Xiaohong Duan
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View article: Correction: ALKBH5 suppresses miR-29a-3p expression, thereby exacerbating the inflammatory response associated with spinal tuberculosis
Correction: ALKBH5 suppresses miR-29a-3p expression, thereby exacerbating the inflammatory response associated with spinal tuberculosis Open
View article: New Dental Phenotypes And Related Genotypes In Nine CCD Patients
New Dental Phenotypes And Related Genotypes In Nine CCD Patients Open
Aim or purpose: Cleidocranial dysplasia (CCD) is a rare genetic disorder characterized by clavicle hypoplasia, delayed fontanelle closure, and dental anomalies. RUNX2 is the pathogenic gene of CCD, and there are few studies to identify whe…
View article: Dental Fluorosis Is Related With CFTR And Clc-3
Dental Fluorosis Is Related With CFTR And Clc-3 Open
Aim or purpose: Dental fluorosis (DF) is a common endemic disease affecting dental enamel. The traditional concept of DF is based on the environmental contamination effect of fluoride. More evidence have shown that genetic variations also …
View article: Identification of cytotoxic constituents from Siegesbeckiae Herba and network pharmacology prediction of their anti-pancreatic cancer mechanisms
Identification of cytotoxic constituents from Siegesbeckiae Herba and network pharmacology prediction of their anti-pancreatic cancer mechanisms Open
Pancreatic cancer remains a challenging malignancy with limited treatment options. This study aimed to isolate bioactive compounds from Siegesbeckiae Herba and explore their potential mechanisms against pancreatic cancer through network ph…
View article: Genetic-environmental Risk Factors for Tooth Agenesis: A Familial Case-control Study in China
Genetic-environmental Risk Factors for Tooth Agenesis: A Familial Case-control Study in China Open
Genetic contribution is more statistically significant in TA patients with more severe phenotypes, and in females. Heritability of TA declined with increased environmental exposure. Multiple genetic modes exist in TA families. Additionally…
View article: ALKBH5 suppresses miR-29a-3p expression, thereby exacerbating the inflammatory response associated with spinal tuberculosis
ALKBH5 suppresses miR-29a-3p expression, thereby exacerbating the inflammatory response associated with spinal tuberculosis Open
ALKBH5 was upregulated in both spinal tuberculosis tissues and cellular models, whereas miR-29a-3p exhibited marked downregulation. Inhibition of miR-29a-3p expression led to increased levels of tumor necrosis factor-α (TNF-α), interleukin…
View article: ABS0684 THE IMPACT OF LIFESTYLE HABITS ON DISEASE ACTIVITY AND IMMUNE PROFILES IN MYOSITIS PATIENTS: A COMPREHENSIVE STUDY
ABS0684 THE IMPACT OF LIFESTYLE HABITS ON DISEASE ACTIVITY AND IMMUNE PROFILES IN MYOSITIS PATIENTS: A COMPREHENSIVE STUDY Open
View article: Arhgap29 Deficiency Directly Leads to Systemic and Craniofacial Skeletal Abnormalities
Arhgap29 Deficiency Directly Leads to Systemic and Craniofacial Skeletal Abnormalities Open
The Arhgap29 gene encodes Rho-GTPase-activating protein 29 (Arhgap29), which plays a crucial role in embryonic tissue development. Mutations in the Arhgap29 gene are significantly associated with non-syndromic cleft lip and palate (NSCL/P)…
View article: Correction: Exposure to major coronary heart disease events reduces lung cancer risk: a Mendelian randomization study based on a European population
Correction: Exposure to major coronary heart disease events reduces lung cancer risk: a Mendelian randomization study based on a European population Open
View article: Expert consensus on classification and diagnosis of congenital orofacial cleft.
Expert consensus on classification and diagnosis of congenital orofacial cleft. Open
Congenital orofacial cleft, the most common birth defect in the maxillofacial region, exhibits a wide range of prognosis depending on the severity of deformity and underlying etiology. Non-syndromic congenital orofacial clefts typically pr…
View article: Exposure to major coronary heart disease events reduces lung cancer risk: a mendelian randomization study based on a European population
Exposure to major coronary heart disease events reduces lung cancer risk: a mendelian randomization study based on a European population Open
This study suggests that MCHDE reduce the risk of NSCLC in the U.K. population and SCLC in the Finnish population. However, given that the underlying mechanism through which MCHDE reduces the risk of NSCLC and SCLC remains unclear, it is p…
View article: Sex disparities in the association between rare earth elements exposure and genetic mutation frequencies in lung cancer patients
Sex disparities in the association between rare earth elements exposure and genetic mutation frequencies in lung cancer patients Open
View article: Spectrum of Craniofacial and Oral Malformations in China, a Multicenter Study
Spectrum of Craniofacial and Oral Malformations in China, a Multicenter Study Open
Objective Craniofacial and oral malformations (COMs) represent an important class of human developmental disorders with profound implications on the anatomical structure, appearance, and various physiological functions. In this study, we a…
View article: Fahr’s Syndrome with Pseudohypoparathyroidism: Oral Features and Genetic Insights
Fahr’s Syndrome with Pseudohypoparathyroidism: Oral Features and Genetic Insights Open
Fahr’s syndrome is a rare neurodegenerative disorder with limited research on its oral manifestations. This study investigates the dental features and genetic background of Fahr’s syndrome through a pedigree analysis and a retrospective li…
View article: Arhgap29 deficiency causes EEC like syndrome in mice
Arhgap29 deficiency causes EEC like syndrome in mice Open
View article: The Effect of Oral Mucosal Disinfection with Povidone-Iodine in Oral and Maxillofacial Surgery
