Xiaohua Ni
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View article: Integrating multimodal ultrasound imaging and machine learning for predicting luminal and non-luminal breast cancer subtypes
Integrating multimodal ultrasound imaging and machine learning for predicting luminal and non-luminal breast cancer subtypes Open
Rationale and Objectives Breast cancer molecular subtypes significantly influence treatment outcomes and prognoses, necessitating precise differentiation to tailor individualized therapies. This study leverages multimodal ultrasound imagin…
View article: Advanced RPL19-TRAPKI-seq method reveals mechanism of action of bioactive compounds
Advanced RPL19-TRAPKI-seq method reveals mechanism of action of bioactive compounds Open
View article: Assessment and Spatiotemporal Changes of Multi-Source Temperature and Precipitation Data in Uzbekistan
Assessment and Spatiotemporal Changes of Multi-Source Temperature and Precipitation Data in Uzbekistan Open
View article: Evapotranspiration over Central Asia: History Characteristics, Future Trends, and Relationships with Climate Factors
Evapotranspiration over Central Asia: History Characteristics, Future Trends, and Relationships with Climate Factors Open
View article: ISCO: Intelligent Framework for Accurate Segmentation and Comparative Analysis of Organoids
ISCO: Intelligent Framework for Accurate Segmentation and Comparative Analysis of Organoids Open
Organoids are self-organizing 3D cell clusters that closely mimic the structure and function of in vivo tissues and organs. Quantifying organoid morphology is critical for advancing our understanding of organ development, drug discovery, a…
View article: Research on the influencing factors of the difference in warming rates between the east, west and central regions of North America during the 21st century
Research on the influencing factors of the difference in warming rates between the east, west and central regions of North America during the 21st century Open
Temperature in North America (NA) is a significant focus of current climate change research. This study focuses on various climate variables and employs linear regression and correlation coefficient analysis to examine the factors influenc…
View article: Epigenetic editing of <i>BRCA1</i> promoter increases cisplatin and olaparib sensitivity of ovarian cancer cells
Epigenetic editing of <i>BRCA1</i> promoter increases cisplatin and olaparib sensitivity of ovarian cancer cells Open
Drug resistance is the primary contributor to the high mortality rate of ovarian cancer (OC). The loss of BRCA1/2 function is linked to drug sensitivity in OC cells. The aim of this study is to enhance the drug sensitivity of OC cel…
View article: Promoter Methylation Changes in DNA Damage-Response Genes in Ovarian Cancer and Their Correlation with Prognosis
Promoter Methylation Changes in DNA Damage-Response Genes in Ovarian Cancer and Their Correlation with Prognosis Open
Background: Ovarian cancer has a poor prognosis, and DNA damage-response (DDR) genes are associated with both its occurrence and prognosis. However, previous studies have mostly focused on genetic mutations, with no clear conclusions on ep…
View article: Dynamic variations in and prediction of COVID-19 with omicron in the four first-tier cities of mainland China, Hong Kong, and Singapore
Dynamic variations in and prediction of COVID-19 with omicron in the four first-tier cities of mainland China, Hong Kong, and Singapore Open
Background The COVID-19 pandemic, which began in late 2019, has resulted in the devastating collapse of the social economy and more than 10 million deaths worldwide. A recent study suggests that the pattern of COVID-19 cases will resemble …
View article: Identification of an Immune Cell Infiltration-Related Prognostic Model to Guide Immunotherapy in Endometrial Carcinoma
Identification of an Immune Cell Infiltration-Related Prognostic Model to Guide Immunotherapy in Endometrial Carcinoma Open
Background: Uterine corpus endometrial carcinoma (UCEC) is a prevalent gynaecologic malignancy. It has been demonstrated that the immune cell infiltration (ICI) pattern plays a critical role in the tumour progression of UCEC. Methods: To f…
View article: Data from Systemic Administration and Targeted Radiosensitization via Chemically Synthetic Aptamer–siRNA Chimeras in Human Tumor Xenografts
Data from Systemic Administration and Targeted Radiosensitization via Chemically Synthetic Aptamer–siRNA Chimeras in Human Tumor Xenografts Open
Radiation therapy is a highly effective tool for treating all stages of prostate cancer, from curative approaches in localized disease to palliative care and enhanced survival for patients with distant bone metastases. The therapeutic inde…
View article: Supplementary Tables 1 and 2 and Supplementary Figures 1 through 3 from Systemic Administration and Targeted Radiosensitization via Chemically Synthetic Aptamer–siRNA Chimeras in Human Tumor Xenografts
Supplementary Tables 1 and 2 and Supplementary Figures 1 through 3 from Systemic Administration and Targeted Radiosensitization via Chemically Synthetic Aptamer–siRNA Chimeras in Human Tumor Xenografts Open
Supplementary Tables: Supplementary Table S1. Sequence of Chemically Synthesized Aptamers and RNA Supplementary Table S2. Sequences of primers for qRT-PCR and 5'RACE. Supplementary Figures: Supplementary Figure S1. 5'RACE analysis of Aptam…
View article: Supplementary Tables 1 and 2 and Supplementary Figures 1 through 3 from Systemic Administration and Targeted Radiosensitization via Chemically Synthetic Aptamer–siRNA Chimeras in Human Tumor Xenografts
Supplementary Tables 1 and 2 and Supplementary Figures 1 through 3 from Systemic Administration and Targeted Radiosensitization via Chemically Synthetic Aptamer–siRNA Chimeras in Human Tumor Xenografts Open
