Xiaohua Peng
YOU?
Author Swipe
View article: H <sub>2</sub> O <sub>2</sub> –Responsive Anticancer Prodrug: Synthesis, Precision Deuteration in Search of In Vivo Metabolites, and Activation Pathway
H <sub>2</sub> O <sub>2</sub> –Responsive Anticancer Prodrug: Synthesis, Precision Deuteration in Search of In Vivo Metabolites, and Activation Pathway Open
Boron-based reactive oxygen species (ROS)-activated prodrugs offer a promising strategy for enhancing cancer selectivity, yet their in vivo activation remains poorly defined. We report a novel H2O2-responsive p…
View article: Abstract 2829 Exploring mechanisms of Vitamin C and ROS-Activated Prodrugs for Targeted and Selective Tumor Killing
Abstract 2829 Exploring mechanisms of Vitamin C and ROS-Activated Prodrugs for Targeted and Selective Tumor Killing Open
View article: Exploiting Vitamin C as a Prooxidant to Activate Ros-Responsive Prodrugs for Potent and Selective Tumor Killing
Exploiting Vitamin C as a Prooxidant to Activate Ros-Responsive Prodrugs for Potent and Selective Tumor Killing Open
View article: Generation of Hydrogen Peroxide in Cancer Cells: Advancing Therapeutic Approaches for Cancer Treatment
Generation of Hydrogen Peroxide in Cancer Cells: Advancing Therapeutic Approaches for Cancer Treatment Open
Cancer cells show altered antioxidant defense systems, dysregulated redox signaling, and increased generation of reactive oxygen species (ROS). Targeting cancer cells through ROS-mediated mechanisms has emerged as a significant therapeutic…
View article: Generation of Hydrogen Peroxide in Cancer Cells: Advancing Therapeutic Approaches for Cancer Treatment
Generation of Hydrogen Peroxide in Cancer Cells: Advancing Therapeutic Approaches for Cancer Treatment Open
Cancer cells show altered antioxidant defense systems, dysregulated redox signaling, and increased generation of reactive oxygen species (ROS). Targeting cancer cells through ROS-mediated mechanisms has emerged as a significant therapeutic…
View article: Improvement of TaC9-ABE mediated correction of human SMN2 gene
Improvement of TaC9-ABE mediated correction of human SMN2 gene Open
Spinal muscular atrophy (SMA) is a devastating neuromuscular disease caused by mutations in the survival motor neuron 1 ( SMN1 ) gene. Gene editing technology repairs the conversion of the 6th base T to C in exon 7 of the paralogous SMN2 g…
View article: Nanocomposite Hydrogel Needles with Self-Controlled Ado Release for Acupoint-Targeted Delivery Against Rheumatoid Arthritis
Nanocomposite Hydrogel Needles with Self-Controlled Ado Release for Acupoint-Targeted Delivery Against Rheumatoid Arthritis Open
View article: Retraction notice to “Generation of a homozygous ARHGAP11B knockout hiPSC line by CRISPR/Cas9 system” <[Stem Cell Res. 61 (2022) 102764]>
Retraction notice to “Generation of a homozygous ARHGAP11B knockout hiPSC line by CRISPR/Cas9 system” <[Stem Cell Res. 61 (2022) 102764]> Open
View article: Bcl-xL Promotes the Survival of Motor Neurons Derived from Neural Stem Cells
Bcl-xL Promotes the Survival of Motor Neurons Derived from Neural Stem Cells Open
Neural stem cell (NSC) transplantation creates new hope for the treatment of neurodegenerative disorders by direct differentiation into neurons. However, this technique is limited by poor survival and functional neuron deficiency. In this …
View article: Selective Separation of Zinc from Germanium-Bearing Iron Cake by a Roast-Leach Processselective Separation of Zinc from Germanium-Bearing Iron Cake by a Roast-Leach Process
Selective Separation of Zinc from Germanium-Bearing Iron Cake by a Roast-Leach Processselective Separation of Zinc from Germanium-Bearing Iron Cake by a Roast-Leach Process Open
View article: Development of 4,4’-Dibromobinaphthalene Analogues with Potent Photo-Inducible DNA Cross-Linking Capability and Cytotoxicity Towards Cancer Cells
Development of 4,4’-Dibromobinaphthalene Analogues with Potent Photo-Inducible DNA Cross-Linking Capability and Cytotoxicity Towards Cancer Cells Open
