Xun Sun
YOU?
Author Swipe
View article: Mechanism of inhibition of acid-mediated transthyretin aggregation by designed peptides
Mechanism of inhibition of acid-mediated transthyretin aggregation by designed peptides Open
Aggregation of transthyretin (TTR) causes TTR cardiomyopathy and polyneuropathy through amyloidosis. To initialize TTR aggregation, the native TTR tetramer first dissociates to a monomeric intermediate, which misfolds and self-assembles to…
View article: Mispacking of the <scp>F87</scp> sidechain drives aggregation‐promoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer
Mispacking of the <span>F87</span> sidechain drives aggregation‐promoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer Open
Aberrant formation and deposition of human transthyretin (TTR) aggregates causes transthyretin amyloidosis. To initialize aggregation, transthyretin tetramers must first dissociate into monomers that partially unfold to promote entry into …
View article: Conformational Dynamics of an Amyloidogenic Intermediate of Transthyretin: Implications for Structural Remodeling and Amyloid Formation
Conformational Dynamics of an Amyloidogenic Intermediate of Transthyretin: Implications for Structural Remodeling and Amyloid Formation Open
View article: Faraday moments of the Southern Twenty-centimeter All-sky Polarization Survey (STAPS)
Faraday moments of the Southern Twenty-centimeter All-sky Polarization Survey (STAPS) Open
Context. Faraday tomography of broadband radio polarization surveys enables us to study magnetic fields and their interaction with the interstellar medium (ISM). Such surveys include the Global Magneto-Ionic Medium Survey (GMIMS), which co…
View article: Mispacking of the F87 sidechain drives aggregation-promoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer
Mispacking of the F87 sidechain drives aggregation-promoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer Open
Aberrant formation and deposition of human transthyretin (TTR) aggregates causes transthyretin amyloidosis. To initialize aggregation, transthyretin tetramers must first dissociate into monomers that partially unfold to promote entry into …
View article: Abstract 1330 Sub-domain dynamics coordinate stepwise reactions for substrate activation in nonribosomal peptide synthetases
Abstract 1330 Sub-domain dynamics coordinate stepwise reactions for substrate activation in nonribosomal peptide synthetases Open
View article: Characterization of an amyloidogenic intermediate of transthyretin by NMR relaxation dispersion
Characterization of an amyloidogenic intermediate of transthyretin by NMR relaxation dispersion Open
The aggregation pathway of transthyretin (TTR) proceeds through rate-limiting dissociation of the tetramer and partial misfolding of the monomers, which assemble into amyloid structures through a downhill polymerization mechanism. The stru…
View article: A206 DUPILUMAB TREATMENT REDUCES THE FREQUENCY OF DYSPHAGIA DAYS AND ACTIONS TO RELIEVE DYSPHAGIA IN PATIENTS WITH EOSINOPHILIC ESOPHAGITIS (EOE): RESULTS FROM THE PHASE 3 LIBERTY EOE TREET STUDY
A206 DUPILUMAB TREATMENT REDUCES THE FREQUENCY OF DYSPHAGIA DAYS AND ACTIONS TO RELIEVE DYSPHAGIA IN PATIENTS WITH EOSINOPHILIC ESOPHAGITIS (EOE): RESULTS FROM THE PHASE 3 LIBERTY EOE TREET STUDY Open
Background Dysphagia is the predominant symptom of EoE in adolescents and adults. Aims To assess change in number of days with dysphagia, number of days with action taken to relieve dysphagia, and change in pain associated with dysphagia i…
View article: A213 DUPILUMAB EFFICACY IN EOSINOPHILIC ESOPHAGITIS PERSISTS FOR HISTOLOGIC, SYMPTOMATIC, AND ENDOSCOPIC OUTCOMES REGARDLESS OF CONCOMITANT HIGH-DOSE PROTON PUMP INHIBITOR USE
A213 DUPILUMAB EFFICACY IN EOSINOPHILIC ESOPHAGITIS PERSISTS FOR HISTOLOGIC, SYMPTOMATIC, AND ENDOSCOPIC OUTCOMES REGARDLESS OF CONCOMITANT HIGH-DOSE PROTON PUMP INHIBITOR USE Open
Background Proton-pump inhibitor (PPI) therapy is the most commonly used first-line therapy for eosinophilic esophagitis (EoE) but data informing long-term outcomes are limited. Aims This pre-specified analysis of data from the phase 3 LIB…
