Xiaobing Fu
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View article: TLR2-PI3K/Akt mediated microbe-mimetic priming boosts the therapeutic paracrine function of GelMA-Encapsulated MSCs for diabetic wound regeneration
TLR2-PI3K/Akt mediated microbe-mimetic priming boosts the therapeutic paracrine function of GelMA-Encapsulated MSCs for diabetic wound regeneration Open
View article: Chinese expert consensus on prevention, diagnosis, and management of venous thromboembolism in adult burn patients (2024)
Chinese expert consensus on prevention, diagnosis, and management of venous thromboembolism in adult burn patients (2024) Open
View article: Activating Ferroptosis of M1 Macrophages: A Novel Mechanism of Asiaticoside Encapsuled in GelMA for Anti‐Inflammation in Diabetic Wounds
Activating Ferroptosis of M1 Macrophages: A Novel Mechanism of Asiaticoside Encapsuled in GelMA for Anti‐Inflammation in Diabetic Wounds Open
Diabetic wounds are characterized by chronic inflammation, partly due to the persistent accumulation of pro‐inflammatory M1 macrophages. Asiaticoside (AS), a triterpenoid extracted from Centella asiatica , has known anti‐inflammatory effec…
View article: Consensus statement on the clinical application of extracorporeal shock wave therapy for diabetic foot ulcers (2025 Edition)
Consensus statement on the clinical application of extracorporeal shock wave therapy for diabetic foot ulcers (2025 Edition) Open
Diabetic foot ulcers (DFUs) are among the most severe late-stage complications in patients with diabetes. It is characterized by complex pathogenic factors, challenging treatments, and high rates of disability and mortality. Therefore, DFU…
View article: Comorbidities, comedications and potential drug–drug interactions among people living with <scp>HIV</scp> in China
Comorbidities, comedications and potential drug–drug interactions among people living with <span>HIV</span> in China Open
Objective With increasing life expectancy among HIV‐positive persons in China, comorbidities, polypharmacy and potential drug–drug interactions (DDIs) present growing challenges. We evaluated these issues in the integrase strand transfer i…
View article: Optimal run-tumble navigation in disordered landscapes
Optimal run-tumble navigation in disordered landscapes Open
Active navigation in disordered media is governed by the interplay between self-propulsion and environmental constraints. Using the chemotaxis of E. coli in agar gels as a model system, we uncover a universal trade-off between persistence …
View article: Stimuli-responsive Hydrogels: An Intelligent Tool for Wound Management
Stimuli-responsive Hydrogels: An Intelligent Tool for Wound Management Open
View article: Application of transurethral blue laser vaporization of the prostate in Patients Aged 80 and Above: A Single-Center Clinical Analysis of 157 Cases
Application of transurethral blue laser vaporization of the prostate in Patients Aged 80 and Above: A Single-Center Clinical Analysis of 157 Cases Open
Purpose: This study aims to assess the safety and effectiveness of transurethral blue laser prostate vaporization (BVP) for elderly patients (≥80 years) with benign prostatic hyperplasia (BPH), focusing on clinical outcomes, recovery, and …
View article: Tophus severity grading and surgical treatment: Chinese medical doctor association multidisciplinary expert consensus statement and recommendations, 2025
Tophus severity grading and surgical treatment: Chinese medical doctor association multidisciplinary expert consensus statement and recommendations, 2025 Open
Background: Tophi, a severe complication of advanced gout, develop in approximately 12–35% of patients with gout, with rates as high as 52.56% being reported. Bone and joint damage and chronic refractory wounds caused by gouty tophus prese…
View article: Deciphering age‑related differences in wound healing: Insights from the interaction between endothelial cells and fibroblasts
Deciphering age‑related differences in wound healing: Insights from the interaction between endothelial cells and fibroblasts Open
Aging impairs wound healing, primarily because of alterations in cell phenotypes and interactions, particularly between endothelial cells (ECs) and fibroblasts (Fibs). The present study investigated the dynamics of EC‑Fib interactions in a…
View article: Ellagic Acid‐Loaded <scp>sEVs</scp> Encapsulated in <scp>GelMA</scp> Hydrogel Accelerate Diabetic Wound Healing by Activating <scp>EGFR</scp> on Skin Repair Cells