View article: The impact of serum thyroid-stimulation hormone levels on the outcome of hepatitis B virus related acute-on-chronic liver failure: an observational study
The impact of serum thyroid-stimulation hormone levels on the outcome of hepatitis B virus related acute-on-chronic liver failure: an observational study Open
View article: Eliminating predictable DNA off-target effects of cytosine base editor by using dual guiders including sgRNA and TALE
Eliminating predictable DNA off-target effects of cytosine base editor by using dual guiders including sgRNA and TALE Open
View article: RETRACTED: Generation of a homozygous ARHGAP11B knockout hiPSC line by CRISPR/ Cas9 system
RETRACTED: Generation of a homozygous ARHGAP11B knockout hiPSC line by CRISPR/ Cas9 system Open
The human specific gene ARHGAP11B is preferentially expressed in neural progenitors of fetal neocortex and plays a key role in the evolutionary expansion of the neocortex. Here, we generated a homozygous ARHGAP11B knockout human induced pl…
View article: Risk factors for underlying comorbidities and complications in patients with hepatitis B virus-related acute-on-chronic liver failure
Risk factors for underlying comorbidities and complications in patients with hepatitis B virus-related acute-on-chronic liver failure Open
Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a severe and life-threatening complication, characterised by multi-organ failure and high short-term mortality. However, there is limited information on the impact of v…
View article: Derivation and Validation of a Nomogram for Predicting 90-Day Survival in Patients With HBV-Related Acute-on-Chronic Liver Failure
Derivation and Validation of a Nomogram for Predicting 90-Day Survival in Patients With HBV-Related Acute-on-Chronic Liver Failure Open
Background: Conventional prognostic models do not fully reflect the severity of hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF). This study aimed to establish an effective and convenient nomogram for patients with HBV…
View article: Activation of Zr, ZrVHf and TiZrV Non-Evaporative Getters Characterized by In Situ Synchrotron Radiation Photoemission Spectroscopy
Activation of Zr, ZrVHf and TiZrV Non-Evaporative Getters Characterized by In Situ Synchrotron Radiation Photoemission Spectroscopy Open
The activation process of Zr, ZrVHf and TiZrV non-evaporative getter (NEG) thin films, prepared by direct current magnetron sputtering, is investigated by in situ synchrotron radiation photoemission spectroscopy. The activation temperature…
View article: Assessment of Phenylboronic Acid Nitrogen Mustards as Potent and Selective Drug Candidates for Triple-Negative Breast Cancer
Assessment of Phenylboronic Acid Nitrogen Mustards as Potent and Selective Drug Candidates for Triple-Negative Breast Cancer Open
Triple-negative breast cancer (TNBC) has limited treatment options and the worst prognosis among all types of breast cancer. We describe two prodrugs, namely, CWB-20145 (1) and its methyl analogue FAN-NM-CH3 (2) th…
View article: Crystallization of Jarosite from FeSO <sub>4</sub>-ZnSO <sub>4</sub>-K <sub>2</sub>SO <sub>4</sub>-Na <sub>2</sub>SO <sub>4</sub> Solution Using Hydrothermal Process in Autocalve Without Neutralizer
Crystallization of Jarosite from FeSO <sub>4</sub>-ZnSO <sub>4</sub>-K <sub>2</sub>SO <sub>4</sub>-Na <sub>2</sub>SO <sub>4</sub> Solution Using Hydrothermal Process in Autocalve Without Neutralizer Open
View article: Trichoderma Harzianum Enhances Resistance to Botrytis Cinerea by Promoting Photosynthesis, Redox Homeostasis and Secondary Metabolites in Tomato
Trichoderma Harzianum Enhances Resistance to Botrytis Cinerea by Promoting Photosynthesis, Redox Homeostasis and Secondary Metabolites in Tomato Open
View article: Narrative review of nutritional characteristics and supportive treatment of hepatitis B virus-related liver diseases
Narrative review of nutritional characteristics and supportive treatment of hepatitis B virus-related liver diseases Open