View article: Conformational Dynamics of an Amyloidogenic Intermediate of Transthyretin: Implications for Structural Remodeling and Amyloid Formation
Conformational Dynamics of an Amyloidogenic Intermediate of Transthyretin: Implications for Structural Remodeling and Amyloid Formation Open
View article: Probing the Dissociation Pathway of a Kinetically Labile Transthyretin Mutant
Probing the Dissociation Pathway of a Kinetically Labile Transthyretin Mutant Open
Aggregation of transthyretin (TTR) is associated with devastating amyloid diseases. Amyloidosis begins with the dissociation of the native homotetramer (a dimer of dimers) to form a monomeric intermediate that assembles into pathogenic agg…
View article: Subdomain dynamics enable chemical chain reactions in non-ribosomal peptide synthetases
Subdomain dynamics enable chemical chain reactions in non-ribosomal peptide synthetases Open
View article: Probing the dissociation pathway of a kinetically labile transthyretin mutant
Probing the dissociation pathway of a kinetically labile transthyretin mutant Open
Aggregation of transthyretin (TTR) is associated with devastating TTR amyloid disease. Amyloidosis begins with dissociation of the native tetramer to form a monomeric intermediate that assembles into pathogenic aggregates. This process is …
View article: Role of conformational dynamics in pathogenic protein aggregation
Role of conformational dynamics in pathogenic protein aggregation Open
View article: A141 DUPILUMAB IMPROVES CLINICAL, SYMPTOMATIC, ENDOSCOPIC, AND HISTOLOGIC ASPECTS OF EOE, REGARDLESS OF PRIOR SWALLOWED TOPICAL STEROID USE
A141 DUPILUMAB IMPROVES CLINICAL, SYMPTOMATIC, ENDOSCOPIC, AND HISTOLOGIC ASPECTS OF EOE, REGARDLESS OF PRIOR SWALLOWED TOPICAL STEROID USE Open
Background Swallowed topical corticosteroids (STC) are a first-line treatment for eosinophilic esophagitis (EoE) but are not uniformly effective. Dupilumab (DPL), a fully human monoclonal antibody, blocks the shared receptor component for …
View article: A transthyretin monomer intermediate undergoes local unfolding and transient interaction with oligomers in a kinetically concerted aggregation pathway
A transthyretin monomer intermediate undergoes local unfolding and transient interaction with oligomers in a kinetically concerted aggregation pathway Open
Transthyretin (TTR) amyloidosis is associated with tissue deposition of TTR aggregates. TTR aggregation is initiated by dissociation of the native tetramer to form a monomeric intermediate, which locally unfolds and assembles into soluble …
View article: Ginsenoside Rg5 Boost Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade through NF- κB Signaling in Colorectal Cancer
Ginsenoside Rg5 Boost Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade through NF- κB Signaling in Colorectal Cancer Open
The authors have requested that this preprint be removed from Research Square.
View article: Front Cover: From mouse to mouse‐ear cress: Nanomaterials as vehicles in plant biotechnology (EXP2 1/2021)
Front Cover: From mouse to mouse‐ear cress: Nanomaterials as vehicles in plant biotechnology (EXP2 1/2021) Open
In the cover of article number 20210002, Chun-Peng Song and colleagues revealed an illustration of how plant biotechnology could potentially revitalize and thrive when presented with the dynamic interplay with nanotechnology.
View article: Thermodynamic Stability and Aggregation Kinetics of EF Helix and EF Loop Variants of Transthyretin
Thermodynamic Stability and Aggregation Kinetics of EF Helix and EF Loop Variants of Transthyretin Open
Misfolding and aggregation of transthyretin (TTR) are linked to amyloid disease. Amyloidosis occurs when the TTR homotetramer dissociates into aggregation-prone monomers that self-assemble into amyloid. In familial transthyretin amyloidosi…
View article: Intermediary conformations linked to the directionality of the aminoacylation pathway of nonribosomal peptide synthetases
Intermediary conformations linked to the directionality of the aminoacylation pathway of nonribosomal peptide synthetases Open
In-solution analysis of conformational changes of NRPS adenylation and peptidyl-carrier protein domains under catalytic conditions reveals a new intermediary conformation.
