Xiaofeng Zhai
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View article: Novel ACE2 binding in bat merbecoviruses expands potential host range
Novel ACE2 binding in bat merbecoviruses expands potential host range Open
Coronaviruses often cross species barriers, with receptor binding dictating their host range and zoonotic potential. Merbecoviruses, such as MERS-CoV, typically utilize DPP4 as their receptor, whereas Sarbecoviruses, like SARS-CoV, rely on…
View article: Arsenic trioxide enhances the inhibitory effect of lenvatinib on hepatocellular carcinoma through HMOX1-mediated ferroptosis
Arsenic trioxide enhances the inhibitory effect of lenvatinib on hepatocellular carcinoma through HMOX1-mediated ferroptosis Open
Currently, Lenvatinib, a tyrosine kinase inhibitor, is used as a first-line treatment for advanced hepatocellular carcinoma (HCC), but its efficacy remains unsatisfactory. Therefore, we investigated the effect of Lenvatinib in combination …
View article: Traditional herbal medicine as an adjuvant therapy for preventing the recurrence of hepatocellular carcinoma after radical resection: Development and validation of a machine learning prediction model
Traditional herbal medicine as an adjuvant therapy for preventing the recurrence of hepatocellular carcinoma after radical resection: Development and validation of a machine learning prediction model Open
View article: Identification of Cyp2e1 as a Target of Oleanolic Acid in Treating Hepatocellular Carcinoma Based on Network Pharmacology and Single-Cell Rna Sequencing
Identification of Cyp2e1 as a Target of Oleanolic Acid in Treating Hepatocellular Carcinoma Based on Network Pharmacology and Single-Cell Rna Sequencing Open
View article: Hepatitis B Virus Knowledge and HBV-Related Surveillance Status Among HBsAg-Positive Patients in Qidong City: A Rural-Based Cross-Sectional Survey
Hepatitis B Virus Knowledge and HBV-Related Surveillance Status Among HBsAg-Positive Patients in Qidong City: A Rural-Based Cross-Sectional Survey Open
Objective: This study aimed to investigate hepatitis B knowledge and hepatitis B virus (HBV)-related surveillance status among HBsAg-positive patients, as well as to further explore the relevant influencing factors. Methods: A cross-sectio…
View article: Attenuated Getah virus confers protection against multiple arthritogenic alphaviruses
Attenuated Getah virus confers protection against multiple arthritogenic alphaviruses Open
Alphaviruses are important arthropod-transmitted pathogens of humans and livestock. Getah virus (GETV) is an arthritogenic alphavirus that causes disease in horses and piglets; it also poses a potential threat to humans. A live attenuated …
View article: Evolving roles of glycosylation in the tug-of-war between virus and host
Evolving roles of glycosylation in the tug-of-war between virus and host Open
View article: LDLR is used as a cell entry receptor by multiple alphaviruses
LDLR is used as a cell entry receptor by multiple alphaviruses Open
Alphaviruses are arboviruses transmitted by mosquitoes and are pathogenic to humans and livestock, causing a substantial public health burden. So far, several receptors have been identified for alphavirus entry; however, they cannot explai…
View article: Research Progress of the Effect and Mechanism of Active Ingredients of Astragalus Membranaceus on Tumor
Research Progress of the Effect and Mechanism of Active Ingredients of Astragalus Membranaceus on Tumor Open
Chinese herbal medicine has a long history of treating malignant tumors in China and is considered to be effective in improving the survival. As a traditional Chinese medicine, the immunomodulatory, anti-tumor, anti-inflammatory, anti-agin…
View article: The crystal structure of 3-((<i>tert</i>-butyldiphenylsilyl)methyl)-5,5-diphenyl-6-(<i>p</i>-tolyl) tetrahydro-2<i>H</i>-pyran-2-one, C<sub>41</sub>H<sub>42</sub>O<sub>2</sub>Si
The crystal structure of 3-((<i>tert</i>-butyldiphenylsilyl)methyl)-5,5-diphenyl-6-(<i>p</i>-tolyl) tetrahydro-2<i>H</i>-pyran-2-one, C<sub>41</sub>H<sub>42</sub>O<sub>2</sub>Si Open
C 41 H 42 O 2 Si, monoclinic, P 2 1 / n (no. 14), a = 14.1100(17) Å, b = 15.8352(19) Å, c = 16.644(2) Å, β = 110.659(2)°, V = 3479.7(7) Å 3 , Z = 4, R gt ( F ) = 0.0540, wR ref ( F 2 ) = 0.1633, T = 296.15 K.
