Xiaofeng Qi
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View article: Realizing the reuse of dye wastewater through Fe2O3 modified loofah biochar activated peroxymonosulfate
Realizing the reuse of dye wastewater through Fe2O3 modified loofah biochar activated peroxymonosulfate Open
View article: Structure of human mitochondrial pyruvate carrier MPC1 and MPC2 complex
Structure of human mitochondrial pyruvate carrier MPC1 and MPC2 complex Open
The Mitochondrial Pyruvate Carrier (MPC) bridges cytosolic and mitochondrial metabolism by transporting pyruvate into mitochondria for ATP production and biosynthesis of various essential molecules. MPC functions as a heterodimer composed …
View article: Neuropharmacology of Neurotransmitter Systems: Current Drugs and Their Effects on Neural and Neuroendocrine Pathways
Neuropharmacology of Neurotransmitter Systems: Current Drugs and Their Effects on Neural and Neuroendocrine Pathways Open
The intricate interplay between neurotransmitter systems, neural circuits, and neuroendocrine pathways underpins brain function and dysfunction in neurological and psychiatric disorders. This review synthesizes contemporary advances in neu…
View article: Damage source localization based on acoustic emission technology in high-demanding aircraft structure fatigue tests
Damage source localization based on acoustic emission technology in high-demanding aircraft structure fatigue tests Open
In response to the challenge of traditional acoustic emission (AE) source localization methods in achieving ideal source localization in high-noise complex aircraft structural fatigue tests, an intelligent damage source precise localizatio…
View article: Inhibiting hedgehog signal by a patched-1 antibody
Inhibiting hedgehog signal by a patched-1 antibody Open
View article: Structure of GGCX-BGP-MK4 complex
Structure of GGCX-BGP-MK4 complex Open
View article: Molecular basis of Wnt biogenesis, secretion, and Wnt7-specific signaling
Molecular basis of Wnt biogenesis, secretion, and Wnt7-specific signaling Open
View article: Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain
Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain Open
View article: Mechanisms and inhibition of Porcupine-mediated Wnt acylation
Mechanisms and inhibition of Porcupine-mediated Wnt acylation Open
View article: Molecular basis of cholesterol efflux via ABCG subfamily transporters
Molecular basis of cholesterol efflux via ABCG subfamily transporters Open
Significance Cholesterol is an essential component of animal cell membranes whose level in cells is maintained within a narrow range. Cholesterol is actively excreted from cells by two ATP-binding cassette (ABC) transporters, ABCG5–ABCG8 (…
View article: Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling
Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling Open
View article: Structure of nevanimibe-bound tetrameric human ACAT1
Structure of nevanimibe-bound tetrameric human ACAT1 Open
View article: Mechanistic Insights into the Generation and Transduction of Hedgehog Signaling
Mechanistic Insights into the Generation and Transduction of Hedgehog Signaling Open
View article: Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments
Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments Open
Two cryo-EM structures of IGF2R at different pH values imply the mechanism for its ligand release in endocytic compartments.
View article: Structural basis for itraconazole-mediated NPC1 inhibition
Structural basis for itraconazole-mediated NPC1 inhibition Open
Niemann-Pick C1 (NPC1), a lysosomal protein of 13 transmembrane helices (TMs) and three lumenal domains, exports low-density-lipoprotein (LDL)-derived cholesterol from lysosomes. TMs 3–7 of NPC1 comprise the Sterol-Sensing Domain (SSD). Pr…
View article: A LysM Receptor Heteromer Mediates Perception of Arbuscular Mycorrhizal Symbiotic Signal in Rice
A LysM Receptor Heteromer Mediates Perception of Arbuscular Mycorrhizal Symbiotic Signal in Rice Open
View article: Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi
Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi Open
View article: Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex
Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex Open
It takes two to signal The Hedgehog (HH) signaling pathway is important in development, and excessive HH signaling is associated with cancer. Signaling occurs through the G protein–coupled receptor Smoothened. The pathway is repressed by t…
View article: Structures of human Patched and its complex with native palmitoylated sonic hedgehog
Structures of human Patched and its complex with native palmitoylated sonic hedgehog Open
View article: Structure and mechanism of a group-I cobalt energy coupling factor transporter
Structure and mechanism of a group-I cobalt energy coupling factor transporter Open
View article: Structural basis of rifampin inactivation by rifampin phosphotransferase
Structural basis of rifampin inactivation by rifampin phosphotransferase Open
Significance Rifampin phosphotransferases (RPH) belong to a recently identified antibiotic-resistance protein family that inactivates rifampin, the first-line drug against tuberculosis, by phosphorylation. By determining the structures of …
View article: Structural basis of intramitochondrial phosphatidic acid transport mediated by <scp>U</scp> ps1‐ <scp>M</scp> dm35 complex
Structural basis of intramitochondrial phosphatidic acid transport mediated by <span>U</span> ps1‐ <span>M</span> dm35 complex Open