The Effect of Oral Mucosal Disinfection with Povidone-Iodine in Oral and Maxillofacial Surgery Open
This study enrolled 60 patients aged 28 to 76 years who were oral malignancy undergoing radical surgery for more than 3 hours to assess the disinfection effect of povidone-iodine in oral and maxillofacial surgery which is a clean-contamina…
View article: Targeting N4BP2L1 for Therapy in IPF and SSc-ILD: Evidence from Mendelian Randomization and Multi-Omics Analysis
Targeting N4BP2L1 for Therapy in IPF and SSc-ILD: Evidence from Mendelian Randomization and Multi-Omics Analysis Open
Background: Systemic sclerosis-associated interstitial lung disease (SSc-ILD) and idiopathic pulmonary fibrosis (IPF) are paradigmatic conditions characterized by similar pathogenic mechanisms involving inflammation and fibrosis. Both diso…
View article: Migraine as Risk Factors for Lung Cancer: A Mendelian Randomization Study
Migraine as Risk Factors for Lung Cancer: A Mendelian Randomization Study Open
Background This study investigates the potential causal association between migraine experiences and an increased risk of lung cancer diagnosis. Utilizing a Mendelian randomization approach with two distinct cohorts, we aim to further exam…
View article: Characterization and mitigation of artifacts derived from NGS library preparation due to structure-specific sequences in the human genome
Characterization and mitigation of artifacts derived from NGS library preparation due to structure-specific sequences in the human genome Open
View article: Atp6v1h Deficiency Blocks Bone Loss in Simulated Microgravity Mice through the Fos-Jun-Src-Integrin Pathway
Atp6v1h Deficiency Blocks Bone Loss in Simulated Microgravity Mice through the Fos-Jun-Src-Integrin Pathway Open
The microgravity conditions in outer space are widely acknowledged to induce significant bone loss. Recent studies have implicated the close relationship between Atp6v1h gene and bone loss. Despite this, the role of Atp6v1h in bone remodel…
View article: Targeting N4BP2L1 for Therapy in IPF and SSc-ILD: Evidence from Mendelian Randomization and Multi-Omics Analysis
Targeting N4BP2L1 for Therapy in IPF and SSc-ILD: Evidence from Mendelian Randomization and Multi-Omics Analysis Open
View article: Potential Theranostic Roles of SLC4 Molecules in Human Diseases
Potential Theranostic Roles of SLC4 Molecules in Human Diseases Open
The solute carrier family 4 (SLC4) is an important protein responsible for the transport of various ions across the cell membrane and mediating diverse physiological functions, such as the ion transporting function, protein-to-protein inte…
View article: A unified DNA‐ and RNA‐based NGS strategy for the analysis of multiple types of variants at the dual nucleic acid level in solid tumors
A unified DNA‐ and RNA‐based NGS strategy for the analysis of multiple types of variants at the dual nucleic acid level in solid tumors Open
Background Targeted next‐generation sequencing (NGS) is a powerful and suitable approach to comprehensively identify multiple types of variants in tumors. RNA‐based NGS is increasingly playing an important role in precision oncology. Both …
View article: MACF1 deficiency suppresses tooth mineralization through IGF1 mediated crosstalk between odontoblasts and ameloblasts
MACF1 deficiency suppresses tooth mineralization through IGF1 mediated crosstalk between odontoblasts and ameloblasts Open
View article: <scp>Genotype‐phenotype</scp> analysis of selective failure of tooth eruption—A systematic review
<span>Genotype‐phenotype</span> analysis of selective failure of tooth eruption—A systematic review Open
Tooth eruption is an important and unique biological process during craniofacial development. Both the genetic and environmental factors can interfere with this process. Here we aimed to find the failure pattern of tooth eruption among fiv…
View article: Molecular Mechanisms of Craniofacial and Dental Abnormalities in Osteopetrosis
Molecular Mechanisms of Craniofacial and Dental Abnormalities in Osteopetrosis Open
Osteopetrosis is a group of genetic bone disorders characterized by increased bone density and defective bone resorption. Osteopetrosis presents a series of clinical manifestations, including craniofacial deformities and dental problems. H…
View article: Randomized Mendelian Study Investigating the Association between College or University Degrees and Lung Cancer Risk
Randomized Mendelian Study Investigating the Association between College or University Degrees and Lung Cancer Risk Open
View article: Unveiling the Metal Mutation Nexus: Exploring the Genomic Impacts of Heavy Metal Exposure in Lung Adenocarcinoma and Colorectal Cancer
Unveiling the Metal Mutation Nexus: Exploring the Genomic Impacts of Heavy Metal Exposure in Lung Adenocarcinoma and Colorectal Cancer Open
View article: Molecular Features in Lymphatic Metastases Reflect the Metastasis Mechanism of Lymph Nodes With Non-Small-Cell Lung Cancers
Molecular Features in Lymphatic Metastases Reflect the Metastasis Mechanism of Lymph Nodes With Non-Small-Cell Lung Cancers Open
Lymphatic metastasis influences clinical treatment and prognosis of patients with non-small-cell lung cancer (NSCLC). There is an urgency to understand the molecular features and mechanisms of lymph node metastasis. We analyzed the molecul…
View article: MACF1 Deficiency Suppresses Tooth Mineralization through IGF1 mediated Crosstalk Between Odontoblasts and Ameloblasts
MACF1 Deficiency Suppresses Tooth Mineralization through IGF1 mediated Crosstalk Between Odontoblasts and Ameloblasts Open
Tooth mineralization is a ubiquitous and tightly regulated process in vertebrates which usually share the similar mechanisms of bone mineralization. However, key molecules in tooth mineralization remain poorly identified. Previously, we sh…