View article: A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding
A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding Open
Significance The transcription factor p53 is a master tumor suppressor that controls the cellular response to genotoxic stress. Following DNA damage, p53 is activated by phosphorylation at multiple sites in the intrinsically disordered N-t…
View article: Dupilumab provides favourable long‐term safety and efficacy in children aged ≥ 6 to < 12 years with uncontrolled severe atopic dermatitis: results from an open‐label phase IIa study and subsequent phase III open‐label extension study
Dupilumab provides favourable long‐term safety and efficacy in children aged ≥ 6 to < 12 years with uncontrolled severe atopic dermatitis: results from an open‐label phase IIa study and subsequent phase III open‐label extension study Open
These safety and efficacy results support the use of dupilumab as a continuous long-term treatment for children aged ≥ 6 to < 12 years with severe AD.
View article: A phase 2, open‐label study of single‐dose dupilumab in children aged 6 months to <6 years with severe uncontrolled atopic dermatitis: pharmacokinetics, safety and efficacy
A phase 2, open‐label study of single‐dose dupilumab in children aged 6 months to <6 years with severe uncontrolled atopic dermatitis: pharmacokinetics, safety and efficacy Open
Background Dupilumab has demonstrated efficacy and acceptable safety in adults and children (aged 6–17 years) with moderate‐to‐severe atopic dermatitis (AD), but effective systemic therapy with a favorable risk–benefit profile in younger c…
View article: Faculty Opinions recommendation of Topological Analysis of Transthyretin Disassembly Mechanism: Surface-Induced Dissociation Reveals Hidden Reaction Pathways.
Faculty Opinions recommendation of Topological Analysis of Transthyretin Disassembly Mechanism: Surface-Induced Dissociation Reveals Hidden Reaction Pathways. Open
The proposed mechanism of fibril formation of transthyretin (TTR) involves self-assembly of partially unfolded monomers.However, the mechanism(s) of disassembly to monomer and potential intermediates involved in this process are not fully …
View article: Kinetic analysis of the multistep aggregation pathway of human transthyretin
Kinetic analysis of the multistep aggregation pathway of human transthyretin Open
Significance Aggregation of amyloidogenic proteins is implicated in a number of debilitating human diseases. A mechanistic understanding of their aggregation behavior requires a quantitative description of the multistep equilibria involved…
View article: Combined toxicity of cadmium and lead on early life stages of the Pacific oyster, Crassostrea gigas
Combined toxicity of cadmium and lead on early life stages of the Pacific oyster, Crassostrea gigas Open
Trace metals cause toxic effect on the early development period of marine animals, however only few studies address the toxic interactions of trace metals on bivalves. In the present study, the individual and combined toxicities of dissolv…
View article: Fluorotryptophan Incorporation Modulates the Structure and Stability of Transthyretin in a Site-Specific Manner
Fluorotryptophan Incorporation Modulates the Structure and Stability of Transthyretin in a Site-Specific Manner Open
Abnormal deposition of aggregated wild-type (WT) human transthyretin (TTR) and its pathogenic variants is responsible for cardiomyopathy and neuropathy related to TTR amyloidosis. The tryptophan (Trp) fluorescence measurements typically us…
View article: Remarkable enhancement of Fe–V–O<sub>x</sub> composite metal oxide to gold catalyst for CO oxidation in the simulated atmosphere of CO<sub>2</sub> laser
Remarkable enhancement of Fe–V–O<sub>x</sub> composite metal oxide to gold catalyst for CO oxidation in the simulated atmosphere of CO<sub>2</sub> laser Open
A novel Au/Fe–V–Ox/Al2O3 displays remarkable activity and good stability for CO oxidation in simulated atmosphere of CO2 laser. The higher Au dispersion and more labile lattice oxygen after modification con…
View article: A series of nano/micro-sized metal–organic frameworks with tunable photoluminescence properties
A series of nano/micro-sized metal–organic frameworks with tunable photoluminescence properties Open
Hierarchically assembled nanostructures of lanthanide-based MOFs with tunable emission have been successfully fabricated via a simple method at room temperature.