Xiaofei Guo
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View article: Docosahexaenoic Acid Ameliorates Mild Cognitive Impairment Mediated by Cannabinoid Receptor 1-Ceramide Axis
Docosahexaenoic Acid Ameliorates Mild Cognitive Impairment Mediated by Cannabinoid Receptor 1-Ceramide Axis Open
View article: Arbuscular Mycorrhizal Fungi Promote Soil Respiration Primarily Through Mediating Microbial and Root Biomass in Rocky Desertification Habitat
Arbuscular Mycorrhizal Fungi Promote Soil Respiration Primarily Through Mediating Microbial and Root Biomass in Rocky Desertification Habitat Open
Arbuscular mycorrhizal (AM) fungi can have complicated interactions with plants and soils, which play a critical role in mediating the soil carbon cycle. However, the mechanism by which AM fungi regulate soil respiration is not well docume…
View article: Acupoint Catgut Embedding at Stellate Ganglion Combined with Oral Mecobalamin Versus Mecobalamin Monotherapy in Managing Taxane-Induced Peripheral Neurotoxicity: A Clinical Observational Study
Acupoint Catgut Embedding at Stellate Ganglion Combined with Oral Mecobalamin Versus Mecobalamin Monotherapy in Managing Taxane-Induced Peripheral Neurotoxicity: A Clinical Observational Study Open
SGCE group produced a more pronounced improvement in symptoms among TIPN patients compared to MeCbl group, enhanced the quality of life of the patients compared with the pre-treatment period, this improvement could be linked to SGCE. Moreo…
View article: Combined multi-omics analysis revealed the aroma characteristics and the formation mechanism in different grape varieties
Combined multi-omics analysis revealed the aroma characteristics and the formation mechanism in different grape varieties Open
Grape flavor is greatly affected by cultivar characteristics, resulting in obvious differences in smell and taste. In this study, SPME-GC/MS (solid-phase microextraction - gas chromatography-mass spectrometry) and RNA-Seq (RNA sequencing) …
View article: Molecular elucidation of the identification of novel saltiness‐enhancing peptides and taste mechanism from soybean protein isolate based on transmembrane channel‐like 4 (<scp>TMC4</scp>)
Molecular elucidation of the identification of novel saltiness‐enhancing peptides and taste mechanism from soybean protein isolate based on transmembrane channel‐like 4 (<span>TMC4</span>) Open
BACKGROUND Saltiness‐enhancing peptides serve as excellent natural substitutes for salt, offering advantages such as safety, widespread availability and low taste thresholds. In the present study, we rapidly screened potential saltiness‐en…
View article: Coffee peel polyphenols ameliorate nonalcoholic fatty liver disease by modulating cannabinoid receptor type‐1‐ceramide axis
Coffee peel polyphenols ameliorate nonalcoholic fatty liver disease by modulating cannabinoid receptor type‐1‐ceramide axis Open
Cannabinoid receptor type‐1 (CB1) signaling plays an important part in maintenance of energy homeostasis, and CB1 blockers have shown promise in the treatment of obesity‐related metabolic dysfunction. Coffee peel contains abundant phytoche…
View article: Identification of diagnostic biomarkers of and immune cell infiltration analysis in bovine respiratory disease
Identification of diagnostic biomarkers of and immune cell infiltration analysis in bovine respiratory disease Open
Background Bovine respiratory disease (BRD) is a prevalent and costly condition in the cattle industry, impacting long-term productivity, antibioticusage, and global food safety. Thus, identifying reliable biomarkers for BRD is crucial for…
View article: Targeting Zfp36 to combat cardiac hypertrophy: Insights into ferroptosis pathways
Targeting Zfp36 to combat cardiac hypertrophy: Insights into ferroptosis pathways Open
Background Cardiac hypertrophy is a precursor to heart failure and represents a significant global cause of mortality, thereby necessitating timely and effective therapeutic interventions. Zinc finger protein 36 (Zfp36) is recognised as a …
View article: Artificial Intelligence‐Guided Identification of <scp>IGFBP7</scp> as a Critical Indicator in Lactic Metabolism Determines Immunotherapy Response in Stomach Adenocarcinoma
Artificial Intelligence‐Guided Identification of <span>IGFBP7</span> as a Critical Indicator in Lactic Metabolism Determines Immunotherapy Response in Stomach Adenocarcinoma Open
Due to considerable tumour heterogeneity, stomach adenocarcinoma (STAD) has a poor prognosis and varies in response to treatment, making it one of the main causes of cancer‐related mortality globally. Recent data point to a significant rol…
View article: Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged and elderly population
Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged and elderly population Open
Aims This meta-analysis and systematic review aimed to comprehensively investigate the effects of vitamin K supplementation on bone mineral density (BMD) at various sites and bone metabolism in middle-aged and older adults. Methods The dat…
View article: A MSTNDel73C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia
A MSTNDel73C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia Open
Mutations in the well-known Myostatin ( MSTN ) produce a ‘double-muscle’ phenotype, which makes it commercially invaluable for improving livestock meat production and providing high-quality protein for humans. However, mutations at differe…
View article: Author response: A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia
Author response: A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia Open
Mutations in the well-known Myostatin (MSTN) produce a "double-muscle" phenotype, which makes it commercially invaluable for improving livestock meat production and providing high-quality protein for humans. However, mutations at different…
View article: A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia
A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia Open
Mutations in the well-known Myostatin (MSTN) produce a “double-muscle” phenotype, which makes it commercially invaluable for improving livestock meat production and providing high-quality protein for humans. However, mutations at different…
View article: Liver injury due to endothelin receptor antagonists: a real-world study based on post-marketing drug monitoring data
Liver injury due to endothelin receptor antagonists: a real-world study based on post-marketing drug monitoring data Open
Background: Liver injury is the hallmark adverse reaction of endothelin receptor antagonist (ERA). Since the first drug, bosentan has been widely used in clinical practice, hepatotoxicity has been accompanied by the history of ERA. The new…
View article: The Changes, Aggregation Processes, and Driving Factors for Soil Fungal Communities during Tropical Forest Restoration
The Changes, Aggregation Processes, and Driving Factors for Soil Fungal Communities during Tropical Forest Restoration Open
Soil fungal communities play crucial roles in mediating the functional associations between above- and belowground components during forest restoration. Forest restoration shapes the alterations in plant and soil environments, which exerts…
View article: Comment on ‘The role of aspirin versus low-molecular-weight heparin for venous thromboembolism prophylaxis after total knee arthroplasty: a meta-analysis of randomized controlled trials’
Comment on ‘The role of aspirin versus low-molecular-weight heparin for venous thromboembolism prophylaxis after total knee arthroplasty: a meta-analysis of randomized controlled trials’ Open
aPediatric orthopedics department, the Sixth Affiliated Hospital of Xinjiang Medical University, 830002, Xinjiang, China bBlood Transfusion Department, the Sixth Affiliated Hospital of Xinjiang Medical University, 830002, Xinjiang, China c…
View article: Epigenetic regulation of programmed cell death in hypoxia-induced pulmonary arterial hypertension
Epigenetic regulation of programmed cell death in hypoxia-induced pulmonary arterial hypertension Open
Pulmonary arterial hypertension (PAH) is a severe progressive disease that may cause early right ventricular failure and eventual cardiac failure. The pathogenesis of PAH involves endothelial dysfunction, aberrant proliferation of pulmonar…
View article: A MSTNDel73C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia
A MSTNDel73C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia Open
Mutations in the well-known Myostatin ( MSTN ) produce a ‘double-muscle’ phenotype, which makes it commercially invaluable for improving livestock meat production and providing high-quality protein for humans. However, mutations at differe…
View article: The Effects of n-3 PUFA Supplementation on Bone Metabolism Markers and Body Bone Mineral Density in Adults: A Systematic Review and Meta-Analysis of RCTs
The Effects of n-3 PUFA Supplementation on Bone Metabolism Markers and Body Bone Mineral Density in Adults: A Systematic Review and Meta-Analysis of RCTs Open
Supplemental n-3 polyunsaturated fatty acids (PUFA) on bone metabolism have yielded inconsistent results. This study aimed to examine the effects of n-3 PUFA supplementation on bone metabolism markers and bone mineral density through a met…
View article: Effect of Lard or Plus Soybean Oil on Markers of Liver Function in Healthy Subjects: A Randomized Controlled-Feeding Trial
