Xiu Shan
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View article: Cancer treatment-induced thrombocytopenia: diagnosis, mechanisms and management
Cancer treatment-induced thrombocytopenia: diagnosis, mechanisms and management Open
Cancer treatment-induced thrombocytopenia (CTIT) is a common adverse effect in malignant tumor patients, significantly increasing the risk of bleeding and negatively impacting treatment efficacy and quality of life. Current treatment optio…
View article: Post-translational modifications at the crossroads of cancer metabolism and immune regulation: therapeutic opportunities and challenges
Post-translational modifications at the crossroads of cancer metabolism and immune regulation: therapeutic opportunities and challenges Open
Post-translational modifications (PTMs) are chemical modifications that occur on specific amino acid residues after protein biosynthesis, which can affect protein function by altering protein structure, localization and activity, thus expa…
View article: Occurrences, spatial distributions, and ecological risks of organic ultraviolet absorbents in surface sediments from Taihu Lake, China
Occurrences, spatial distributions, and ecological risks of organic ultraviolet absorbents in surface sediments from Taihu Lake, China Open
The occurrences and spatial distributions of eight organic ultraviolet absorbents (UVAs) were investigated in surface sediments from Taihu Lake, China. The detection frequencies and concentrations of UVAs in 2016 were significantly higher …
View article: Ginsenoside Rg3 decreases breast cancer stem-like phenotypes through impairing MYC mRNA stability
Ginsenoside Rg3 decreases breast cancer stem-like phenotypes through impairing MYC mRNA stability Open
Breast cancer stem cells (BCSCs) are responsible for breast cancer metastasis, recurrence and treatment resistance, all of which make BCSCs potential drivers of breast cancer aggression. Ginsenoside Rg3, a traditional Chinese herbal medici…
View article: Intracranial complete remissions in an aumolertinib-treated EGFR mutation-positive non-small cell lung cancer (NSCLC) patient with symptomatic brain metastases and Eastern Cooperative Oncology Group performance status (ECOG PS) up to 4: a case report
Intracranial complete remissions in an aumolertinib-treated EGFR mutation-positive non-small cell lung cancer (NSCLC) patient with symptomatic brain metastases and Eastern Cooperative Oncology Group performance status (ECOG PS) up to 4: a case report Open
Our case presented a patient with EGFR-mutant NSCLC with symptomatic brain metastases. Aumolertinib proved to be a highly effective and well-tolerated treatment option for sustained disease control and comprehensive future studies are need…
View article: Norcantharidin overcomes vemurafenib resistance in melanoma by inhibiting pentose phosphate pathway and lipogenesis via downregulating the mTOR pathway
Norcantharidin overcomes vemurafenib resistance in melanoma by inhibiting pentose phosphate pathway and lipogenesis via downregulating the mTOR pathway Open
Melanoma is the most aggressive type of skin cancer with a high incidence and low survival rate. More than half of melanomas present the activating BRAF mutations, along which V600E mutant represents 70%–90%. Vemurafenib (Vem) is an FDA-ap…
View article: Age-Based Disparities in Metastatic Melanoma Patients Treated in the Immune Checkpoint Inhibitors (ICI) Versus Non-ICI Era: A Population-Based Study
Age-Based Disparities in Metastatic Melanoma Patients Treated in the Immune Checkpoint Inhibitors (ICI) Versus Non-ICI Era: A Population-Based Study Open
Immune checkpoint inhibitors (ICIs) have revolutionized metastatic melanoma treatment, but our knowledge of ICI activity across age groups is insufficient. Patients in different age groups with advanced melanoma were selected based on the …
View article: Administration of a Probiotic Mixture Ameliorates Cisplatin-Induced Mucositis and Pica by Regulating 5-HT in Rats
Administration of a Probiotic Mixture Ameliorates Cisplatin-Induced Mucositis and Pica by Regulating 5-HT in Rats Open
Probiotic-based therapies have been shown to be beneficial for chemotherapy-induced mucositis. Previous research has demonstrated that a probiotic mixture (Bifidobacterium brevis, Lactobacillus acidophilus, Lactobacillus casei, and Strepto…
View article: No Overall Survival Difference in the Immunotherapy Era for Rare Subtypes of Melanoma
No Overall Survival Difference in the Immunotherapy Era for Rare Subtypes of Melanoma Open
LETTER TO THE EDITOR Pathol. Oncol. Res., 17 June 2021 https://doi.org/10.3389/pore.2021.639004
View article: Efficacy and safety of endostatin in combination with chemotherapy in small cell lung cancer: a phase 2 single-arm multicenter open-label trial
Efficacy and safety of endostatin in combination with chemotherapy in small cell lung cancer: a phase 2 single-arm multicenter open-label trial Open
Endostatin combined with platinum-etoposide is safe and effective in the treatment of SCLC.
