Xiaohong Chang
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View article: Association Between the C-Reactive Protein–Albumin–Lymphocyte Index and Endometriosis: Insights from the 1999–2006 National Health and Nutrition Examination Survey
Association Between the C-Reactive Protein–Albumin–Lymphocyte Index and Endometriosis: Insights from the 1999–2006 National Health and Nutrition Examination Survey Open
A significant inverse association was observed between the CALLY index and endometriosis prevalence among American adults, supporting its potential as a novel inflammatory marker for identifying individuals at elevated risk. However, as a …
View article: Mesenchymal stem cells: opening a new chapter in the treatment of gynecological diseases
Mesenchymal stem cells: opening a new chapter in the treatment of gynecological diseases Open
In recent years, mesenchymal stem cells (MSCs) have garnered significant attention as promising therapeutic tools for various diseases. To date, over ten MSC-based therapies have been approved and marketed worldwide, with their potential a…
View article: The Detection of Lymph Node Metastasis Metastases Using a Near-Infrared Fluorescent Probe Based on Tumor-Targeted Monoclonal Antibody Antibodies Specific: A Prospective Study in a Nude Mouse Model
The Detection of Lymph Node Metastasis Metastases Using a Near-Infrared Fluorescent Probe Based on Tumor-Targeted Monoclonal Antibody Antibodies Specific: A Prospective Study in a Nude Mouse Model Open
Background: To identify the metastatic lymph nodes and remove them accurately, the fluorescent surgical navigation ability of the ovarian cancer-specific fluorescent probe COC183B2-800 was assessed to verify the metastatic lymph nodes in t…
View article: Predicting CD27 expression and clinical prognosis in serous ovarian cancer using CT-based radiomics
Predicting CD27 expression and clinical prognosis in serous ovarian cancer using CT-based radiomics Open
Background This study aimed to develop and evaluate radiomics models to predict CD27 expression and clinical prognosis before surgery in patients with serous ovarian cancer (SOC). Methods We used transcriptome sequencing data and contrast-…
View article: Relationship between the change of ATP level controlled by ectonucleotidases and endometriosis-associated infertility and pain
Relationship between the change of ATP level controlled by ectonucleotidases and endometriosis-associated infertility and pain Open
Background The dysfunction of the immune system is one of the pathogeneses of endometriosis. Immune cells can not only affect the microenvironment of the endometrium by secreting cytokines and defensins but also promote angiogenesis, growt…
View article: Precise capture of circulating endometrial cells in endometriosis
Precise capture of circulating endometrial cells in endometriosis Open
Background: Endometriosis (EM) is a complex benign gynecological disease, but it has malignant biological behavior and can invade any part of the body. Clinical manifestations include pelvic pain, dysmenorrhea, infertility, pelvic nodules,…
View article: PRKDC-Mediated NHEJ May Play a Crucial Role in Aneuploidy of Chromosome 8-Driven Progression of Ovarian Cancer
PRKDC-Mediated NHEJ May Play a Crucial Role in Aneuploidy of Chromosome 8-Driven Progression of Ovarian Cancer Open
High malignancy is a prominent characteristic of epithelial ovarian cancer (EOC), emphasizing the necessity for further elucidation of the potential mechanisms underlying cancer progression. Aneuploidy and copy number variation (CNV) parti…
View article: Single-cell analysis reveals insights into epithelial abnormalities in ovarian endometriosis
Single-cell analysis reveals insights into epithelial abnormalities in ovarian endometriosis Open
Ovarian endometriosis is characterized by the growth of endometrial tissue within the ovary, causing infertility and chronic pain. However, its pathophysiology remains unclear. Utilizing high-precision single-cell RNA sequencing, we profil…
View article: Design and Synthesis of 4-Fluorophenyl-5-methylene-2(5<i>H</i>)-furanone Derivatives as Potent Quorum Sensing Inhibitors
Design and Synthesis of 4-Fluorophenyl-5-methylene-2(5<i>H</i>)-furanone Derivatives as Potent Quorum Sensing Inhibitors Open
Quorum sensing inhibitors (QSIs) are a class of compounds that can reduce the pathogenicity of bacteria without affecting bacterial growth. In this study, we designed and synthesized four series of 4-fluorophenyl-5-methylene-2(5H)-furanone…
View article: Characterization of candidate factors associated with the metastasis and progression of high-grade serous ovarian cancer
Characterization of candidate factors associated with the metastasis and progression of high-grade serous ovarian cancer Open
Background: High-grade serous ovarian cancer (HGSOC) is the biggest cause of gynecological cancer-related mortality because of its extremely metastatic nature. This study aimed to explore and evaluate the characteristics of candidate facto…
View article: Data from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
Data from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer Open
High-grade serous cancer (HGSC) is the most common subtype of ovarian cancer. HGSC is highly aggressive with poor patient outcomes, and a deeper understanding of HGSC tumorigenesis could help guide future treatment development. To systemat…
View article: Supplementary Table from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
Supplementary Table from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer Open