Effect of Lard or Plus Soybean Oil on Markers of Liver Function in Healthy Subjects: A Randomized Controlled-Feeding Trial Open
Humans have consumed lard for thousands of years, but in recent decades, it has become much less popular because it is regarded as saturated fat. Animal studies showed that lard plus soybean oil (blend oil) was more advantageous for liver …
View article: Higher intakes of lysine, threonine and valine are inversely associated with non-alcoholic fatty liver disease risk: a community-based case-control study in the Chinese elderly
Higher intakes of lysine, threonine and valine are inversely associated with non-alcoholic fatty liver disease risk: a community-based case-control study in the Chinese elderly Open
The associations of individual amino acid with non-alcoholic fatty liver disease (NAFLD) risk remained unclear. The present study aimed to investigate the associations between the two in the Chinese elderly. Methods: A community-based heal…
View article: A <i>MSTN</i> <sup>Del273C</sup> mutation with <i>FGF5</i> knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia
A <i>MSTN</i> <sup>Del273C</sup> mutation with <i>FGF5</i> knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia Open
Mutations in the well-known Myostatin ( MSTN ) produce a “double-muscle” phenotype, which makes it commercially invaluable for improving livestock meat production and providing high-quality protein for humans. However, mutations at differe…
View article: Association between postterm pregnancy and adverse growth outcomes in preschool-age children
Association between postterm pregnancy and adverse growth outcomes in preschool-age children Open
View article: Analysis of the effect of NEKs on the prognosis of patients with non-small-cell lung carcinoma based on bioinformatics
Analysis of the effect of NEKs on the prognosis of patients with non-small-cell lung carcinoma based on bioinformatics Open
View article: Dietary Alpha-Linolenic Acid Supports High Retinal DHA Levels
Dietary Alpha-Linolenic Acid Supports High Retinal DHA Levels Open
The retina requires docosahexaenoic acid (DHA) for optimal function. Alpha-linolenic acid (ALA) and DHA are dietary sources of retinal DHA. This research investigated optimizing retinal DHA using dietary ALA. Previous research identified 1…
View article: Effects of Supplementation of Moringa Oleifera Leaf Powder on Some Reproductive Performance in Laying Hens
Effects of Supplementation of Moringa Oleifera Leaf Powder on Some Reproductive Performance in Laying Hens Open
This study aimed to evaluate the effects of adding Moringa oleifera leaf powder (MOLP) to the basal diets of chickens at late laying period on clutch trait, reproductive organs, serum reproductive hormones and reproduction-related genes ex…
View article: Effects of whole grain intake on glycemic traits: A systematic review and meta-analysis of randomized controlled trials
Effects of whole grain intake on glycemic traits: A systematic review and meta-analysis of randomized controlled trials Open
Whole grains (WGs) may have various health benefits, including lowering blood glucose and improving insulin sensitivity. To conduct a meta-analysis of the effects of WGs compared with non-WGs on changes in fasting glucose, fasting insulin,…
View article: Prevalence of Chronic Diseases and Alterations of Gut Microbiome in People of Ningxia China During Urbanization: An Epidemiological Survey
Prevalence of Chronic Diseases and Alterations of Gut Microbiome in People of Ningxia China During Urbanization: An Epidemiological Survey Open
The continuous development of urbanization has dramatically changed people’s living environment and lifestyle, accompanied by the increased prevalence of chronic diseases. However, there is little research on the effect of urbanization on …
View article: DNAJC3-AS1 Is Associated with Proliferation, Metastasis, and Poor Prognosis of Breast Cancer
DNAJC3-AS1 Is Associated with Proliferation, Metastasis, and Poor Prognosis of Breast Cancer Open
Objective. Long noncoding RNA DNAJC3-AS1 (DNAJC3-AS1) was a newly identified tumor-related lncRNA. The aim of the present study was to explore the prognostic value and diagnostic of DNAJC3-AS1 (DNAJC3-AS1) expression in breast cancer (BC) …
View article: Analysis of the effect of NEKs on the prognosis of patients with Non-small-cell lung carcinoma based on bioinformatics
Analysis of the effect of NEKs on the prognosis of patients with Non-small-cell lung carcinoma based on bioinformatics Open
NEKs are proteins that are involved in various cell processes and play important roles in the formation and development of cancer. However, few studies have examined the role of NEKs in the development of non-small-cell lung carcinoma (NSC…