View article: Overall Survival in Heart Disease–Related Death in Non-Small Cell Lung Cancer Patients: Nonimmunotherapy Versus Immunotherapy Era: Population-Based Study
Overall Survival in Heart Disease–Related Death in Non-Small Cell Lung Cancer Patients: Nonimmunotherapy Versus Immunotherapy Era: Population-Based Study Open
The cardiotoxicity during immunotherapy administration leads to mortality by more than 42% and heart disease-related mortality among immunotherapy-linked cancers is still considered to be underestimated. In this study, the advanced stage o…
View article: Role of fucosyltransferase IV in the migration and invasion of human melanoma cells
Role of fucosyltransferase IV in the migration and invasion of human melanoma cells Open
Malignant melanoma is one of the most aggressive human tumor types, mainly due to its high invasion capability, metastatic properties, and the absence of effective treatments. Glycosylation serves a pivotal role in the migration and invasi…
View article: GRK2 desensitizes flow-induced responses in osteoblasts
GRK2 desensitizes flow-induced responses in osteoblasts Open
Bone desensitization after mechanical loading is essential for bone to adapt to its mechanical environment. However, the desensitization mechanism is unknown. Previous studies suggest that G protein-coupled receptors (GPCRs), including P2Y…
View article: Rg3 and down-regulating HDAC3 expression increase p53 acetylation and transcription activity.
Rg3 and down-regulating HDAC3 expression increase p53 acetylation and transcription activity. Open
Cells were treated with Rg3 (0, 50 µg/mL) for 24 h. (A) Western blotting analysis of the expression levels of Ac-p53 (k373/382) in A375, C8161 and SK-MEL-28 cells. (B) Immunofluorescent staining analysis of expression levels of Ac-p53 (k37…
View article: Rg3 inhibits the growth of melanoma xenograft tumors <i>in vivo</i>.
Rg3 inhibits the growth of melanoma xenograft tumors <i>in vivo</i>. Open
A375 cells xenografted nude mice were injected with vehicle or vector (control), Rg3 (20 mg/kg), shHDAC3 (150 µg DNA/mouse) or Rg3 (20 mg/kg) combined with shHDAC3 (150 µg DNA/mouse). The animal experiment was carried out for 28 days. (A) …
View article: Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down-regulating FUT4
Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down-regulating FUT4 Open
The epithelial-mesenchymal transition (EMT) is an important factor in lung cancer metastasis, and targeting EMT is a potential therapeutic strategy. Fucosyltransferase IV (FUT4) and its synthetic cancer sugar antigen Lewis Y (LeY) was abno…
View article: Down-regulating HDAC3 expression inhibits melanoma cell proliferation.
Down-regulating HDAC3 expression inhibits melanoma cell proliferation. Open
HDAC3 was detected by real-time PCR (A) and Western blotting (B) in A375 cells after tansfection with HDAC3 siRNAs. Cell viability was determined by CCK-8 assay in A375 and C8161 cells (C). PCNA protein expression in A375 and C8161 cells (…
View article: Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death
Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death Open
Abnormal glycosylation is catalyzed by the specific glycosyltransferases and correlates with tumor cell apoptosis. Increased fucosyltransferase IV (FUT4) is seen in many types of cancer, and manipulating FUT4 expression through specific si…
View article: Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta‐catenin signaling pathway
Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta‐catenin signaling pathway Open
Glycosylation plays a significant role in determining the receptivity of the uterine endometrium to embryo. Fucosyltransferase IV (FUT4) is expressed stage‐specifically in the uterine endometrium of mammalians, and considered as a marker o…
View article: Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/LeY expression
Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/LeY expression Open
Malignant melanoma is a destructive and lethal form of skin cancer with poor prognosis. An effective treatment for melanoma is greatly needed. Ginsenoside Rg3 is a herbal medicine with high antitumor activity. It is reported that abnormal …