Xiaofeng Cong
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View article: Development and landscape of maintenance therapy after first-line treatment of advanced or metastatic urothelial carcinoma
Development and landscape of maintenance therapy after first-line treatment of advanced or metastatic urothelial carcinoma Open
Overall survival (OS) in patients with advanced or metastatic urothelial carcinoma (UC) is not optimistic. For a long time, the standard platinum-based chemotherapy has been one of the preferred treatment strategies. Despite the high initi…
View article: Changing landscape of first-line treatment for locally advanced or metastatic urothelial carcinoma: the progression from platinum-based chemotherapy to platinum-free therapy
Changing landscape of first-line treatment for locally advanced or metastatic urothelial carcinoma: the progression from platinum-based chemotherapy to platinum-free therapy Open
Urothelial carcinoma (UC) represents the most common pathological type of bladder cancer. For patients with locally advanced or metastatic UC (la/m UC), the standard of care with platinum-based chemotherapy as the cornerstone has greatly i…
View article: Updated overall survival data and predictive biomarkers of autologous NK cells plus Sintilimab as second-line treatment for advanced non-small cell lung cancer
Updated overall survival data and predictive biomarkers of autologous NK cells plus Sintilimab as second-line treatment for advanced non-small cell lung cancer Open
Purpose Combination strategies involving immune checkpoint inhibitors (ICIs) have been a prominent focus of research in the treatment of non-small cell lung cancer (NSCLC). Our prior findings demonstrated that the combination of autologous…
View article: Metastatic MiT family/TFE translocation renal cell carcinoma in adults: case series reports and literature reviews
Metastatic MiT family/TFE translocation renal cell carcinoma in adults: case series reports and literature reviews Open
This article presents a case study of three patients diagnosed with MiT/TFE tRCC at our hospital. The tumors were located in the left kidney of all three patients, with two of them being under 30 years old. Within a short timeframe, two of…
View article: Case report: Pancreatic metastasis from small-cell lung cancer appears as primary G2 pancreatic neuroendocrine tumor on combined contrast PET imaging with three probes
Case report: Pancreatic metastasis from small-cell lung cancer appears as primary G2 pancreatic neuroendocrine tumor on combined contrast PET imaging with three probes Open
Pancreatic metastasis is a rare malignant tumor; when it comes to multiple cancers, it may be a challenge to identify the primary lesion of new pancreatic metastases. With the continuous advancement of imaging technology, the PET/computed …
View article: Lorlatinib in the treatment of a rare pulmonary mucoepidermoid carcinoma with EML4-ALK fusion: a case report and literature review
Lorlatinib in the treatment of a rare pulmonary mucoepidermoid carcinoma with EML4-ALK fusion: a case report and literature review Open
Pulmonary mucoepidermoid carcinoma (PMEC) is a rare tumor with limited clinical data available due to its low incidence. So far, there are no universal treatment guidelines for this malignant tumor. We present here the case of a 59-year-ol…
View article: Case report: Dual dabrafenib and trametinib therapy for treating BRAF V600E mutated lung adenocarcinoma with BRCA2 germline mutation post multiline progression
Case report: Dual dabrafenib and trametinib therapy for treating BRAF V600E mutated lung adenocarcinoma with BRCA2 germline mutation post multiline progression Open
The v-raf murine sarcoma viral oncogenic homolog B1 (BRAF) V600E is a rare mutation that functions as an oncogenic driver in patients with non-small cell lung cancer (NSCLC) leading to the overactivation of the RAS-RAF-MEK-ERK (MAPK) pathw…
View article: Deep Learning-Based Point Cloud Registration: A Comprehensive Survey and Taxonomy
Deep Learning-Based Point Cloud Registration: A Comprehensive Survey and Taxonomy Open
Point cloud registration involves determining a rigid transformation to align a source point cloud with a target point cloud. This alignment is fundamental in applications such as autonomous driving, robotics, and medical imaging, where pr…
View article: Sintilimab combined with axitinib in the treatment of advanced chromophobe renal cell carcinoma: a case report
Sintilimab combined with axitinib in the treatment of advanced chromophobe renal cell carcinoma: a case report Open