Ellagic Acid‐Loaded <span>sEVs</span> Encapsulated in <span>GelMA</span> Hydrogel Accelerate Diabetic Wound Healing by Activating <span>EGFR</span> on Skin Repair Cells Open
Delayed diabetic wound healing is partially attributed to the functional disorder of skin repair cells caused by high glucose (HG). Small extracellular vehicles (sEVs) loaded with small‐molecule drugs represent a highly promising therapeut…
View article: Dvelopment and application of similar material for physical model test of an ultradeep foundation pit in round gravel strata
Dvelopment and application of similar material for physical model test of an ultradeep foundation pit in round gravel strata Open
The raw-material mix ratio and preparation of similar materials are crucial for the success of physical model tests and for accurately reflecting prototype properties. In this study, an optimum similar material for plateau alluvial and lac…
View article: Hypoxia‐Driven Neurovascular Impairment Underlies Structural‐Functional Dissociation in Diabetic Sudomotor Dysfunction
Hypoxia‐Driven Neurovascular Impairment Underlies Structural‐Functional Dissociation in Diabetic Sudomotor Dysfunction Open
Sudomotor dysfunction in diabetic patients increases the risk of fissures, infections, and diabetic foot ulcers (DFUs), thereby reducing the quality of life. Despite its clinical importance, the mechanisms underlying this dysfunction remai…
View article: Global, regional, and national burden and attributable risk factors of depressive disorders among older adults, 1990-2021
Global, regional, and national burden and attributable risk factors of depressive disorders among older adults, 1990-2021 Open
For three decades, improved health conditions had not resulted in the expected decline in depressive disorders burdens among older adults, highlighting the need for health policy attention, especially in countries with low to medium Socio-…
View article: Advances in stem cell therapy for erectile dysfunction: preclinical evidence and emerging therapeutic approaches
Advances in stem cell therapy for erectile dysfunction: preclinical evidence and emerging therapeutic approaches Open
The inability to get or sustain an erection strong enough for fulfilling sexual performance is the hallmark of the common disorder known as erectile dysfunction (ED). It mostly affects a significant percentage of men worldwide, particularl…
View article: A Systematic Review and Meta-Analysis of Implicit Stigma Toward People with Mental Illness Among Different Groups: Measurement, Extent, and Correlates
A Systematic Review and Meta-Analysis of Implicit Stigma Toward People with Mental Illness Among Different Groups: Measurement, Extent, and Correlates Open
The findings indicated that the selection of concept and attribute words, as well as the processing of data measuring implicit stigma, was not standardized. No reliable correlation was found between implicit and explicit measures. Despite …
View article: A thermally stable bioactive chitosan scaffold with pH-responsive exosome adsorption and release function promotes wound healing
A thermally stable bioactive chitosan scaffold with pH-responsive exosome adsorption and release function promotes wound healing Open
Chitosan is an excellent carrier material for bioactive substances, and its binding ability is affected by the pH value of surrounding environments. Healthy skin is maintained in a slightly acidic environment, whereas the wound healing env…
View article: Intranasal delivery of hMSC-derived supernatant for treatment of ischemic stroke by inhibiting the pro-inflammatory polarization of neutrophils
Intranasal delivery of hMSC-derived supernatant for treatment of ischemic stroke by inhibiting the pro-inflammatory polarization of neutrophils Open
View article: Fully Integrated Multifunctional Flexible Ultrasonic–Electric‐Coupled Patches for Advancing Wound Care Paradigms
Fully Integrated Multifunctional Flexible Ultrasonic–Electric‐Coupled Patches for Advancing Wound Care Paradigms Open
Wound repair in adults lacks natural regenerative capacity seen during fetal period, frequently resulting in the formation of tissue fibrosis and functional impairments. By transforming the repair process into regenerative healing, it is p…
View article: HIV-1 Molecular&nbsp;Transmission Networks and Pretreatment Drug Resistance Among&nbsp;Sentinel Surveillance of MSM in Guangdong Province, 2016-2023
HIV-1 Molecular Transmission Networks and Pretreatment Drug Resistance Among Sentinel Surveillance of MSM in Guangdong Province, 2016-2023 Open
