Explanipedia

From iPSCs to myotubes: Identifying potential biomarkers for human FSHD by single‐cell transcriptomics Open

Wénwén Liú, Hao Chen, Jiao Jiao, Qinxin Zhang, Dong Liang , et al. · 2025

Rab14 promotes lipophagy and apoptosis of granulosa cells from POAT removed mice Open

Dan Zhong, Liangting Li, Juan Zhang, Yaping Guo, Yan Su , et al. · 2025

Peri-ovarian adipose tissue (POAT) plays an important role in the regulation of female reproductive, but its specific cellular mechanism is still unclear. Our study aimed to explore the effect of POAT removal on the development of mouse gr…

CircPAPPA binds to PAPPA and promotes trophoblast proliferation in spontaneous abortion through the formation of circPAPPA-PAPPA complexes Open

Shengtao Zhou, Liang Yu, Xiaojing Hou, Siqi Chen, Bo Liu , et al. · 2025

Altogether, our study shows that circPAPPA binds to PAPPA, enhancing trophoblast proliferation in vitro, and suggests that targeting the circPAPPA-PAPPA interaction might be a novel therapeutic strategy for addressing spontaneous abortion.

Peptide derived from <span>RAGE</span> efficiently improves oocyte development through attenuating oxidative stress in oocytes of mice with polycystic ovary syndrome Open

Xiaojing Hou, Zhonghui Ling, Yaping Guo, Yan Su, Hanbin Wang , et al. · 2024

Polycystic ovary syndrome (PCOS) is a common and complex endocrine disorder in reproductive‐aged women that frequently leads to infertility due to poor oocyte quality. In this study, we identified a new active peptide (advanced glycation e…

Multi-omics reveal the metabolic patterns in mouse cumulus cells during oocyte maturation Open

Ming Chen, Weizheng Yang, Yueshuai Guo, Xiaojing Hou, Shuai Zhu , et al. · 2023

Bi-directional communication between cumulus cells and the surrounded oocytes is important for the development and functions of both compartments. However, the metabolic framework in cumulus cells has not been systematically described. In …

Comparative assessment of embryotoxicity of 2,4,6-triiodophenol to mouse blastoid and pre-implantation embryo models Open

Xiaoqian Zhang, Shiyu An, Siya Liu, Jingfan Qiu, Wenyi Zhang , et al. · 2023

Embryonic developmental effects of disinfection by-products, which are generated during drinking water treatment and widely detected in environment, have gained more and more attention nowadays, calling for construction of in vitro researc…

Additional file 1 of Multi-omics reveal the metabolic patterns in mouse cumulus cells during oocyte maturation Open

Ming Chen, Weizheng Yang, Yueshuai Guo, Xiaojing Hou, Shuai Zhu , et al. · 2023

Additional file 1: Supplementary Table 1. Related to Fig. 1. Metabolomic profiling in cumulus cells surrounding GV/GVBD/MII oocyte.

Additional file 2 of Multi-omics reveal the metabolic patterns in mouse cumulus cells during oocyte maturation Open

Ming Chen, Weizheng Yang, Yueshuai Guo, Xiaojing Hou, Shuai Zhu , et al. · 2023

Additional file 2: Supplementary Table 2. Related to Fig. 2. Differentially Expressed Proteins in cumulus cells surrounding GV/GVBD/MII oocyte.

Protective Effect of Minocycline Hydrochloride on the Mouse Embryonic Development Against Suboptimal Environment Open

Xiaojing Hou, Changming Cai, Yuanlin He, Shiyu An, Shuqin Zhao , et al. · 2022

Numerous studies have reported how inner cell mass (ICM) and trophectoderm (TE) was determined during the process of early mouse embryonic development from zygotes into organized blastocysts, however, multiple mysteries still remain. It is…

Loss of PDK1 Induces Meiotic Defects in Oocytes From Diabetic Mice Open

Juan Ge, Na Zhang, Shoubin Tang, Feifei Hu, Xiaojing Hou , et al. · 2021

Maternal diabetes has been shown to impair oocyte quality; however, the underlying mechanisms remain unclear. Here, using a streptozotocin (STZ)-induced diabetic mouse model, we first detected and reduced expression of pyruvate dehydrogena…

Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation Open

Ling Li, Shuai Zhu, Wenjie Shu, Yueshuai Guo, Yusheng Guan , et al. · 2020

In vitro fertilization is associated with the onset and progression of preeclampsia Open

Jing Gui, Zhonghui Ling, Xiaojing Hou, Yuru Fan, Kaipeng Xie , et al. · 2019

IVF is associated with the onset and progression of PE. Defective placentation and placental insufficiency may predispose IVF patients to PE and may manifest as first-trimester bleeding.

