte population after damage. However, the low proportion and shared markers with epithelial cell…
View article: Rapid Analysis of Heavy Metal Element Adsorption by SCG Based on LIBS Technology
Rapid Analysis of Heavy Metal Element Adsorption by SCG Based on LIBS Technology Open
Rapid evaluation and real-time detection of adsorption materials are particularly critical in the adsorption treatment of heavy metal wastewater. However, most elemental analysis methods have complex pretreatment procedures and are time-co…
View article: BioLLM: A Standardized Framework for Integrating and Benchmarking Single-Cell Foundation Models
BioLLM: A Standardized Framework for Integrating and Benchmarking Single-Cell Foundation Models Open
The application and evaluation of single cell foundational models (scFMs) present significant challenges stemming from the heterogeneity of architectural frameworks and coding standards. To address these issues, we introduce BioLLM, a fram…
View article: Keep it accurate and robust: An enhanced nuclei analysis framework
Keep it accurate and robust: An enhanced nuclei analysis framework Open
Accurate segmentation and classification of nuclei in histology images is critical but challenging due to nuclei heterogeneity, staining variations, and tissue complexity. Existing methods often struggle with limited dataset variability, w…
View article: Comparison of single-cell landscapes among three amniotes reveals conservation and innovation in avian immune systems
Comparison of single-cell landscapes among three amniotes reveals conservation and innovation in avian immune systems Open
Molecular characterization of chicken cells is essential for understanding avian physiology and vertebrate evolution, yet an organism-wide single-cell atlas in chicken is still lacking. Here we describe a comprehensive reference atlas of t…
View article: Achieving superior aluminum-steel dissimilar joining via ultrasonic spot welding: Microstructure and fracture behavior
Achieving superior aluminum-steel dissimilar joining via ultrasonic spot welding: Microstructure and fracture behavior Open
View article: A high-quality genome of the early diverging tychoplanktonic diatom Paralia guyana
A high-quality genome of the early diverging tychoplanktonic diatom Paralia guyana Open
The diatom Paralia guyana is a tychoplanktonic microalgal species that represents one of the early diverging diatoms. P. guyana can thrive in both planktonic and benthic habitats, making a significant contribution to the occurrence of red …
View article: The increased tendency for anemia in traditional Chinese medicine deficient body constitution is associated with the gut microbiome
The increased tendency for anemia in traditional Chinese medicine deficient body constitution is associated with the gut microbiome Open
Background Constitution is a valuable part of traditional Chinese medicine theory; it is defined as the internal foundation for the occurrence, development, transformation and outcome of diseases, and has its characteristic gut microbiota.…
View article: Beneficial effects of dietary herbs on high-fat diet-induced obesity linking with modulation of gut microbiota
Beneficial effects of dietary herbs on high-fat diet-induced obesity linking with modulation of gut microbiota Open
Obesity, a pervasive global public health challenge, impacts human well-being, and there is a growing interest in the potential of herbs for their anti-obesity effects. However, the specific herbs that possess these properties are not well…
View article: Baseline and early dynamic changes in inflammatory and nutritional status can predict survival in patients with advanced biliary tract carcinoma receiving immunotherapy: A retrospective cohort study
Baseline and early dynamic changes in inflammatory and nutritional status can predict survival in patients with advanced biliary tract carcinoma receiving immunotherapy: A retrospective cohort study Open
Background Inflammatory and nutritional indicators are established prognostic factors in patients with various types of solid tumors. However, it remains unclear whether differences in the baseline and early dynamic changes in these factor…
View article: Publisher Correction: Exploring high-quality microbial genomes by assembling short-reads with long-range connectivity
Publisher Correction: Exploring high-quality microbial genomes by assembling short-reads with long-range connectivity Open
View article: Two high-quality <i>Prototheca zopfii</i> genomes provide new insights into their evolution as obligate algal heterotrophs and their pathogenicity
Two high-quality <i>Prototheca zopfii</i> genomes provide new insights into their evolution as obligate algal heterotrophs and their pathogenicity Open
The majority of the nearly 10,000 described species of green algae are photoautotrophs; however, some species have lost their ability to photosynthesize and become obligate heterotrophs that rely on parasitism for survival. Two high-qualit…
View article: Exploring high-quality microbial genomes by assembling short-reads with long-range connectivity
Exploring high-quality microbial genomes by assembling short-reads with long-range connectivity Open
Although long-read sequencing enables the generation of complete genomes for unculturable microbes, its high cost limits the widespread adoption of long-read sequencing in large-scale metagenomic studies. An alternative method is to assemb…
View article: Whole exome sequencing identified a homozygous novel variant in DOP1A gene in the Pakistan family with neurodevelopmental disabilities: case report and literature review
Whole exome sequencing identified a homozygous novel variant in DOP1A gene in the Pakistan family with neurodevelopmental disabilities: case report and literature review Open
Background Hereditary neurodevelopmental disorders (NDDs) are prevalent in poorly prognostic pediatric diseases, but the pathogenesis of NDDs is still unclear. Irregular myelination could be one of the possible causes of NDDs. Case present…
View article: VCF2PCACluster: a simple, fast and memory-efficient tool for principal component analysis of tens of millions of SNPs
VCF2PCACluster: a simple, fast and memory-efficient tool for principal component analysis of tens of millions of SNPs Open
View article: Design and Synthesis of Novel Structures with Anti-Tumor Effects: Targeting Telomere G-Quadruplex and hTERT
Design and Synthesis of Novel Structures with Anti-Tumor Effects: Targeting Telomere G-Quadruplex and hTERT Open
View article: A Pathomics-Based Deep Learning Model for Predicting Oral Squamous Cell Carcinoma Prognosis
A Pathomics-Based Deep Learning Model for Predicting Oral Squamous Cell Carcinoma Prognosis Open