The liver is an important metabolic and synthetic organ of the human body. When liver injury and function decline, abnormal metabolism of various nutrients and different degrees of malnutrition may occur, and many studies have confirmed th…
View article: Derivation and validation of prognostic nomogram for HBV-related acute-on-chronic liver failure
Derivation and validation of prognostic nomogram for HBV-related acute-on-chronic liver failure Open
View article: Efficacy of ventriculoperitoneal shunting in patients with cryptococcal meningitis with intracranial hypertension
Efficacy of ventriculoperitoneal shunting in patients with cryptococcal meningitis with intracranial hypertension Open
View article: Effect of Triazole-Modified Thymidines on DNA and RNA Duplex Stability
Effect of Triazole-Modified Thymidines on DNA and RNA Duplex Stability Open
Previous reports showed that consecutive incorporations of triazole-modified 2′-deoxyuridines stabilized DNA·DNA and DNA·RNA duplexes due to additional π-stacking between triazole moieties. In this work, several triazole-modified thymidine…
View article: Nano-Brick Wall Architectures Account for Super Oxygen Barrier PET Film by Quadlayer Assembly of Polyelectrolytes and α-ZrP Nanoplatelets
Nano-Brick Wall Architectures Account for Super Oxygen Barrier PET Film by Quadlayer Assembly of Polyelectrolytes and α-ZrP Nanoplatelets Open
Nanobrick wall hybrid coating with super oxygen barrier properties were fabricated on polyethylene terephthalate (PET) film using a quadlayer (QL) assembly of polyelectrolytes and nanoplateles. A quadlayer assembly consists of three repeat…
View article: Enhanced Properties of Biodegradable Poly(Propylene Carbonate)/Polyvinyl Formal Blends by Melting Compounding
Enhanced Properties of Biodegradable Poly(Propylene Carbonate)/Polyvinyl Formal Blends by Melting Compounding Open
Polyvinyl formal (PVF) was first synthesized via the reaction of poly(vinyl alcohol) (PVA) and formaldehyde. The synthesized PVF exhibits a high decomposition temperature, glass transition temperature, and low melting point compared to pri…
View article: Biodegradable and Toughened Composite of Poly(Propylene Carbonate)/Thermoplastic Polyurethane (PPC/TPU): Effect of Hydrogen Bonding
Biodegradable and Toughened Composite of Poly(Propylene Carbonate)/Thermoplastic Polyurethane (PPC/TPU): Effect of Hydrogen Bonding Open
The blends of Poly(propylene carbonate) (PPC) and polyester-based thermoplastic polyurethane (TPU) were melt compounded in an internal mixer. The compatibility, thermal behaviors, mechanical properties and toughening mechanism of the blend…
View article: Corrigendum: Photoinduced DNA Interstrand Cross‐Link Formation by Naphthalene Boronates via a Carbocation
Corrigendum: Photoinduced DNA Interstrand Cross‐Link Formation by Naphthalene Boronates via a Carbocation Open
The authors learned of an error in the publication of their manuscript, where Figure 3 was duplicated and mistakenly placed in the position of Figure 1. This error was introduced during the final production and typesetting stage and was no…
View article: Power Line Interference Suppression for ECG Signal Recovery
Power Line Interference Suppression for ECG Signal Recovery Open
The electrocardiogram (ECG) recovery is very important for clinical diagnosis, especially in the presence of power line interference (PLI). In this work, to suppress the PLI, it is modeled as a linear combination of sinusoidal signals that…
View article: The Association between Expression of NK Cells and Prognosis of Patients with HBV Acute-on-Chronic Liver Failure in Advanced Phase
The Association between Expression of NK Cells and Prognosis of Patients with HBV Acute-on-Chronic Liver Failure in Advanced Phase Open
Acute-on-chronic liver failure (Acute-on-chronic liver failure, ACLF) is acute liver function decompensation on the basis of chronic liver disease. The progression of ACLF develops from advanced phase, plateau phase to remission phase. The…