Explanipedia

Placental Vascular Resistance and Offspring Growth From Birth to Age 2 Years Open

Luli Xu, Junbin Zhang, Xiaohan Dong, Xiya Qin, Mingzhao Huang , et al. · 2025

Importance Umbilical artery Doppler indices provide indirect measures of placental function, with elevated vascular resistance associated with adverse perinatal outcomes, but their association with postnatal growth remains understudied. Ob…

Hepatic Arterial Infusion Chemotherapy with Serplulimab and the Bevacizumab Biosimilar HLX04 for Advanced Hepatocellular Carcinoma: A Prospective, Observational Phase II Clinical Trial Open

Huikai Li, Tongguo Si, Rentao Li, Xiao‐Jing Xie, Yang Liu , et al. · 2025

Background/Objectives: Advanced hepatocellular carcinoma (HCC) presents limited treatment options; however, immunotherapy demonstrates encouraging outcomes and acceptable adverse reactions in advanced HCC. This study evaluates the efficacy…

Improper arterial catheter blood sampling method affects hemoglobin test results: A cautionary tale Open

Jinle Wang, Huihui Jiang, Qingqing Bi, Kegang Tian, Xiaofeng Mu , et al. · 2025

Arterial catheter blood sampling is widely used among critically ill patients to minimize repeated punctures; however, improper techniques may lead to misleading laboratory results. This case report presents a clinically significant hemogl…

Maternal air temperature exposure and risk of small vulnerable newborn: Identifying critical windows Open

Mingzhao Huang, Jian Fang, Yaqi Zhang, Luli Xu, Xiya Qin , et al. · 2025

While the overall exposure-response relationship exhibits a U-shaped pattern throughout gestation, our findings reveal substantial heterogeneity in temperature sensitivity across developmental windows. Some gestational stages are more susc…

Association of gestational weight gain patterns with preterm birth subtypes in a population based cohort study from China Open

Yiyang Guo, Kai Chen, Jine Zhang, Yiming Zhang, Zhiguo Xia , et al. · 2025

Radiation-Induced Lymphopenia Prognosis and Risk Factors in Postmastectomy Radiotherapy Patients Open

Wenjie Ni, Xiunan Wang, Sophia Wang, Yawen Ge, Xiaofeng Mu · 2025

G3 RIL led to poor DFS in postmastectomy radiotherapy patients. BMI, RT modality, and heart and sternum exposure dose were noted to be independent RIL risk factors.

Associations of prenatal blood pressure trajectory and variability with child neurodevelopment at 2 years old Open

Luli Xu, Jiayi Cheng, Xiaohan Dong, Menglan Guo, Kai Chen , et al. · 2024

Background The patterns of blood pressure (BP) change throughout the pregnancy were related to adverse birth outcomes. However, little is known about the long-term effect of BP change patterns on child neurodevelopment. This study aimed to…

Peripheral Blood CD8+ CD28+ T Cells as an Independent Predictor of Treatment Response and Survival After Concurrent Chemoradiotherapy in Pediatric High-Grade Glioma Patients Open

Shuo Wang, Xiaofeng Mu, Xiaoli Wang, Li Chen, Changyu Lu , et al. · 2024

Backgroud: The tumor immune microenvironment influences the efficiency of concurrent chemoradiotherapy (CCRT) in high-grade glioma (HGG). This study investigated peripheral blood T lymphocyte subsets as clinical indicators of therapeutic r…

Blood inflammatory markers and cytokines in patients with COVID-19 and bacterial coinfections Open

Qingqing Bi, Jie Zhu, Jinju Zheng, Qingyun Xu, Lei Zhang , et al. · 2023

Background Bacterial coinfection in patients with SARS-CoV-2 infection is an important risk factor for death. This study investigated and analyzed whether there were differences in the levels of serum PCT and CRP and the expression of 12 c…

Enhancing Chinese Address Parsing in Low-Resource Scenarios through In-Context Learning Open

Guangming Ling, Xiaofeng Mu, Chao Wang, Aiping Xu · 2023

Address parsing is a crucial task in natural language processing, particularly for Chinese addresses. The complex structure and semantic features of Chinese addresses present challenges due to their inherent ambiguity. Additionally, differ…