Corrigendum to “Mitofusin1 in oocyte is essential for female fertility” [Redox Biol. 21 (2019) 101110] Open

Xiaojing Hou, Shuai Zhu, Hao Zhang, Chunling Li, Danhong Qiu , et al. · 2019

Mitofusin1 in oocyte is essential for female fertility Open

Xiaojing Hou, Shuai Zhu, Hao Zhang, Chunling Li, Danhong Qiu , et al. · 2019

Mitofusins (Mfn) are the important regulators of mitochondrial organization in mammalian cells; however, their roles during oocyte development remain unknown. In the present study, we generated mice with oocyte-specific knockout of Mfn1 or…

<span>SIRT</span>4 is essential for metabolic control and meiotic structure during mouse oocyte maturation Open

Juan Zeng, Man‐Xi Jiang, Xinghan Wu, Feiyang Diao, Danhong Qiu , et al. · 2018

SIRT 4 modulates energy homeostasis in multiple cell types and tissues. However, its role in meiotic oocytes remains unknown. Here, we report that mouse oocytes overexpressing SIRT 4 are unable to completely progress through meiosis, showi…

Sirt2‐BubR1 acetylation pathway mediates the effects of advanced maternal age on oocyte quality Open

Danhong Qiu, Xiaojing Hou, Longsen Han, Xiaoyan Li, Juan Ge , et al. · 2017

Summary The level of Sirt2 protein is reduced in oocytes from aged mice, while exogenous expression of Sirt2 could ameliorate the maternal age‐associated meiotic defects. To date, the underlying mechanism remains unclear. Here, we confirme…

Sirt3-dependent deacetylation of SOD2 plays a protective role against oxidative stress in oocytes from diabetic mice Open

Xiaohui Liu, Liang Zhang, Pan Wang, Xiaoyan Li, Danhong Qiu , et al. · 2017

Maternal diabetes has been demonstrated to adversely affect oocyte quality in mouse oocytes. However, the potential molecular mechanisms are poorly understood. Here, we established a type I diabetic mouse model and detected the increased r…

Epsin2 promotes polarity establishment and meiotic division through activating Cdc42 in mouse oocyte Open

Ling Li, Longsen Han, Jiaqi Zhang, Xiaohui Liu, Rujun Ma , et al. · 2016

Epsins are a conserved family of endocytic adaptors essential for diverse biological events. However, its role in oocytes remains completely unknown. Here, we report that specific depletion of Epsin2 in mouse oocytes significantly disrupts…

Rab6a is a novel regulator of meiotic apparatus and maturational progression in mouse oocytes Open

Xiaojing Hou, Jiaqi Zhang, Ling Li, Rujun Ma, Juan Ge , et al. · 2016

Sirt6 depletion causes spindle defects and chromosome misalignment during meiosis of mouse oocyte Open

Longsen Han, Juan Ge, Liang Zhang, Rujun Ma, Xiaojing Hou , et al. · 2015

Sirt3 prevents maternal obesity-associated oxidative stress and meiotic defects in mouse oocytes Open

Liang Zhang, Longsen Han, Rujun Ma, Xiaojing Hou, Yang Yu , et al. · 2015

Maternal obese environment has been reported to induce oxidative stress and meiotic defects in oocytes, however the underlying molecular mechanism remains unclear. Here, using mice fed a high fat diet (HFD) as an obesity model, we first de…

Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation Open

Xiaojing Hou, Liang Zhang, Longsen Han, Juan Ge, Rujun Ma , et al. · 2015

Pyruvate dehydrogenase kinases (PDKs) modulate energy homeostasis in multiple tissues and cell types, under various nutrient conditions, through phosphorylation of the α subunit (PDHE1α, also known as PDHA1) of the pyruvate dehydrogenase (…

Xiaojing Hou YOU? Author Swipe