Chromophobe renal cell carcinoma (ChRCC) is a rare pathological type of renal cell carcinoma (RCC). Related systematic studies involving large numbers of patients are lacking, and more importantly, there is currently no international conse…
View article: Anti-cancer treatment within two weeks serves as a risk factor for clinical outcomes among cancer patients with COVID-19
Anti-cancer treatment within two weeks serves as a risk factor for clinical outcomes among cancer patients with COVID-19 Open
Background The coronavirus disease 2019 (COVID-19) pandemic has resulted in infections among patients with cancer. Our study aimed to investigate the potential adverse impact of anti-cancer treatments within 2 weeks of COVID-19 infection o…
View article: Concurrent sintilimab with sequential chemoradiotherapy for unresectable, stage III non-small cell lung cancer: a retrospective study
Concurrent sintilimab with sequential chemoradiotherapy for unresectable, stage III non-small cell lung cancer: a retrospective study Open
Background Concurrent programmed death 1 (PD-1) or programmed death ligand 1 (PD-L1) inhibitors with sequential chemoradiotherapy (SCRT) have been reported in only a limited number of studies involving patients with unresectable stage III …
View article: Sintilimab plus autologous NK cells as second-line treatment for advanced non-small-cell lung cancer previous treated with platinum-containing chemotherapy
Sintilimab plus autologous NK cells as second-line treatment for advanced non-small-cell lung cancer previous treated with platinum-containing chemotherapy Open
This pilot study (NCT03958097; https://www.clinicaltrials.gov/ct2/show/NCT03958097 ) was aimed to evaluate the efficacy and safety of PD-1 antibody combined autologous NK cells in the treatment of patients with stage IIIB/IIIC or IV non-sm…
View article: Endometrial clear cell carcinoma: A population-based study
Endometrial clear cell carcinoma: A population-based study Open
Background A systematic analysis of prognostic factors concerning endometrial clear cell carcinoma (ECCC) is lacking. The current study aimed to construct nomograms predicting the overall survival (OS) of ECCC patients. Methods We performe…
View article: Sintilimab Plus Autologous NK Cells as Second-Line Treatment for Advanced Non-Small-Cell Lung Cancer Previous Treated with Platinum-Containing Chemotherapy
Sintilimab Plus Autologous NK Cells as Second-Line Treatment for Advanced Non-Small-Cell Lung Cancer Previous Treated with Platinum-Containing Chemotherapy Open
View article: Primary uterine broad ligament ependymoma with <scp><i>CHEK2</i></scp><i>p.<scp>H371Y</scp></i> germline mutation: A <scp>CARE</scp>‐compliant case report uterine broad ligament ependymoma
Primary uterine broad ligament ependymoma with <span><i>CHEK2</i></span><i>p.<span>H371Y</span></i> germline mutation: A <span>CARE</span>‐compliant case report uterine broad ligament ependymoma Open
Ependymomas arise from ependymal cells lining the ventricles and central canal of the spinal cord and can occur throughout the whole neuraxis. The lesion rarely occurs in extracranial or extraspinal regions, particularly in the uterine bro…
View article: Successful treatment of 2 patients with brain metastases from non-small cell lung cancer with epidermal growth factor receptor mutation receiving dacomitinib
Successful treatment of 2 patients with brain metastases from non-small cell lung cancer with epidermal growth factor receptor mutation receiving dacomitinib Open
Rationale: Approximately 20% of patients with non-small cell lung cancer (NSCLC) are diagnosed with brain metastasis, which is related to poor survival outcomes. The ability of tyrosine kinase inhibitor drugs to penetrate the blood–brain b…
View article: Adenosquamous Carcinoma of the Cervix: A Population-Based Analysis
Adenosquamous Carcinoma of the Cervix: A Population-Based Analysis Open
Background Due to the rarity of adenosquamous carcinoma of the cervix (ASCC), studies on the incidence, prognostic factors, and treatment outcomes of ASCC remain scarce. Therefore, we performed a retrospective population-based study to sys…
View article: Mutation Profile Assessed by Next‐Generation Sequencing (NGS) of Circulating Tumor DNA (ctDNA) in Chinese Lung Adenocarcinoma Patients: Analysis of Real‐World Data
Mutation Profile Assessed by Next‐Generation Sequencing (NGS) of Circulating Tumor DNA (ctDNA) in Chinese Lung Adenocarcinoma Patients: Analysis of Real‐World Data Open
Background . Genomic testing gives guidance to the treatment options in lung adenocarcinoma patients, but some patients are unable to obtain tissue samples due to lesion location or intolerance. Cell‐free circulating tumor DNA (ctDNA) test…
View article: Successful treatment of a patient with small cell lung cancer receiving hemodialysis, with concurrent oral etoposide and radiotherapy