Spatial transcriptomics: Technologies, applications and experimental considerations Open

Ye Wang, Bin Liu, Gexin Zhao, Yoojin Lee, Anton Buzdin , et al. · 2023

The diverse cell types of an organ have a highly structured organization to enable their efficient and correct function. To fully appreciate gene functions in a given cell type, one needs to understand how much, when and where the gene is …

Enhancing Chinese Address Parsing in Low-Resource Scenarios through In-Context Learning Open

Guangming Ling, Xiaofeng Mu, Chao Wang, Aiping Xu · 2023

Address parsing is a crucial task in natural language processing, particularly for Chinese addresses. The complex structure and semantic features of Chinese addresses present challenges due to their inherent ambiguity. Additionally, differ…

Enhancing Chinese Address Parsing in Low-Resource Scenarios through In-Context Learning Open

Guangming Ling, Xiaofeng Mu, Chao Wang, Aiping Xu · 2023

Address parsing is a crucial task in natural language processing, particularly for Chinese addresses. The complex structure and semantic features of Chinese addresses present challenges due to their inherent ambiguity. Additionally, differ…

Construction and validation of prognostic risk model based on radiosensitivity-related immune genes in rectal cancer Open

Hui Ying Yang, Yin Liu, Xiaofeng Mu, Kun Wang, Mengdi Hao , et al. · 2023

Background Radiotherapy is closely related to the tumor immune microenvironment, but the role of immune genes in radiosensitivity and prognosis of rectal cancer (RC) is still unclear. This study aims to construct a prognostic risk model ba…

Single-walled carbon nanotubes-based RNA protection and extraction improves RT-qPCR sensitivity for SARS-CoV-2 detection Open

Yong Li, Xiangning Han, Xiaofeng Mu, Ye Wang, Chao Shi , et al. · 2022

Construction of Entity and Entity Relationship Annotation Corpus for Test Identification Open

Bo Wang, Zixi Xu, Jianmei Huang, Teng Sun, Xiaofeng Mu · 2022

Currently, the test identification corpus faces the problems of small scale, poor consistency and poor standardization, which is difficult to meet the needs of intelligent applications such as knowledge mapping, question answering system a…

Domain-Adaptive Pre-training BERT Model for Test and Identification Domain NER Task Open

Bo Wang, Jianmei Huang, Ruicheng Yan, Yaofeng Su, Xiaofeng Mu · 2022

Name entity recognition (NER) is the foundation of a wide range of natural language processing (NLP) task in the domain of test identification. In this paper, we continue to train the pre-trained BERT model by unlabeled texts related to th…

Author Correction: Immunogenicity and reactogenicity of SARS-CoV-2 vaccines BNT162b2 and CoronaVac in healthy adolescents Open

Jaime S. Rosa Duque, Xiwei Wang, Daniel Leung, Samuel M. S. Cheng, Carolyn A. Cohen , et al. · 2022

Glucose metabolism controls human γδ T-cell-mediated tumor immunosurveillance in diabetes Open

Xiaofeng Mu, Zheng Xiang, Yan Xu, Jing He, Jianwen Lu , et al. · 2022

Safety and Immunogenicity of 3 Doses of BNT162b2 and CoronaVac in Children and Adults with Inborn Errors of Immunity Open

Daniel Leung, Xiaofeng Mu, Jaime S. Rosa Duque, Samuel Cheng, Manni Wang , et al. · 2022

Background Safety and immunogenicity of 3 doses of BNT162b2 and CoronaVac in adult and pediatric patients with inborn errors of immunity (IEIs) remain unknown. Intradermal vaccination may improve immunogenicity in immunocompromised patient…

CD137 Costimulation Enhances the Antitumor Activity of Vγ9Vδ2-T Cells in IL-10-Mediated Immunosuppressive Tumor Microenvironment Open

