Xiaohan Tong
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View article: Cytokine-independent induction of LGP2/DHX58 in viral infection
Cytokine-independent induction of LGP2/DHX58 in viral infection Open
Laboratory of genetics and physiology 2 (LGP2, also known as DHX58) is unique among members of the RIG-I-like receptor (RLR) family as it lacks the caspase activation and recruitment domain. Although LGP2 per se cannot directly activate do…
View article: Assessing the Role of Large Language Models Between ChatGPT and DeepSeek in Asthma Education for Bilingual Individuals: Comparative Study
Assessing the Role of Large Language Models Between ChatGPT and DeepSeek in Asthma Education for Bilingual Individuals: Comparative Study Open
Background Asthma is a chronic inflammatory airway disease requiring long-term management. Artificial intelligence (AI)–driven tools such as large language models (LLMs) hold potential for enhancing patient education, especially for multil…
View article: Reducing the availability of endogenous copper and glucose for cascade starvation therapy and chemodynamic therapy
Reducing the availability of endogenous copper and glucose for cascade starvation therapy and chemodynamic therapy Open
The rapid growth of tumors relies heavily on a continuous supply of essential nutrients, including glucose and copper. Disrupting the nutrient supply to tumors has become an increasingly focal point in tumor therapy. However, solely blocki…
View article: Synergistic toxicity of nanoplastics and Helicobacter pylori on digestive system in mice
Synergistic toxicity of nanoplastics and Helicobacter pylori on digestive system in mice Open
Nanoplastics, in combination with pathogenic microorganisms or toxic substances, have been shown to induce oxidative stress and disrupt energy and lipid metabolism, posing significant health risks. This study evaluated the toxic effects of…
View article: A Novel Single-Stage Boost Single-Phase Inverter and Its Composite Control Strategy to Suppress Low-Frequency Input Ripples
A Novel Single-Stage Boost Single-Phase Inverter and Its Composite Control Strategy to Suppress Low-Frequency Input Ripples Open
Low-frequency pulsating ripples exist on the input side of a single-phase inverter, which bring some adverse effects and harm to the inverter and photovoltaic power generation system. In order to suppress the low-frequency pulsating ripple…
View article: Mucin1 as a potential molecule for cancer immunotherapy and targeted therapy
Mucin1 as a potential molecule for cancer immunotherapy and targeted therapy Open
Mucin1 is a highly glycosylated type 1 transmembrane mucin that ranks second among 75 tumor-related antigens published by the National Cancer Institute, and has been identified as a possible therapeutic target over the past 30 years. MUC1 …
View article: A Dual Stimuli‐Responsive Nanoplatform Loaded Pt<sup>IV</sup>‐Triptolide Prodrug for Achieving Synergistic Therapy toward Breast Cancer
A Dual Stimuli‐Responsive Nanoplatform Loaded Pt<sup>IV</sup>‐Triptolide Prodrug for Achieving Synergistic Therapy toward Breast Cancer Open
To strengthen the antitumor efficacy and avoid toxicity to normal cells of cisplatin and triptolide, herein, an acid and glutathione (GSH) dual‐controlled nanoplatform for enhanced cancer treatment through the synergy of both “1+1” apoptos…
View article: Metformin Ameliorates D-Galactose-Induced Senescent Human Bone Marrow-Derived Mesenchymal Stem Cells by Enhancing Autophagy
Metformin Ameliorates D-Galactose-Induced Senescent Human Bone Marrow-Derived Mesenchymal Stem Cells by Enhancing Autophagy Open
Human bone marrow-derived mesenchymal stem cells (hBMSCs) are promising candidates for stem cell therapy in clinical trials. Applications of hBMSCs in clinical therapy are limited by cellular senescence due to long-term ex vivo expansion. …
View article: Helicobacter pylori regulates ILK signaling pathways to influence autophagy in gastric epithelial cells
Helicobacter pylori regulates ILK signaling pathways to influence autophagy in gastric epithelial cells Open
BackgroundThe ability of Helicobacter pylori to manipulate host autophagy is an important pathogenic mechanism.ResultsWe found a negative correlation between the expression of ILK and the autophagy marker protein LC3B in H. pylori-positive…
View article: Dietary supplementation of total flavonoids from Rhizoma Drynariae improves bone health in older caged laying hens
Dietary supplementation of total flavonoids from Rhizoma Drynariae improves bone health in older caged laying hens Open
Caged layer osteoporosis (CLO) is a common bone metabolism diseases and poses a great threat to the production of laying hens. So far, there is no effective nutrition intervention to prevent CLO. The objective of this study was to evaluate…
View article: Structural Characterization of the Helicase nsp10 Encoded by Porcine Reproductive and Respiratory Syndrome Virus
Structural Characterization of the Helicase nsp10 Encoded by Porcine Reproductive and Respiratory Syndrome Virus Open
Porcine reproductive and respiratory syndrome virus (PRRSV) is a major respiratory disease agent in pigs that causes enormous economic losses to the global swine industry. PRRSV helicase nsp10 is a multifunctional protein with translocatio…
View article: Structural Basis for Inhibiting Porcine Epidemic Diarrhea Virus Replication with the 3C-Like Protease Inhibitor GC376
Structural Basis for Inhibiting Porcine Epidemic Diarrhea Virus Replication with the 3C-Like Protease Inhibitor GC376 Open
Porcine epidemic diarrhea virus (PEDV), being highly virulent and contagious in piglets, has caused significant damage to the pork industries of many countries worldwide. There are no commercial drugs targeting coronaviruses (CoVs), and fe…