Supplementary Table from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
View article: Supplementary Table from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
Supplementary Table from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer Open
Supplementary Table from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
View article: Supplementary Data from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
Supplementary Data from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer Open
Supplementary Data from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
View article: Supplementary Data from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
Supplementary Data from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer Open
Supplementary Data from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
View article: Supplementary Table from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
Supplementary Table from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer Open
Supplementary Table from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
View article: Supplementary Table from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
Supplementary Table from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer Open
Supplementary Table from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
View article: Supplementary Table from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
Supplementary Table from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer Open
Supplementary Table from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
View article: Supplementary Figure from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
Supplementary Figure from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer Open
Supplementary Figure from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
View article: Supplementary Data from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
Supplementary Data from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer Open
Supplementary Data from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
View article: Supplementary Data from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
Supplementary Data from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer Open
Supplementary Data from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
View article: Data from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
Data from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer Open
High-grade serous cancer (HGSC) is the most common subtype of ovarian cancer. HGSC is highly aggressive with poor patient outcomes, and a deeper understanding of HGSC tumorigenesis could help guide future treatment development. To systemat…
View article: Supplementary Table from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
Supplementary Table from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer Open
Supplementary Table from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
View article: Supplementary Figure from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
Supplementary Figure from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer Open
Supplementary Figure from Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
View article: Influence of assisted reproductive technology and uterine leiomyoma on pregnancy outcomes in women with adenomyosis
Influence of assisted reproductive technology and uterine leiomyoma on pregnancy outcomes in women with adenomyosis Open
Aim To assess whether adverse pregnancy outcomes in women with adenomyosis are different according to the method of conception and the concurrent of uterine leiomyoma (UL). Methods We performed a retrospective study. Fifty-three singleton …
View article: Therapeutic drug monitoring (TDM) as intervention: A cross-sectional analysis of characteristics of 173 registered clinical trials
Therapeutic drug monitoring (TDM) as intervention: A cross-sectional analysis of characteristics of 173 registered clinical trials Open
The trials were mainly conducted in several economically prosperous countries. The number of registered trials had gradually increased during the past years. Novel biological drugs have increasingly become the research hotspot. We expect t…
View article: Influence of previous laparoscopic surgical and pathological diagnosis of endometriosis on pregnancy outcomes in women with adenomyosis
Influence of previous laparoscopic surgical and pathological diagnosis of endometriosis on pregnancy outcomes in women with adenomyosis Open
Objectives Previous studies demonstrated that endometriosis and adenomyosis are closely linked to lots of adverse pregnancy outcomes while the role of endometriosis in pregnant women with adenomyosis has not been explored yet. The present …
View article: Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer
Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer Open
High-grade serous cancer (HGSC) is the most common subtype of ovarian cancer. HGSC is highly aggressive with poor patient outcomes, and a deeper understanding of HGSC tumorigenesis could help guide future treatment development. To systemat…
View article: FGA Controls VEGFA Secretion to Promote Angiogenesis by Activating the VEGFR2-FAK Signalling Pathway
FGA Controls VEGFA Secretion to Promote Angiogenesis by Activating the VEGFR2-FAK Signalling Pathway Open
Background Our previous work revealed the high expression of fibrinogen alpha chain (FGA) in patients with endometriosis (EM) and that it could promote the migration and invasion of endometrial stromal cells. Angiogenesis is the key condit…