Supplementary Tables: Supplementary Table S1. Sequence of Chemically Synthesized Aptamers and RNA Supplementary Table S2. Sequences of primers for qRT-PCR and 5'RACE. Supplementary Figures: Supplementary Figure S1. 5'RACE analysis of Aptam…
View article: Data from Systemic Administration and Targeted Radiosensitization via Chemically Synthetic Aptamer–siRNA Chimeras in Human Tumor Xenografts
Data from Systemic Administration and Targeted Radiosensitization via Chemically Synthetic Aptamer–siRNA Chimeras in Human Tumor Xenografts Open
Radiation therapy is a highly effective tool for treating all stages of prostate cancer, from curative approaches in localized disease to palliative care and enhanced survival for patients with distant bone metastases. The therapeutic inde…
View article: Supplementary Methods, Figures 1-5, Tables 1-2 from miR-21: An Androgen Receptor–Regulated MicroRNA that Promotes Hormone-Dependent and Hormone-Independent Prostate Cancer Growth
Supplementary Methods, Figures 1-5, Tables 1-2 from miR-21: An Androgen Receptor–Regulated MicroRNA that Promotes Hormone-Dependent and Hormone-Independent Prostate Cancer Growth Open
Supplementary Methods, Figures 1-5, Tables 1-2 from miR-21: An Androgen Receptor–Regulated MicroRNA that Promotes Hormone-Dependent and Hormone-Independent Prostate Cancer Growth
View article: Data from miR-21: An Androgen Receptor–Regulated MicroRNA that Promotes Hormone-Dependent and Hormone-Independent Prostate Cancer Growth
Data from miR-21: An Androgen Receptor–Regulated MicroRNA that Promotes Hormone-Dependent and Hormone-Independent Prostate Cancer Growth Open
Androgen receptor (AR)–mediated oncogenic pathways have not been fully elucidated. In this study, we used high-throughput microarray analysis on two AR-positive prostate cancer (CaP) cell lines to identify 16 AR-responsive microRNAs (miRNA…
View article: Supplementary Methods, Figures 1-5, Tables 1-2 from miR-21: An Androgen Receptor–Regulated MicroRNA that Promotes Hormone-Dependent and Hormone-Independent Prostate Cancer Growth
Supplementary Methods, Figures 1-5, Tables 1-2 from miR-21: An Androgen Receptor–Regulated MicroRNA that Promotes Hormone-Dependent and Hormone-Independent Prostate Cancer Growth Open
Supplementary Methods, Figures 1-5, Tables 1-2 from miR-21: An Androgen Receptor–Regulated MicroRNA that Promotes Hormone-Dependent and Hormone-Independent Prostate Cancer Growth
View article: Data from miR-21: An Androgen Receptor–Regulated MicroRNA that Promotes Hormone-Dependent and Hormone-Independent Prostate Cancer Growth
Data from miR-21: An Androgen Receptor–Regulated MicroRNA that Promotes Hormone-Dependent and Hormone-Independent Prostate Cancer Growth Open
Androgen receptor (AR)–mediated oncogenic pathways have not been fully elucidated. In this study, we used high-throughput microarray analysis on two AR-positive prostate cancer (CaP) cell lines to identify 16 AR-responsive microRNAs (miRNA…
View article: Profiling the DNA methylation patterns of imprinted genes in abnormal semen samples by next-generation bisulfite sequencing
Profiling the DNA methylation patterns of imprinted genes in abnormal semen samples by next-generation bisulfite sequencing Open
View article: A DNA Aptamer Based Method for Detection of SARS-CoV-2 Nucleocapsid Protein
A DNA Aptamer Based Method for Detection of SARS-CoV-2 Nucleocapsid Protein Open
View article: Hypermethylation of the PTTG1IP promoter leads to low expression in early‑stage non‑small cell lung cancer
Hypermethylation of the PTTG1IP promoter leads to low expression in early‑stage non‑small cell lung cancer Open
Despite the clinical requirement for early diagnosis, the early events in lung cancer and their mechanisms are not fully understood. Pituitary tumor transforming gene 1 binding factor (PTTG1IP) is a tumor-associated gene; however, t…
View article: Identification of gene mutations in patients with primary periodic paralysis using targeted next-generation sequencing
Identification of gene mutations in patients with primary periodic paralysis using targeted next-generation sequencing Open
View article: Virulence difference of five type I dengue viruses and the intrinsic molecular mechanism
Virulence difference of five type I dengue viruses and the intrinsic molecular mechanism Open
Dengue virus (DENV) is the most important vector-borne virus globally. The safe and effective vaccines are still under development and there are no antiviral drugs for DENV induced diseases. In this study, we obtained five DENV1 isolates (…
View article: USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1
USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1 Open
Controlling translation initiation is an efficient way to regulate gene expression at the post-transcriptional level. However, current knowledge regarding regulatory proteins and their modes of controlling translation initiation is still l…
View article: Systemic Administration and Targeted Radiosensitization via Chemically Synthetic Aptamer–siRNA Chimeras in Human Tumor Xenografts
Systemic Administration and Targeted Radiosensitization via Chemically Synthetic Aptamer–siRNA Chimeras in Human Tumor Xenografts Open
Radiation therapy is a highly effective tool for treating all stages of prostate cancer, from curative approaches in localized disease to palliative care and enhanced survival for patients with distant bone metastases. The therapeutic inde…
View article: A functional screen identifies miRNAs that inhibit DNA repair and sensitize prostate cancer cells to ionizing radiation
A functional screen identifies miRNAs that inhibit DNA repair and sensitize prostate cancer cells to ionizing radiation Open
MicroRNAs (miRNAs) have been implicated in DNA repair pathways through transcriptional responses to DNA damaging agents or through predicted miRNA regulation of DNA repair genes. We hypothesized that additional DNA damage regulating miRNAs…