View article: Application of SPORT medical care model and nursing practice of hematopoietic stem cells collection for related donors of allogeneic hematopoietic stem cell transplantation
Application of SPORT medical care model and nursing practice of hematopoietic stem cells collection for related donors of allogeneic hematopoietic stem cell transplantation Open
Objective To summarize the Application of SPORT medical care model and nursing practice of hematopoietic stem cells collection for related donors of allogeneic hematopoietic stem cell transplantation. Methods A retrospective analysis was c…
View article: Restoring sweat gland function in mice using regenerative sweat gland cells derived from chemically reprogrammed human epidermal keratinocytes
Restoring sweat gland function in mice using regenerative sweat gland cells derived from chemically reprogrammed human epidermal keratinocytes Open
The regeneration of sweat glands (SwGs) plays a pivotal role in the functional recovery of extensive skin wounds. Recent research has illuminated the possibility of reprogramming human epidermal keratinocytes (HEKs) into induced SwG cells …
View article: Neutrophil extracellular traps with low concentrations induce proliferation and migration of human fibroblasts via activating CCDC25/ILK/PI3K/AKT pathway
Neutrophil extracellular traps with low concentrations induce proliferation and migration of human fibroblasts via activating CCDC25/ILK/PI3K/AKT pathway Open
Neutrophil plays an important role in the early stage of wound healing. Excessive neutrophil extracellular traps (NETs) which are produced by neutrophil have been proved as a significant unfavorable factor for wound healing by impairing th…
View article: Electrospun nanofibrous membranes meet antibacterial nanomaterials: From preparation strategies to biomedical applications
Electrospun nanofibrous membranes meet antibacterial nanomaterials: From preparation strategies to biomedical applications Open
Electrospun nanofibrous membranes (eNFMs) have been extensively developed for bio-applications due to their structural and compositional similarity to the natural extracellular matrix. However, the emergence of antibiotic resistance in bac…
View article: Hepatitis C virus subtype distribution and resistance-associated substitutions in high-risk population groups in Guangdong Province, China
Hepatitis C virus subtype distribution and resistance-associated substitutions in high-risk population groups in Guangdong Province, China Open
The HCV subtypes are expanding in high-risk populations in Guangdong. Drug use by other risk groups and commercial sex by DU may bridge the dissemination of 6a from DU to other populations. The RAS profiles of 1b and 3a differed from those…
View article: Mechano‐YAP/TAZ‐regulated smooth muscle cells are an important source of Wnt signalling for gut regeneration
Mechano‐YAP/TAZ‐regulated smooth muscle cells are an important source of Wnt signalling for gut regeneration Open
View article: Hydrogels loaded with MSC‐derived small extracellular vesicles: A novel cell‐free tissue engineering system for diabetic wound management
Hydrogels loaded with MSC‐derived small extracellular vesicles: A novel cell‐free tissue engineering system for diabetic wound management Open
With the aging and obesity era, the increasing incidence of diabetes and diabetic complications, especially the non‐healing wounds, imposes a serious economic burden on both patients and society. The complex microenvironments, including hy…
View article: Chitosan-taurine nanoparticles cross-linked carboxymethyl chitosan hydrogels facilitate both acute and chronic diabetic wound healing
Chitosan-taurine nanoparticles cross-linked carboxymethyl chitosan hydrogels facilitate both acute and chronic diabetic wound healing Open
Wound dressing diligently facilitate healing by fostering hemostasis, immunoregulation, the angiogenesis, and collagen deposition. Our methodology entails fabricating chitosan-taurine nanoparticles (CS-Tau) through an ionic gelation method…
View article: Advances and applications of biomimetic biomaterials for endogenous skin regeneration
Advances and applications of biomimetic biomaterials for endogenous skin regeneration Open
View article: Factors associated with antiretroviral treatment adherence among people living with HIV in Guangdong Province, China: a cross sectional analysis
Factors associated with antiretroviral treatment adherence among people living with HIV in Guangdong Province, China: a cross sectional analysis Open