Successful treatment of a patient with small cell lung cancer receiving hemodialysis, with concurrent oral etoposide and radiotherapy Open
Though etoposide capsule is an old drug, its use should be considered in SCLC patients with renal insufficiency undergoing hemodialysis. However, treatment guidelines and research data for such patients are still lacking and further studie…
View article: Sertoli-Leydig cell tumor in two siblings with DICER1 syndrome
Sertoli-Leydig cell tumor in two siblings with DICER1 syndrome Open
Rationale: DICER1 syndrome is an autosomal-dominant tumor predisposition syndrome associated with numerous cancerous and noncancerous conditions. The most common sex cord-stromal tumor associated with DICER1 syndrome is Sertoli-Leydig cell…
View article: Amrubicin for relapsed Extensive-Disease small-cell lung cancer: a systematic review and meta-analysis
Amrubicin for relapsed Extensive-Disease small-cell lung cancer: a systematic review and meta-analysis Open
Background: Amrubicin (AMR), a third-generation anthracycline and potent topoisomerase II inhibitor, has been known to be effective treatment for previously treated Extensive-Disease Small-Cell Lung Cancer (ED-SCLC). However, the efficacy …
View article: Prognostic factors for overall survival in prostate cancer patients with different site-specific visceral metastases: A study of 1358 patients
Prognostic factors for overall survival in prostate cancer patients with different site-specific visceral metastases: A study of 1358 patients Open
This is the first Surveillance, Epidemiology, and End Results-based study to determine prognostic factors affecting OS in PCa patients with different site-specific VM. Clinical assessments of these crucial prognostic factors become necessa…
View article: Intrathecal pemetrexed combined with involved-field radiotherapy as a first-line intra-CSF therapy for leptomeningeal metastases from solid tumors: a phase I/II study
Intrathecal pemetrexed combined with involved-field radiotherapy as a first-line intra-CSF therapy for leptomeningeal metastases from solid tumors: a phase I/II study Open
Purpose: A phase I/II study of intrathecal pemetrexed (IP) combined with involved-field radiotherapy (IFRT) was performed to determine feasibility, safety, and antitumor activity for leptomeningeal metastases (LM) from solid tumors. Method…
View article: <p><em>KIF5B-RET</em> fusion gene and its correlation with clinicopathological and prognosis features in lung cancer: a meta-analysis</p>
<em>KIF5B-RET</em> fusion gene and its correlation with clinicopathological and prognosis features in lung cancer: a meta-analysis Open
The KIF5B-RETfusion gene occurred predominantly in young female patients with lung cancer. However, the relationship between the expression of the fusion gene and the prognosis of lung patients remains unclear.
View article: Treatment of uterine high-grade endometrial stromal sarcoma with apatinib combined with chemotherapy
Treatment of uterine high-grade endometrial stromal sarcoma with apatinib combined with chemotherapy Open
Rationale: The standard treatment for uterine high-grade endometrial stromal sarcoma (HGESS) is chemotherapy after surgery. However, the traditional combination chemotherapy has certain limitation, for example, the cancer cells will quickl…
View article: Metastases to the nose from clear cell renal cell carcinoma
Metastases to the nose from clear cell renal cell carcinoma Open
Rationale: Patients with nasal metastases are seldom seen among clear cell renal cell carcinoma (CCRCC). We report a rare case presenting as a solitary nasal cutaneous nodule, and summarize the therapeutic experience of tyrosine kinase inh…
View article: Low-dose radiation modulates human mesenchymal stem cell proliferation through regulating CDK and Rb.
Low-dose radiation modulates human mesenchymal stem cell proliferation through regulating CDK and Rb. Open
Low-dose radiation (LDR) has been known to stimulate cell proliferation. The effect of LDR on human bone marrow mesenchymal stem cells (BMSCs), however, remains to be determined. The current study, therefore, aimed to investigate the effec…
View article: The Clinicopathological Significance of Epigenetic Silencing of VHL Promoter and Renal Cell Carcinoma: A Meta-Analysis
The Clinicopathological Significance of Epigenetic Silencing of VHL Promoter and Renal Cell Carcinoma: A Meta-Analysis Open
Background/Aims: Von Hippel-Lindau gene (VHL) has been reported as a tumor-suppressor gene in some cancers. However, the association between VHL promoter hypermethylation and renal cell carcinoma (RCC) remains to be clarified. We are the f…