Yujun Pei, Zheng Xiang, Kun Wen, Chloe Ran Tu, Xiwei Wang , et al. · 2022

Although γδ-T cell-based tumor immunotherapy using phosphoantigens to boost γδ-T cell immunity has shown success in some cancer patients, the clinical application is limited due to the rapid exhaustion of Vγ9Vδ2-T cells caused by repetitiv…

Exosomes derived from γδ-T cells synergize with radiotherapy and preserve antitumor activities against nasopharyngeal carcinoma in immunosuppressive microenvironment Open

Xiwei Wang, Yanmei Zhang, Xiaofeng Mu, Chloe Ran Tu, Yuet Chung , et al. · 2022

Background Radiotherapy is the first-line treatment for patients nasopharyngeal carcinoma (NPC), but its therapeutic efficacy is poor in some patients due to radioresistance. Adoptive T cell-based immunotherapy has also shown promise to co…

FDA-Approved and Emerging Next Generation Predictive Biomarkers for Immune Checkpoint Inhibitors in Cancer Patients Open

Ye Wang, Zhuang Tong, Wen‐Hua Zhang, Weizhen Zhang, Anton Buzdin , et al. · 2021

A patient’s response to immune checkpoint inhibitors (ICIs) is a complex quantitative trait, and determined by multiple intrinsic and extrinsic factors. Three currently FDA-approved predictive biomarkers (progra1mmed cell death ligand-1 (P…

Characterization of the Vaginal Microbiome in Women with Infertility and Its Potential Correlation with Hormone Stimulation during In Vitro Fertilization Surgery Open

Changying Zhao, Zefeng Wei, Junjie Yang, Jiaming Zhang, Chunna Yu , et al. · 2020

The microbiome had been hypothesized to be involved in the physiology and pathophysiology of assisted reproduction before the first success in IVF, while the data supporting or refuting this hypothesis were less than conclusive. Thanks to …

CD137 costimulation enhances the antiviral activity of Vγ9Vδ2-T cells against influenza virus Open

Yujun Pei, Kun Wen, Zheng Xiang, Chunyu Huang, Xiwei Wang , et al. · 2020

Changing Technologies of RNA Sequencing and Their Applications in Clinical Oncology Open

Ye Wang, Michael J. Mashock, Zhuang Tong, Xiaofeng Mu, Hong Chen , et al. · 2020

RNA sequencing (RNAseq) is one of the most commonly used techniques in life sciences, and has been widely used in cancer research, drug development, and cancer diagnosis and prognosis. Driven by various biological and technical questions, …

Group B Streptococcus colonization induces Prevotella and Megasphaera abundance-featured vaginal microbiome compositional change in non-pregnant women Open

Xiaofeng Mu, Changying Zhao, Junjie Yang, Xiaofang Wei, Jiaming Zhang , et al. · 2019

Background Previous studies have indicated that variations in the vaginal microbiome result in symptomatic conditions. Group B Streptococcus (GBS) is a significant neonatal pathogen and maternal vaginal colonization has been recognized as …

A Character-Level BiLSTM-CRF Model With Multi-Representations for Chinese Event Detection Open

Xiaofeng Mu, Aiping Xu · 2019

Using the word as a basic unit may undermine Chinese event detection model’s performance because of the inaccurate word boundaries generated by segmentation tools. Besides, word embeddings are contextual independent and cannot handle the p…

Dysbiosis of the Salivary Microbiome Is Associated With Non-smoking Female Lung Cancer and Correlated With Immunocytochemistry Markers Open

Junjie Yang, Xiaofeng Mu, Ye Wang, Dequan Zhu, Jiaming Zhang , et al. · 2018

Background: Association between oral bacteria and increased risk of lung cancer have been reported in several previous studies, however, the potential association between salivary microbiome and lung cancer in non-smoking women have…

Development of a GeXP-Based Multiplex RT-PCR Assay for Detection of Long Noncoding RNA in Hepatocellular Carcinoma Open

Xiaofeng Mu, Wen Chen, Junying Shi, Xinmin Li, Ye Wang · 2018

The GeXP-based multiplex RT-PCR assay may be used as an alternative method for assisting in the histopathological diagnosis of HCC in liver lesions.

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