View article: Transcriptome screening identifies TIPARP as an antiviral host factor against the Getah virus
Transcriptome screening identifies TIPARP as an antiviral host factor against the Getah virus Open
Alphaviruses are emerging and re-emerging viruses that cause severe disease and threaten public health worldwide. To advance the understanding of the underlying mechanisms of alphavirus replication and identify new host restriction factors…
View article: Acceptance and attitude towards the traditional chinese medicine among asymptomatic COVID-19 patients in Shanghai Fangcang hospital
Acceptance and attitude towards the traditional chinese medicine among asymptomatic COVID-19 patients in Shanghai Fangcang hospital Open
View article: Study of the permeation-promoting effect and mechanism of solid microneedles on different properties of drugs
Study of the permeation-promoting effect and mechanism of solid microneedles on different properties of drugs Open
In transdermal drug delivery systems, the physicochemical properties of the drug affect its percutaneous permeability. However, whether the physicochemical properties of drugs change their transdermal permeability in the presence of pores …
View article: Hypoxia-induced exosomes facilitate lung pre-metastatic niche formation in hepatocellular carcinoma through the miR-4508-RFX1-IL17A-p38 MAPK-NF-κB pathway
Hypoxia-induced exosomes facilitate lung pre-metastatic niche formation in hepatocellular carcinoma through the miR-4508-RFX1-IL17A-p38 MAPK-NF-κB pathway Open
Background: Hypoxia plays an important role in the lung metastasis of hepatocellular carcinoma (HCC). However, the process by which hypoxia promotes the formation of a pre-metastatic niche (PMN) and its underlying mechanism remain u…
View article: Relationship between thick or greasy tongue-coating microbiota and tongue diagnosis in patients with primary liver cancer
Relationship between thick or greasy tongue-coating microbiota and tongue diagnosis in patients with primary liver cancer Open
Tongue diagnosis is a unique aspect of traditional Chinese medicine for diagnosing diseases before determining proper means of treatment, but it also has the disadvantage of relying on the subjective experience of medical practitioners and…
View article: Early Genomic Surveillance and Phylogeographic Analysis of Getah Virus, a Reemerging Arbovirus, in Livestock in China
Early Genomic Surveillance and Phylogeographic Analysis of Getah Virus, a Reemerging Arbovirus, in Livestock in China Open
Although livestock is known to be the primary reservoir of Getah virus (GETV) in Asian countries, where identification is largely based on serology, the evolutionary history and spatial epidemiology of GETV in these regions remain largely …
View article: Impact of treatment-duration-ratio of traditional Chinese medicine on survival period of primary liver cancer —A real-world study
Impact of treatment-duration-ratio of traditional Chinese medicine on survival period of primary liver cancer —A real-world study Open
View article: Acceptance and Attitude towards the Traditional Chinese Medicine among Asymptomatic COVID-19 Patients: A cross-sectional study in Shanghai Fangcang hospital
Acceptance and Attitude towards the Traditional Chinese Medicine among Asymptomatic COVID-19 Patients: A cross-sectional study in Shanghai Fangcang hospital Open
Objective The Coronavirus Disease 2019 (COVID-19) has brought severe damage to global health and socioeconomics. In China, traditional Chinese medicine (TCM) is the most important complementary and alternative medicine (CAM) and it has sho…
View article: Prognostic Comparison between cTACE and H101-TACE in Unresectable Hepatocellular Carcinoma (HCC): A Propensity-Score Matching Analysis
Prognostic Comparison between cTACE and H101-TACE in Unresectable Hepatocellular Carcinoma (HCC): A Propensity-Score Matching Analysis Open
Background. Transarterial chemoembolization (TACE) is the most common treatment for patients with HCC who are unsuitable for radical therapies. Conventional TACE (cTACE) takes advantage of the preferential hepatic arterial supply of HCC fo…
View article: Identifying the Mechanism of Polygoni Cuspidati Rhizoma et Radix in Treating Acute Liver Failure Based on Network Pharmacology and Molecular Docking
Identifying the Mechanism of Polygoni Cuspidati Rhizoma et Radix in Treating Acute Liver Failure Based on Network Pharmacology and Molecular Docking Open
Background and Objective. Acute liver failure (ALF) is a rare clinical syndrome with a poor prognosis and leads to multiple organ failure. Polygoni Cuspidati Rhizoma et Radix (PCRR) is a commonly used Chinese medicine, which is recognized …
View article: Combined Network Pharmacology, Molecular Docking, and Experimental Verification Approach to Investigate the Potential Mechanisms of Polydatin Against COVID-19
Combined Network Pharmacology, Molecular Docking, and Experimental Verification Approach to Investigate the Potential Mechanisms of Polydatin Against COVID-19 Open
Background: Coronavirus disease 2019 (COVID-19) has posed a serious threat to human health and there is an urgent need for drug development. In this study, we explored the potential mechanisms underlying the efficacy of polydatin against C…
View article: Attenuation of Getah Virus by a Single Amino Acid Substitution at Residue 253 of the E2 Protein that Might Be Part of a New Heparan Sulfate Binding Site on Alphaviruses
Attenuation of Getah Virus by a Single Amino Acid Substitution at Residue 253 of the E2 Protein that Might Be Part of a New Heparan Sulfate Binding Site on Alphaviruses Open
Due to decades of inadequate monitoring and lack of vaccines and specific treatment, a large number of people have been infected with alphaviruses. GETV is a re-emerging alphavirus that has the potential to infect humans.
View article: Sphingosine-1-phosphate transporter spinster homolog 2 is essential for iron-regulated metastasis of hepatocellular carcinoma
Sphingosine-1-phosphate transporter spinster homolog 2 is essential for iron-regulated metastasis of hepatocellular carcinoma Open
View article: m6A RNA Methylation Regulators Elicit Malignant Progression and Predict Clinical Outcome in Hepatocellular Carcinoma
m6A RNA Methylation Regulators Elicit Malignant Progression and Predict Clinical Outcome in Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and N6-methyladenosine (m6A) is a predominant internal modification of RNA in various cancers. We obtained the expression profiles of m6A-related genes fo…
View article: Snapshot of the evolution and mutation patterns of SARS-CoV-2
Snapshot of the evolution and mutation patterns of SARS-CoV-2 Open
The COVID-19 pandemic is the most important public health threat in recent history. Here we study how its causal agent, SARS-CoV-2, has diversified genetically since its first emergence in December 2019. We have created a pipeline combinin…
View article: Comparison of Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Binding to ACE2 Receptors from Human, Pets, Farm Animals, and Putative Intermediate Hosts
Comparison of Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Binding to ACE2 Receptors from Human, Pets, Farm Animals, and Putative Intermediate Hosts Open
SARS-CoV-2 is threatening people worldwide, and there are no drugs or vaccines available to mitigate its spread. The origin of the virus is still unclear, and whether pets and livestock can be infected and transmit SARS-CoV-2 are important…
View article: COVID-19: Epidemiology, Evolution, and Cross-Disciplinary Perspectives
COVID-19: Epidemiology, Evolution, and Cross-Disciplinary Perspectives Open
View article: Sec62 promotes early recurrence of hepatocellular carcinoma through activating integrinα/CAV1 signalling
Sec62 promotes early recurrence of hepatocellular carcinoma through activating integrinα/CAV1 signalling Open
Postsurgical recurrence within 2 years is the major cause of poor survival of hepatocellular carcinoma (HCC) patients. However, the molecular mechanism underlying HCC recurrence remains unclear. Here, we distinguish the function and mechan…
View article: Antiviral Activity of Germacrone against Pseudorabies Virus in Vitro
Antiviral Activity of Germacrone against Pseudorabies Virus in Vitro Open
Pseudorabies virus (PRV), a member of the Herpesviridae, is the causative agent of an acute infectious disease in a variety of animals. The emergence of a novel variant strain brought huge economic losses to the pig industry since classica…
View article: Antiviral Effect of Lithium Chloride and Diammonium Glycyrrhizinate on Porcine Deltacoronavirus In Vitro
Antiviral Effect of Lithium Chloride and Diammonium Glycyrrhizinate on Porcine Deltacoronavirus In Vitro Open
Porcine deltacoronavirus (PDCoV) is an emerging global swine virus that has a propensity for interspecies transmission. It was identified in Hong Kong in 2012. Given that neither specific antiviral drugs nor vaccines are available for newl…